Abstract: The present disclosure relates to compounds that act as protein kinase inhibitors, especially RPS6K1 and the synthesis of the same. Further, the present disclosure teaches the utilization of such compounds in a treatment for proliferative diseases, including cancer, particularly breast cancer, and especially ER+ and/or HER2+ breast cancer, prostate cancer, lung cancer, and metastatic cancer.

Abstract: In one embodiment, a device receives, via a user interface, definition of a first sequence of transactional milestones performed by users of an online application and identified using a first type of identifier. The device also receives, via the user interface, definition of a second sequence of transactional milestones performed by users of the online application and identified using a second type of identifier. The device further receives, via the user interface, definition of a key transition associated with at least one transactional milestone in the first sequence of transactional milestones or second sequence of transactional milestones that links the first type of identifier with the second type of identifier. The device represents, using the key transition, performance of the first sequence of transactional milestones and the second sequence of transactional milestones by a particular user of the online application as a unified sequence.

Abstract: Disclosed embodiments provide techniques for monitoring and evaluating the effectiveness of key value pairs (KVPs) used in a document processing system. In embodiments, KVPs are obtained from multiple extractors of a document processing system. A score is computed for the KVPs by computing an effectiveness metric for each KVP from the multiple KVPs. In response to the computed score being below a predetermined threshold, a model retraining process is performed to generate a new set of KVP extractors, and provide the new set of KVPs to the document processing system.

Abstract: Disclosed are systems and methods for traffic pattern prediction under abnormal behavior through collaborative knowledge transferring from node to node. In one example, a system includes a processor and a memory having instructions that cause the processor to determine vehicle traffic flows at each of a plurality of nodes using a general model that utilizes hyperparameters that derive relationships between and within each node of the plurality of nodes and observed data from sensors monitoring the plurality of nodes. The observed data includes real-world traffic data affected by hidden parameters. Using an understandable algorithm, the general model derives correlations between the hidden parameters from the observed data at multiple levels.

Abstract: Modified zeolite may include a microporous framework including a plurality of micropores having diameters of less than or equal to 2 nm, wherein the microporous framework includes at least silicon atoms and oxygen atoms; a plurality of mesopores having diameters of greater than 2 nm and less than or equal to 50 nm, wherein the plurality of mesopores are ordered with cubic symmetry. The modified zeolite also includes: isolated terminal primary amine functionalities bonded to silicon atoms of the microporous framework; or silazane functionalities, wherein the nitrogen atom of the silazane bridges two silicon atoms of the microporous framework; or both.

Abstract: A method for training a machine learning model for categorizing data is provided. The method comprising receiving labeled positive training data and negative training data. The positive training data and negative training data are lemmatized and then vectorizing the lemmatized into a vector space. A machine learning model is trained with the vectorized positive training data and negative training data to identify a new category of data from existing categories in the positive training data and negative training data.

Abstract: A turbine engine for an aircraft. The turbine engine includes a combustor and a steam system. Fuel and steam are injected into the combustor to mix with compressed air to generate a fuel and air mixture. The fuel and air mixture is combusted in the combustor to generate combustion gases. The steam system is fluidly coupled to the combustor as the steam source to provide steam to the combustor. The steam system includes a hot gas path and a steam hot gas path component. The hot gas path is fluidly coupled to the combustor to receive the combustion gases and to route the combustion gases through the steam system. The steam hot gas path component includes a wall having a combustion-gas-facing surface facing the hot gas path and a hydrophobic coating formed on the combustion-gas-facing surface.

Abstract: Systems, methods, and software of performing an Authentication and Key Management for Applications (AKMA) authentication service. In one embodiment, an AKMA element (1200) handles an enriched AKMA Key Identifier (A-KID) (800) having an identifier format with a username (802) and a realm (804) separated by an @-symbol (806). The username includes a Routing Indicator (RID) (812), an AKMA Temporary UE Identifier (A-TID) (814), and at least one supplemental character (810) that distinguishes the RID from the A-TID in the username. The AKMA element performs a function of the AKMA authentication service based on the enriched A-KID.

Abstract: Methods and systems are provided for transforming images from one energy level to another. In an example, a method includes obtaining an image at a first energy level, identifying a contrast phase of the image, entering the image as input to a segmentation model trained to output an anatomy mask that identifies each tissue type in the image, generating a guide image from the image and the anatomy mask using a regression model, entering the image and the guide image as input into an energy transformation model trained to output a transformed image at a different, second energy level, the energy transformation model selected from among a plurality of energy transformation models based on the contrast phase, and displaying a final transformed image and/or saving the final transformed image in memory, wherein the final transformed image is the transformed image or is generated based on the transformed image.

Abstract: Devices and techniques including process steps make use of recesses in conductive interconnect structures to form reliable low temperature metallic bonds. A fill layer is deposited into the recesses prior to bonding. First conductive interconnect structures are bonded at ambient temperatures to second metallic interconnect structures using direct bonding techniques, with the fill layers in the recesses in one or both of the first and second interconnect structures.

Abstract: Various methods and systems are provided for transforming images from one energy level to another. In an example, a method includes obtaining an image at a first energy level acquired with a single-energy computed tomography (CT) imaging system, identifying a contrast phase of the image, entering the image as input into an energy transformation model trained to output a transformed image at a second energy level, different than the first energy level, the energy transformation model selected from among a plurality of energy transformation models based on the contrast phase, and displaying a final transformed image and/or saving the final transformed image in memory, wherein the final transformed image is the transformed image or is generated based on the transformed image.

Abstract: A system, method, and device for generating data visualizations are disclosed. The method includes (i) obtaining a natural language query, (ii) determining an intent for the natural language query, (iii) generating one or more data requests to one or more selected data sources, the one or more data requests being based at least in part on the intent, (iv) abstracting result data to obtain a data abstraction, the result data being responsive to the one or more data requests, and (v) generating a visualization for the result data based at least in part on the data abstraction.

Abstract: A system, device and method are provided for assessing actions of authenticated persons within an enterprise system. The illustrative method includes extracting metadata comprising a plurality of categories from a plurality of data sources, and applying an unsupervised machine learning process to the extracted metadata. A plurality of clusters of the plurality of categories of the extracted metadata is generated, and thereafter one or more review criteria are applied thereto to generate curated clusters. The method includes training a supervised machine learning model with the curated clusters. The method includes, in response to receiving a new metadata input, processing the new metadata input with the trained supervised machine learning model. Data associated with the new metadata input is ingested based on respective clusters output by the trained supervised machine learning model for categories of the new metadata input.

Abstract: An electronic device includes a GaN power FET, a GaN driver coupled to the GaN power FET and a gate bias circuit coupled to the GaN driver. The GaN power FET and the GaN driver are monolithically integrated on a single GaN die. The gate bias circuit is predominately monolithically integrated on the single GaN die and includes only one active component external to the single GaN die. In one embodiment, the only active component external to the single GaN die is a linear regulator. In another embodiment, the only active component external to the single GaN die is a shunt regulator. In yet another embodiment, the only active component external to the single GaN die is a Zener diode.

Abstract: A catheter for electrophysiology applications is disclosed herein that includes a tubular member and an end effector. The end effector is coupled to a distal portion of the tubular member. The end effector includes first, second, and third loop members configured so that the first loop member defines a first plane, the second loop member defines a second plane at an angle to the first plane, and the third loop member defines a third plane at an angle to the first plane and at an angle to the second plane. Each of the first, second, and third loop members are configured as a respective single axis magnetic coil, and the first, second, and third loop members are collectively configured to function as a three axis magnetic sensor.

Abstract: Embodiments described herein are generally directed to the use of sidecars to perform dynamic Application Programming Interface (API) contract generation and conversion. In an example, a first sidecar of a source microservice intercepts a first call to a first API exposed by a destination microservice. The first call makes use of a first API technology specified by a first contract and is originated by the source microservice. An API technology is selected from multiple API technologies. The selected API technology is determined to be different than the first API technology. Based on the first contract, a second contract is dynamically generated that specifies an intermediate API that makes use of the selected API technology. A second sidecar of the destination microservice is caused to generate the intermediate API and connect the intermediate API to the first API.

Abstract: Compositions that include a bupivacaine salt are provided. The compositions may include bupivacaine linoleate, bupivacaine linolenate or bupivacaine laurate, at least one thermosensitive polymer, and at least one mucoadhesive or dermoadhesive agent. Also provided are methods for the treatment of an inflammatory or ulcerative condition with the disclosed compositions.

Abstract: Approaches for writing data objects to a distributed file system are described. In an example, a size of a data object to be created within a distributed file system may be determined based on a client request. Based on the size of the data object, data content of the data object is inserted into one of the object location table, object data table or a data container within the distributed file system. In an example, metadata corresponding to the data object may be written to an object location table.

Abstract: A system and method for hydraulic fracturing a subterranean formation with fracturing fluid to generate fractures, and intermittently adjusting a characteristic of the fracturing fluid conveying proppant to form pillars of proppant in the fractures.

Abstract: A turbine engine for an aircraft. The turbine engine includes a combustor and a steam system. Fuel and steam are injected into the combustor to mix with compressed air to generate a fuel and air mixture. The fuel and air mixture is combusted in the combustor to generate combustion gases. The steam system is fluidly coupled to the combustor as the steam source to provide steam to the combustor. The steam system includes a hot gas path and a steam hot gas path component. The hot gas path is fluidly coupled to the combustor to receive the combustion gases and to route the combustion gases through the steam system. The steam hot gas path component includes a wall having a combustion-gas-facing surface facing the hot gas path and a hydrophobic coating formed on the combustion-gas-facing surface.