Abstract: A building component manufacturing method may include providing an insulated structural component of a building. The insulated structural component may include a frame comprising a plurality of outer components coupled together to define an outer periphery of one or more sections. At least one of the sections may include a cavity. The method may include applying a pour-in-place insulation material within the cavity to insulate the component. The pour-in-place insulation material may transition from a liquid state to a solid state to form a first layer of insulation within the cavity. The method may include monitoring a fill level within the cavity while applying the pour-in-place insulation material. The method may include controlling a flow rate of the pour-in-place insulation material based on the monitoring of the fill level within the cavity.

Abstract: A building component manufacturing method may include providing an insulated structural component of a building. The insulated structural component may include a frame comprising a plurality of outer components coupled together to define an outer periphery of one or more sections. At least one of the sections may include a cavity. The method may include applying a pour-in-place insulation material within the cavity to insulate the component. The pour-in-place insulation material may transition from a liquid state to a solid state to form a first layer of insulation within the cavity. The method may include monitoring a fill level within the cavity while applying the pour-in-place insulation material. The method may include controlling a flow rate of the pour-in-place insulation material based on the monitoring of the fill level within the cavity.

Abstract: Disclosed herein is a recombinant adeno-associated virus (AAV) vector comprising (a) a variant AAV2 capsid protein, wherein the variant AAV2 capsid protein comprises at least four amino acid substitutions with respect to a wild type AAV2 capsid protein; wherein the at least four amino acid substitutions are present at the following positions in an AAV2 capsid protein sequence: 457, 492, 499 and 533; and (b) a heterologous nucleic acid comprising a nucleotide sequence encoding a gene product.

Abstract: A building component manufacturing method may include providing an insulated structural component of a building. The insulated structural component may include a frame comprising a plurality of outer components coupled together to define an outer periphery of one or more sections. At least one of the sections may include a cavity. The method may include applying a pour-in-place insulation material within the cavity to insulate the component. The pour-in-place insulation material may transition from a liquid state to a solid state to form a first layer of insulation within the cavity. The method may include monitoring a fill level within the cavity while applying the pour-in-place insulation material. The method may include controlling a flow rate of the pour-in-place insulation material based on the monitoring of the fill level within the cavity.

Abstract: Disclosed herein is a recombinant adeno-associated virus (AAV) vector comprising (a) a variant AAV2 capsid protein, wherein the variant AAV2 capsid protein comprises at least four amino acid substitutions with respect to a wild type AAV2 capsid protein; wherein the at least four amino acid substitutions are present at the following positions in an AAV2 capsid protein sequence: 457, 492, 499 and 533; and (b) a heterologous nucleic acid comprising a nucleotide sequence encoding a gene product.

Abstract: The present disclosure relates to viral particles for use in treating tauopathies, particularly Alzheimer's disease, by gene therapy. More specifically, the present invention relates to a viral particle for use in treating tauopathies by gene therapy in a subject in need thereof, said viral particle comprising a nucleic acid construct including a transgene encoding a glucocerebro sidase.

Abstract: A fiberglass reinforced aerogel composite may include coarse glass fibers, glass microfibers, aerogel particles, and a binder. The coarse glass fibers may have an average fiber diameter between about 8 ?m and about 20 ?m. The glass microfibers may have an average fiber diameter between about 0.5 ?m and about 3 ?m. The glass microfibers may be homogenously dispersed within the coarse glass fibers. The aerogel particles may be homogenously dispersed within the coarse glass fibers and the glass microfibers. The fiberglass reinforced aerogel composite may include between about 50 wt. % and about 75 wt. % of the aerogel particles. The binder bonds the coarse glass fibers, the glass microfibers, and the aerogel particles together.

Abstract: The present invention relates to a method and apparatus for determining correlations between text or text-derived data and numerical data. Specifically the present invention relates to determining correlation(s) between text-derived and numerical data in order to generate estimated numerical data using the determined correlation(s) for specific text-derived data. Aspects and/or embodiments seek to provide a method for estimating numerical data using historical numerical data and historical text-derived data. Aspects and/or embodiments also seek to determine a correlation between the historical numerical data and historical text-derived data for use in generating the estimated numerical data using text-derived data, optionally to identify relevant trends in text-derived data that can be used to generate estimated/predicted numerical data, and optionally in order to train a computer implemented model to generate estimates of numerical data for given text-derived data.

Abstract: A movable ballast system for an aircraft includes first and second ballast docks secured to the aircraft. The first ballast dock includes a first housing and a first ballast tray secured within the first housing. The first ballast tray includes a plurality of channels. The second ballast dock is positioned aft of a CG of the aircraft and includes a second housing and a second ballast tray secured within the second housing. The second ballast tray includes a plurality of channels. The movable ballast system includes a plurality of movable ballasts, each movable ballast of the plurality of movable ballasts being configured to fit within at least one channel of each of the plurality of channels of the first and second ballast trays.

Abstract: The present disclosure relates to viral particles for use in treating synucleinopathies, particularly sporadic Parkinson Diseases by gene therapy. More specifically, the present invention relates to a viral particle for use in treating synucleinopathy by gene therapy in a subject in need thereof, said viral particle comprising a nucleic acid construct including a transgene encoding a glucocerebrosidase.

Abstract: A fuel sample extractor (FSE) for an aircraft includes a sample chamber, a lid configured to seal the sample chamber, a pump in selective fluid communication with an upper portion of the sample chamber, and a straw in selective fluid communication with a lower portion of the sample chamber and a fuel tank.

Abstract: A method of adjusting a center of gravity (CG) of an aircraft includes: inputting at least one load parameter into a flight computer, determining, via a processer of the flight computer, the CG of the aircraft. Responsive to a determination by the processor that the CG is outside of a CG envelope, moving at least a first movable ballast of a plurality of movable ballasts from a first ballast dock to a second ballast dock to move the CG toward the CG envelope. Each of the first and second ballast docks may include a housing and a first ballast tray secured within the housing and comprising a plurality of channels.

Abstract: Disclosed herein is a recombinant adeno-associated virus (AAV) vector comprising (a) a variant AAV2 capsid protein, wherein the variant AAV2 capsid protein comprises at least four amino acid substitutions with respect to a wild type AAV2 capsid protein; wherein the at least four amino acid substitutions are present at the following positions in an AAV2 capsid protein sequence: 457, 492, 499 and 533; and (b) a heterologous nucleic acid comprising a nucleotide sequence encoding a gene product.

Abstract: A movable ballast system for an aircraft includes first and second ballast docks secured to the aircraft. The first ballast dock includes a first housing and a first ballast tray and a first stop plate secured within the first housing. The first ballast tray includes a plurality of channels. The second ballast dock is positioned aft of a CG of the aircraft and includes a second housing and a second ballast tray and a second stop plate secured within the second housing. The second ballast tray includes a plurality of channels. The movable ballast system includes a plurality of movable ballasts, each movable ballast of the plurality of movable ballasts being configured to fit within at least one channel of each of the plurality of channels of the first and second ballast trays.

Abstract: A movable ballast system for an aircraft includes first and second ballast docks secured to the aircraft. The first ballast dock includes a first housing and a first ballast tray secured within the first housing. The first ballast tray includes a plurality of channels. The second ballast dock is positioned aft of a CG of the aircraft and includes a second housing and a second ballast tray secured within the second housing. The second ballast tray includes a plurality of channels. The movable ballast system includes a plurality of movable ballasts, each movable ballast of the plurality of movable ballasts being configured to fit within at least one channel of each of the plurality of channels of the first and second ballast trays.

Abstract: A fiber reinforced insulation product may include a first layer of fiber reinforced aerogel composite and a second layer of fiber reinforced aerogel composite. The first layer may include entangled fibers, aerogel particles dispersed within the entangled fibers, and a first binder that may form a first binding framework that bonds the entangled fibers and the aerogel particles of the first layer together. The second layer may include entangled fibers, aerogel particles dispersed within the entangled fibers, and a second binder that may form a second binding framework that bonds the entangled fibers and the aerogel particles of the second layer together. The fiber reinforced insulation product may further include a third binder that may form a third binding framework that bonds the first layer and the second layer together. The third binder may be dispersed throughout the first layer and the second layer.

Abstract: According to one embodiment, an insulated structure includes a frame comprising a plurality of wall studs coupled together and a plurality of foam boards attached to the frame to form a continuous insulative wall. A plurality of fasteners attaches the foam boards to the frame. Each fastener includes an elongate shaft and a cap. The elongate shaft is configured to penetrate through a foam board and into a wall stud to couple the components together. The cap is configured to be positioned atop a foam board to distribute a load relatively evenly to the foam board. A sealing tape is applied across seams between adjacent foam boards and over the fasteners' caps to seal the wall. A sealing caulk is applied to secondary fasteners and penetrations to seal the wall. In some embodiments, the structure has a fastener density of about 1 fastener per 243 in2 of foam board.

Abstract: A secondary system operates on a vehicle to avoid a collision when a problem occurs with a primary system. For example, the secondary system may operate independently from the primary system to take over control of the vehicle from the primary system when the secondary system detects a potential collision, when an error occurs with the primary system, and so on. In examples, the primary system may implement first techniques, such as Artificial Intelligence (AI) techniques, to understand an environment around the vehicle and/or instruct the vehicle to move within the environment. In examples, the secondary system may implement second techniques that are based on positioning, velocity, acceleration, etc. of the vehicle and/or objects around the vehicle.

Abstract: Disclosed herein is a recombinant adeno-associated virus (AAV) vector comprising (a) a variant AAV2 capsid protein, wherein the variant AAV2 capsid protein comprises at least four amino acid substitutions with respect to a wild type AAV2 capsid protein; wherein the at least four amino acid substitutions are present at the following positions in an AAV2 capsid protein sequence: 457, 492, 499 and 533; and (b) a heterologous nucleic acid comprising a nucleotide sequence encoding a gene product.

Abstract: A polyiso foam wall board includes a polyisocyanurate foam core produced from an isocyanate and a polyol. The wall board also includes a facer material applied to an outer surface of the polyisocyanurate foam core and an intumescent coating applied to the facer material.