Abstract: The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

Abstract: Provided herein are aluminum alloys and methods of making these alloys. The aluminum alloys described herein are produced with a high content of recycled scrap. The recycled scrap may include used beverage can scrap and mixed alloy scrap (e.g., automotive scrap containing one or more of 5xxx, 6xxx, and/or 7xxx series aluminum alloys). Surprisingly, aluminum alloy products produced from the aluminum alloys including a high content of recycled scrap as described herein exhibit mechanical properties comparable to those displayed by high-performance aluminum alloy products, such as high tensile strength, good formability without cracking and/or fracture, and/or high elongation before fracture.

Abstract: A device includes, in a first region, a first conductive interconnect, an electrode structure on the first conductive interconnect, where the electrode structure includes a first conductive hydrogen barrier layer and a first conductive fill material. A memory device including a ferroelectric material or a paraelectric material is on the electrode structure. A second dielectric includes an amorphous, greater than 90% film density hydrogen barrier material laterally surrounds the memory device. A via electrode including a second conductive hydrogen barrier material is on at least a portion of the memory device. A second region includes a conductive interconnect structure embedded within a less than 90% film density material.

Abstract: The present disclosure relates to alternative, cost effective, rapid and simple methods for bacterial capsular polysaccharide (CPS) manufacturing resulting in 1) simultaneous sizing and purification of CPS 2) high CPS yield, 3) improved CPS purity and removal of protein and nucleic acid contaminants, 4) CPS with preserved epitopic conformation and 5) stable and immunogenic polysaccharide-protein conjugate vaccines comprising of said size reduced and purified CPS The method particularly comprises subjecting crude/native bacterial polysaccharide to an oxidizing agent to obtain high purity, high yield and structurally intact CPS having optimal molecular size and other desirable CPS attributes. The method is amenable for commercial scale manufacturing of polysaccharide-protein conjugate vaccines.

Abstract: A system and method for providing decentralized vehicle computing using blockchain that include determining at least one computing task to be executed to complete a computing operation of a vehicle. The system and method also include accessing the blockchain and analyzing ledgers associated with resource vehicles to be utilized to process the decentralized vehicle computing of the at least one computing task, wherein at least one resource vehicle is determined to be used to execute the at least one computing task. The system and method additionally include controlling computing resources of the at least one resource vehicle to execute the at least one computing task. The system and method further include facilitating a transaction associated with the execution of the at least one computing task by the at least one resource vehicle through the blockchain.

Abstract: Embodiments described herein relate to techniques for state export for a network device. The method may include receiving a state export request; selecting a state hierarchy walk starting location based on the state export request; initiating a state hierarchy walk beginning at the state hierarchy walk starting location; making a first determination that a state export pause condition exists; pausing the state hierarchy walk in response to the first determination; making a second determination that a state export resume condition exists; and resuming the state hierarchy walk in response to the second determination.

Abstract: A UE may transmit to a base station, and the base station may receive from the UE, via an RRC message, an IDC interference indication. The IDC interference indication may be associated with at least one victim reception or at least one aggressor transmission. The IDC interference indication may include at least one of a first frequency range associated with the at least one victim reception, information associated with the at least one aggressor transmission, a first requested BWP associated with the at least one victim reception, or a second requested BWP associated with the at least one aggressor transmission. The base station may identify at least one interference mitigation measure based on the IDC interference indication. The UE and the base station may communicate based on the at least one interference mitigation measure.

Abstract: The present invention relates to the use of a Raman spectral signature of nitrate, as a biomarker for an early, real-time diagnosis of nitrogen status in growing plants in a non-invasive or non-destructive way in order to detect nitrogen deficiency before the onset of any visible symptoms. The early, real-time diagnosis of nitrogen deficiency in plants makes it possible to correct nitrogen deficiency for the avoidance of negative effects on the yield and biomass of growing plants or leafy vegetables.

Abstract: One aspect of the present invention relates to double-stranded RNA (dsRNA) agent capable of inhibiting the expression of a target gene. The sense strand of the dsRNA agent comprises at least one thermally destabilizing nucleotide, and at least one said thermally destabilizing nucleotide occurring at a site opposite to the seed region (positions 2-8) of the antisense strand; and the antisense strand of the dsRNA agent comprises at least two modified nucleotides that provide the nucleotide a steric bulk that is less than or equal to the steric bulk of a 2?-OMe modification, wherein said modified nucleotides are separated by 11 nucleotides in length. Other aspects of the invention relates to pharmaceutical compositions comprising these dsRNA agents suitable for therapeutic use, and methods of inhibiting the expression of a target gene by administering these dsRNA agents, e.g., for the treatment of various disease conditions.

Abstract: Systems and methods for automated linkage of enriched transaction data to a record of charge are provided. Electronic enriched transaction data, such as receipt information, provided by merchants, merchant aggregators, or third parties may be automatically associated with the corresponding transaction, and transmitted after the sale, or after authorization of the transaction, without user intervention. The enriched transaction data may be automatically associated with the record of charge at the acquirer or issuer end. Transaction account holders are able to view and/or download the electronic enriched transaction data with the record of charge, without the need for manually initiating emailing or attaching or the electronic enriched transaction data.

Abstract: A system and method for management of access to customer data is provided. The system includes a communication device of the customer and an application server. The communication device receives credentials of the customer. The application server generates a communication link with the communication device and a profile of the customer is created at a storage unit and a unique anonymous ID is appended to the same. In the event a future service provider requests for access to customer data, the credentials are appended to the profile at the application server received from the communication device for a pre-determined time period and a secure channel is generated between the future service provider communication device and the application server to allow the future service provider to access the customer data. The secure channel is terminated and the appended credentials to the profile are erased, thereby maintaining anonymity of the customer.

Abstract: Approaches for data compression involve a compression circuit packing non-zero data elements of a succession of words of a plurality of blocks into packed words by packing non-zero data elements of one or more words of the succession in each packed word, and restricting each packed word to data elements of one uncompressed block. The compression circuit writes each packed word in a RAM and within a compressed address range associated with the uncompressed block when the packed word is full of non-zero data elements, or before the packed word is full if the next input word is of another uncompressed block.

Abstract: A method of fabricating a polishing layer of a polishing pad includes successively depositing a plurality of layers with a 3D printer, each layer of the plurality of polishing layers deposited by ejecting a pad material precursor from a nozzle and solidifying the pad material precursor to form a solidified pad material.

Abstract: Providing an Artificial Intelligence (AI) and Internet of Things (IoT) based system and method that predicts the chronological requirements for various components of the file-being-stored, and then takes an appropriate storage action on each component based on the predicted chronological requirements.

Abstract: The invention provides methods, systems and computer program products for job management and for allocating resources for cloud based or remote device based job processing. The invention provides a scalable architecture for job management and for allocating resources for cloud based or remote device based job processing comprising a primary job manager machine, having a resource pool of secondary job manager machines assigned thereto. Each secondary job manager machine has a resource pool of computing machines assigned thereto—for execution jobs or computing tasks assigned to the secondary job manager machine by the primary job manager machine. In an embodiment, each secondary job manager machine has one or more accelerator cache proxies for enabling low latency data object retrieval for computing tasks being executed by the computing machines assigned to the secondary job manager.

Abstract: Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.

Abstract: The invention provides methods, systems and computer program products for job management and for allocating resources for cloud based or remote device based job processing. The invention provides a scalable architecture for job management and for allocating resources for cloud based or remote device based job processing comprising a job manager machine, having a resource pool of secondary job manager machines assigned thereto. The job manager machine has a resource pool of computing machines assigned thereto—comprising at least a gateway machine and a non-gateway machine. Received jobs or computing tasks are selectively transmitted to one of the gateway machine and the non-gateway machine. Each of the gateway machine and the non-gateway machine are configured to respond differently to forwarded job or computing task.

Abstract: At least some embodiments are directed to an entity matching detection system. The entity matching detection system includes a latent similarity identification machine learning model that receives one or more data records and generates a final similarity score indicative of a latent similarity between the one or more data records and a second data record. The entity matching detection system can identify lexical and semantic similarities between attribute values and can analyze and compute similarity scores for direct-linked attribute values and cross-linked attribute values extracted from different data records.

Abstract: Endurance mechanisms are introduced for memories such as non-volatile memories for broad usage including caches, last-level cache(s), embedded memory, embedded cache, scratchpads, main memory, and storage devices. Here, non-volatile memories (NVMs) include magnetic random-access memory (MRAM), resistive RAM (ReRAM), ferroelectric RAM (FeRAM), phase-change memory (PCM), etc. In some cases, features of endurance mechanisms (e.g., randomizing mechanisms) are applicable to volatile memories such as static random-access memory (SRAM), and dynamic random-access memory (DRAM). The endurance mechanisms include a wear leveling scheme that uses index rotation, outlier compensation to handle weak bits, and random swap injection to mitigate wear out attacks.

Abstract: A sleeping mask includes a signal processor for processing sensor data, an infrared light source coupled to the signal processor and configured to emit infrared light toward an eyelid of a user, and an array of infrared sensors coupled to the signal processor and configured to receive infrared light reflected from the eyelid of the user.