Patents by Inventor Ralph Stankowski

Ralph Stankowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190078046
    Abstract: A bioreactor system and packaging is provided. The bioreactor system includes a vessel for housing biomaterials for processing and a support structure. The vessel includes a flexible material defining a chamber and a mixing system positioned within the chamber. The mixing system includes an agitator for imparting motion and mixing to the contents of the vessel and includes a base affixed to the flexible material at a base section of the chamber, a shaft moveably mounted in the base and extending from the base into the chamber and at least one mixing element mounted to the shaft, the shaft configured to be driven by a motor magnetically coupled to the shaft and external to the lower portion of the chamber. The support structure is connected to the mixing system such that the shaft is moveable therein and configured to cooperate with an external structure to provide support for the shaft.
    Type: Application
    Filed: October 11, 2016
    Publication date: March 14, 2019
    Applicant: GE Healthcare Bio-Sciences Corp.
    Inventors: Steven James Forsberg, Ralph Stankowski, Colin R. Tuohey
  • Publication number: 20180346864
    Abstract: A filter holding device (1; 41; 75; 81) arranged for providing at least one filter (7; 43a, 43b; 85) inside a flexible bag (3; 71), said filter holding device comprising attaching means (19a-d, 21a-d; 79; 83) for attaching the filter holding device to an inner surface of the flexible bag such that the at least one filter held by the filter holding device is provided at a distance from the inner surface of the flexible bag.
    Type: Application
    Filed: September 12, 2016
    Publication date: December 6, 2018
    Applicant: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Eric Faldt, Ralph Stankowski
  • Publication number: 20180266600
    Abstract: A connection clamping device (21; 61; 81; 131; 151) arranged for connecting a flexible tube (1) to a barbed end (5b) of a connection means (5), whereby the barbed end (5b) comprises a barb (9) and the connection means during connection is arranged to protrude into an end of the flexible tube (1), characterized in that said connection clamping device comprises two halves (23a, 23b) which, during connection when the connection means protrudes into an end of the flexible tube, are arranged to be connected and locked to each other by a locking mechanism (33a,33b,34a,34b; 63a, 63b, 64a, 64b) around the connection means (5) and the flexible tube (1), such that the flexible tube (1) is compressed against the connection means (5) by a rib (41a, 41b) provided on the inner circumference of the connection clamping device.
    Type: Application
    Filed: October 3, 2016
    Publication date: September 20, 2018
    Applicant: GE HEALTHCARE BIO-SCIENCES CORP.
    Inventor: Ralph Stankowski
  • Publication number: 20170218320
    Abstract: The present invention provides a system for the insertion of a pre-sterilized sensor probe into a sterile vessel. The system of the invention provides a reliable and straightforward way to insert one or more sterile probes into a sterile vessel. The present invention also provides a sterile vessel that includes one or more of the systems of the invention. The sterile vessel can be a flexible or semi-rigid bag or tubing of the type typically used for carrying out biochemical and/or biological processes and/or manipulating liquids and other products of such processes. Furthermore, the present invention provides a method for aseptically inserting a probe into a sterile vessel where the method makes use of the system of the invention.
    Type: Application
    Filed: July 30, 2015
    Publication date: August 3, 2017
    Inventors: Vincent Francis PIZZI, Jeffrey CARTER, Ralph STANKOWSKI
  • Publication number: 20170183127
    Abstract: The invention discloses a plastic bag comprising: at least one longitudinal end weld (112), wherein the end weld comprises an elongate transversely-oriented weld (114) bounded by a first pair (116) and a second pair (118) of coterminous oblique welds (116a, 116b, 118a, 118b) extending along an oblique angle from the first (114a) and second (114b) ends of transversely-oriented weld (114), respectively, such that each pair of oblique welds (116a, 116b, 118a, 118b) forms a first (120a) and second (120b) apex, respectively, adjacent its respective end (114a, 114b) of the transversely-oriented weld (114), a first (122) and second (124) planar gusset attached to the bag (110) along or within the first (116a, 116b) and second (118a, 118b) pair of oblique welds so as to overlie the first (120a) and second (120b) apex, respectively.
    Type: Application
    Filed: June 10, 2015
    Publication date: June 29, 2017
    Inventors: Ralph Stankowski, Michael Miller
  • Publication number: 20170107471
    Abstract: A bioreactor system and packaging is provided. The bioreactor system includes a vessel for housing biomaterials for processing and a support structure. The vessel includes a flexible material defining a chamber and a mixing system positioned within the chamber. The mixing system includes an agitator for imparting motion and mixing to the contents of the vessel and includes a base affixed to the flexible material at a base section of the chamber, a shaft moveably mounted in the base and extending from the base into the chamber and at least one mixing element mounted to the shaft, the shaft configured to be driven by a motor magnetically coupled to the shaft and external to the lower portion of the chamber. The support structure is connected to the mixing system such that the shaft is moveable therein and configured to cooperate with an external structure to provide support for the shaft.
    Type: Application
    Filed: October 16, 2015
    Publication date: April 20, 2017
    Inventors: Steven James FORSBERG, Ralph STANKOWSKI, Colin R. TUOHEY
  • Publication number: 20170073624
    Abstract: The invention discloses a bioreactor assembly comprising: a) a plurality of cultivation bags; b) at least one flexible temperature control bag comprising a thermostating fluid, and; c) a tray adapted to rock back and forth around at least one axis, wherein the flexible temperature control bag is mounted on the tray and the cultivation bags are located on the flexible temperature control bag.
    Type: Application
    Filed: November 29, 2016
    Publication date: March 16, 2017
    Inventors: Ralph Stankowski, Asa Lundstrom, Andreas Castan, Michael Miller, Yvette Klingberg
  • Publication number: 20170044477
    Abstract: The invention discloses a flexible bag assembly for cultivation of cells, comprising one or more bags forming a plurality of cultivation compartments, wherein a drain port in at least a first cultivation compartment is adapted to be fluidically connected with a second cultivation compartment upon opening of a valve means. It also discloses a bioreactor with the bag assembly mounted on a rocking tray and a method of cultivating cells in the assembly.
    Type: Application
    Filed: April 27, 2015
    Publication date: February 16, 2017
    Inventors: Klaus Gebauer, Andreas Castan, Camilla Estmer-Nilsson, Thomas Falkman, Anders Wilen, Michael Miller, Ralph Stankowski
  • Publication number: 20110266204
    Abstract: A manifold adaptor plate useful as a gasket having liquid pathways which permit passing of a filtrate, a feed and a retentate wherein admixture of the filtrate with the feed or the retentate is prevented is provided and is formed of an elastomeric layer, a rigid intermediate layer and a polymer layer. The elastomeric layer functions as a gasket and is bonded to the polymeric layer through the liquid pathways of the intermediate plate. An elastomer layer may be formed on both layers as well and optionally a second polymer layer between the intermediate layer and the second elastomer layer may also be used.
    Type: Application
    Filed: June 3, 2011
    Publication date: November 3, 2011
    Applicant: Millipore Corporation
    Inventors: Mark Chisholm, Stephen J. Dzengeleski, Tom Janko, James E. Kelly, JR., Ralph Stankowski
  • Patent number: 7959805
    Abstract: A manifold adaptor plate useful as a gasket having liquid pathways which permit passing of a filtrate, a feed and a retentate wherein admixture of the filtrate with the feed or the retentate is prevented is provided and is formed of an elastomeric layer, a rigid intermediate layer and a polymer layer. The elastomeric layer functions as a gasket and is bonded to the polymeric layer through the liquid pathways of the intermediate plate. An elastomer layer may be formed on both layers as well and optionally a second polymer layer between the intermediate layer and the second elastomer layer may also be used.
    Type: Grant
    Filed: July 9, 2007
    Date of Patent: June 14, 2011
    Assignee: Millipore Corporation
    Inventors: Mark Chisholm, Stephen J. Dzengeleski, Tom Janko, James E. Kelly, Jr., Ralph Stankowski
  • Patent number: 7521012
    Abstract: A method is disclosed for making a substantially flat filter plate comprising a substantially flat polymer, preferably thermoplastic, frame and substantially flat filter material seated fixedly therein. The method is characterized by its reduced exposure of the filter material to adverse mechanical stresses resultant of polymeric frame formation and curing. Toward such end, the substantially flat polymeric frame is formed in at least two separate steps, in the course of which said substantially flat filter material is incorporated. The portion formed first serves as a mechanical restraint, insulating the later incorporated filter material from any propensity of the second “embedding” portion to shrink or otherwise warp during its formation.
    Type: Grant
    Filed: June 10, 2005
    Date of Patent: April 21, 2009
    Assignee: Millipore Corporation
    Inventors: Ralph Stankowski, James J. Vigna
  • Patent number: 7378017
    Abstract: Fluid separation assembly that allows easy and fast change-out even in confined spaces, and also minimizes or eliminates leakage during change-out. A fluid separation unit having a housing containing separation means, the housing having an inlet and an outlet spaced from the inlet, each including a fitting for attachment of the housing to a manifold or other device allowing fluid communication through the separation means to a point of use is provided. The fittings are designed for quick connect/disconnect, and for minimal or no leakage. The fittings may be on opposite ends, with top and bottom fittings of different configurations, thereby ensuring proper installation of the assembly. The particular medium to be separated is not particularly limited, and can include slurries, fluids including water, and pre-loaded chromatography columns.
    Type: Grant
    Filed: May 16, 2006
    Date of Patent: May 27, 2008
    Assignee: Entegris, Inc.
    Inventors: Ralph Stankowski, J. Karl Niermeyer, William Wacks
  • Publication number: 20080029451
    Abstract: A manifold adaptor plate useful as a gasket having liquid pathways which permit passing of a filtrate, a feed and a retentate wherein admixture of the filtrate with the feed or the retentate is prevented is provided and is formed of an elastomeric layer, a rigid intermediate layer and a polymer layer. The elastomeric layer functions as a gasket and is bonded to the polymeric layer through the liquid pathways of the intermediate plate. An elastomer layer may be formed on both layers as well and optionally a second polymer layer between the intermediate layer and the second elastomer layer may also be used.
    Type: Application
    Filed: July 9, 2007
    Publication date: February 7, 2008
    Applicant: Millipore Corporation
    Inventors: Mark Chisholm, Stephen Dzengeleski, Tom Janko, James Kelly, Ralph Stankowski
  • Publication number: 20070102924
    Abstract: A separation module is provided having a housing, a filter within the housing and at least one outlet and one inlet. The outlet and inlet are positioned to mate with fittings of a pump housing. A stationary receptor positioned between the pump housing and the separation module has a pivot line and two shelves on its outer surface which permit fitting the separation module in a stationary receptor adjacent the pumping housing.
    Type: Application
    Filed: November 14, 2006
    Publication date: May 10, 2007
    Inventors: J. Niermeyer, Marc Laverdiere, Ralph Stankowski, Joseph Smith
  • Publication number: 20070017879
    Abstract: A depth filter design is disclosed which has little if any open void area upstream of the media. Preferably, it also has little if any open void area downstream of the media as well. A preferred embodiment uses layers of stacked, fibrous media with several of the layers being separated from the others by spacers which serve to compress the media and to prevent the bypass of fluid around the media adjacent the inner wall of the housing. Several designs for attaching the end caps which allow for the compression of the media are also disclosed.
    Type: Application
    Filed: March 13, 2006
    Publication date: January 25, 2007
    Inventors: Stephen Proulx, George Perivolotis, Zhenwu Lin, Gregory Straeffer, George Gagne, Kenneth King, Ralph Stankowski, Stephen Hunt
  • Patent number: 7153425
    Abstract: The present invention comprises a process for filtering a slurry and a filter cartridge construction for filtering a slurry having a filtration medium formed of a depth filter such as a cylindrical seamless fibrous depth filter comprising a nonwoven fibrous mass, woven fibers, a plurality of nonwoven fibrous layers or a fibrous felt or the like or a wound depth filter retained within a housing substantially free of an open void volume upstream of the depth filter which causes separation of solid particles from a slurry being filtered The filtration medium is divided into a plurality of depth filter segments by spacers which are spaced apart from each other along the length of a filter cartridge housing which houses the depth filter, The spacers serve to divide the depth filter medium into depth filter segments and to allow fluid to pass there through along a defined path defined by the configuration of the open portions of the spacers.
    Type: Grant
    Filed: August 13, 2004
    Date of Patent: December 26, 2006
    Assignee: Entegris, Inc.
    Inventors: Ralph Stankowski, Stephen G. Hunt
  • Patent number: 7141198
    Abstract: A method is disclosed for making a substantially flat filter plate comprising a substantially flat thermoplastic polymer frame and substantially flat filter material seated fixedly therein. The method is characterized by its reduced exposure of the filter material to adverse mechanical stresses resultant of thermoplastic frame formation and curing. Toward such end, the substantially flat thermoplastic frame is formed in at least two separate steps, in the course of which said substantially flat filter material is incorporated. The portion formed first serves as a mechanical restraint, insulating the later incorporated filter material from any propensity of the second “embedding” portion to shrink or otherwise warp during its formation.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: November 28, 2006
    Assignee: Millipore Corporation
    Inventors: Ralph Stankowski, James J. Vigna
  • Publication number: 20060201866
    Abstract: Fluid separation assembly that allows easy and fast change-out even in confined spaces, and also minimizes or eliminates leakage during change-out. A fluid separation unit having a housing containing separation means, the housing having an inlet and an outlet spaced from the inlet, each including a fitting for attachment of the housing to a manifold or other device allowing fluid communication through the separation means to a point of use is provided. The fittings are designed for quick connect/disconnect, and for minimal or no leakage. The fittings may be on opposite ends, with top and bottom fittings of different configurations, thereby ensuring proper installation of the assembly. The particular medium to be separated is not particularly limited, and can include slurries, fluids including water, and pre-loaded chromatography columns.
    Type: Application
    Filed: May 16, 2006
    Publication date: September 14, 2006
    Inventors: Ralph Stankowski, J. Niermeyer, William Wacks
  • Patent number: 7056436
    Abstract: Fluid separation assembly that allows easy and fast change-out even in confined spaces, and also minimizes or eliminates leakage during change-out. A fluid separation unit having a housing containing separation means, the housing having an inlet and an outlet spaced from the inlet, each including a fitting for attachment of the housing to a manifold or other device allowing fluid communication through the separation means to a point of use is provided. The fittings are designed for quick connect/disconnect, and for minimal or no leakage. The fittings may be on opposite ends, with top and bottom fittings of different configurations, thereby ensuring proper installation of the assembly. The particular medium to be separated is not particularly limited, and can include slurries, fluids including water, and pre-loaded chromatography columns.
    Type: Grant
    Filed: August 25, 2003
    Date of Patent: June 6, 2006
    Assignee: Mykrolis Corporation
    Inventors: Ralph Stankowski, J. Karl Niermeyer, William Wacks
  • Publication number: 20050280179
    Abstract: A method is disclosed for making a substantially flat filter plate comprising a substantially flat thermoplastic polymer frame and substantially flat filter material seated fixedly therein. The method is characterized by its reduced exposure of the filter material to adverse mechanical stresses resultant of thermoplastic frame formation and curing. Toward such end, the substantially flat thermoplastic frame is formed in at least two separate steps, in the course of which said substantially flat filter material is incorporated. The portion formed first serves as a mechanical restraint, insulating the later incorporated filter material from any propensity of the second “embedding” portion to shrink or otherwise warp during its formation.
    Type: Application
    Filed: June 17, 2004
    Publication date: December 22, 2005
    Inventors: Ralph Stankowski, James Vigna