Patents by Inventor Ramakanth Sarabu

Ramakanth Sarabu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Para-amine substituted phenylamide glucokinase activators
    Publication number: 20030060625
    Abstract: Para-alkyl, aryl, cycloheteroalkyl or heteroaryl [carbonyl or sulfonyl] amino substituted phenyl amides active as glucokinase activators to increase insulin secretion which makes them useful for treating type II diabetes.
    Type: Application
    Filed: September 26, 2002
    Publication date: March 27, 2003
    Inventors: Fred Thomas Bizzarro, Nancy-Ellen Haynes, Ramakanth Sarabu
  • Urea derivatives
    Patent number: 6528543
    Abstract: Glucokinase activating compounds of the formula wherein R1 and R2 are independently hydrogen, halo, amino, nitro, cyano, sulfonamido, lower alkyl, perfluoro-lower alkyl, lower alkyl thio, perfluoro-lower alkyl thio, lower alkyl sulfonyl, or perfluoro-lower alkyl sulfonyl; R3 is cycloalkyl having from 3 to 7 carbon atoms or lower alkyl having from 2 to 4 carbon atoms; R4 is hydrogen, lower alkyl, lower alkenyl, hydroxy lower alkyl, halo lower alkyl, R5 and R6 are hydrogen or lower alkyl; and n is 0, 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof
    Type: Grant
    Filed: March 21, 2000
    Date of Patent: March 4, 2003
    Assignee: Hoffman-La Roche Inc.
    Inventors: Fred Thomas Bizzarro, Wendy Lea Corbett, Antonio Focella, Joseph Francis Grippo, Nancy-Ellen Haynes, George William Holland, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • Alpha-acyl- and alpha-heteroatom-substituted benzene acetamide glucokinase activators
    Publication number: 20020198200
    Abstract: Substituted benzene acetamide compounds and pharmaceutically acceptable salts thereof are useful as glucokinase activators.
    Type: Application
    Filed: June 25, 2002
    Publication date: December 26, 2002
    Inventors: Robert F. Kester, Ramakanth Sarabu
  • Para-amine substituted phenylamide glucokinase activators
    Patent number: 6489485
    Abstract: Para-alkyl, aryl, cycloheteroalkyl or heteroaryl [carbonyl or sulfonyl] amino substituted phenyl amides active as glucokinase activators to increase insulin secretion which makes them useful for treating type II diabetes.
    Type: Grant
    Filed: May 1, 2001
    Date of Patent: December 3, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Fred Thomas Bizzarro, Nancy-Ellen Haynes, Ramakanth Sarabu
  • &agr;-acyl- and &agr;-heteroatom-substituted benzene acetamide glucokinase activators
    Patent number: 6486184
    Abstract: Substituted benzene acetamide compounds which are glucokinase activators and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: November 26, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert Francis Kester, Ramakanth Sarabu
  • Fused heteroaromatic glucokinase activators
    Patent number: 6448399
    Abstract: Glucokinase activating amides are useful for increasing insulin secretion in the treatment of type II diabetes.
    Type: Grant
    Filed: December 4, 2001
    Date of Patent: September 10, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • Fused heteroaromatic glucokinase activators
    Patent number: 6441184
    Abstract: Glucokinase activating amides are useful for increasing insulin secretion in the treatment of type II diabetes.
    Type: Grant
    Filed: December 4, 2001
    Date of Patent: August 27, 2002
    Assignee: Hoffmann-LA Roche Inc.
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • FUSED HETEROAROMATIC GLUCOKINASE ACTIVATORS
    Publication number: 20020111372
    Abstract: Glucokinase activating amides are useful for increasing insulin secretion in the treatment of type II diabetes.
    Type: Application
    Filed: December 4, 2001
    Publication date: August 15, 2002
    Inventors: Wendy L. Corbett, Joseph S. Grimsby, Nancy-Ellen Haynes, Robert F. Kester, Paige E. Mahaney, Ramakanth Sarabu
  • Fused heteroaromatic glucokinase activators
    Patent number: 6433188
    Abstract: Glucokinase activating amides as herein disclosed are useful for increasing insulin secretion in the treatment of type II diabetes.
    Type: Grant
    Filed: December 4, 2001
    Date of Patent: August 13, 2002
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • FUSED HETEROAROMATIC GLUCOKINASE ACTIVATORS
    Publication number: 20020107396
    Abstract: Glucokinase activating amides are useful for increasing insulin secretion in the treatment of type II diabetes.
    Type: Application
    Filed: December 4, 2001
    Publication date: August 8, 2002
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • Fused heteroaromatic glucokinase activators
    Publication number: 20020103199
    Abstract: Glucokinase activating amides are useful for increasing insulin secretion in the treatment of type II diabetes.
    Type: Application
    Filed: December 4, 2001
    Publication date: August 1, 2002
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • FUSED HETEROAROMATIC GLUCOKINASE ACTIVATORS
    Publication number: 20020103241
    Abstract: Glucokinase activating amides are useful for increasing insulin secretion in the treatment of type II diabetes.
    Type: Application
    Filed: December 4, 2001
    Publication date: August 1, 2002
    Inventors: Wendy L. Corbett, Josehp S. Grimsby, Nancy-ellen Haynes, Robert F. Kester, Paige E. Mahaney, Ramakanth Sarabu
  • Para-aryl or heterocyclic substituted phenyl glucokinase activators
    Patent number: 6384220
    Abstract: Para-aryl or heteroaryl substituted phenyl amides which are active as glucokinase activators to increase insulin secretion which makes them useful for treating type II diabetes.
    Type: Grant
    Filed: May 1, 2001
    Date of Patent: May 7, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Wendy Lea Corbett, Nancy-Ellen Haynes, Ramakanth Sarabu
  • Alpha-acyl- and alpha-heteroatom-substituted benzene acetamide glucokinase activators
    Publication number: 20020042512
    Abstract: Substituted benzene acetamide compounds which are glucokinase activators and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: July 13, 2001
    Publication date: April 11, 2002
    Inventors: Robert F. Kester, Ramakanth Sarabu
  • Trans olefinic glucokinase activators
    Patent number: 6353111
    Abstract: 2,3-Di-substituted trans olefinic N-heteroaromatic or urido propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
    Type: Grant
    Filed: December 1, 2000
    Date of Patent: March 5, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Wendy Lea Corbett, Ramakanth Sarabu, Achyutharao Sidduri
  • Para-aryl or heterocyclic substituted phenyl glucokinase activators
    Publication number: 20020002190
    Abstract: Para-aryl or heteroaryl substituted phenyl amides which are active as glucokinase activators to increase insulin secretion which makes them useful for treating type II diabetes.
    Type: Application
    Filed: May 1, 2001
    Publication date: January 3, 2002
    Inventors: Wendy L. Corbett, Nancy-Ellen Haynes, Ramakanth Sarabu
  • Para-amine substituted phenylamide glucokinase activators
    Publication number: 20010051731
    Abstract: Para-alkyl, aryl, cycloheteroalkyl or heteroaryl [carbonyl or sulfonyl] amino substituted phenyl amides active as glucokinase activators to increase insulin secretion which makes them useful for treating type II diabetes.
    Type: Application
    Filed: May 1, 2001
    Publication date: December 13, 2001
    Inventors: Fred T. Bizzarro, Nancy-Ellen Haynes, Ramakanth Sarabu
  • Heteroaromatic glucokinase activators
    Patent number: 6320050
    Abstract: 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
    Type: Grant
    Filed: March 15, 2000
    Date of Patent: November 20, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Fred Thomas Bizzarro, Wendy Lea Corbett, Joseph Francis Grippo, Nancy-Ellen Haynes, George William Holland, Robert Francis Kester, Ramakanth Sarabu
  • Heteroaromatic glucokinase activators
    Publication number: 20010039344
    Abstract: 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
    Type: Application
    Filed: March 15, 2000
    Publication date: November 8, 2001
    Inventors: Fred Thomas Bizzarro, Wendy Lea Corbett, Joseph Francis Grippo, Nancy-Ellen Haynes, George William Holland, Robert Francis Kester, Ramakanth Sarabu