Patents by Inventor Ramsey Ibrahim ZEITOUN

Ramsey Ibrahim ZEITOUN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYNUCLEOTIDES, REAGENTS, AND METHODS FOR NUCLEIC ACID HYBRIDIZATION
    Publication number: 20240043920
    Abstract: Provided herein are compositions, methods and systems relating to libraries of polynucleotides such that the libraries allow for accurate and efficient hybridization after binding to target sequences. Further provided herein are probes, blockers, additives, buffers, and methods that result in improved hybridization. Such compositions and methods are useful for improvement of Next Generation Sequencing applications, such as reducing off-target binding or reducing workflow times.
    Type: Application
    Filed: June 26, 2023
    Publication date: February 8, 2024
    Inventors: Ramsey Ibrahim ZEITOUN, Siyuan CHEN, Richard GANTT, Kristin D. BUTCHER, E. Hutson CHILTON
  • Polynucleotides, reagents, and methods for nucleic acid hybridization
    Patent number: 11732294
    Abstract: Provided herein are compositions, methods and systems relating to libraries of polynucleotides such that the libraries allow for accurate and efficient hybridization after binding to target sequences. Further provided herein are probes, blockers, additives, buffers, and methods that result in improved hybridization. Such compositions and methods are useful for improvement of Next Generation Sequencing applications, such as reducing off-target binding or reducing workflow times.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: August 22, 2023
    Assignee: Twist Bioscience Corporation
    Inventors: Ramsey Ibrahim Zeitoun, Siyuan Chen, Richard Gantt, Kristin D. Butcher, E. Hutson Chilton
  • METHODS FOR GENERATING BARCODED COMBINATORIAL LIBRARIES
    Publication number: 20230227810
    Abstract: Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive engineering. Further provided herein are methods and compositions for multiplex engineering. Further provided herein are methods and compositions for enriching for editing and trackable engineered sequences and cells using nucleic acid-guided nucleases.
    Type: Application
    Filed: January 20, 2023
    Publication date: July 20, 2023
    Inventors: Ryan T. Gill, Andrew Garst, Tanya Elizabeth Warnecke Lipscomb, Marcelo Colika Bassalo, Ramsey Ibrahim Zeitoun
  • NUCLEIC ACID BASED DATA STORAGE USING ENZYMATIC BIOENCRYPTION
    Publication number: 20230153452
    Abstract: Provided herein are compositions, devices, systems and methods for the generation and use of secured biomolecule-based information for storage. Further described herein are compositions, devices, systems and methods for bioencryption or biodecryption of information. Conversion of a digital sequence to a nucleic based sequence includes a step of selection of one or more bioencryption methods.
    Type: Application
    Filed: December 5, 2022
    Publication date: May 18, 2023
    Inventors: Bill James PECK, Ramsey Ibrahim ZEITOUN
  • Methods for generating barcoded combinatorial libraries
    Patent number: 11584928
    Abstract: Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive engineering. Further provided herein are methods and compositions for multiplex engineering. Further provided herein are methods and compositions for enriching for editing and trackable engineered sequences and cells using nucleic acid-guided nucleases.
    Type: Grant
    Filed: March 7, 2019
    Date of Patent: February 21, 2023
    Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, INSCRIPTA, INC.
    Inventors: Ryan T. Gill, Andrew Garst, Tanya Elizabeth Warnecke Lipscomb, Marcelo Colika Bassalo, Ramsey Ibrahim Zeitoun
  • Nucleic acid based data storage using enzymatic bioencryption
    Patent number: 11550939
    Abstract: Provided herein are compositions, devices, systems and methods for the generation and use of secured biomolecule-based information for storage. Further described herein are compositions, devices, systems and methods for bioencryption or biodecryption of information. Conversion of a digital sequence to a nucleic based sequence includes a step of selection of one or more bioencryption methods.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: January 10, 2023
    Assignee: TWIST BIOSCIENCE CORPORATION
    Inventors: Bill James Peck, Ramsey Ibrahim Zeitoun
  • Polynucleotides, reagents, and methods for nucleic acid hybridization
    Patent number: 11492665
    Abstract: Provided herein are compositions, methods and systems relating to libraries of polynucleotides such that the libraries allow for accurate and efficient hybridization after binding to target sequences. Further provided herein are probes, blockers, additives, buffers, and methods that result in improved hybridization. Such compositions and methods are useful for improvement of Next Generation Sequencing applications, such as reducing off-target binding or reducing workflow times.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: November 8, 2022
    Assignee: Twist Bioscience Corporation
    Inventors: Ramsey Ibrahim Zeitoun, Siyuan Chen, Richard Gantt, Kristin D. Butcher, E. Hutson Chilton
  • LIBRARIES FOR IDENTIFICATION OF GENOMIC VARIANTS
    Publication number: 20220277808
    Abstract: Provided herein are compositions and methods for identifying genomic variants. Further provided herein are compositions and methods for capture of genomic sequences. Further provided herein are compositions and methods for capturing genomic DNA comprising single nucleotide polymorphisms.
    Type: Application
    Filed: February 17, 2022
    Publication date: September 1, 2022
    Inventors: Leonardo ARBIZA, Siyuan CHEN, Ramsey Ibrahim ZEITOUN
  • HYBRIDIZATION METHODS AND REAGENTS
    Publication number: 20220106590
    Abstract: Provided herein are compositions and methods for improving hybridization reactions. Further provided herein are synthetic blocking libraries. Further provided herein are methods for designing synthetic blocking libraries, and application towards methylome analysis.
    Type: Application
    Filed: October 4, 2021
    Publication date: April 7, 2022
    Inventors: Bryan N. HÖGLUND, Kristin D. BUTCHER, Holly CORBITT, Brenton I.M. GRAHAM, Leonardo ARBIZA, Ramsey Ibrahim ZEITOUN
  • POLYNUCLEOTIDE LIBRARIES HAVING CONTROLLED STOICHIOMETRY AND SYNTHESIS THEREOF
    Publication number: 20210348220
    Abstract: Provided herein are compositions, methods and systems relating to libraries of polynucleotides having preselected stoichiometry with regard to species of polynucleotides such that the libraries allow for predetermined application outcomes, e.g., controlled representation after amplification and uniform enrichment after binding to target sequences. Further provided herein are polynucleotide probes and applications thereof for uniform and accurate next generation sequencing.
    Type: Application
    Filed: June 17, 2021
    Publication date: November 11, 2021
    Inventors: Ramsey Ibrahim ZEITOUN, Siyuan CHEN
  • POLYNUCLEOTIDES, REAGENTS, AND METHODS FOR NUCLEIC ACID HYBRIDIZATION
    Publication number: 20200102611
    Abstract: Provided herein are compositions, methods and systems relating to libraries of polynucleotides such that the libraries allow for accurate and efficient hybridization after binding to target sequences. Further provided herein are probes, blockers, additives, buffers, and methods that result in improved hybridization. Such compositions and methods are useful for improvement of Next Generation Sequencing applications, such as reducing off-target binding or reducing workflow times.
    Type: Application
    Filed: October 1, 2019
    Publication date: April 2, 2020
    Inventors: Ramsey Ibrahim ZEITOUN, Siyuan CHEN, Richard GANTT, Kristin D. BUTCHER, E. Hutson CHILTON
  • POLYNUCLEOTIDES, REAGENTS, AND METHODS FOR NUCLEIC ACID HYBRIDIZATION
    Publication number: 20200017907
    Abstract: Provided herein are compositions, methods and systems relating to libraries of polynucleotides such that the libraries allow for accurate and efficient hybridization after binding to target sequences. Further provided herein are probes, blockers, additives, buffers, and methods that result in improved hybridization. Such compositions and methods are useful for improvement of Next Generation Sequencing applications, such as reducing off-target binding or reducing workflow times.
    Type: Application
    Filed: May 20, 2019
    Publication date: January 16, 2020
    Inventors: Ramsey Ibrahim ZEITOUN, Siyuan CHEN, Richard GANTT, Kristin D. BUTCHER, E. Hutson CHILTON
  • METHODS FOR GENERATING BARCODED COMBINATORIAL LIBRARIES
    Publication number: 20190194650
    Abstract: Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive engineering. Further provided herein are methods and compositions for multiplex engineering. Further provided herein are methods and compositions for enriching for editing and trackable engineered sequences and cells using nucleic acid-guided nucleases.
    Type: Application
    Filed: March 7, 2019
    Publication date: June 27, 2019
    Inventors: Ryan T. Gill, Andrew Garst, Tanya Elizabeth Warnecke Lipscomb, Marcelo Colika Bassalo, Ramsey Ibrahim Zeitoun
  • Methods for generating barcoded combinatorial libraries
    Patent number: 10294473
    Abstract: Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive engineering. Further provided herein are methods and compositions for multiplex engineering. Further provided herein are methods and compositions for enriching for editing and trackable engineered sequences and cells using nucleic acid-guided nucleases.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: May 21, 2019
    Assignees: The Regents of the University of Colorado, a body corporate, Inscripta, Inc.
    Inventors: Ryan T. Gill, Andrew Garst, Tanya Elizabeth Warnecke Lipscomb, Marcelo Colika Bassalo, Ramsey Ibrahim Zeitoun
  • Methods for generating barcoded combinatorial libraries
    Patent number: 10287575
    Abstract: Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive engineering. Further provided herein are methods and compositions for multiplex engineering. Further provided herein are methods and compositions for enriching for editing and trackable engineered sequences and cells using nucleic acid-guided nucleases.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: May 14, 2019
    Assignees: The Regents of the University of Colorado, a body corporate, Inscripta, Inc.
    Inventors: Ryan T. Gill, Andrew Garst, Tanya Elizabeth Warnecke Lipscomb, Marcelo Colika Bassalo, Ramsey Ibrahim Zeitoun
  • NUCLEIC ACID BASED DATA STORAGE
    Publication number: 20180253563
    Abstract: Provided herein are compositions, devices, systems and methods for the generation and use of secured biomolecule-based information for storage. Further described herein are compositions, devices, systems and methods for bioencryption or biodecryption of information. Conversion of a digital sequence to a nucleic based sequence includes a step of selection of one or more bioencryption methods.
    Type: Application
    Filed: February 22, 2018
    Publication date: September 6, 2018
    Inventors: Bill James PECK, Ramsey Ibrahim ZEITOUN
  • METHODS FOR GENERATING BARCODED COMBINATORIAL LIBRARIES
    Publication number: 20180230461
    Abstract: Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive engineering. Further provided herein are methods and compositions for multiplex engineering. Further provided herein are methods and compositions for enriching for editing and trackable engineered sequences and cells using nucleic acid-guided nucleases.
    Type: Application
    Filed: April 9, 2018
    Publication date: August 16, 2018
    Inventors: Ryan T. GILL, Andrew GARST, Tanya Elizabeth Warnecke LIPSCOMB, Marcelo Colika BASSALO, Ramsey Ibrahim ZEITOUN
  • METHODS FOR GENERATING BARCODED COMBINATORIAL LIBRARIES
    Publication number: 20180230460
    Abstract: Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive engineering. Further provided herein are methods and compositions for multiplex engineering. Further provided herein are methods and compositions for enriching for editing and trackable engineered sequences and cells using nucleic acid-guided nucleases.
    Type: Application
    Filed: April 9, 2018
    Publication date: August 16, 2018
    Inventors: Ryan T. GILL, Andrew GARST, Tanya Elizabeth Warnecke LIPSCOMB, Marcelo Colika BASSALO, Ramsey Ibrahim ZEITOUN
  • Methods for generating barcoded combinatorial libraries
    Patent number: 10017760
    Abstract: Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive engineering. Further provided herein are methods and compositions for multiplex engineering. Further provided herein are methods and compositions for enriching for editing and trackable engineered sequences and cells using nucleic acid-guided nucleases.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: July 10, 2018
    Assignees: Inscripta, Inc., The Regents of the University of Colorado, a Body Corporate
    Inventors: Ryan T. Gill, Andrew Garst, Tanya Elizabeth Warnecke Lipscomb, Marcelo Colika Bassalo, Ramsey Ibrahim Zeitoun
  • POLYNUCLEOTIDE LIBRARIES HAVING CONTROLLED STOICHIOMETRY AND SYNTHESIS THEREOF
    Publication number: 20180142289
    Abstract: Provided herein are compositions, methods and systems relating to libraries of polynucleotides having preselected stoichiometry with regard to species of polynucleotides such that the libraries allow for predetermined application outcomes, e.g., controlled representation after amplification and uniform enrichment after binding to target sequences. Further provided herein are polynucleotide probes and applications thereof for uniform and accurate next generation sequencing.
    Type: Application
    Filed: November 17, 2017
    Publication date: May 24, 2018
    Inventors: Ramsey Ibrahim ZEITOUN, Siyuan CHEN