Patents by Inventor Rajesh K. Gaur

Rajesh K. Gaur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Artificial riboswitch for controlling pre-mRNA splicing
    Patent number: 7563601
    Abstract: The present invention relates to riboswitches that have been engineered to regulate pre-mRNA splicing. In particular, the insertion of a high affinity theophylline binding aptamer into the 3? splice site region, 5? splice site region, or branchpoint sequence (BPS) of a pre-mRNA modulates RNA splicing in the presence of theophylline. Accordingly, the aspects of the present invention include, but are not limited to, theophylline-dependent riboswitches which modulate RNA splicing, methods of modulating RNA splicing using theophylline and its corresponding riboswitches, methods of improving/identifying theophylline-dependent riboswitches, methods of treating diseases associated with or caused by abnormal RNA splicing.
    Type: Grant
    Filed: June 1, 2006
    Date of Patent: July 21, 2009
    Assignee: City of Hope
    Inventor: Rajesh K. Gaur
  • ARTIFICIAL RIBOSWITCH FOR CONTROLLING PRE-MRNA SPLICING
    Publication number: 20090170793
    Abstract: The present invention relates to riboswitches that have been engineered to regulate pre-mRNA splicing. In particular, the insertion of a high affinity theophylline binding aptamer into the 3? splice site region, 5? splice site region, or branchpoint sequence (BPS) of a pre-mRNA modulates RNA splicing in the presence of theophylline. Accordingly, the aspects of the present invention include, but are not limited to, theophylline-dependent riboswitches which modulate RNA splicing, methods of modulating RNA splicing using theophylline and its corresponding riboswitches, methods of improving/identifying theophylline-dependent riboswitches, methods of treating diseases associated with or caused by abnormal RNA splicing.
    Type: Application
    Filed: June 1, 2006
    Publication date: July 2, 2009
    Inventor: Rajesh K. Gaur
  • Artificial riboswitch for controlling pre-mRNA splicing
    Patent number: RE43000
    Abstract: The present invention relates to riboswitches that have been engineered to regulate pre-mRNA splicing. In particular, the insertion of a high affinity theophylline binding aptamer into the 3? splice site region, 5? splice site region, or branchpoint sequence (BPS) of a pre-mRNA modulates RNA splicing in the presence of theophylline. Accordingly, the aspects of the present invention include, but are not limited to, theophylline-dependent riboswitches which modulate RNA splicing, methods of modulating RNA splicing using theophylline and its corresponding riboswitches, methods of improving/identifying theophylline-dependent riboswitches, methods of treating diseases associated with or caused by abnormal RNA splicing.
    Type: Grant
    Filed: May 6, 2010
    Date of Patent: December 6, 2011
    Assignee: City of Hope
    Inventors: Rajesh K. Gaur, Sailesh Gopalakrishna Pillai