Patents by Inventor Ralf Schumacher

Ralf Schumacher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-OX40L antibodies
    Publication number: 20100166740
    Abstract: This invention relates to anti-OX40L antibodies and, in particular, to anti-OX40L antibodies and variants thereof that contain a Fc part derived from human origin and do not bind complement factor C1q. These antibodies have new and inventive properties causing a benefit for a patient suffering from inflammatory diseases.
    Type: Application
    Filed: December 5, 2008
    Publication date: July 1, 2010
    Inventors: Joseph Endl, Elsie M. Eugui, Maria Elena Fuentes, Yvo Graus, Aran Frank Labrijn, Martin Lanzendoerfer, Paul Parren, Frank Rebers, Ralf Schumacher, Stefan Seeber, Jan Van de Winkel, Martine Van Vugt
  • Plug connector with an adaptor housing for receiving a plug or socket arrangement
    Patent number: 7670060
    Abstract: A fiber optic connector arrangement includes a locking device for fastening together a pair of male plug and female socket components, which locking device consists of locking elements mounted solely on a pair of telescopic adapter housings that support the plug and socket components when in the engaged condition. In order to increase the operational life of the connector components, one of the plug and socket components contains a recess for receiving an auxiliary second locking device that extends longitudinally in a normally non-stressed unlocked inoperative condition from the other component.
    Type: Grant
    Filed: January 6, 2009
    Date of Patent: March 2, 2010
    Assignee: Weidmuller Interface GmbH & Co. KG
    Inventors: Juergen Ziemke, Ralf Schumacher, Michaela Muecke, Andreas Muhs, Volker Schroeder
  • Antibodies against CCR5 and uses thereof
    Patent number: 7615216
    Abstract: Antibodies that specifically bind to CCR5 are useful for treating immunosuppressive disease.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: November 10, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Michael Brandt, Surya Sankuratri, Ralf Schumacher, Stefan Seeber
  • ANTIBODIES AGAINST INSULIN-LIKE GROWTH FACTOR I RECEPTOR AND USES THEREOF
    Publication number: 20090275126
    Abstract: Antibodies against insulin like growth factor I receptor (IGF-IR), methods for their production, pharmaceutical compositions containing said antibodies, and uses for such antibodies are disclosed. Such antibodies are implicated in antitumor therapy.
    Type: Application
    Filed: July 17, 2009
    Publication date: November 5, 2009
    Inventors: Yvo Graus, Erhard Kopetzki, Klaus-Peter Kuenkele, Olaf Mundigl, Paul Parren, Frank Rebers, Ralf Schumacher, Jan van de Winkel, Martine Vriesema-van Vugt
  • Antibody selection method against IGF-IR
    Patent number: 7579157
    Abstract: Antibodies against insulin like growth factor I receptor (IGF-IR), methods for their production, pharmaceutical compositions containing the antibodies, and uses for the antibodies are disclosed. Antibodies against IGF-IR are implicated in antitumor therapy.
    Type: Grant
    Filed: July 8, 2004
    Date of Patent: August 25, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Yvo Graus, Erhard Kopetzki, Klaus-Peter Kuenkele, Olaf Mundigl, Paul Parren, Frank Rebers, Ralf Schumacher, Jan van de Winkel, Martine Vriesema-van Vugt
  • Antibodies against insulin-like growth factor I receptor and uses thereof
    Patent number: 7572897
    Abstract: Antibodies against insulin like growth factor I receptor (IGF-IR), methods for their production, pharmaceutical compositions containing said antibodies, and uses for such antibodies are disclosed. Antibodies against IGF-IR are implicated in antitumor therapy.
    Type: Grant
    Filed: October 9, 2007
    Date of Patent: August 11, 2009
    Assignee: Hoffman-La Roche Inc.
    Inventors: Yvo Graus, Erhard Kopetzki, Klaus-Peter Kuenkele, Olaf Mundigl, Paul Parren, Frank Rebers, Ralf Schumacher, Jan van de Winkel, Martine Vriesema-van Vugt
  • ANTIBODIES AGAINST INTERLEUKIN-1 RECEPTOR AND USES THEREOF
    Publication number: 20090191187
    Abstract: The present invention relates to antibodies against interleukin-1 receptor (IL-1R), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof. The antibodies of the present invention are particularly useful for treating a variety of inflammatory diseases including, but not limited to, rheumatoid arthritis.
    Type: Application
    Filed: February 13, 2009
    Publication date: July 30, 2009
    Inventors: Ilse Bartke, Francis Carr, Richard Anthony Chizzonite, Elsie M. Eugui, Georg Fertig, Anita Hamilton, Martin Lanzendoerfer, Petra Rueger, Ralf Schumacher, Theresa Patricia Truitt
  • Plug connector with an adapter housing for receiving a plug or socket arrangement
    Publication number: 20090185777
    Abstract: A fiber optic connector arrangement includes a locking device for fastening together a pair of male plug and female socket components, which locking device consists of locking elements mounted solely on a pair of telescopic adapter housings that support the plug and socket components when in the engaged condition. In order to increase the operational life of the connector components, one of the plug and socket components contains a recess for receiving an auxiliary second locking device that extends longitudinally in a normally non-stressed unlocked inoperative condition from the other component.
    Type: Application
    Filed: January 6, 2009
    Publication date: July 23, 2009
    Inventors: Juergen Ziemke, Ralf Schumacher, Michaela Muecke, Andreas Muhs, Volker Schroeder
  • Interferon-alpha polypeptides and conjugates
    Patent number: 7541163
    Abstract: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: June 2, 2009
    Assignees: Maxygen, Inc., Roche Palo Alto LLC
    Inventors: Phillip A. Patten, Sridhar Viswanathan, Torben Lauesgaard Nissen, Anne Vogt, Harald Kropshofer, Ralf Schumacher, Stephan Fischer, Stefan Seeber, Adelbert Grossmann, Friederike Hesse
  • Interferon-alpha polypeptides and conjugates
    Patent number: 7541436
    Abstract: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
    Type: Grant
    Filed: May 4, 2007
    Date of Patent: June 2, 2009
    Assignees: Maxygen, Inc., Roche Palo Alto LLC
    Inventors: Phillip A. Patten, Sridhar Viswanathan, Torben Lauesgaard Nissen, Anne Vogt, Harald Kropshofer, Ralf Schumacher, Stephan Fischer, Stefan Seeber, Andreas Schaubmar, Hans Koll
  • Interferon-alpha polypeptides and conjugates
    Patent number: 7537755
    Abstract: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
    Type: Grant
    Filed: August 15, 2007
    Date of Patent: May 26, 2009
    Assignees: Maxygen, Inc., Roche Palo Alto LLC
    Inventors: Phillip A. Patten, Sridhar Viswanathan, Torben Lauesgaard Nissen, Anne Vogt, Harald Kropshofer, Ralf Schumacher, Stephan Fischer, Stefan Seeber, Andreas Schaubmar, Hans Koll
  • Interferon-alpha polypeptides and conjugates
    Patent number: 7531324
    Abstract: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
    Type: Grant
    Filed: September 13, 2006
    Date of Patent: May 12, 2009
    Assignee: Maxygen, Inc.
    Inventors: Phillip A. Patten, Sridhar Viswanathan, Torben Lauesgaard Nissen, Anne Vogt, Harald Kropshofer, Ralf Schumacher, Stephan Fischer, Stefan Seeber, Andreas Schaubmar, Roberto Falkenstein
  • Interferon-alpha polypeptides and conjugates
    Patent number: 7531630
    Abstract: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
    Type: Grant
    Filed: September 13, 2006
    Date of Patent: May 12, 2009
    Assignee: Maxygen, Inc.
    Inventors: Phillip A. Patten, Sridhar Viswanathan, Torben Lauesgaard Nissen, Anne Vogt, Harald Kropshofer, Ralf Schumacher, Stephan Fischer, Stefan Seeber, Andreas Schaubmar, Hans Koll
  • Mutants of IGF Binding Proteins and Methods of Production of Antagonists Thereof
    Publication number: 20090117662
    Abstract: The present invention provides a crystal suitable for X-ray diffraction, comprising a complex of insulin-like growth factor I or II (IGF) and a polypeptide consisting of the amino acids 40-92 of IGFBP-5 or a fragment thereof consisting at least of the 9th to 12th cysteine of IGFBP-5 methods for the determination of the atomic coordinates of such a crystal; IGFBP mutants with enhanced binding affinity for IGF-I and/or IGF-II, and methods to identify and optimize small molecules which displace IGFs from their binding proteins.
    Type: Application
    Filed: August 5, 2008
    Publication date: May 7, 2009
    Inventors: Hans-Georg Beisel, Dirk Demuth, Richard Engh, Tadeusz Holak, Robert Huber, Kurt Lang, Ralf Schumacher, Wojciech Zeslawski
  • Anti-OX40L antibodies
    Patent number: 7501496
    Abstract: This invention relates to anti-OX40L antibodies and, in particular, to anti-OX40L antibodies and variants thereof that contain a Fc part derived from human origin and do not bind complement factor C1q. These antibodies have new and inventive properties causing a benefit for a patient suffering from inflammatory diseases.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: March 10, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: Joseph Endl, Elsie M. Eugui, Maria Elena Fuentes, Yvo Graus, Aran Frank Labrijn, Martin Lanzendoerfer, Paul Parren, Frank Rebers, Ralf Schumacher, Stefan Seeber, Jan Van De Winkel, Martine Van Vugt
  • Conjugate of an antibody against CCR5 and an antifusogenic peptide
    Publication number: 20090028881
    Abstract: The current invention is related to a conjugate comprising one or more antifusogenic peptides and an anti-CCR5 antibody (mAb CCR5) characterized in that one to eight antifusogenic peptides are each conjugated to one terminus of the heavy and/or light chains of said anti-CCR5 antibody and to the pharmaceutical use of said conjugate.
    Type: Application
    Filed: August 17, 2007
    Publication date: January 29, 2009
    Inventors: Michael Brandt, Stephan Fischer, Erhard Kopetzki, Suryanarayana Sankuratri, Ralf Schumacher
  • IGF-1 RECEPTOR INTERACTING PROTEINS
    Publication number: 20090018312
    Abstract: The invention comprises a nucleic acid molecule with the sequence SEQ ID NO:5 and the complementary sequence, and its use in diagnosis and therapy. This nucleic acid molecule (IIP-10) is a gene which encodes an IGF-1 receptor binding polypeptide.
    Type: Application
    Filed: September 13, 2007
    Publication date: January 15, 2009
    Inventors: Tanja Ligensa, Ralf Schumacher, Michael Weidner
  • INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES
    Publication number: 20080171363
    Abstract: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
    Type: Application
    Filed: August 14, 2007
    Publication date: July 17, 2008
    Inventors: Phillip A. Patten, Sridhar Viswanathan, Torben Lauesgaard Nissen, Anne Vogt, Harald Kropshofer, Ralf Schumacher, Stephan Fischer, Stefan Seeber, Adelbert Grossmann, Friederike Hesse, Andreas Schaubmar, Roberto Falkenstein, Hans Koll, Markus Dembowski
  • ANTIBODIES AGAINST INSULIN-LIKE GROWTH FACTOR I RECEPTOR AND USES THEREOF
    Publication number: 20080132686
    Abstract: Antibodies against insulin like growth factor I receptor (IGF-IR), methods for their production, pharmaceutical compositions containing said antibodies, and uses for such antibodies are disclosed. Such antibodies are implicated in antitumor therapy.
    Type: Application
    Filed: October 9, 2007
    Publication date: June 5, 2008
    Inventors: Yvo Graus, Erhard Kopetzki, Klaus-Peter Kuenkele, Olaf Mundigl, Paul Parren, Frank Rebers, Ralf Schumacher, Jan van de Winkel, Martine Vriesema-van Vugt
  • Connector
    Patent number: D613246
    Type: Grant
    Filed: December 9, 2008
    Date of Patent: April 6, 2010
    Assignee: Weidmueller Interface GmbH & Co. KG
    Inventors: Michaela Muecke, Ralf Schumacher, Andreas Muhs, Simon Seereiner, Barbara Weithaas