Patents by Inventor Randall Davis

Randall Davis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190175910
    Abstract: A system for electrically stimulating a user comprising: a first housing portion defining an array of openings; an array of permeable bodies with portions exposed through the array of openings and wetted with a solution that facilitates electrical coupling between the system and a body region of the user, wherein each permeable body has a cavity at a proximal portion and a distal portion and is configured to transmit the solution to the body region of the user; a substrate region defining an array of protrusions configured to support the array of permeable bodies and composed of a conductive polymer; and a set of conductors in communication with the substrate region and including a first conductor that provides a first subset of the array of permeable bodies with a first polarity and a second conductor that provides a second subset of the array of permeable bodies with a second polarity.
    Type: Application
    Filed: February 15, 2019
    Publication date: June 13, 2019
    Inventors: Brett Wingeier, Tal Bar-Or, Colin Davis, Victoria Hammett, Randall Lin
  • Patent number: 10316360
    Abstract: Provided is a method for detecting a target molecule. The method includes providing a chip, the chip including a nanopore in a membrane that is disposed adjacent to or in proximity to a sensing electrode. A nucleic acid molecule is then directed through the nanopore, the nucleic acid molecule being associated with a reporter molecule. The nucleic acid molecule also includes an address region and a probe region, the reporter molecule being associated with the nucleic acid molecule at the probe region. The reporter molecule is also coupled to a target molecule. While the nucleic acid molecule is directed through the nanopore, the address region can be sequenced to determine a nucleic acid sequence of the address region. The target molecule can then be identified, with the aid of a computer processor, based upon the nucleic acid sequence of the address region.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: June 11, 2019
    Assignee: GENIA TECHNOLOGIES, INC.
    Inventors: Randall Davis, Roger Chen
  • Publication number: 20190169687
    Abstract: Provided are methods of nucleic acid sample preparation for analysis, including analysis using nanopore sequencing applications. In particular provided are methods that allow for the creation of circular and linear DNA samples that contain asymmetric ends to ligate different and desired adaptors to the end of the sample, methods to create single nucleic acid molecules that automatically form concatemers for higher sequencing throughput; methods to create multiple copies (temperature dependent, multi-primed, open-fold replication) of one original nucleic acid sample, or to create single nucleic acid molecules containing multiple copies of more than one original nucleic acid sample (concatemerized samples) for improved accuracy and throughput are described; and methods for improved modified base calling.
    Type: Application
    Filed: October 4, 2018
    Publication date: June 6, 2019
    Inventors: Randall Davis, Michael Dorwart, Janine Mok
  • Patent number: 10260093
    Abstract: Systems and methods of polynucleotide sequencing are provided. Systems and methods optimize control, speed, movement, and/or translocation of a sample (e.g., a polynucleotide) within, through, or at least partially through a nanopore or a type of protein or mutant protein in order to accumulate sufficient time and current blocking information to identify contiguous nucleotides or plurality of nucleotides in a single-stranded area of a polynucleotide.
    Type: Grant
    Filed: November 1, 2012
    Date of Patent: April 16, 2019
    Assignees: GENIA TECHNOLOGIES, INC., LIFE TECHNOLOGIES CORPORATION
    Inventors: Timothy Geiser, Randall Davis, Roger Chen
  • Patent number: 10240195
    Abstract: This disclosure provides systems and methods for attaching nanopore-detectable tags to nucleotides. The disclosure also provides methods for sequencing nucleic acids using the disclosed tagged nucleotides.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: March 26, 2019
    Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, GENIA TECHNOLOGIES, INC.
    Inventors: Carl W. Fuller, Shiv Kumar, Jingyue Ju, Randall Davis, Roger Chen
  • Publication number: 20190085386
    Abstract: The present disclosure provides biochips and methods for making biochips. A biochip can comprise a nanopore in a membrane (e.g., lipid bilayer) adjacent or in proximity to an electrode. Methods are described for forming the membrane and inserting the nanopore into the membrane. The biochips and methods can be used for nucleic acid (e.g., DNA) sequencing. The present disclosure also describes methods for detecting, sorting, and binning molecules (e.g., proteins) using biochips.
    Type: Application
    Filed: November 10, 2017
    Publication date: March 21, 2019
    Inventors: Randall DAVIS, Roger CHEN
  • Publication number: 20190076078
    Abstract: Systems and methods are disclosed for detecting tremors in a subject. One method comprises receiving data from a digital device, the data comprising a plurality of digital device positions and a plurality of timestamps, each timestamp in the plurality of timestamps being associated with a digital device position in the plurality of digital device positions. The method further comprises determining a plurality of frequencies of hand movements of the subject based on the plurality of digital device positions and plurality of timestamps. The method further comprises determining a subportion of the data corresponding to frequencies of hand movements above a low tremor threshold, and determining a magnitude of tremors of the subject's hand based, at least in part, on the subportion of the data.
    Type: Application
    Filed: September 7, 2018
    Publication date: March 14, 2019
    Inventors: Randall Davis, Catherine Medlock, Bruce Musicus, Alan V. Oppenheim, Dana L. Penney, William A. Souillard-Mandar
  • Publication number: 20180353105
    Abstract: A method includes receiving data representing graphomotor motion during a succession of executions of graphomotor diagnostic tasks performed in a medical context by a subject, processing the received data using a computer, including determining a first set of quantitative features from a first execution of a task by the subject, and determining a second set of quantitative features from a second execution of a task by the subject, determining one or more metrics based on a comparison to the successive executions, including using at least the first set of quantitative features and the second set of quantitative features to determine said metrics, and providing a diagnostic report associated with neurocognitive mechanisms underlying the subject's execution of the tasks based on the determined metrics.
    Type: Application
    Filed: January 10, 2018
    Publication date: December 13, 2018
    Inventors: Randall Davis, Dana Penney
  • Publication number: 20180223351
    Abstract: This disclosure provides systems and methods for molecular identification and polymer (e.g., nucleic acid) sequencing using nanopores. The polymer may be passed through or in proximity to the nanopore and various subunits of the polymer may affect the current flowing through the nanopore. The various subunits may be identified by measuring the current at a plurality of voltages applied across the nanopore and/or membrane. In some cases, the polymerization of tagged nucleotides presents tag molecules to the nanopore that can be identified by measuring the current at a plurality of voltages applied across the nanopore and/or membrane. Also provided herein are systems and methods for sequencing both the sense and anti-sense strand of a double stranded nucleic acid molecule with a nanopore and methods for using ribonucleic acid (RNA) speed bump molecules to slow the passage of a nucleic acid molecule through or in proximity to a nanopore.
    Type: Application
    Filed: September 13, 2017
    Publication date: August 9, 2018
    Applicant: Genia Technologies, Inc.
    Inventors: Randall Davis, Roger Chen
  • Publication number: 20180073071
    Abstract: This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to compositions, methods, and systems for sequencing nucleic acids using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule.
    Type: Application
    Filed: September 22, 2017
    Publication date: March 15, 2018
    Applicants: The Trustees of Columbia University in the City of New York, Genia Technologies, Inc.
    Inventors: Jingyue JU, Randall DAVIS, Roger CHEN
  • Patent number: 9895085
    Abstract: A method includes receiving data representing graphomotor motion during a succession of executions of graphomotor diagnostic tasks performed in a medical context by a subject, processing the received data using a computer, including determining a first set of quantitative features from a first execution of a task by the subject, and determining a second set of quantitative features from a second execution of a task by the subject, determining one or more metrics based on a comparison to the successive executions, including using at least the first set of quantitative features and the second set of quantitative features to determine said metrics, and providing a diagnostic report associated with neurocognitive mechanisms underlying the subject's execution of the tasks based on the determined metrics.
    Type: Grant
    Filed: June 18, 2013
    Date of Patent: February 20, 2018
    Assignees: Massachusetts Institute of Technology, Lahey Clinic Foundation, Inc.
    Inventors: Randall Davis, Dana L. Penney
  • Publication number: 20180030524
    Abstract: This disclosure provides chips, systems and methods for sequencing a nucleic acid sample. Tagged nucleotides are provided into a reaction chamber comprising a nanopore in a membrane. An individual tagged nucleotide of the tagged nucleotides can contain a tag coupled to a nucleotide, which tag is detectable with the aid of the nanopore. Next, an individual tagged nucleotide of the tagged nucleotides can be incorporated into a growing strand complementary to a single stranded nucleic acid molecule derived from the nucleic acid sample. With the aid of the nanopore, a tag associated with the individual tagged nucleotide can be detected upon incorporation of the individual tagged nucleotide. The tag can be detected with the aid of the nanopore when the tag is released from the nucleotide.
    Type: Application
    Filed: March 27, 2017
    Publication date: February 1, 2018
    Inventors: Randall Davis, Roger Chen, Arkadiusz Bibillo, Daniel Korenblum
  • Patent number: 9850534
    Abstract: The present disclosure provides biochips and methods for making biochips. A biochip can comprise a nanopore in a membrane (e.g., lipid bilayer) adjacent or in proximity to an electrode. Methods are described for forming the membrane and inserting the nanopore into the membrane. The biochips and methods can be used for nucleic acid (e.g., DNA) sequencing. The present disclosure also describes methods for detecting, sorting, and binning molecules (e.g., proteins) using biochips.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: December 26, 2017
    Inventors: Randall Davis, Roger Chen
  • Publication number: 20170316012
    Abstract: Systems and methods are disclosed for ranking electronic content using a trained topic model to correlate a collection of source content to externally specified target content. Unstructured content is converted to elemental sub-content or interrelated sub-content. A probability vector for the converted externally specified content is generated by use of trained topic model. The externally specified topic probability vector is correlated against a collection of source content, previously converted to vectors that were generated using the same topic model, and a plurality of correlation methods. Rank ordered correlation results are merged to provide the user with a ranked set of source content. Source content from the ranked results can be fed back into the system to adjust the target vector.
    Type: Application
    Filed: April 27, 2017
    Publication date: November 2, 2017
    Applicant: DynAgility LLC
    Inventors: Stephen GLANOWSKI, Randall DAVIS
  • Patent number: 9605309
    Abstract: This disclosure provides chips, systems and methods for sequencing a nucleic acid sample. Tagged nucleotides are provided into a reaction chamber comprising a nanopore in a membrane. An individual tagged nucleotide of the tagged nucleotides can contain a tag coupled to a nucleotide, which tag is detectable with the aid of the nanopore. Next, an individual tagged nucleotide of the tagged nucleotides can be incorporated into a growing strand complementary to a single stranded nucleic acid molecule derived from the nucleic acid sample. With the aid of the nanopore, a tag associated with the individual tagged nucleotide can be detected upon incorporation of the individual tagged nucleotide. The tag can be detected with the aid of the nanopore when the tag is released from the nucleotide.
    Type: Grant
    Filed: November 6, 2013
    Date of Patent: March 28, 2017
    Assignee: Genia Technologies, Inc.
    Inventors: Randall Davis, Roger Chen, Arkadiusz Bibillo, Daniel Korenblum
  • Patent number: 9494554
    Abstract: The present disclosure provides devices, systems and methods for sequencing nucleic acid molecules. Nucleic acid molecules can be sequenced with a high accuracy (e.g., greater than 97% in a single pass) using a chip comprising an array of independently addressable nanopore sensors at a density of at least about 500 sites per 1 mm2. An individual nanopore sensor can include a nanopore in a membrane that is adjacent or in proximity to a sensing electrode.
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: November 15, 2016
    Assignee: Genia Technologies, Inc.
    Inventors: Randall Davis, Roger Chen, Arkadiusz Bibillo, Kevin Deierling
  • Publication number: 20160281430
    Abstract: A drilling system includes a drilling assembly and a control assembly. The control assembly is operably connected to the drilling assembly such that simultaneous movement of multiple portions of the drilling assembly is enabled.
    Type: Application
    Filed: March 27, 2015
    Publication date: September 29, 2016
    Applicant: Caterpillar Inc.
    Inventors: Randall Davis, Jonathan Anderton
  • Publication number: 20160092035
    Abstract: There is provided a system and method for user generated gameplay in chat. The system including a memory storing a text and multimedia messaging software application, and a processor configured to execute the text and multimedia messaging software application to initiate a message exchange session with a remote mobile device, in response to a request received from a user of the mobile device, the message exchange session displaying a user interface for exchanging text and multimedia messages, provide a plurality of games for selection by the user to be played during the message exchange session and within the user interface for exchanging text and multimedia messages, receive a selection of one of the plurality of games by the user after initiating the message exchange session, and initiate the one of the plurality of games for playing within the user interface for exchanging text and multimedia messages.
    Type: Application
    Filed: September 29, 2014
    Publication date: March 31, 2016
    Inventors: John Crocker, Randall Davis, Orrin Shively, Christopher W. Heatherly, James Molinets
  • Publication number: 20150368710
    Abstract: This disclosure provides systems and methods for attaching nanopore-detectable tags to nucleotides. The disclosure also provides methods for sequencing nucleic acids using the disclosed tagged nucleotides.
    Type: Application
    Filed: March 23, 2015
    Publication date: December 24, 2015
    Applicants: The Trustees of Columbia University in the City of New York, Genia Technologies, Inc.
    Inventors: Carl W. Fuller, Shiv Kumar, Jingyue Ju, Randall Davis, Roger Chen
  • Publication number: 20150337366
    Abstract: The present disclosure provides biochips and methods for making biochips. A biochip can comprise a nanopore in a membrane (e.g., lipid bilayer) adjacent or in proximity to an electrode. Methods are described for forming the membrane and inserting the nanopore into the membrane. The biochips and methods can be used for nucleic acid (e.g., DNA) sequencing. The present disclosure also describes methods for detecting, sorting, and binning molecules (e.g., proteins) using biochips.
    Type: Application
    Filed: February 15, 2013
    Publication date: November 26, 2015
    Inventors: Randall DAVIS, Roger CHEN