Patents by Inventor Randal Mills

Randal Mills has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11865227
    Abstract: A bone implant comprising cancellous bone that is essentially free of blood cells, and which has been treated with at least one loosening agent, such as collagenase or a digestive enzyme, for a time and at a concentration to loosen the osteogenic cells in the cancellous bone matrix. The osteogenic cells in the matrix are viable cells. The treatment of the cancellous bone with at least one loosening agent enables the osteogenic cells to be more available for carrying out their osteogenic function and to provide for an increased rate of bone formation. Such implant also may include demineralized bone, such as demineralized cortical bone, which enhances the bone regenerative capacity of the cancellous bone.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: January 9, 2024
    Assignee: NuVasive, Inc.
    Inventors: Michelle LeRoux Williams, Charles Randal Mills, Rodney Monroy, Robert A. Zambon, Dayna Buskirk, Earl Fender
  • Patent number: 11779680
    Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: October 10, 2023
    Assignee: RTI Surgical, Inc.
    Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell, Jr.
  • Patent number: 11471560
    Abstract: A bone implant comprising cancellous bone that is essentially free of blood cells, and which has been treated with at least a loosening agent, such as collagenase and/or a digestive enzyme, for a time and at a concentration to loosen the osteogenic cells in the cancellous bone matrix. The osteogenic cells in the matrix are viable cells. The treatment of the cancellous bone with at least one loosening agent enables the osteogenic cells to be more available for carrying out their osteogenic function and to provide for an increased rate of bone formation.
    Type: Grant
    Filed: November 15, 2019
    Date of Patent: October 18, 2022
    Assignee: NuVasive, Inc.
    Inventors: Michelle Leroux Williams, Charles Randal Mills, Rodney Monroy
  • Patent number: 11235160
    Abstract: A connector block that permits simultaneous and continuous interconnection of the three leads of the epicardial pacing wires, the pacemaker, and the ECG monitor on clear separately labeled connectors is provided. Circuitry is provided that allows the display of epicardial signals on the telemetry unit, while still preserving the ability to pace the heart from the pacemaker. When pacing the connector block prevents excessive loading of the pacer signals by the ECG monitor and/or damage to the monitor by the high-voltage pacer signals. The connector block may be used universally on all monitors without the need for sophisticated understanding of the electrical characteristics of the ECG monitor or concern for damage or improper signal loading.
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: February 1, 2022
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Nicholas Von Bergen, Philip Terrien, Matthew Knoespel, Connor Sheedy, James Olson, Randal Mills
  • Publication number: 20210128784
    Abstract: A bone implant comprising cancellous bone that is essentially free of blood cells, and which has been treated with at least one loosening agent, such as collagenase or a digestive enzyme, for a time and at a concentration to loosen the osteogenic cells in the cancellous bone matrix. The osteogenic cells in the matrix are viable cells. The treatment of the cancellous bone with at least one loosening agent enables the osteogenic cells to be more available for carrying out their osteogenic function and to provide for an increased rate of bone formation. Such implant also may include demineralized bone, such as demineralized cortical bone, which enhances the bone regenerative capacity of the cancellous bone.
    Type: Application
    Filed: December 17, 2020
    Publication date: May 6, 2021
    Inventors: Michelle LeRoux Williams, Charles Randal Mills, Rodney Monroy, Robert A. Zambon, Dayna Buskirk, Earl Fender
  • Publication number: 20210046215
    Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.
    Type: Application
    Filed: October 26, 2020
    Publication date: February 18, 2021
    Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell, JR.
  • Patent number: 10898611
    Abstract: A bone implant comprising cancellous bone that is essentially free of blood cells, and which has been treated with at least one loosening agent, such as collagenase or a digestive enzyme, for a time and at a concentration to loosen the osteogenic cells in the cancellous bone matrix. The osteogenic cells in the matrix are viable cells. The treatment of the cancellous bone with at least one loosening agent enables the osteogenic cells to be more available for carrying out their osteogenic function and to provide for an increased rate of bone formation. Such implant also may include demineralized bone, such as demineralized cortical bone, which enhances the bone regenerative capacity of the cancellous bone.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: January 26, 2021
    Assignee: NuVasive, Inc.
    Inventors: Michelle LeRoux Williams, Charles Randal Mills, Rodney Monroy, Robert A. Zambon, Dayna Buskirk, Earl Fender
  • Patent number: 10814034
    Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: October 27, 2020
    Assignee: RTI Surgical, Inc.
    Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell, Jr.
  • Publication number: 20200101196
    Abstract: A bone implant comprising cancellous bone that is essentially free of blood cells, and which has been treated with at least a loosening agent, such as collagenase and/or a digestive enzyme, for a time and at a concentration to loosen the osteogenic cells in the cancellous bone matrix. The osteogenic cells in the matrix are viable cells. The treatment of the cancellous bone with at least one loosening agent enables the osteogenic cells to be more available for carrying out their osteogenic function and to provide for an increased rate of bone formation.
    Type: Application
    Filed: November 15, 2019
    Publication date: April 2, 2020
    Inventors: Michelle LeRoux Williams, Charles Randal Mills, Rodney Monroy
  • Publication number: 20200069950
    Abstract: A connector block that permits simultaneous and continuous interconnection of the three leads of the epicardial pacing wires, the pacemaker, and the ECG monitor on clear separately labeled connectors is provided. Circuitry is provided that allows the display of epicardial signals on the telemetry unit, while still preserving the ability to pace the heart from the pacemaker. When pacing the connector block prevents excessive loading of the pacer signals by the ECG monitor and/or damage to the monitor by the high-voltage pacer signals. The connector block may be used universally on all monitors without the need for sophisticated understanding of the electrical characteristics of the ECG monitor or concern for damage or improper signal loading.
    Type: Application
    Filed: November 7, 2019
    Publication date: March 5, 2020
    Inventors: Nicholas Von Bergen, Philip Terrien, Matthew Knoespel, Connor Sheedy, James Olson, Randal Mills
  • Patent number: 10507265
    Abstract: A bone implant comprising cancellous bone that is essentially free of blood cells, and which has been treated with at least a loosening agent, such as collagenase and/or a digestive enzyme, for a time and at a concentration to loosen the osteogenic cells in the cancellous bone matrix. The osteogenic cells in the matrix are viable cells. The treatment of the cancellous bone with at least one loosening agent enables the osteogenic cells to be more available for carrying out their osteogenic function and to provide for an increased rate of bone formation.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: December 17, 2019
    Assignee: NuVasive, Inc.
    Inventors: Michelle LeRoux Williams, Charles Randal Mills, Rodney Monroy
  • Patent number: 10471261
    Abstract: A connector block that permits simultaneous and continuous interconnection of the three leads of the epicardial pacing wires, the pacemaker, and the ECG monitor on clear separately labeled connectors is provided. Circuitry is provided that allows the display of epicardial signals on the telemetry unit, while still preserving the ability to pace the heart from the pacemaker. When pacing the connector block prevents excessive loading of the pacer signals by the ECG monitor and/or damage to the monitor by the high-voltage pacer signals. The connector block may be used universally on all monitors without the need for sophisticated understanding of the electrical characteristics of the ECG monitor or concern for damage or improper signal loading.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: November 12, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Nicholas Von Bergen, Philip Terrien, Matthew Knoespel, Connor Sheedy, James Olson, Randal Mills
  • Publication number: 20180326119
    Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.
    Type: Application
    Filed: July 16, 2018
    Publication date: November 15, 2018
    Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell, JR.
  • Patent number: 10022472
    Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: July 17, 2018
    Assignee: RTI Surgical, Inc.
    Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell, Jr.
  • Publication number: 20180071102
    Abstract: This invention is directed to an assembled implant comprising two or more portions of bone that are held together in appropriate juxtaposition with one or more biocompatible pins to form a graft unit. Preferably, the pins are cortical bone pins. Typically, the cortical pins are press-fitted into appropriately sized holes in the bone portions to achieve an interference fit. The bone portions are allograft or xenograft.
    Type: Application
    Filed: September 19, 2017
    Publication date: March 15, 2018
    Inventors: John R. Bianchi, C. Randal Mills, P. J. Gorham, Michael Esch, Kevin C. Carter, Pat Coleman, Kevin Ross, Harry W. Rambo, Darren G. Jones, Dayna Buskirk
  • Publication number: 20180036542
    Abstract: A connector block that permits simultaneous and continuous interconnection of the three leads of the epicardial pacing wires, the pacemaker, and the ECG monitor on clear separately labeled connectors is provided. Circuitry is provided that allows the display of epicardial signals on the telemetry unit, while still preserving the ability to pace the heart from the pacemaker. When pacing the connector block prevents excessive loading of the pacer signals by the ECG monitor and/or damage to the monitor by the high-voltage pacer signals. The connector block may be used universally on all monitors without the need for sophisticated understanding of the electrical characteristics of the ECG monitor or concern for damage or improper signal loading.
    Type: Application
    Filed: August 5, 2016
    Publication date: February 8, 2018
    Inventors: Nicholas Von Bergen, Philip Terrien, Matthew Knoespel, Connor Sheedy, James Olson, Randal Mills
  • Publication number: 20170281348
    Abstract: A bone implant comprising cancellous bone that is essentially free of blood cells, and which has been treated with at least one loosening agent, such as collagenase or a digestive enzyme, for a time and at a concentration to loosen the osteogenic cells in the cancellous bone matrix. The osteogenic cells in the matrix are viable cells. The treatment of the cancellous bone with at least one loosening agent enables the osteogenic cells to be more available for carrying out their osteogenic function and to provide for an increased rate of bone formation. Such implant also may include demineralized bone, such as demineralized cortical bone, which enhances the bone regenerative capacity of the cancellous bone.
    Type: Application
    Filed: June 14, 2017
    Publication date: October 5, 2017
    Inventors: Michelle LeRoux Williams, Charles Randal Mills, Rodney Monroy, Robert A. Zambon, Dayna Buskirk, Earl Fender
  • Patent number: 9763787
    Abstract: This invention is directed to an assembled implant comprising two or more portions of bone that are held together in appropriate juxtaposition with one or more biocompatible pins to form a graft unit. Preferably, the pins are cortical bone pins. Typically, the cortical pins are press-fitted into appropriately sized holes in the bone portions to achieve an interference fit. The bone portions are allograft or xenograft.
    Type: Grant
    Filed: January 19, 2010
    Date of Patent: September 19, 2017
    Assignee: RTI Surgical, Inc.
    Inventors: John R. Bianchi, C. Randal Mills, P. J. Gorham, Michael Esch, Kevin C. Carter, Pat Coleman, Kevin Ross, Harry W. Rambo, Darren G. Jones, Dayna Buskirk
  • Publication number: 20170246349
    Abstract: A bone implant comprising cancellous bone that is essentially free of blood cells, and which has been treated with at least a loosening agent, such as collagenase and/or a digestive enzyme, for a time and at a concentration to loosen the osteogenic cells in the cancellous bone matrix. The osteogenic cells in the matrix are viable cells. The treatment of the cancellous bone with at least one loosening agent enables the osteogenic cells to be more available for carrying out their osteogenic function and to provide for an increased rate of bone formation.
    Type: Application
    Filed: May 16, 2017
    Publication date: August 31, 2017
    Inventors: Michelle LeRoux Williams, Charles Randal Mills, Rodney Monroy
  • Publication number: 20160317708
    Abstract: The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.
    Type: Application
    Filed: June 24, 2016
    Publication date: November 3, 2016
    Inventors: C. Randal Mills, John R. Bianchi, Michael R. Roberts, David T. Cheung, Chandrasekaran Nataraj, John W. Howell