Abstract: Embodiments relate to device, system and methods for personalised drug dosing via a device, the device comprising a first chamber comprising a drug reservoir unit; a second chamber comprising an electronic unit comprising a control component; a third chamber comprising a drug delivery unit and a flow control component controlled via the electronic unit; wherein the device is fully implanted in a subject during its intended operational modes, and wherein the device releases a body temperature stable drug formulation into the subject at a flow rate such that a variation in the flow rate is within ±15% by volume.

Abstract: A composition comprising an yttria-rare earth-doped zirconium oxide is provided that has a tetragonal structure and a formula: YaLnbCexZr1-a-b-xO2-? where Ln is a mixture of rare earth elements; 0.01?a?0.051; 0.01?b?0.051 such that Y and each rare earth element is included in the composition in substantially equal molar amounts; 0.05?(a+b)?0.07; 0?x?0.051; and 0???0.05. Methods of forming a coating that includes this composition, along with the resulting coated components, are also provided.

Abstract: A composition is provided of a rare earth-doped zirconium oxide having a tetragonal structure and having a formula: YaLnbTaxNbzZr1-a-b-x-zO2-? where Ln is a rare earth element or a mixture of rare earth elements; 0?a?0.06; 0.06?b?0.12; 0?x?0.1; 0?z?0.1; 0.08?(x+z)?0.1; 0.16?(a+b+x+z)?0.22; and 0.01???0.05. Methods of forming a coating with this composition, along with the coated components, are also provided.

Abstract: A composition comprising a rare earth-doped zirconium/hafnium oxide is provided that has a defect-fluorite structure or a pyrochlore structure. The rare earth-doped zirconium/hafnium oxide has a formula: (Ln1aLn2aLn3aLn4aLn5b)2M2O7 where each of Ln1, Ln2, Ln3, Ln4, and Ln5 is a different rare earth element such that Ln1 and M have a first atomic radius ratio that is 1.35 to 1.45, Ln2 and M have a second atomic radius ratio that is 1.35 to 1.45, Ln3 and M have a third atomic radius ratio that is 1.46 to 1.78, and Ln4 and M have a fourth radius ratio that is 1.46 to 1.78; a is 0.2 or 0.25; b is 0.2 when a is 0.2, and b is 0 when a is 0.25; and M is Zr, Hf, or a mixture thereof. Methods of forming a coating that includes this composition, along with the resulting coated components, are also provided.

Abstract: A technique to provision a converted infrastructure (CI) includes generating task definitions to configure respective ones of compute, storage, and network components of a converged infrastructure (CI) when invoked. Each task definition includes a task identifier (ID), one or more component configuration commands, and one or more task arguments through which one or more corresponding component configuration parameters are passed to corresponding ones of the one or more component commands. The technique further includes automatically invoking each of the task definitions by task ID according to an ordered sequence in order to configure the CI. The automatically invoking includes providing the one or more component configuration commands and the corresponding one or more passed configuration parameters of each invoked task definition to the respective ones of the CI components.

Abstract: A technique to bootstrap a converged infrastructure design includes receiving a package specification unit (PU) representative of a design of a converged infrastructure (CI) including compute, storage, network, and virtualization components, the PU including component readable tasks that perform operations on the CI components. The PU further includes an inventory task model associated with tasks to read inventory information from the CI components, an assessment task model associated with tasks to assess the CI components, a configuration task model associated with tasks to configure the CI components, and a user input model to generate prompts to solicit and receive CI component information from a user, and provide the received information to the other PU models. The technique displays a PU model menu from which the PU models may be selected, and receives a selection of one of the PU models through the PU model menu.

Abstract: The present invention provides probes and methods of use thereof in the diagnosis and/or prognosis of certain types of cancers, particularly human papillomavirus (HPV)-associated cancers. The probes are designed for hybridization with genomic material in a manner indicative of one or more aberrations in the genetic material present in the test sample. The identified aberrations are biomarkers of HPV-associated cancer. The methods of the invention comprise contacting a sample to one or more probes, allowing any genetic material in the sample to hybridize to the genomic regions provided in the probes, analyzing the hybridizations, and analyzing the hybridizations to identify detected aberrations as biomarkers indicative of HPV-associated cancer progression.

Abstract: The present invention provides probes and methods of use thereof in the diagnosis and/or prognosis of certain types of cancers, particularly human papillomavirus (HPV)-associated cancers. The probes are designed for hybridization with genomic material in a manner indicative of one or more aberrations in the genetic material present in the test sample. The identified aberrations are biomarkers of HPV-associated cancer. The methods of the invention comprise contacting a sample to one or more probes, allowing any genetic material in the sample to hybridize to the genomic regions provided in the probes, analyzing the hybridizations, and analyzing the hybridizations to identify detected aberrations as biomarkers indicative of HPV-associated cancer progression.

Abstract: Systems and methods for optimizing processor requirements for a complex hardware system are disclosed. A set of complex hardware system configuration constraints are formulated as an objective function and a set of linear inequalities, and a convex polytope is formed from the set of linear inequalities. The objective function is optimized over the convex polytope using mixed integer linear programming means to obtain an optimal solution. Processor requirements for the complex hardware system are determined based on the optimal solution.

Abstract: The present invention provides probes and methods of use thereof in the diagnosis and/or prognosis of certain types of cancers, particularly human papillomavirus (HPV)-associated cancers. The probes are designed for hybridization with genomic material in a manner indicative of one or more aberrations in the genetic material present in the test sample. The identified aberrations are biomarkers of HPV-associated cancer. The methods of the invention comprise contacting a sample to one or more probes, allowing any genetic material in the sample to hybridize to the genomic regions provided in the probes, analyzing the hybridizations, and analyzing the hybridizations to identify detected aberrations as biomarkers indicative of HPV-associated cancer progression.

Abstract: Systems and methods for serving offline ads in a mobile device are provided. The mobile device includes a processor configured to determine whether the mobile device is online or offline. The mobile device includes a screen configured to display an offline ad in an active mobile application when the mobile device is offline. The mobile device includes an impression database configured to store impression information with the displayed offline ad and a communication unit configured to synchronize information between the mobile device and an online ads server when the mobile device is online. The synchronized information includes at least one of the following: offline ads impression counts, offline personalization information, and ads related to the offline personalization information.

Abstract: The present invention provides a novel, highly sensitive and specific probe panel which detects the type of renal cortical neoplasm present in a biopsy sample. As such, the invention permits diagnosis of the predominant subtypes of renal cortical neoplasms without the use of invasive methods. The present invention further provides a molecular cytogenetic method for detecting and analyzing the type of renal cortical neoplasm present in a renal biopsy sample.

Abstract: A technique to provision a converted infrastructure (CI) includes generating task definitions to configure respective ones of compute, storage, and network components of a converged infrastructure (CI) when invoked. Each task definition includes a task identifier (ID), one or more component configuration commands, and one or more task arguments through which one or more corresponding component configuration parameters are passed to corresponding ones of the one or more component commands. The technique further includes automatically invoking each of the task definitions by task ID according to an ordered sequence in order to configure the CI. The automatically invoking includes providing the one or more component configuration commands and the corresponding one or more passed configuration parameters of each invoked task definition to the respective ones of the CI components.

Abstract: A technique to bootstrap a converged infrastructure design includes receiving a package specification unit (PU) representative of a design of a converged infrastructure (CI) including compute, storage, network, and virtualization components, the PU including component readable tasks that perform operations on the CI components. The PU further includes an inventory task model associated with tasks to read inventory information from the CI components, an assessment task model associated with tasks to assess the CI components, a configuration task model associated with tasks to configure the CI components, and a user input model to generate prompts to solicit and receive CI component information from a user, and provide the received information to the other PU models. The technique displays a PU model menu from which the PU models may be selected, and receives a selection of one of the PU models through the PU model menu.

Abstract: Configuration models are accessed, each configuration model defining configuration attributes to be collected from a respective one of compute, storage, and network components of a converged infrastructure and collecting actual configuration attributes from each of the compute, storage, and network components of the converged infrastructure in accordance with the configuration models. A policy is accessed that defines configuration attribute rules corresponding to each of the configuration attributes collected from the compute, storage, and network components and comparing the collected configuration attributes to the configuration attribute rules for each of the compute, storage, and network components. Results of the comparing are reported, including which of the collected configuration attributes violate the corresponding configuration rules.

Abstract: A human-readable cable specification for a model converged infrastructure (CI) is converted to a machine-readable cable specification specifying model port mappings between model components of the model CI. The machine-readable cable specification is imported into a controller, which is in communication with an actual CI that includes operating components and actual connections between input/output (I/O) signal ports of the components. Port configurations are collected from the operating components, and actual port mappings are generated that identify the connections between the actual ports. The actual port mappings are compared against the model port mappings. A compliance report is generated indicating port mapping mismatches, if any, between the model and actual port mappings based on the comparing.

Abstract: A software module apparatus for enabling a user to generate a virtual tripwire through a geographic area of interest using a plurality of sensors. The apparatus may make use of an input for allowing a user to input a digital elevation model (DEM) of the area of interest. An input responsive to a user controlled device may also be used for defining a swath of the area of interest, the swath representing a subregion laying over, or adjacent to, a border to be monitored. A display may be generated for illustrating computed locations of a plurality of independent sensors used to form the virtual tripwire through the swath of the area of interest.

Abstract: A method for optimum sensor layout for detecting an intruder may include selecting candidate sensor locations within a representation of an area of regard. The method may also include determining a sub-region of detection for each sensor based on a preset probability of detection of the intruder traversing a sub-region associated with each sensor. The method may additionally include determining each pair of sensors with overlapping sub-regions of detection and determining a lowest probability of detection for any path between each pair of sensors with overlapping sub-regions of detection. The method may further include determining an optimum layout of sensor locations or sensors from candidate sensor locations based on a path of the lowest probability of detection for any path between each pair of sensors with overlapping sub-regions of detection.

Abstract: A first technique is provided for automatically building multiple signature patterns representative of corresponding converged infrastructures (CIs), and a second technique is provided for automatically detecting pattern matches between one or more of the multiple signature patterns (and thus the model CIs) built using the first technique and an operating converged infrastructure (CI). Each of the signature patterns includes a compilation of component signatures representative of model compute, storage, and network components of the corresponding model CI. The second technique includes collecting component signatures from, and representative of, each of compute, storage, and network components of an operating converged infrastructure (CI), and pattern matching each of the collected component signatures against one or more of the signature patterns that represent the model CIs. The second technique also includes declaring match results based on the pattern matching.

Abstract: The present invention provides a novel, highly sensitive and specific probe panel which detects the type of renal cortical neoplasm present in a biopsy sample. As such, the invention permits diagnosis of the predominant subtypes of renal cortical neoplasms without the use of invasive methods. The present invention further provides a molecular cytogenetic method for detecting and analyzing the type of renal cortical neoplasm present in a renal biopsy sample.