Abstract: The invention relates to activators of FXR useful in the treatment of autoimmune disorders, liver disease, intestinal disease, kidney disease, cancer, and other diseases in which FXR plays a role, having the Formula (I): wherein L1, A, X1, X2, R1, R2, and R3 are described herein.

Abstract: An apparatus for generating a three-dimensional (3D) model of anatomical object via machine-learning, wherein the apparatus includes a process and a memory containing instructions configuring the processor to receive a set of images of an anatomical object pertaining to a subject, generate an 3D data structure representing the anatomical object as a function of the set of images using an anatomy modeling model, generate an initial 3D model of the anatomical object and refine the generated initial 3D model of the anatomical object as a function of the 3D data structure representing the anatomical object.

Abstract: Aspects of the subject disclosure may include, for example, obtaining a natural language statement of an optimization problem that is to be solved, analyzing the natural language statement to select a template included within a plurality of templates, generating a definition for the optimization problem using the template, constructing a model in accordance with the definition, resulting in a constructed model, and validating the constructed model, resulting in a validated model. Other embodiments are disclosed.

Abstract: A cable reel that includes a one-piece frame body, a flange separate from the frame body, and a hub member therebetween. The one-piece frame body includes an outer frame portion and an inner flange portion. The flange has an inner side that faces the inner side of the one-piece frame body. The hub member is located between the one-piece frame body and the flange along a central longitudinal axis of the cable reel. The hub member has a first end that rotatably couples to the inner flange portion of the one-piece frame body and a second end that couples to the flange. The hub member is configured to support a coil of cable and is sized to be received inside of an inner diameter of the coil of cable. The flange and the hub member rotate together with respect to the one-piece frame body.

Abstract: The invention relates to novel melon plants producing fruits displaying a combination of a long shelf-life trait as well as a maturity indicator trait. The invention also relates to seeds and parts of said plants, for example fruits. The invention further relates to methods of making and using such seeds and plants. The invention also relates to novel genetic sequences associated with a rind-turning phenotype at maturity, which, when combined with a long shelf-life allele, significantly alters the characteristics of the maturing melon fruit, functions as a reliable maturity indicator while retaining suitable marketable features and results in a novel melon plant type.

Abstract: An electronic device package comprises a primary microphone having a frequency response having a first resonance frequency, and a reference microphone having a frequency response including a second resonance frequency, the primary microphone and the reference microphone configured to substantially simultaneously receive a same acoustic signal to produce a transduced signal of the primary microphone and a transduced signal of the reference microphone, the second resonance frequency of the reference microphone being different than the first resonance frequency of the primary microphone, the package having dimensions that cause the primary microphone and reference microphone to be acoustically isolated from one another at the resonance frequency of the primary microphone, there being less than 3 dB of acoustic coupling between the primary microphone and reference microphone at the first resonance frequency.

Abstract: Systems/techniques that facilitate deep learning multi-planar reformatting of medical images are provided. In various embodiments, a system can access a three-dimensional medical image. In various aspects, the system can localize, via execution of a machine learning model, a set of landmarks depicted in the three-dimensional medical image, a set of principal anatomical planes depicted in the three-dimensional medical image, and a set of organs depicted in the three-dimensional medical image. In various instances, the system can determine an anatomical orientation exhibited by the three-dimensional medical image, based on the set of landmarks, the set of principal anatomical planes, or the set of organs. In various cases, the system can rotate the three-dimensional medical image, such that the anatomical orientation now matches a predetermined anatomical orientation.

Abstract: Systems and methods include establishing a cryptographically secure communication between an application module and an audio module. The application module is configured to execute on an information-handling machine, and the audio module is coupled to the information-handling machine. The establishment of the cryptographically secure communication may be at least partially facilitated by a mutually trusted module.

Abstract: Methods that are useful in semiconductor chip design are presented. A microarchitectural structured flow chart can be processed and converted into register transfer level hardware description language code. Processing of the flow chart can include detecting shapes, lines, colors, and text. The shapes that are detected can be rounded, rhombus, and rectangle and a rounded shape can represent a state, a rhombus can represent a decision, and a rectangle can represent an assignment for a finite state machine.

Abstract: Technologies for reducing the impact of inductors on electrical traces are disclosed. In an illustrative embodiment, conductive ink is applied in a silk screen layer on top of a solder mask of a circuit board. The conductive ink forms shield regions under and near where inductors are placed and/or where a power plane is routed. The conductive shield regions may be coupled to a ground plane in the circuit board. The conductive shield regions can partially shield traces under and near the inductor, reducing the noise induced on nearby traces. The conductive shield regions can allow traces for high-speed input/output signals to be routed closer to the inductor, reducing the size, number of layers, and/or cost of the circuit board. In some embodiments, the conductive shield regions can shield emissions from the power plane, reducing interference on antennas of a device.

Abstract: Methods, apparatus, and computer programs are disclosed to detect computing system hardware defects using a portable storage device. In one embodiment, a method includes accessing a portable storage device to obtain an identifier and a set of test patterns to test a set of circuits of a computing system, the identifier to map to the set of test patterns. The method further includes determining that the set of test patterns is to be executed on the computing system based on the identifier to be obtained from accessing the portable storage device. Responsive to the determination, and executing the set of test patterns loaded from the portable storage device on the set of circuits of the computing system to detect one or more hardware defects of the set of circuits.

Abstract: Cache invalidation circuitry responds to a cache invalidation command specifying invalidation scope information indicative of at least one invalidation condition, to control a cache to perform an invalidation process to invalidate cache entries satisfying the invalidation condition(s). Cache lookup circuitry issues to the cache a cache lookup request specifying address information, to request that the cache returns a cache lookup response.

Abstract: This application discloses an information determining method and apparatus, a communication device, and a readable storage medium. The information determining method according to an embodiment of this application includes: determining, by a communication device, that a referred resource associated with a CSI report is located in a first time domain unit, where the first time domain unit includes at least one time domain unit that is at least N time units subsequent to a first time domain resource, and the first time domain resource is a time domain resource for an uplink channel carrying the CSI report, where N is a positive integer.

Abstract: A system and method for maintaining data quality, including: periodically updating, at a first computing apparatus, a source data table maintained at a second computing apparatus at a first time interval; periodically updating, in an iterative or recursive manner at the first computing apparatus, a batch data table maintained at the second computing apparatus at a second time interval; obtaining, at the second computing apparatus from an information system, one or more data tables, metadata, and one or more transaction tables; determining, at the second computing apparatus, whether a refresh timestamp or a modification timestamp is within a predetermined time period from a timestamp of the one or more transaction tables; when it is within the predetermined time period, updating a data visualization application for reviewing the timestamp negative result, wherein the data visualization application comprises a graphical user interface that is accessible using a third computing apparatus.

Abstract: Modified ribosomes that were selected using a dipeptidyl-puromycin aminonucleoside are used to mediate site-specific incorporation of one or more peptides and peptidomimetics into protein in a cell free translation system. In addition, new fluorescent dipeptidomimetics have been synthesized and incorporated into proteins, as well as modified proteins containing one or more non-naturally occurring dipeptides.

Abstract: A method of providing channel content in a broadcast content reception and distribution system includes: receiving, by a broadcast content reception device, information that identifies a channel that provides channel content, from a content player device; receiving, by the broadcast content reception device, a signal that transmits the channel content, from an antenna; receiving, by the broadcast content reception device, information that indicates a signal strength corresponding to the channel based on the signal that transmits the channel content received from the antenna; determining, by the broadcast content reception device, that the signal strength is less than or equal to a threshold value based on the information that indicates the signal strength; and transmitting, by the broadcast content reception device, a message to the content player device in response to the determining that the signal strength is less than or equal to the threshold value.

Abstract: A lateral III-N device has a vertical gate module with III-N material orientated in an N-polar or a group-III polar orientation. A III-N material structure has a III-N buffer layer, a III-N barrier layer, and a III-N channel layer. A compositional difference between the III-N barrier layer and the III-N channel layer causes a 2DEG channel to be induced in the III-N channel layer. A p-type III-N body layer is disposed over the III-N channel layer in a source side access region but not over a drain side access region. A n-type III-N capping layer over the p-type III-N body layer. A source electrode that contacts the n-type III-N capping layer is electrically connected to the p-type III-N body layer and is electrically isolated from the 2DEG channel when the gate electrode is biased relative to the source electrode at a voltage that is below a threshold voltage.

Abstract: Apparatus for generating electro-anatomical mapping and methods used therein include a processor and a memory connected to the processor, wherein the memory contains instructions configuring the processor to receive input data, generate, using at least a machine learning model, an electro-anatomical mapping as a function of the input data, and display the electro-anatomical mapping using a user interface, wherein receiving the input data includes receiving, from an imaging device, at least a medical image and receiving, from a signal capturing device, at least an electrogram, wherein the at least a machine learning model is trained using electro-anatomical mapping training data including exemplary medical images and exemplary electrograms as input correlated to exemplary electro-anatomical mappings as output.

Abstract: A user-interface method of selecting and presenting a collection of content items based on user navigation and selection actions associated with the content is provided. The method includes associating a relevance weight on a per user basis with content items to indicate a relative measure of likelihood that the user desires the content item. The method includes receiving a user's navigation and selections actions for identifying desired content items, and in response, adjusting the associated relevance weight of the selected content item and group of content items containing the selected item. The method includes, in response to subsequent user input, selecting and presenting a subset of content items and content groups to the user ordered by the adjusted associated relevance weights assigned to the content items and content groups.

Abstract: Described herein are systems and methods for responding to user input using an agent orchestrator. A system may include a cardiac catheter, a user interface, and a computing device configured to receive, from the user interface, a first user input, receive, from the catheter, the procedure data, determine, using an agent orchestrator, a first agent selection datum, wherein determining the first agent selection datum includes generating the first agent selection datum as a function of the first user input using a trained agent selection machine learning model, using a first agent corresponding to the first agent selection datum, determine a first agent output, wherein determining the first agent output includes inputting into the first agent the procedure data, and receiving, as an output from the first agent, the first agent output, and display, using the user interface, the first agent output.