Patents by Inventor Rajaram Krishnan

Rajaram Krishnan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170072395
    Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.
    Type: Application
    Filed: October 13, 2016
    Publication date: March 16, 2017
    Inventors: Rajaram KRISHNAN, David CHARLOT, Eugene TU, James MCCANNA, Lucas KUMOSA, Paul SWANSON, Robert TURNER, Kai YANG, Irina DOBROVOLSKAYA, David LIU
  • Patent number: 9499812
    Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: November 22, 2016
    Assignee: BIOLOGICAL DYNAMICS, INC.
    Inventors: Rajaram Krishnan, David Charlot, Eugene Tu, James McCanna, Lucas Kumosa, Paul Swanson, Robert Turner, Kai Yang, Irina Dobrovolskaya, David Liu
  • Publication number: 20160327549
    Abstract: Disclosed are methods, devices and systems of an immunoassay using an alternate current electrokinetic platform. Also disclosed are methods of separating and detecting analytes from a sample using the disclosed methods.
    Type: Application
    Filed: May 4, 2016
    Publication date: November 10, 2016
    Inventors: David CHARLOT, Juan Pablo HINESTROSA SALAZAR, George Maroor THOMAS, Jacob Isaac GRIMBERG, Rajaram KRISHNAN
  • Publication number: 20160271622
    Abstract: The present invention includes methods, devices and systems for isolating nanoparticulates, including nucleic acids, from biological samples. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity isolation of biological components from complex fluids such as blood or environmental samples.
    Type: Application
    Filed: June 2, 2016
    Publication date: September 22, 2016
    Inventors: David CHARLOT, Juan Pablo HINESTROSA SALAZAR, Irina V. DOBROVOLSKAYA, Kai YANG, Paul SWANSON, Rajaram KRISHNAN
  • Patent number: 9387489
    Abstract: The present invention includes methods, devices and systems for isolating nanoparticulates, including nucleic acids, from biological samples. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity isolation of biological components from complex fluids such as blood or environmental samples.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: July 12, 2016
    Assignee: BIOLOGICAL DYNAMICS, INC.
    Inventors: David Charlot, Juan Pablo Hinestrosa Salazar, Irina V. Dobrovolskaya, Kai Yang, Paul Swanson, Rajaram Krishnan
  • Publication number: 20160046926
    Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.
    Type: Application
    Filed: October 28, 2015
    Publication date: February 18, 2016
    Inventors: Rajaram KRISHNAN, David CHARLOT, Eugene TU, James MCCANNA, Lucas KUMOSA, Paul SWANSON, Robert TURNER, Kai YANG, Irina DOBROVOLSKAYA, David LIU
  • Patent number: 9206416
    Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.
    Type: Grant
    Filed: October 30, 2013
    Date of Patent: December 8, 2015
    Assignee: BIOLOGICAL DYNAMICS, INC.
    Inventors: Rajaram Krishnan, David Charlot, Eugene Tu, James McCanna, Lucas Kumosa, Paul Swanson, Robert Turner, Kai Yang, Irina Dobrovolskaya, David Liu
  • Publication number: 20150283553
    Abstract: The present invention includes methods, devices and systems for isolating nanoparticulates, including nucleic acids, from biological samples. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity isolation of biological components from complex fluids such as blood or environmental samples.
    Type: Application
    Filed: April 7, 2015
    Publication date: October 8, 2015
    Inventors: David Charlot, Juan Pablo HINESTROSA SALAZAR, Irina V. DOBROVOLSKAYA, Kai Yang, Paul SWANSON, Rajaram Krishnan
  • Publication number: 20150219618
    Abstract: The present invention includes methods, devices and systems for isolating a target biological material from a biological sample. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in isolated target biological material from complex fluids such as blood or environmental samples.
    Type: Application
    Filed: July 18, 2013
    Publication date: August 6, 2015
    Inventors: Rajaram Krishnan, David Charlot, Eugene Tu, Jerry Lu
  • Patent number: 9034579
    Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: May 19, 2015
    Assignee: BIOLOGICAL DYNAMICS, INC
    Inventors: Rajaram Krishnan, David J. Charlot, Eugene Tu, James McCanna, Lucas Kumosa, Paul D. Swanson, Robert Turner, Kai Yang, Irina Dobrovolskaya, David Liu, Juan Pablo Hinestrosa Salazar, Juscilene Menezes
  • Patent number: 9034578
    Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: May 19, 2015
    Assignee: BIOLOGICAL DYNAMICS, INC.
    Inventors: Rajaram Krishnan, David Charlot, Eugene Tu, James McCanna, Lucas Kumosa, Paul Swanson, Robert Turner, Kai Yang, Irina Dobrovolskaya, David Liu
  • Publication number: 20150104858
    Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.
    Type: Application
    Filed: October 10, 2014
    Publication date: April 16, 2015
    Inventors: Rajaram KRISHNAN, David J. CHARLOT, Eugene TU, James MCCANNA, Lucas KUMOSA, Paul D. SWANSON, Robert TURNER, Kai YANG, Irina DOBROVOLSKAYA, David LIU, Juan Pablo HINESTROSA SALAZAR, Juscilene MENEZES
  • Patent number: 9005941
    Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: April 14, 2015
    Assignee: Biological Dynamics, Inc.
    Inventors: Rajaram Krishnan, David Charlot, Eugene Tu, James McCanna, Lucas Kumosa, Paul D. Swanson, Robert Turner, Kai Yang, Irina Dobrovolskaya, David Liu
  • Publication number: 20150083595
    Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.
    Type: Application
    Filed: October 7, 2014
    Publication date: March 26, 2015
    Inventors: Rajaram KRISHNAN, David CHARLOT, Eugene TU, James MCCANNA, Lucas KUMOSA, Paul SWANSON, Robert TURNER, Kai YANG, Irina DOBROVOLSKAYA, David LIU
  • Patent number: 8969059
    Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.
    Type: Grant
    Filed: February 28, 2014
    Date of Patent: March 3, 2015
    Assignee: Biological Dynamics, Inc.
    Inventors: Rajaram Krishnan, David Charlot, Eugene Tu, James McCanna, Lucas Kumosa, Paul Swanson, Robert Turner, Kai Yang, Irina Dobrovolskaya, David Liu
  • Patent number: 8932447
    Abstract: Devices and techniques are described that involve a combination of multidimensional electrokinetic, dielectrophoretic, electrophoretic and fluidic forces and effects for separating cells, nanovesicles, nanoparticulates and biomarkers (DNA, RNA, antibodies, proteins) in high conductance (ionic) strength biological samples and buffers. In disclosed embodiments, a combination of continuous and/or pulsed dielectrophoretic (DEP) forces, continuous and/or pulsed field DC electrophoretic forces, microelectrophoresis and controlled fluidics are utilized with arrays of electrodes. In particular, the use of chambered DEP devices and of a properly scaled relatively larger electrode array devices that combines fluid, electrophoretic and DEP forces enables both larger and/or clinically relevant volumes of blood, serum, plasma or other samples to be more directly, rapidly and efficiently analyzed. The invention enables the creation of “seamless” sample-to-answer diagnostic systems and devices.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: January 13, 2015
    Assignee: The Regents of the University of California
    Inventors: Michael Heller, Benjamin Sullivan, Rajaram Krishnan, Dennis Carson, Sadik C. Esener
  • Patent number: 8932815
    Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: January 13, 2015
    Assignee: Biological Dynamics, Inc.
    Inventors: Rajaram Krishnan, David J. Charlot, Eugene Tu, James McCanna, Lucas Kumosa, Paul D. Swanson, Robert Turner, Kai Yang, Irina Dobrovolskaya, David Liu, Juan Pablo Hinestrosa Salazar, Juscilene Menezes
  • Publication number: 20150001082
    Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.
    Type: Application
    Filed: September 4, 2014
    Publication date: January 1, 2015
    Inventors: Rajaram KRISHNAN, David CHARLOT, Eugene TU, James MCCANNA, Lucas KUMOSA, Paul D. SWANSON, Robert TURNER, Kai YANG, Irina DOBROVOLSKAYA, David LlU
  • Publication number: 20140356877
    Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.
    Type: Application
    Filed: June 20, 2014
    Publication date: December 4, 2014
    Inventors: Rajaram KRISHNAN, David J. CHARLOT, Eugene TU, James MCCANNA, Lucas KUMOSA, Paul D. SWANSON, Robert TURNER, Kai YANG, Irina DOBROVOLSKAYA, David LIU, Juan Pablo HINESTROSA SALAZAR, Juscilene MENEZES
  • Patent number: 8877470
    Abstract: The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: November 4, 2014
    Assignee: Biological Dynamics, Inc.
    Inventors: Rajaram Krishnan, David Charlot, Eugene Tu, James McCanna, Lucas Kumosa, Paul Swanson, Robert Turner, Kai Yang, Irina Dobrovolskaya, David Liu