Patents by Inventor Ramakanth Sarabu

Ramakanth Sarabu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DPP IV inhibitors
    Patent number: 7314884
    Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
    Type: Grant
    Filed: December 13, 2004
    Date of Patent: January 1, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Markus Boehringer, Daniel Hunziker, Holger Kuehne, Bernd Michael Loeffler, Ramakanth Sarabu, Hans Peter Wessel
  • Thiazolo-pyrimidine/pyridine urea derivatives
    Publication number: 20070270433
    Abstract: There are presented compounds of the formula or a pharmaceutically acceptable salt thereof, which are active adenosine A2B receptor antagonists and useful in the treatment of diabetes, diabetic retinopathy, asthma and diarrhea.
    Type: Application
    Filed: May 11, 2007
    Publication date: November 22, 2007
    Inventors: John A. Brinkman, Adrian Wai-Hing Cheung, Fariborz Firooznia, Kevin Richard Guertin, Nicholas Marcopulos, Lida Qi, Jagdish Kumar Racha, Ramakanth Sarabu, Jenny Tan, Jefferson Wright Tilley
  • DPP IV INHIBITORS
    Publication number: 20070259925
    Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
    Type: Application
    Filed: July 17, 2007
    Publication date: November 8, 2007
    Inventors: Markus Boehringer, Daniel Hunziker, Holger Kuehne, Bernd Loeffler, Ramakanth Sarabu, Hans Peter Wessel
  • Heteroaromatic glucokinase activators
    Publication number: 20070203207
    Abstract: 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
    Type: Application
    Filed: April 23, 2007
    Publication date: August 30, 2007
    Inventors: Fred Bizzarro, Wendy Corbett, Joseph Grippo, Nancy-Ellen Haynes, George Holland, Robert Kester, Paige Mahaney, Ramakanth Sarabu
  • Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators
    Patent number: 7259166
    Abstract: 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a polar ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
    Type: Grant
    Filed: April 10, 2006
    Date of Patent: August 21, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Jagdish Kumar Racha, Ramakanth Sarabu, Ka Wang
  • Heteroaromatic glucokinase activators
    Patent number: 7223868
    Abstract: 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
    Type: Grant
    Filed: April 4, 2005
    Date of Patent: May 29, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Fred Thomas Bizzarro, Wendy Lea Corbett, Joseph Francis Grippo, Nancy-Ellen Haynes, George William Holland, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • 5-substituted-six-membered heteroaromatic glucokinase activators
    Patent number: 7132425
    Abstract: The present invention provides a compound according to formula I where the substituent designations are provided in the specification. Pharmaceutical compositions comprising a compound according to formula I are also provided.
    Type: Grant
    Filed: December 10, 2003
    Date of Patent: November 7, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Shaoqing Chen, Wendy Lea Corbett, Kevin Richard Guertin, Nancy-Ellen Haynes, Robert Francis Kester, Francis A. Mennona, Steven Gregory Mischke, Yimin Qian, Ramakanth Sarabu, Nathan Robert Scott, Kshitij Chhabilbhai Thakkar
  • Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators
    Patent number: 7105671
    Abstract: 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a polar ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
    Type: Grant
    Filed: April 23, 2003
    Date of Patent: September 12, 2006
    Assignee: Hoffmann-la Roche Inc.
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Jagdish Kumar Racha, Ramakanth Sarabu, Ka Wang
  • Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators
    Publication number: 20060178429
    Abstract: 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a polar ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
    Type: Application
    Filed: April 10, 2006
    Publication date: August 10, 2006
    Inventors: Wendy Corbett, Joseph Grimsby, Nancy-Ellen Haynes, Robert Kester, Paige Mahaney, Jagdish Racha, Ramakanth Sarabu, Ka Wang
  • Heteroaromatic glucokinase activators
    Publication number: 20050261503
    Abstract: 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
    Type: Application
    Filed: April 4, 2005
    Publication date: November 24, 2005
    Inventors: Fred Bizzaro, Wendy Corbett, Joseph Grippo, Nancy-Ellen Haynes, George Holland, Robert Kester, Paige Mahaney, Ramakanth Sarabu
  • Heteroaromatic glucokinase activators
    Patent number: 6951945
    Abstract: 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
    Type: Grant
    Filed: July 9, 2003
    Date of Patent: October 4, 2005
    Assignee: Hoffman-La Roche Inc.
    Inventors: Fred Thomas Bizzarro, Wendy Lea Corbett, Joseph Francis Grippo, Nancy-Ellen Haynes, George William Holland, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • DPP IV inhibitors
    Publication number: 20050096348
    Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
    Type: Application
    Filed: December 13, 2004
    Publication date: May 5, 2005
    Inventors: Markus Boehringer, Daniel Hunziker, Holger Kuehne, Bernd Loeffler, Ramakanth Sarabu, Hans Wessel
  • DPP IV inhibitors
    Patent number: 6861440
    Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
    Type: Grant
    Filed: October 14, 2002
    Date of Patent: March 1, 2005
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Markus Boehringer, Daniel Hunziker, Holger Kuehne, Bernd Michael Loeffler, Ramakanth Sarabu, Hans Peter Wessel
  • 5-Substituted-six-membered heteroaromatic glucokinase activators
    Publication number: 20040147748
    Abstract: The present invention provides a compound according to formula I 1
    Type: Application
    Filed: December 10, 2003
    Publication date: July 29, 2004
    Inventors: Shaoqing Chen, Wendy Lea Corbett, Kevin Richard Guertin, Nancy-Ellen Haynes, Robert Francis Kester, Francis A. Mennona, Steven Gregory Mischke, Yimin Qian, Ramakanth Sarabu, Nathan Robert Scott, Kshitij Chhabilbhai Thakkar
  • Heteroaromatic glucokinase activators
    Publication number: 20040014968
    Abstract: 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
    Type: Application
    Filed: July 9, 2003
    Publication date: January 22, 2004
    Inventors: Fred Thomas Bizzarro, Wendy Lea Corbett, Joseph Francis Grippo, Nancy-Ellen Haynes, George William Holland, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators
    Publication number: 20030225283
    Abstract: 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a polar ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
    Type: Application
    Filed: April 23, 2003
    Publication date: December 4, 2003
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Jagdish Kumar Racha, Ramakanth Sarabu, Ka Wang
  • Heteroaromatic glucokinase activators
    Patent number: 6610846
    Abstract: 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: August 26, 2003
    Assignee: Hoffman-La Roche Inc.
    Inventors: Fred Thomas Bizzarro, Wendy Lea Corbett, Joseph Francis Grippo, Nancy-Ellen Haynes, George William Holland, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • &agr;-acyl- and &agr;-heteroatom-substituted benzene acetamide glucokinase activators
    Patent number: 6608218
    Abstract: Substituted benzene acetamide compounds and pharmaceutically acceptable salts thereof are useful as glucokinase activators.
    Type: Grant
    Filed: June 25, 2002
    Date of Patent: August 19, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert Francis Kester, Ramakanth Sarabu
  • DPP IV inhibitors
    Publication number: 20030130281
    Abstract: The present invention relates to compounds of formula (I) 1
    Type: Application
    Filed: October 14, 2002
    Publication date: July 10, 2003
    Inventors: Markus Boehringer, Daniel Hunziker, Holger Kuehne, Bernd M. Loeffler, Ramakanth Sarabu, Hans P. Wessel
  • Fused heteroaromatic glucokinase activators
    Patent number: 6545155
    Abstract: Glucokinase activating amides useful for increasing insulin secretion in the treatment of type II diabetes are disclosed.
    Type: Grant
    Filed: December 4, 2001
    Date of Patent: April 8, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu