Patents by Inventor Rajeshwar Singh

Rajeshwar Singh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-oxo-1-azetidine sulfonic acid derivatives as potent .beta.-lactamase inhibitors
    Patent number: 5888998
    Abstract: A compound of formula (I) ##STR1## wherein R.sub.1 is selected from the group consisting of 2-thienyl, 2-furyl, 2-pyrrolyl, 1-methyl-2-pyrrolyl, 2-amino-1-thiazolyl and 5-isothiazolyl;R.sub.2 is selected from the group consisting of: ##STR2## and M is hydrogen or a pharmaceutically acceptable cation; wherein the oxyimino fragment (.dbd.N--OR.sub.2) in formula (I) is in the `anti` orientation.
    Type: Grant
    Filed: April 24, 1997
    Date of Patent: March 30, 1999
    Assignees: Synphar Laboratories, Inc., Taiho Pharmaceutical Co., Ltd.
    Inventors: Samarendra N. Maiti, Eduardo L. Setti, Oludotun A. Phillips, Andhe V. Narender Reddy, Ronald G. Micetich, Rajeshwar Singh, Fusahiro Higashitani, Chieko Kunugita, Koichi Nishida, Tatsuya Uji
  • 3-(7-oxo-1-aza-4-oxabicyclo[3.2.0]hept-3-yl)alanine derivative as antitumor agent
    Patent number: 5652234
    Abstract: The present invention relates to the use of 3-(7-oxo-1-aza-4-oxabicyclo[3.2.0]hept-3-yl)alanine derivatives of formula (I) or a pharmaceutically acceptable salt thereof, as antitumor agents. ##STR1## Wherein R is: hydrogen or COOR.sub.2 wherein R.sub.2 is C.sub.1 -C.sub.3 alkyl group which may be substituted with aryl group.Wherein R.sub.1 is:hydrogen or C.sub.1 -C.sub.3 alkyl group which may be substituted with one or two aryl groups.
    Type: Grant
    Filed: October 6, 1995
    Date of Patent: July 29, 1997
    Assignees: Taiho Pharmaceutical Co., Limited, SynPhar Laboratories, Inc.
    Inventors: Rajeshwar Singh, Tomohiro Yamashita, Charles Fiakpui, George Thomas, Chan Ha, Hiroshi Matsumoto, Toshio Otani, Shinji Oie, Ronald Micetich
  • 4-oxa-1-azabicyclo [3,2,0] heptan-7-one derivatives as antitumor agents
    Patent number: 5561126
    Abstract: The present invention relates to the use of 4-oxa-1-azabicyclo [3,2,0] heptan-7-one derivatives of formula (I) or a pharmaceutically acceptable salt thereof, as antitumor agents. ##STR1## Wherein R is --OCOR.sub.1 group wherein R.sub.1 is hydrogen atom, a C.sub.1-9 alkyl group which may be substituted by either one or two substituents selected together from halogen atom, hydroxy, carboxy group or (3RS,5SR)-(4-oxo-1-azabicyclo[3,2,0]heptan-7-one-3-yl) methyloxycarbonyl, a C.sub.2-17 alkenyl group, which may be substituted by carboxy group or (3RS,5SR)-(4-oxa-1-azabicyclo [3,2,0]heptan-7-one-3-yl)methyloxycarbonyl, A C.sub.2-4 alkynyl group, a C.sub.3-6 cycloalkyl group which may be substituted by carboxy group or phenyl group which may have 1, 2 or 3 substituents selected from the group consisting of cyano group, halogen atom, C.sub.1-6 alkoxy group which may be substituted by carboxy group, C.sub.1-6 alkyl group, amino group or hydroxy group.--OR.sub.2 wherein R.sub.
    Type: Grant
    Filed: March 16, 1995
    Date of Patent: October 1, 1996
    Assignees: Taiho Pharmaceutical Co., Ltd., Synphar Laboratories, Inc.
    Inventors: Toshio Otani, Shinji Oie, Hiroshi Matsumoto, Mark Tempest, Ronald Micetich, Rajeshwar Singh, Tomohiro Yamashita
  • 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds and 7-(substituted triazolyl pyrrolidin-1-yl) 4-oxoquinoline-3-carboxylic acid derivatives useful as antibacterial agents
    Patent number: 5342846
    Abstract: Substituted quinoline compounds and intermediates thereto, processes for producing those compounds and intermediates, pharmaceutical compositions using those compounds, methods for treating bacterial infections using those compounds, and methods for disinfecting using those compounds.
    Type: Grant
    Filed: July 14, 1992
    Date of Patent: August 30, 1994
    Assignee: SynPhar Laboratories, Inc.
    Inventors: Rajeshwar Singh, Rakhshandeh Fathi-Afshar, Inder P. Singh, George Thomas, Thomas R. Doerksen, Maya P. Singh, Ronald G. Micetich