Abstract: The subject matter presented herein provides an efficacious system and method for diagnosing orthostatic intolerance and for treating orthostatic hypotension. A dynamic compression garment that comprises a servo-controlled splanchnic venous compression with automated binder system is used to regulate blood flow, for instance, during orthostasis. The system includes a programmable controller and a computing device in communication with the controller, an inflator, one or more sensors, and a power supply. The system can collect a user's biometric data, which may be transmitted to the user, a physician in charge of the user, or a third-party. Moreover, the biometric data may be incorporated into a machine learning model that can be used to further program the controller.

Abstract: A surgical navigation system has a computer with a memory and display connected to a surgical instrument or pointer and position tracking system, so that the location and orientation of the pointer are tracked in real time and conveyed to the computer. The computer memory is loaded with data from an MRI, CT, or other volumetric scan of a patient, and this data is utilized to dynamically display 3-dimensional perspective images in real time of the patient's anatomy from the viewpoint of the pointer. The images are segmented and displayed in color to highlight selected anatomical features and to allow the viewer to see beyond obscuring surfaces and structures. The displayed image tracks the movement of the instrument during surgical procedures. The instrument may include an imaging device such as an endoscope or ultrasound transducer, and the system displays also the image for this device from the same viewpoint, and enables the two images to be fused so that a combined image is displayed.

Abstract: A surgical navigation system has a computer with a memory and display connected to a surgical instrument or pointer and position tracking system, so that the location and orientation of the pointer are tracked in real time and conveyed to the computer. The computer memory is loaded with data from an MRI, CT, or other volumetric scan of a patient, and this data is utilized to dynamically display 3-dimensional perspective images in real time of the patient's anatomy from the viewpoint of the pointer. The images are segmented and displayed in color to highlight selected anatomical features and to allow the viewer to see beyond obscuring surfaces and structures. The displayed image tracks the movement of the instrument during surgical procedures. The instrument may include an imaging device such as an endoscope or ultrasound transducer, and the system displays also the image for this device from the same viewpoint, and enables the two images to be fused so that a combined image is displayed.

Abstract: A surgical navigation system has a computer with a memory and display connected to a surgical instrument or pointer and position tracking system, so that the location and orientation of the pointer are tracked in real time and conveyed to the computer. The computer memory is loaded with data from an MRI, CT, or other volumetric scan of a patient, and this data is utilized to dynamically display 3-dimensional perspective images in real time of the patient's anatomy from the viewpoint of the pointer. The images are segmented and displayed in color to highlight selected anatomical features and to allow the viewer to see beyond obscuring surfaces and structures. The displayed image tracks the movement of the instrument during surgical procedures. The instrument may include an imaging device such as an endoscope or ultrasound transducer, and the system displays also the image for this device from the same viewpoint, and enables the two images to be fused so that a combined image is displayed.

Abstract: Methods for simulation of heat transport phenomena applicable to the design of a near-field microwave ablation device, the design of such a device based on simulation and a patient planning and monitoring station using simulated thermal ablation of tissue are provided.

Abstract: The method of some embodiments of the invention assists a user in guiding a medical instrument to a subsurface target site in a patient. This method generates at least one intraoperative ultrasonic images. The method indicates a target site on the ultrasonic image(s). The method determines 3-D coordinates of the target site in a reference coordinate system. The method (1) tracks the position of the instrument in the reference coordinate system, (2) projects onto a display device a view field as seen from the position with respect to the tool in the reference coordinate system, and (3) projects onto the displayed view field indicia of the target site corresponding to the position. In some embodiments, the field of view is a view not only from the position of the instrument but also from a known orientation of the instrument in the reference coordinate system.

Abstract: The method of some embodiments of the invention assists a user in guiding a medical instrument to a subsurface target site in a patient. This method generates one or more intraoperative images. The method indicates a target site on the image(s). The method determines 3-D coordinates of the target site in a reference coordinate system. The method (1) tracks the position of the instrument in the reference coordinate system, (2) projects onto a display device a view field as seen from the position with respect to the tool in the reference coordinate system, and (3) projects onto the displayed view field indicia of the target site corresponding to the position. In some embodiments, the field of view is a view not only from the position of the instrument but also from a known orientation of the instrument in the reference coordinate system.

Abstract: Intraoperative image(s) of a patient target site are generated by an intraoperative imaging system (e.g., ultrasound or X-ray). The intraoperative imaging system is tracked with respect to the patient target site and surgical instrument(s) (e.g., a pointer, endoscope or other intraoperative video or optical device). The intraoperative images, surgical instruments, and patient target site are registered into a common coordinate system. Spatial feature(s) of the patient target site are indicated on the images of the patient target site. Indicia relating the position and orientation of the surgical instrument(s) to the spatial feature(s) of the patient target site are projected on the images, with the indicia being used to correlate the position and orientation of the surgical instruments with respect to the target feature.

Abstract: Systems and methods are disclosed for assisting a user in guiding a medical instrument to a subsurface target site in a patient by indicating a spatial feature of a patient target site on an intraoperative image (e.g., endoscopic image), determining 3-D coordinates of the patient target site spatial feature in a reference coordinate system using the spatial feature of the target site indicated on the intraoperative image (e.g., ultrasound image, determining a position of the instrument in the reference coordinate system, projecting onto a display device a view field from a predetermined position relative to the instrument in the reference coordinate system, and projecting onto the view field an indicia of the spatial feature of the target site corresponding to the predetermined position.

Abstract: Systems and methods are disclosed for assisting a user in guiding a medical instrument to a subsurface target site in a patient by indicating a spatial feature of a patient target site on an intraoperative image (e.g., endoscopic image), determining 3-D coordinates of the patient target site spatial feature in a reference coordinate system using the spatial feature of the target site indicated on the intraoperative image (e.g., ultrasound image, determining a position of the instrument in the reference coordinate system, projecting onto a display device a view field from a predetermined position relative to the instrument in the reference coordinate system, and projecting onto the view field an indicia of the spatial feature of the target site corresponding to the predetermined position.

Abstract: The invention provides a system for enhancing the ability of a surgeon to access a target site within a patient. The system includes a data file containing volumetric scan data of a region of the patient that includes the target site, a display device, and a movable imagining tool for producing on the display device, an image of visible patient structure seen by the tool. A computer in the system operates to (i) determine the position and/or orientation of the tool in the frame of reference of the patient, (ii) identify the scan-data coordinates (either x,y or x,y,z coordinates) of the target site, and (iii) project on the video image on the display device, indicia that indicate the lateral position of the target site with respect to the patient structure imaged on the display device.

Abstract: An apparatus, method and system for tracking a medical instrument, as it is moved in an operating space to a patient target site in the space, by constructing a composite, 3-D rendition of at least a part of the operating space based on an algorithm that registers pre-operative 3-D diagnostic scans of the operating space with real-time, stereo x-ray or radiograph images of the operating space. The invention has particular utility in tracking a flexible medical instrument and/or a medical instrument that moves inside the patient's body and is not visible to the surgeon.

Abstract: An apparatus and method for adjusting the orientation of a surgical viewing instrument, which may be used to view a patient target site and any intervening tissue from outside the body, as the position of the instrument is changed by a user. The instrument is attached to a robotic arm assembly and is movable by both the user and the robot. As the user moves the instrument to a different position, the robot automatically corrects the orientation of the instrument to maintain a viewing trajectory defined by the axis of the instrument and a target coordinate in the patient target site. In another aspect there is an apparatus and method for using a surgical robot and attached ultrasound probe to track a moving target in a patient's body. The ultrasound probe has a pressure sensor in its tip, which is maintained in contact with a tissue surface at a specific location at a constant pressure.

Abstract: A method and system for obtaining desired subsurface views of a patient target site are disclosed. The system includes a scan-data file for storing, in digital form, volumetric scan data of a surgical site of a patient, a pointer for indicating the position and orientation of desired views, and a display screen for placement near the patient target region. A computational device operatively connected to the data file, pointer, and display screen functions to reconstruct a 2-D shadowgraph images of the patient region from the position and orientation of the pointer. By moving the pointer to selected positions and orientations, the user can view optimal and desired shadowgraph images of the patient in real time.

Abstract: A surgical navigation system has a computer with a memory and display connected to a surgical instrument or pointer and position tracking system, so that the location and orientation of the pointer are tracked in real time and conveyed to the computer. The computer memory is loaded with data from an MRI, CT, or other volumetric scan of a patient, and this data is utilized to dynamically display 3-dimensional perspective images in real time of the patient's anatomy from the viewpoint of the pointer. The images are segmented and displayed in color to highlight selected anatomical features and to allow the viewer to see beyond obscuring surfaces and structures. The displayed image tracks the movement of the instrument during surgical procedures. The instrument may include an imaging device such as an endoscope or ultrasound transducer, and the system displays also the image for this device from the same viewpoint, and enables the two images to be fused so that a combined image is displayed.

Abstract: An image guided surgical procedure using an improved registration of pre-operative volumetric scan data is described. Volumetric scan data, acquired before surgery, is registered with respect to the patient and used to construct a volumetric perspective image of the surgical site. The improved registration of the volumetric scan data can be accomplished by generating a pattern of light on the patient's surface by moving a laser beam over the surgical site. The pattern of light is recorded by at least two cameras from different known fixed positions, digitized and used to form a laser reconstruction of the patient surface. This digital surface can then aligned with the volumetric scan data forming an improved volumetric perspective image of the surgical site.

Abstract: A surgical navigation system has a computer with a memory and display connected to a surgical instrument or pointer and position tracking system, so that the location and orientation of the pointer are tracked in real time and conveyed to the computer. The computer memory is loaded with data from an MRI, CT, or other volumetric scan of a patient, and this data is utilized to dynamically display 3-dimensional perspective images in real time of the patient's anatomy from the viewpoint of the pointer. The images are segmented and displayed in color to highlight selected anatomical features and to allow the viewer to see beyond obscuring surfaces and structures. The displayed image tracks the movement of the instrument during surgical procedures. The instrument may include an imaging device such as an endoscope or ultrasound transducer, and the system displays also the image for this device from the same viewpoint, and enables the two images to be fused so that a combined image is displayed.

Abstract: An apparatus for use in calibrating lens position and field of view in an endoscope is disclosed. The apparatus includes tracking elements mounted at fixed positions on the endoscope's shaft, a holder providing an object or pattern to be viewed by the endoscope, when the endoscope is placed in the holder, and positional elements mounted on the holder at known positions. A processor in the apparatus operates to determine the positions of the tracking and positional elements, with the endoscope shaft received in the holder guide, and calculate from the determined positions, the coordinates of the endoscope lens with respect to the tracking elements, and the field of the view of the lens. Also disclosed is a calibration method which employs the apparatus.

Abstract: Systems and methods for performing transformations between a view orientation in a virtual space and a view orientation with respect to a target site in a patient's body where surgery is being performed. The view in virtual space enables the surgeon to see the internal structures in the target site in a variety of ways and orientations including from behind the site.

Abstract: An apparatus, method and system for tracking a medical instrument, as it is moved in an operating space to a patient target site in the space, by constructing a composite, 3-D rendition of at least a part of the operating space based on an algorithm that registers preoperative 3-D diagnostic scans of the operating space with real-time, stereo x-ray or radiograph images of the operating space. The invention has particular utility in tracking a flexible medical instrument and/or a medical instrument that moves inside the patient's body and is not visible to the surgeon.