Abstract: The present invention provides a modified RNAi agent comprising a sense strand and an antisense strand, wherein the antisense strand targets an HBV mRNA; all of the nucleotide sugars of the RNAi agent are 2?-modified; and at least one of the sense and antisense strands is conjugated to at least one targeting ligand that comprises two or more building blocks connected to a biantennary or triantennary branched linker, optionally via one or more linking groups.

Abstract: Aspects of the subject disclosure may include, for example, determining whether a past throughput of past traffic communicated between a communication device and a communication network meets a first threshold value, resulting in a first determination; responsive to the first determination being that the past throughput meets the first threshold, transmitting an instruction to the communication device to restrict a first subsequent throughput of first subsequent traffic to no greater than a second threshold value; determining whether the first subsequent throughput has been restricted, resulting in a second determination; and responsive to the second determination being that the first subsequent throughput has not been restricted, taking one or more actions to enforce a second subsequent throughput of second subsequent traffic to no greater than a third threshold value, wherein the third threshold value is lower than the second threshold value. Other embodiments are disclosed.

Abstract: A system and related method includes receiving an ambient temperature adjacent to a system, an electric current value of electricity that is conducted into or out of a battery coupled with the system, and a voltage of a battery circuit that includes the battery. An internal temperature of the battery is determined based at least in part on the ambient temperature, the current value, and the voltage. One or more conditions for charging or discharging the battery are determined based at least in part on the internal temperature of the battery, the current value, and the voltage. The battery is charged or discharged based on least on the one or more conditions.

Abstract: Techniques disclosed herein are directed towards streaming keyphrase detection which can be customized to detect one or more particular keyphrases, without requiring retraining of any model(s) for those particular keyphrase(s). Many implementations include processing audio data using a speaker separation model to generate separated audio data which isolates an utterance spoken by a human speaker from one or more additional sounds not spoken by the human speaker, and processing the separated audio data using a text independent speaker identification model to determine whether a verified and/or registered user spoke a spoken utterance captured in the audio data. Various implementations include processing the audio data and/or the separated audio data using an automatic speech recognition model to generate a text representation of the utterance.

Abstract: An apparatus and configuring scheme where a paraelectric capacitive input circuit can be programmed to perform different logic functions by adjusting the switching threshold of the paraelectric capacitive input circuit. Digital inputs are received by respective capacitors on first terminals of those capacitors. The second terminals of the capacitors are connected to a summing node. A pull-up and pull-down device are coupled to the summing node. The pull-up and pull-down devices are controlled separately. During a reset phase, the pull-up and/or pull-down devices are turned on or off in a sequence, and inputs to the capacitors are set to condition the voltage on node n1. As such, a threshold for the capacitive input circuit is set. After the reset phase, an evaluation phase follows. In the evaluation phase, the output of the capacitive input circuit is determined based on the inputs and the logic function configured during the reset phase.

Abstract: An overlay of millimeter wave (mmWave)-capable cells are added to a citizens broadband radio service (CBRS) network to provide coverage in a next generation fixed wireless (NGFW) network. The availability of mmWave spectrum, with limited reach, can be utilized as a wireless backhaul for subsequent hops. In one aspect, integrated access front-haul nodes (IAFHNs) that are utilized for mmWave transmissions at a second (and/or subsequent) hop can be deployed with self-aligning receivers. Further, the IAFHNs can facilitate adaptive resource allocation scheduling in an integrated access and backhaul (IAB) chain. In addition, an interface between macro access points can be enhanced to enable the adaptive resource allocation on the IAB chain. In one aspect, a fixed user equipment (UE) can be configured with dual connectivity (DC) and a network operator can offer different tiers of services based on a location of the UE.

Abstract: A memory is provided which comprises a capacitor including non-linear polar material. The capacitor may have a first terminal coupled to a node (e.g., a storage node) and a second terminal coupled to a plate-line. The capacitors can be a planar capacitor or non-planar capacitor (also known as pillar capacitor). The memory includes a transistor coupled to the node and a bit-line, wherein the transistor is controllable by a word-line, wherein the plate-line is parallel to the bit-line. The memory includes a refresh circuitry to refresh charge on the capacitor periodically or at a predetermined time. The refresh circuit can utilize one or more of the endurance mechanisms. When the plate-line is parallel to the bit-line, a specific read and write scheme may be used to reduce the disturb voltage for unselected bit-cells. A different scheme is used when the plate-line is parallel to the word-line.

Abstract: An apparatus and configuring scheme where a paraelectric capacitive input circuit can be programmed to perform different logic functions by adjusting the switching threshold of the paraelectric capacitive input circuit. Digital inputs are received by respective capacitors on first terminals of those capacitors. The second terminals of the capacitors are connected to a summing node. A pull-up and pull-down device are coupled to the summing node. The pull-up and pull-down devices are controlled separately. During a reset phase, the pull-up and/or pull-down devices are turned on or off in a sequence, and inputs to the capacitors are set to condition the voltage on node n1. As such, a threshold for the capacitive input circuit is set. After the reset phase, an evaluation phase follows. In the evaluation phase, the output of the capacitive input circuit is determined based on the inputs and the logic function configured during the reset phase.

Abstract: Stable lyophilized immunogenic compositions include inter alia live attenuated recombinant flaviviruses, more preferably live attenuated recombinant dengue viruses, at least one carbohydrate, at least one amino acid and is particularly amenable to rapid freeze-drying treatments wherein, the composition preserves desired characteristics of a virus, including virus viability, immunogenicity and stability. The immunogenic composition is devoid of preservatives, polymers and surfactants. The methods for manufacturing the stable lyophilized immunogenic compositions are also provided.

Abstract: This invention relates to a container (1) which is pre-filled or pre-fillable with one or more substances, such as a medical liquid and similar, comprising a squeezable activation compartment (2) intended to contain said one or more substances, a dispensing compartment (3) including a first portion (31) equipped with at least one dispensing member (311, 312, 314) of said one or more substances, and a second portion (32), wherein said second portion (32) of said dispensing compartment (3) and said activation compartment (2) are fluid-dynamically connected, and an activator element (4) arranged inside said container (1). This invention also relates to a method for dispensing at least one substance by means of a container (1), and to a production method of a container (1).

Abstract: A stethoscope sterilization device is disclosed. A base unit adapted to accommodate a stethoscope. A diaphragm attachment assembled with the base unit, wherein the diaphragm attachment comprises an aperture, wherein the diaphragm attachment provides a surface for placing a diaphragm of the stethoscope. A heating element provided to heat the surface of the diaphragm to maintain a desirable temperature. A luminometer to monitor the diaphragm of the stethoscope for determining contamination in real-time. A dispensing unit positioned underneath the diaphragm attachment, wherein the dispensing unit is configured to dispense a disinfectant solution stored in a disinfectant reservoir over the surface of the diaphragm of the stethoscope for the sterilization via the aperture. A sponge placed over the base unit, wherein the sponge enables wiping off of excess disinfectant solution accumulated over the surface of the diaphragm of the stethoscope upon sterilization.

Abstract: Provided herein are compositions for gene modification or editing and methods of using same to treat or prevent certain conditions. Specific compositions and methods capable of safely and effectively editing gene targets expressed in the liver to durably lower LDL-C thereby treating a leading cause of cardiovascular disease are disclosed.

Abstract: Provided herein are compositions for gene modification or editing and methods of using same to treat or prevent certain conditions. Specific compositions and methods capable of safely and effectively editing gene targets expressed in the liver to durably lower LDL-C thereby treating a leading cause of cardiovascular disease are disclosed.

Abstract: Described herein are dirt-repelling compositions and methods of use thereof. The compositions provide improved shine and color, as well as a non-oily finish. The compositions are durable and will prevent, for example, dirt and dust from sticking on an automotive surface.

Abstract: An example network device includes a memory configured to store a plurality of counts of packets of a data flow. The network device also includes one or more processors in communication with the memory. The one or more processors are configured to determine the plurality of counts of packets of the data flow, wherein each count of the plurality of counts includes a number of packets occurring in a predetermined time period. The one or more processors are configured to assign a corresponding range to each count of the plurality of counts, so as to assign a plurality of corresponding ranges. The one or more processors are also configured to determine a pattern in the plurality of corresponding ranges and send a number of active probe packets based on the determined pattern.

Abstract: Fifth Generation (5G) Millimeter Wave (mmWave) cellular networks are expected to serve a large set of throughput intensive, ultra-reliable, and ultra-low latency applications. To meet these stringent requirements, while minimizing the network cost, the 3rd Generation Partnership Project has proposed a new transport architecture, where certain functional blocks can be placed closer to the network edge. In this architecture, however, blockages and shadowing in 5G mmWave cellular networks may lead to frequent handovers (HOs) causing significant performance degradation. To meet the ultra-reliable and low-latency requirements of applications and services in an environment with frequent HOs, a Fast Inter-Base Station Ring (FIBR) architecture is described, in which base stations that are in close proximity are grouped together, interconnected by a bidirectional counter-rotating buffer insertion ring network.

Abstract: Asynchronous circuits implemented using threshold gate(s) and/or majority gate(s) (or minority gate(s)) are described. The new class of asynchronous circuits can operate at lower power supply levels (e.g., less than 1V on advanced technology nodes) because stack of devices between a supply node and ground are significantly reduced compared to traditional asynchronous circuits. The asynchronous circuits here result in area reduction (e.g., 3× reduction compared to traditional asynchronous circuits) and provide higher throughput/mm2 (e.g., 2× higher throughput compared to traditional asynchronous circuits). The threshold gate(s), majority/minority gate(s) can be implemented using capacitive input circuits. The capacitors can have linear dielectric or non-linear polar material as dielectric.

Abstract: Apparatus and method for processing virtual graphics processor telemetry data based on quanta.

Abstract: Disclosed herein are system, method, and computer program product embodiments for providing a data model application programming interface (“API”) to customizable live applications in a cloud collaboration platform. The cloud collaboration platform provides data storage, a data model, and an API to embedded third-party live applications to allow the live applications to securely create, store, and access data within the cloud collaboration platform. The data model allows records stored in the cloud collaboration platform to sync independently, merge intelligently, and function offline.

Abstract: Method for monitoring network performance in a telecommunication network coupled with a plurality of Virtual Machines (VM) arranged in a cluster format is disclosed. A packet is received at a VM smart cluster device. Metadata is extracted from the packet. The packet can be distributed to one of the plurality of VMs. Key performance indicator (KPI) session related data associated with a subscriber in one of the plurality of VMs that receives the distributed packet can be generated.