Patents by Inventor Rajaram Krishnan

Rajaram Krishnan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND SYSTEMS FOR DETECTION AND DISCOVERY OF BIOMARKERS
    Publication number: 20240069035
    Abstract: Provided herein are methods and systems for discovering biomarkers associated with risk of disease and methods using identified biomarkers for detecting disease prognosis and progression.
    Type: Application
    Filed: January 12, 2022
    Publication date: February 29, 2024
    Inventors: Rajaram KRISHNAN, Robert TURNER, Juan Pablo HINESTROSA SALAZAR, Jean LEWIS, Iryna CLARK, David SEARSON
  • Dielectric materials
    Patent number: 11883833
    Abstract: The present disclosure describes methods, devices and systems comprising materials comprising dielectrics. In various aspects, electrodes layered or imbedded with these dielectrics provide enhanced properties for a wide range of applications, such as the enhanced separation of analytes, such as biological molecules or particles (nucleic acids, viruses) with an electrokinetic field.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: January 30, 2024
    Assignee: BIOLOGICAL DYNAMICS, INC.
    Inventors: Juan Pablo Hinestrosa Salazar, Rajaram Krishnan, Scott Conradson, Tyler Lee Harris, Robert Paul Turner, George Maroor Thomas
  • METHODS AND DEVICES FOR DETECTION OF MULTIPLE ANALYTES FROM A BIOLOGICAL SAMPLE
    Publication number: 20230338956
    Abstract: The present invention includes methods, devices and systems for isolating, identifying, analyzing, and quantifying biological materials from fluid samples. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity biological materials from complex fluids such as blood, serum, or plasma.
    Type: Application
    Filed: June 23, 2023
    Publication date: October 26, 2023
    Inventors: Rajaram KRISHNAN, Juan Pablo HINESTROSA SALAZAR, Robert Paul TURNER, David Joseph SEARSON, James Gregory MADSEN, Robert KOVELMAN
  • Methods and devices for detection of multiple analytes from a biological sample
    Patent number: 11731132
    Abstract: The present invention includes methods, devices and systems for isolating, identifying, analyzing, and quantifying biological materials from fluid samples. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity biological materials from complex fluids such as blood, serum, or plasma.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: August 22, 2023
    Assignee: BIOLOGICAL DYNAMICS, INC.
    Inventors: Rajaram Krishnan, Juan Pablo Hinestrosa Salazar, Robert Paul Turner, David Joseph Searson, James Gregory Madsen, Robert Kovelman
  • MODIFICATION OF METALLIC SURFACES WITH PHOSPHONIC ACIDS
    Publication number: 20230250536
    Abstract: Provided herein are methods and reagents for functionalization of metallic surfaces, including platinum, gold, palladium, iridium, and rhodium. The methods and reagents provided herein use phosphonic acid or phosphonate ester reagents as a source of attachment for various functionalities, thereby allowing modification of the surface with desired properties. The modified surfaces provided herein are useful for a variety of applications, including prevention of biofouling on metallic surfaces.
    Type: Application
    Filed: July 9, 2021
    Publication date: August 10, 2023
    Inventors: Tyler Lee HARRIS, Robert Paul TURNER, Juan Pablo HINESTROSA SALAZAR, Rajaram KRISHNAN
  • DISPOSABLE FLUIDIC CARTRIDGE AND COMPONENTS
    Publication number: 20230182132
    Abstract: Disclosed are cartridge components, cartridges, systems, and methods for isolating analytes from biological samples. In various aspects, the cartridge components, cartridges, systems, and methods may allow for a rapid procedure that requires a minimal amount of material from complex fluids.
    Type: Application
    Filed: December 15, 2022
    Publication date: June 15, 2023
    Inventors: Robert TURNER, James MADSEN, Kai YANG, Juan Pablo HINESTROSA SALAZAR, Rajaram KRISHNAN, Pedro David SIMON HERRERA
  • Compact device for detection of nanoscale analytes
    Patent number: 11534756
    Abstract: Disclosed are cartridge components, cartridges, systems, and methods for isolating analytes from biological samples. In various aspects, the cartridge components, cartridges, systems, and methods may allow for a rapid procedure that requires a minimal amount of material from complex fluids.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: December 27, 2022
    Assignee: Biological Dynamics, Inc.
    Inventors: Robert Turner, James Madsen, Kai Yang, Juan Pablo Hinestrosa Salazar, Rajaram Krishnan, Pedro David Simon Herrera
  • METHODS AND DEVICES FOR DETECTING AND QUANTIFYING CELL-FREE DNA FRAGMENTS
    Publication number: 20210214798
    Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.
    Type: Application
    Filed: December 19, 2018
    Publication date: July 15, 2021
    Inventors: Rajaram KRISHNAN, Juan Pablo HINESTROSA SALAZAR, Robert Paul TURNER, Robert KOVELMAN
  • DIELECTRIC MATERIALS
    Publication number: 20210146378
    Abstract: The present disclosure describes methods, devices and systems comprising materials comprising dielectrics. In various aspects, electrodes layered or imbedded with these dielectrics provide enhanced properties for a wide range of applications, such as the enhanced separation of analytes, such as biological molecules or particles (nucleic acids, viruses) with an electrokinetic field.
    Type: Application
    Filed: April 1, 2019
    Publication date: May 20, 2021
    Inventors: Juan Pablo HINESTROSA SALAZAR, Rajaram KRISHNAN, Scott CONRADSON, Tyler Lee HARRIS, Robert Paul TURNER, George Maroor THOMAS
  • METHODS AND DEVICES FOR DETECTION OF MULTIPLE ANALYTES FROM A BIOLOGICAL SAMPLE
    Publication number: 20210101150
    Abstract: The present invention includes methods, devices and systems for isolating, identifying, analyzing, and quantifying biological materials from fluid samples. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity biological materials from complex fluids such as blood, serum, or plasma.
    Type: Application
    Filed: December 19, 2018
    Publication date: April 8, 2021
    Inventors: Rajaram KRISHNAN, Juan Pablo HINESTROSA SALAZAR, Robert Paul TURNER, David Joseph SEARSON, James Gregory MADSEN, Robert KOVELMAN
  • METHODS AND SYSTEMS FOR ANALYTE INFORMATION PROCESSING
    Publication number: 20210020275
    Abstract: Systems, devices, media, methods, and kits are disclosed to integrate and exchange information of analyte analysis kits. Analyte analysis can be performed and presented using in association with advertising or questions.
    Type: Application
    Filed: September 25, 2020
    Publication date: January 21, 2021
    Inventors: Rajaram KRISHNAN, Iryna CLARK, Robert TURNER, Robert KOVELMAN, Juan Pablo HINESTROSA SALAZAR, David LIU
  • Methods and systems for analyte information processing
    Patent number: 10818379
    Abstract: Systems, devices, media, methods, and kits are disclosed to integrate and exchange information of analyte analysis kits. Analyte analysis can be performed and presented using in association with advertising or questions.
    Type: Grant
    Filed: May 8, 2018
    Date of Patent: October 27, 2020
    Assignee: BIOLOGICAL DYNAMICS, INC.
    Inventors: Rajaram Krishnan, Iryna Clark, Robert Turner, Robert Kovelman, Juan Pablo Hinestrosa Salazar, David Liu
  • DISPOSABLE FLUIDIC CARTRIDGE AND COMPONENTS
    Publication number: 20190210023
    Abstract: Disclosed are cartridge components, cartridges, systems, and methods for isolating analytes from biological samples. In various aspects, the cartridge components, cartridges, systems, and methods may allow for a rapid procedure that requires a minimal amount of material from complex fluids.
    Type: Application
    Filed: March 15, 2019
    Publication date: July 11, 2019
    Inventors: Robert TURNER, James MADSEN, Kai YANG, Juan Pablo HINESTROSA SALAZAR, Rajaram KRISHNAN, Pedro David SIMON HERRERA
  • PARTICLE BASED IMMUNOASSAY WITH ALTERNATING CURRENT ELECTROKINETICS
    Publication number: 20180345284
    Abstract: Disclosed are methods, devices and systems of an immunoassay using an alternate current electrokinetic platform. Also disclosed are methods of separating and detecting analytes from a sample using the disclosed methods.
    Type: Application
    Filed: May 4, 2016
    Publication date: December 6, 2018
    Inventors: David CHARLOT, Juan Pablo HINESTROSA SALAZAR, George Maroor THOMAS, Jacob Isaac GRIMBERG, Rajaram KRISHNAN
  • METHODS AND SYSTEMS FOR ANALYTE INFORMATION PROCESSING
    Publication number: 20180322941
    Abstract: Systems, devices, media, methods, and kits are disclosed to integrate and exchange information of analyte analysis kits. Analyte analysis can be performed and presented using in association with advertising or questions.
    Type: Application
    Filed: May 8, 2018
    Publication date: November 8, 2018
    Inventors: Rajaram KRISHNAN, Iryna CLARK, Robert TURNER, Robert KOVELMAN, Juan Pablo HINESTROSA SALAZAR, David LIU
  • NUCLEIC ACID SAMPLE PREPARATION
    Publication number: 20180274014
    Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.
    Type: Application
    Filed: May 29, 2018
    Publication date: September 27, 2018
    Inventors: Rajaram KRISHNAN, David J. CHARLOT, Eugene TU, James MCCANNA, Lucas KUMOSA, Paul D. SWANSON, Robert TURNER, Kai YANG, Irina DOBROVOLSKAYA, David LIU, Juan Pablo HINESTROSA SALAZAR, Juscilene MENEZES
  • Nucleic acid sample preparation
    Patent number: 10006083
    Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: June 26, 2018
    Assignee: BIOLOGICAL DYNAMICS, INC.
    Inventors: Rajaram Krishnan, David J. Charlot, Eugene Tu, James McCanna, Lucas Kumosa, Paul D. Swanson, Robert Turner, Kai Yang, Irina Dobrovolskaya, David Liu, Juan Pablo Hinestrosa Salazar, Juscilene Menezes
  • Nucleic acid sample preparation
    Patent number: 9827565
    Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: November 28, 2017
    Assignee: BIOLOGICAL DYNAMICS, INC.
    Inventors: Rajaram Krishnan, David Charlot, Eugene Tu, James McCanna, Lucas Kumosa, Paul Swanson, Robert Turner, Kai Yang, Irina Dobrovolskaya, David Liu
  • Devices for separation of biological materials
    Patent number: 9682385
    Abstract: The present invention includes methods, devices and systems for isolating nanoparticulates, including nucleic acids, from biological samples. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity isolation of biological components from complex fluids such as blood or environmental samples.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: June 20, 2017
    Assignee: BIOLOGICAL DYNAMICS, INC.
    Inventors: David Charlot, Juan Pablo Hinestrosa Salazar, Irina V. Dobrovolskaya, Kai Yang, Paul Swanson, Rajaram Krishnan
  • NUCLEIC ACID SAMPLE PREPARATION
    Publication number: 20170137870
    Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.
    Type: Application
    Filed: June 19, 2015
    Publication date: May 18, 2017
    Inventors: Rajaram KRISHNAN, David J. CHARLOT, Eugene TU, James MCCANNA, Lucas KUMOSA, Paul D. SWANSON, Robert TURNER, Kai YANG, Irina DOBROVOLSKAYA, David LIU, Juan Pablo HINESTROSA SALAZAR, Juscilene MENEZES