Abstract: Described is a method for the specific modulation of the expression of target genes in cells and/or tissues of the CNS and/or eye, wherein a composition comprising one or more doubled stranded oligoribonucleotides (dsRNA) is introduced into the cell, tissue or organism outside the blood-brain or blood-retina barriers. Furthermore, a method for the identification and validation of the function of a gene is provided, wherein the method provides a test cell, test tissue or test organism, which allow information to be gained on the function of the target gene. In addition, compositions and kits are described useful for those methods. In particular, components and methods for the diagnostic use and/or therapy of disorders related to the CNS and/or eye are provided which are based on RNA interference.

Abstract: According to the present invention there is provided a compound in the form of a transition metal compound including a transition metal, a phosphorus containing ligand, and a cyclic organic ligand. The phosphorus containing ligand is a heterocyclic organic compound with a ligating phosphorus atom which ligates with the transition metal, and which ligating phosphorus atom is an atom in the heterocyclic ring structure of the heterocyclic organic compound. The cyclic organic ligand is a cyclic organic compound with a ligating carbon atom in the cyclic ring structure of the cyclic organic compound which ligates with the transition metal by means of a double bound. The invention also relates to a method preparing such a compound and a metathesis reaction wherein such a compound is used as a catalyst.

Abstract: In a spring shock absorber for a motor vehicle, with a first body part and a second body part, the first body part forms a first changeable volume with the second body part by way of a first rolling bellows, and the second body part forms a second changeable volume with a roll-off piston connected to the first body part by way of a second rolling bellows. The two rolling bellows are arranged in such a way that they are guided in the radial direction during a rolling motion by lateral contours of the two body parts and the roll-off piston. The two volumes are connected to one another via a throttle element and form a hermetically closed two-volume system with respect to a deflection of the spring shock absorber. The roll-off piston is guided through the second body part in a longitudinally displaceable manner by means of a sealing element.

Abstract: A dashpot featuring amplitude-dependent shock absorption, especially intended for the wheel of a vehicle and including a hydraulically parallel cylindrical pressure-compensation chamber (8). The pressure-compensation chamber is partitioned by an axially displaceable floating piston (10). At least one face (25) of the floating piston is provided with a resilient bumper (18). The object is a dashpot with a floating piston that arrives more gently at its limit inside the pressure-compensation chamber (8). The bumper is accordingly accommodated in an axial hollow (17) that extends through the body (15) of the floating piston.

Abstract: According to the present invention there is provided a compound in the form of a transition metal compound including a transition metal, a phosphorus containing ligand, and a cyclic organic ligand. The phosphorus containing ligand is a heterocyclic organic compound with a ligating phosphorus atom which ligates with the transition metal, and which ligating phosphorus atom is an atom in the heterocyclic ring structure of the heterocyclic organic compound. The cyclic organic ligand is a cyclic organic compound with a ligating carbon atom in the cyclic ring structure of the cyclic organic compound which ligates with the transition metal by means of a double bound. The invention also relates to a method preparing such a compound and a metathesis reaction wherein such a compound is used as a catalyst.

Abstract: A dashpot featuring amplitude-dependent shock absorption, especially intended for the wheel of a vehicle and including a hydraulically parallel cylindrical pressure-compensation chamber (8). The pressure-compensation chamber is partitioned by an axially displaceable floating piston (10). At least one face (25) of the floating piston is provided with a resilient bumper (18). The object is a dashpot with a floating piston that arrives more gently at its limit inside the pressure-compensation chamber (8). The bumper is accordingly accommodated in an axial hollow (17) that extends through the body (15) of the floating piston.

Abstract: A piston rod has a hollow section with an open end, a housing, and a fastening connection for a piston. The housing includes a cap welded to the open end, a tubular intermediate piece welded to the cap, and a bottom part attached to the fastening connection. The cap has a shoulder received in the intermediate piece to form an annular space which functions as a labyrinth seal to receive any weld spatters formed during the friction welding process. The outside surface of the piston rod is machined to final dimensions and surface coated following welding.

Abstract: A pari-mutual wagering system offering a plurality of wagering options to bettors for individual predictions of the individual outcomes sporting contests in contest groupings having a plurality of such sporting contests. At least one of the individual sporting contests of each plurality will have a at least one overtime period to determine a contest winner in the event of a tie at the end of regulation play. The wagering options include a bet on a tie at the end of regulation play and before such an overtime period for contests which have an overtime period. Winners from the bettors betting on any grouping would receive larger prize awards correlating to their correct number of outcomes. The system can also be employed as a game for fun where points are awarded for the most correct predictions of outcomes or a prize is awarded to the bettor with the most correct predictions.

Abstract: A piston rod has a hollow piston rod section, a housing axially spaced from the end portion of the hollow piston rod, and a cup located between the end portion of the rod section and the housing and welded to the latter.

Abstract: In a shock absorber for a motor vehicle for damping the relative movement between a vehicle wheel and a vehicle body, comprising a damper housing filled with an operating medium and a piston rod with a piston disposed in the damper housing so as to divide the interior of the damper housing into two operating chambers and forming a first damper element, a second damper element is disposed in the piston rod and is in communication with the two operating chambers by way of bypass bores extending through the piston rod.

Abstract: A dashpot featuring amplitude-dependent shock absorption, especially intended for the wheel of a vehicle and including a hydraulically parallel cylindrical pressure-compensation chamber (8). The pressure-compensation chamber is partitioned by an axially displaceable floating piston (10). At least one face (25) of the floating piston is provided with a resilient bumper (18). The object is a dashpot with a floating piston that arrives more gently at its limit inside the pressure-compensation chamber (8). The bumper is accordingly accommodated in an axial hollow (17) that extends through the body (15) of the floating piston.

Abstract: The invention deals with the technical problem to devise a process for the extended use of electrolytes which economically ensures a high electrolyte quality without having to accept production interruptions for regeneration. Especially, it is envisaged to conduct the process for the precipitation of non-glaring metal coatings in such a manner that work can proceed in three shifts for five days per week, without encountering production interruptions due to coagulation of the fine dispersal phase, respectively, and without the additional operating cost of a heating/cooling circuit. The invention solves the problem in that during the extended use of an electrolyte a partial flow is split off which is filtered and, if applicable, regenerated by the addition of active substances and reintegrated in the operating cycle.