Abstract: The invention concerns method of treating multiple sclerosis (MS) by administering a therapeutically effective dose of LOU064 or a pharmaceutically acceptable salt thereof.

Abstract: The invention relates to new anti-hCD3 antibodies that, in contrast to prior art anti-CD3 antibodies, bind specifically to human CD3 at acidic pH, but do not significantly bind to human CD3 at neutral or physiological pH, methods to produce these antibodies and therapeutic uses of these antibodies. These antibodies are able to activate T cells at acidic pH while having significantly reduced activity at neutral or physiological pH.

Abstract: In some embodiments, methods and systems are provided for managing emergency notifications and incident reports at a commercial facility. A graphical interface enables a worker associated with a facility to input information regarding an ongoing/impending emergency event, e.g., Active Threat, Acts of Violence, Fire/Explosion, Injury, Power Failure, Missing Child, Severe Weather, Robbery, Hazmat, Bomb Threat, Covid-19, Store Closure, Special Events etc. This information is processed via an analytical engine that evaluates the entered information in view of various business rules in order to identify the appropriate workers to notify, and generates and transmits the notifications to the employees determined to be suitable for receiving a notification. In response to the generation of the emergency notification, an incident report engine evaluates the entered emergency, and automatically generates an incident report, which may be later accessed and/or modified by workers having a suitable employee access level.

Abstract: In some embodiments, methods and systems are provided for managing emergency notifications and incident reports at a commercial facility. A graphical interface enables a worker associated with a facility to input information regarding an ongoing/impending emergency event, e.g., Active Threat, Acts of Violence, Fire/Explosion, Injury, Power Failure, Missing Child, Severe Weather, Robbery, Hazmat, Bomb Threat, Covid-19, Store Closure, Special Events etc. This information is processed via an analytical engine that evaluates the entered information in view of various business rules in order to identify the appropriate workers to notify, and generates and transmits the notifications to the employees determined to be suitable for receiving a notification. In response to the generation of the emergency notification, an incident report engine evaluates the entered emergency, and automatically generates an incident report, which may be later accessed and/or modified by workers having a suitable employee access level.

Abstract: The present invention generally relates to a self-charging system for electric vehicles comprises at least one gearbox comprises an input end and an output end mechanically coupled to one of the wheels of a vehicle to the input end to generate a rotational energy with an increased output of one of the torque or speed (RPM) to the output end; an auxiliary generator connected to the output end of the at least one gearbox to convert the rotational energy into electrical energy; a controller equipped with a maximum power point tracker to produce maximum power output; and a charger controller coupled to the maximum power point tracker to charge a batter of the vehicle upon limiting electric current rate of the power output to protect against electrical overload, overcharging, and overvoltage.

Abstract: The invention relates to new anti-hCD3 antibodies that, in contrast to prior art anti-CD3 antibodies, bind specifically to human CD3 at acidic pH, but do not significantly bind to human CD3 at neutral or physiological pH, methods to produce these antibodies and therapeutic uses of these antibodies. These antibodies are able to activate T cells at acidic pH while having significantly reduced activity at neutral or physiological pH.

Abstract: Methods for diagnosing cancer in a subject are disclosed. The method includes detecting the level of expression of one or more cancer markers in a biological sample obtained from the subject; and comparing the level of expression of the one or more cancer markers in the biological sample to a normal level of expression of the one or more cancer markers. The one or more cancer markers comprises CXCL13 or CXCR5 or both CXCL13 and CXCR5. Also disclosed is a kit for detecting cancer or monitoring cancer progression.

Abstract: A method for copying first data stored at a primary data center to a secondary data center is provided. The method includes initiating a first replication task to copy the first data from the primary data center to the secondary data center. The method also includes receiving a first portion of the first data from the primary data center via a first access point, wherein a first bandwidth between the primary data center and the first access point is greater than a second bandwidth between the primary data center and the secondary data center. The method further includes storing the first portion of data in a first cache associated with the first access point. The method also includes transmitting the first portion of data from the first cache to the secondary data center. A system and non-transitory computer-readable medium are also provided.

Abstract: This disclosure generally relates to devices, systems, and computer-implemented methods for simulating one or more inventories in a distribution network. Specifically, methods are described that comprise the operations of receiving inventory data for one or more inventories to be simulated, wherein the inventory data includes lead time data and demand data; determining, based on the inventory data, probability distributions for each of lead time and demand for the one or more inventories to be simulated; determining a lead time demand probability distribution of the one or more inventories to be simulated based on the determined probability distributions for the lead time and the demand; determining a predictive state of the one or more inventories to be simulated based on the lead time demand probability distribution; and outputting one or more evaluation parameters associated with the predictive state of the one or more inventories to be simulated.

Abstract: The present application relates to a nanoparticle compositions and methods for targeted delivery of a bioactive agent to a plant. In one embodiment, the nanoparticle composition includes a coronatine-coated nanoparticle formulated to deliver one or more bioactive agent through plant stomata. A variety of bioactive agents may be included in the nanoparticles, including one or more bactericides, fungicides, insecticides, acaricides, miticides, nemanticides, molluscicides, herbicides, plant nutrients, fertilizers, plant growth regulators, or combinations thereof.

Abstract: The present application relates to a nanoparticle compositions and methods for targeted delivery of a bioactive agent to a plant. In one embodiment, the nanoparticle composition includes a coronatine-coated nanoparticle formulated to deliver one or more bioactive agent through plant stomata. A variety of bioactive agents may be included in the nanoparticles, including one or more bactericides, fungicides, insecticides, acaricides, miticides, nemanticides, molluscicides, herbicides, plant nutrients, fertilizers, plant growth regulators, or combinations thereof.

Abstract: A method for copying first data stored at a primary data center to a secondary data center is provided. The method includes initiating a first replication task to copy the first data from the primary data center to the secondary data center. The method also includes receiving a first portion of the first data from the primary data center via a first access point, wherein a first bandwidth between the primary data center and the first access point is greater than a second bandwidth between the primary data center and the secondary data center. The method further includes storing the first portion of data in a first cache associated with the first access point. The method also includes transmitting the first portion of data from the first cache to the secondary data center. A system and non-transitory computer-readable medium are also provided.

Abstract: A system and method for deploying clients at a target site with disaster recovery considerations uses recovery profiles with multiple recovery parameter settings, which can be associated with a client to be deployed. The recovery profile associated with the client is used to automatically initiate a recovery-related operation for the client using a recovery parameter setting defined in the recovery profile associated with the client.

Abstract: A method for copying first data stored at a primary data center to a secondary data center is provided. The method includes initiating a first replication task to copy the first data from the primary data center to the secondary data center. The method also includes receiving a first portion of the first data from the primary data center via a first access point, wherein a first bandwidth between the primary data center and the first access point is greater than a second bandwidth between the primary data center and the secondary data center. The method further includes storing the first portion of data in a first cache associated with the first access point. The method also includes transmitting the first portion of data from the first cache to the secondary data center. A system and non-transitory computer-readable medium are also provided.

Abstract: The present application relates to a nanoparticle compositions and methods for targeted delivery of a bioactive agent to a plant. In one embodiment, the nanoparticle composition includes a coronatine-coated nanoparticle formulated to deliver one or more bioactive agent through plant stomata. A variety of bioactive agents may be included in the nanoparticles, including one or more bactericides, fungicides, insecticides, acaricides, miticides, nemanticides, molluscicides, herbicides, plant nutrients, fertilizers, plant growth regulators, or combinations thereof.

Abstract: This disclosure describes tools for navigating within applications, and in particular business applications. For example, a menu system may incorporate a notification system, such that notifications of events received at a business application are displayed within the context of the menu system. The user can be allowed to select an event from the menu system, allowing the user to quickly navigate to a context, within the application, corresponding to the event.

Abstract: A system and method for deploying clients at a target site with disaster recovery considerations uses recovery profiles with multiple recovery parameter settings, which can be associated with a client to be deployed. The recovery profile associated with the client is used to automatically initiate a recovery-related operation for the client using a recovery parameter setting defined in the recovery profile associated with the client.

Abstract: A method for copying first data stored at a primary data center to a secondary data center is provided. The method includes initiating a first replication task to copy the first data from the primary data center to the secondary data center. The method also includes receiving a first portion of the first data from the primary data center via a first access point, wherein a first bandwidth between the primary data center and the first access point is greater than a second bandwidth between the primary data center and the secondary data center. The method further includes storing the first portion of data in a first cache associated with the first access point. The method also includes transmitting the first portion of data from the first cache to the secondary data center. A system and non-transitory computer-readable medium are also provided.

Abstract: Methods for detecting cancer or monitoring cancer progression in a subject are disclosed. The method includes detecting the level of expression of one or more cancer markers in a biological sample obtained from the subject; and comparing the level of expression of the one or more cancer markers in the biological sample to a normal level of expression of the one or more cancer markers. The one or more cancer markers comprises CXCL16 or CXCR6 or both CXCL16 and CXCR6. Also disclosed is a kit for detecting cancer or monitoring cancer progression.

Abstract: This disclosure generally relates to devices, systems, and computer-implemented methods for simulating one or more inventories in a distribution network. Specifically, methods are described that comprise the operations of receiving inventory data for one or more inventories to be simulated, wherein the inventory data includes lead time data and demand data; determining, based on the inventory data, probability distributions for each of lead time and demand for the one or more inventories to be simulated; determining a lead time demand probability distribution of the one or more inventories to be simulated based on the determined probability distributions for the lead time and the demand; determining a predictive state of the one or more inventories to be simulated based on the lead time demand probability distribution; and outputting one or more evaluation parameters associated with the predictive state of the one or more inventories to be simulated.