Abstract: Aspects of the present disclosure relate to modular expansion systems for use in head-worn computing systems. In an head-worn computer, an electrical connector is adapted to electrically connect with a modular expansion module, wherein the modular expansion module adds a capability to the head-worn computer and is removeably mounted to the head-worn computer, and a mount is adapted to physically secure the modular expansion module to the head-worn computer.

Abstract: Disclosed herein is a recombinant adeno-associated virus (AAV) vector comprising (a) a variant AAV2 capsid protein, wherein the variant AAV2 capsid protein comprises at least four amino acid substitutions with respect to a wild type AAV2 capsid protein; wherein the at least four amino acid substitutions are present at the following positions in an AAV2 capsid protein sequence: 457, 492, 499 and 533; and (b) a heterologous nucleic acid comprising a nucleotide sequence encoding a gene product.

Abstract: The invention relates to a printing machine with hybrid printing technology for printing on a continuous material web.

Abstract: Aspects of the present invention relate to speaker assemblies for head worn computers, including speaker assemblies in a temple portion of a head-worn computer.

Abstract: Methods and systems for presenting digital content on a see-through display are disclosed. In some embodiments, the digital content is presented based on a display attribute associated with personal information related to a user of a wearable head device comprising the see-through display. In some embodiments, the digital content is associated with a geo-spatial location of a physical structure, and presenting the digital content on the see-through display comprises indicating a spatial relationship between the digital content and the physical structure.

Abstract: An apparatus includes an eye cover adapted to be removably mounted on a head-worn computer with a see-through computer display and a flexible audio headset mounted to the eye cover. The flexible audio headset is mounted to the eye cover with a magnetic connection.

Abstract: A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways comprising: a cushion member that includes a retaining structure and a seal-forming structure permanently connected to the retaining structure; a frame member attachable to the retaining structure; and a positioning and stabilising structure attachable to the frame member.

Abstract: Aspects of the present invention relate to providing see-through computer display optics.

Abstract: A speaker can have a main body with a generally spheroidal shape, which can be supported standing on its end. The speaker can include a subwoofer that faces forward. A plurality of mid-range drivers can be distributed around the sub-woofer, facing generally forward and radially outward. A plurality of tweeters can be distributed around the sub-woofer, facing generally forward and generally outward. The outer housing portion of the speaker can be covered with a fabric material. A user interface ring 162 can be touch sensitive to receive input, and can have a plurality of lights that can be illuminated separately to convey information to the user.

Abstract: The present invention relates to antibodies binding to IL13 and IL22. The invention provides novel multi-specific antibodies that bind to both IL13 and IL22 and compositions comprising an antibody that binds to IL13 and an antibody that binds to IL22. The invention further relates to therapeutic uses of the combination of anti-IL13 and anti-IL22 antibodies and multi-specific antibodies that bind to both IL13 and IL22.

Abstract: A building component manufacturing method may include providing an insulated structural component of a building. The insulated structural component may include a frame comprising a plurality of outer components coupled together to define an outer periphery of one or more sections. At least one of the sections may include a cavity. The method may include applying a pour-in-place insulation material within the cavity to insulate the component. The pour-in-place insulation material may transition from a liquid state to a solid state to form a first layer of insulation within the cavity. The method may include monitoring a fill level within the cavity while applying the pour-in-place insulation material. The method may include controlling a flow rate of the pour-in-place insulation material based on the monitoring of the fill level within the cavity.

Abstract: Disclosed herein is a recombinant adeno-associated virus (AAV) vector comprising (a) a variant AAV2 capsid protein, wherein the variant AAV2 capsid protein comprises at least four amino acid substitutions with respect to a wild type AAV2 capsid protein; wherein the at least four amino acid substitutions are present at the following positions in an AAV2 capsid protein sequence: 457, 492, 499 and 533; and (b) a heterologous nucleic acid comprising a nucleotide sequence encoding a gene product.

Abstract: The present disclosure relates to viral particles for use in treating tauopathies, particularly Alzheimer's disease, by gene therapy. More specifically, the present invention relates to a viral particle for use in treating tauopathies by gene therapy in a subject in need thereof, said viral particle comprising a nucleic acid construct including a transgene encoding a glucocerebro sidase.

Abstract: A fiberglass reinforced aerogel composite may include coarse glass fibers, glass microfibers, aerogel particles, and a binder. The coarse glass fibers may have an average fiber diameter between about 8 ?m and about 20 ?m. The glass microfibers may have an average fiber diameter between about 0.5 ?m and about 3 ?m. The glass microfibers may be homogenously dispersed within the coarse glass fibers. The aerogel particles may be homogenously dispersed within the coarse glass fibers and the glass microfibers. The fiberglass reinforced aerogel composite may include between about 50 wt. % and about 75 wt. % of the aerogel particles. The binder bonds the coarse glass fibers, the glass microfibers, and the aerogel particles together.

Abstract: The present invention relates to a method and apparatus for determining correlations between text or text-derived data and numerical data. Specifically the present invention relates to determining correlation(s) between text-derived and numerical data in order to generate estimated numerical data using the determined correlation(s) for specific text-derived data. Aspects and/or embodiments seek to provide a method for estimating numerical data using historical numerical data and historical text-derived data. Aspects and/or embodiments also seek to determine a correlation between the historical numerical data and historical text-derived data for use in generating the estimated numerical data using text-derived data, optionally to identify relevant trends in text-derived data that can be used to generate estimated/predicted numerical data, and optionally in order to train a computer implemented model to generate estimates of numerical data for given text-derived data.

Abstract: A movable ballast system for an aircraft includes first and second ballast docks secured to the aircraft. The first ballast dock includes a first housing and a first ballast tray secured within the first housing. The first ballast tray includes a plurality of channels. The second ballast dock is positioned aft of a CG of the aircraft and includes a second housing and a second ballast tray secured within the second housing. The second ballast tray includes a plurality of channels. The movable ballast system includes a plurality of movable ballasts, each movable ballast of the plurality of movable ballasts being configured to fit within at least one channel of each of the plurality of channels of the first and second ballast trays.

Abstract: The present disclosure relates to viral particles for use in treating synucleinopathies, particularly sporadic Parkinson Diseases by gene therapy. More specifically, the present invention relates to a viral particle for use in treating synucleinopathy by gene therapy in a subject in need thereof, said viral particle comprising a nucleic acid construct including a transgene encoding a glucocerebrosidase.

Abstract: A fuel sample extractor (FSE) for an aircraft includes a sample chamber, a lid configured to seal the sample chamber, a pump in selective fluid communication with an upper portion of the sample chamber, and a straw in selective fluid communication with a lower portion of the sample chamber and a fuel tank.

Abstract: A method of adjusting a center of gravity (CG) of an aircraft includes: inputting at least one load parameter into a flight computer, determining, via a processer of the flight computer, the CG of the aircraft. Responsive to a determination by the processor that the CG is outside of a CG envelope, moving at least a first movable ballast of a plurality of movable ballasts from a first ballast dock to a second ballast dock to move the CG toward the CG envelope. Each of the first and second ballast docks may include a housing and a first ballast tray secured within the housing and comprising a plurality of channels.

Abstract: Disclosed herein is a recombinant adeno-associated virus (AAV) vector comprising (a) a variant AAV2 capsid protein, wherein the variant AAV2 capsid protein comprises at least four amino acid substitutions with respect to a wild type AAV2 capsid protein; wherein the at least four amino acid substitutions are present at the following positions in an AAV2 capsid protein sequence: 457, 492, 499 and 533; and (b) a heterologous nucleic acid comprising a nucleotide sequence encoding a gene product.