Abstract: Some fluid coupling devices described herein are configured for use in fluid systems. For example, some embodiments described in this document are single-use, aseptic fluid coupling devices that can be coupled to create a sterile flow path therethrough. Some such aseptic couplings are genderless couplings such that two identical aseptic couplings can be coupled together and then latched to form a robust connection between the aseptic couplings.

Abstract: A hybrid cable includes a central strength member, residing in a center of the cable. At least two insulated conductors are abutting the central strength member. One or more buffer tubes are included in the cable, each with at least one optical fiber. One or more filler rods are optionally included in the cable. A shielding layer and jacket surround the elements. In one embodiment, four large insulated conductors and two filler rods abut the central strength member. A first water-blocking tape surrounds the four large insulated conductors, filler rods and central strength member to form an inner core. A concentric core surrounds the central core. The concentric core includes two insulated conductors, plural buffer tubes and a second water-blocking tape surrounding the two insulated conductors and the plural buffer tubes. The shielding layer surrounds the concentric core, and the jacket surrounds the shielding layer. A toning signal carrying medium may also exist outside of the shielding layer.

Abstract: Provided herein are methods for the treatment of bone disorders that are associated with kidney disease wherein the methods comprise administration of Activin-ActRIIA inhibitors to a subject in need of the treatment. Also provided herein are methods and compositions for the treatment of low turnover bone disorders wherein the methods comprise administration of Activin-ActRIIA inhibitors to a subject in need of the treatment. Further provided herein are compositions for the treatment of bone disorders that are associated with kidney disease and compositions for the treatment of low turnover bone disorders and vascular calcification.

Abstract: An electronic parking brake control system and method for controlling a parking brake of a vehicle. The system includes an electronic parking brake variable switch configured to produce an application signal based on an amount or an amount of time the switch is pulled upward or pushed downward. The system also includes an indicator configured to indicate an amount of application of the parking brake based on the application signal. The system also includes an electronic brake unit coupled to the electronic parking brake variable switch. The electronic brake unit is configured to receive the application signal, and transmit a rear brake signal to a plurality of rear brake actuators to apply a plurality of rear brakes based on the application signal when a speed of the vehicle is below a threshold speed or the vehicle is in a low gear.

Abstract: A hybrid cable includes a central strength member, residing in a center of the cable. At least two insulated conductors are abutting the central strength member. One or more buffer tubes are included in the cable, each with at least one optical fiber. One or more filler rods are optionally included in the cable. A shielding layer and jacket surround the elements. In one embodiment, four large insulated conductors and two filler rods abut the central strength member. A first water-blocking tape surrounds the four large insulated conductors, filler rods and central strength member to form an inner core. A concentric core surrounds the central core. The concentric core includes two insulated conductors, plural buffer tubes and a second water-blocking tape surrounding the two insulated conductors and the plural buffer tubes. The shielding layer surrounds the concentric core, and the jacket surrounds the shielding layer. A toning signal carrying medium may also exist outside of the shielding layer.

Abstract: The invention provides methods, compositions, and kits for using substituted (4-(amino)piperidin-1-yl)(6-(((tetrahydro-2H-pyran-2-yl)methyl)amino)pyrimidin-4-yl)methanone compounds to treat a coronavirus infection and related medical conditions.

Abstract: The invention provides methods and compositions for sequential dosing of capsaicin to treat knee joint pain in a patient, such as knee joint pain due to osteoarthritis, while minimizing transient burning sensation experienced by patients due to capsaicin administration.

Abstract: The invention provides methods and compositions for treatment of pain, such as joint pain, using capsaicin in a procedure that attenuates transient burning sensation experienced by patients due to capsaicin administration. The methods desirably provide relief from joint pain, such as osteoarthritic knee joint pain, for an extended duration, such as at least about 3 months, 6 months, 9 months, or 1 year. To attenuate the adverse side effect of a transient burning sensation caused by capsaicin-induced neuronal excitation, the methods utilize a cooling article, such as a material wrap cooled via a circulating fluid, to reduce the temperature of tissue to be exposed to capsaicin to within a certain range for certain durations of time, optionally in combination with administering a local anesthetic agent, resulting in the substantial reduction or even elimination of transient burning sensation caused by capsaicin.

Abstract: An electronic parking brake control system and method for controlling a parking brake of a vehicle. The system includes an electronic parking brake variable switch configured to produce an application signal based on an amount or an amount of time the switch is pulled upward or pushed downward. The system also includes an indicator configured to indicate an amount of application of the parking brake based on the application signal. The system also includes an electronic brake unit coupled to the electronic parking brake variable switch. The electronic brake unit is configured to receive the application signal, and transmit a rear brake signal to a plurality of rear brake actuators to apply a plurality of rear brakes based on the application signal when a speed of the vehicle is below a threshold speed or the vehicle is in a low gear.

Abstract: The invention provides methods and compositions for treatment of pain, such as joint pain, using capsaicin in a procedure that attenuates transient burning sensation experienced by patients due to capsaicin administration. The methods desirably provide relief from joint pain, such as osteoarthritic knee joint pain, for an extended duration, such as at least about 3 months, 6 months, 9 months, or 1 year. To attenuate the adverse side effect of a transient burning sensation caused by capsaicin-induced neuronal excitation, the methods utilize a cooling article, such as a material wrap cooled via a circulating fluid, to reduce the temperature of tissue to be exposed to capsaicin to within a certain range for certain durations of time, optionally in combination with administering a local anesthetic agent, resulting in the substantial reduction or even elimination of transient burning sensation caused by capsaicin.

Abstract: The invention provides methods and compositions for treatment of pain, such as joint pain, using capsaicin in a procedure that attenuates transient burning sensation experienced by patients due to capsaicin administration. The methods desirably provide relief from joint pain, such as osteoarthritic knee joint pain, for an extended duration, such as at least about 3 months, 6 months, 9 months, or 1 year. To attenuate the adverse side effect of a transient burning sensation caused by capsaicin-induced neuronal excitation, the methods utilize a cooling article, such as a material wrap cooled via a circulating fluid, to reduce the temperature of tissue to be exposed to capsaicin to within a certain range for certain durations of time, optionally in combination with administering a local anesthetic agent, resulting in the substantial reduction or even elimination of transient burning sensation caused by capsaicin.

Abstract: A method of ameliorating pain for a duration of at least 3 months due to an intermetatarsal neuroma in a patient, comprising administering by injection into or adjacent to the patient's intermetatarsal space having an intermetatarsal neuroma at least a first dose of capsaicin and a second dose of capsaicin, no sooner than one month after the first dose, to ameliorate pain due to the intermetatarsal neuroma.

Abstract: The invention provides methods and compositions for treatment of pain, such as joint pain, using capsaicin in a procedure that attenuates transient burning sensation experienced by patients due to capsaicin administration. The methods desirably provide relief from joint pain, such as osteoarthritic knee joint pain, for an extended duration, such as at least about 3 months, 6 months, 9 months, or 1 year. To attenuate the adverse side effect of a transient burning sensation caused by capsaicin-induced neuronal excitation, the methods utilize a cooling article, such as a material wrap cooled via a circulating fluid, to reduce the temperature of tissue to be exposed to capsaicin to within a certain range for certain durations of time, optionally in combination with administering a local anesthetic agent, resulting in the substantial reduction or even elimination of transient burning sensation caused by capsaicin.

Abstract: Provided herein are methods for the treatment of bone disorders that are associated with kidney disease wherein the methods comprise administration of Activin-ActRIIA inhibitors to a subject in need of the treatment. Also provided herein are methods and compositions for the treatment of low turnover bone disorders wherein the methods comprise administration of Activin-Act-RIIA inhibitors to a subject in need of the treatment. Further provided herein are compositions for the treatment of bone disorders that are associated with kidney disease and compositions for the treatment of low turnover bone disorders and vascular calcification.

Abstract: Methods of treating, managing or preventing liver disease are disclosed. Specific methods encompass the administration of apremilast, alone or in combination with additional active agents or treatment regimens.

Abstract: Provided herein are methods for the treatment of bone disorders that are associated with kidney disease wherein the methods comprise administration of Activin-ActRIIA inhibitors to a subject in need of the treatment. Also provided herein are methods and compositions for the treatment of low turnover bone disorders wherein the methods comprise administration of Activin-ActRIIA inhibitors to a subject in need of the treatment. Further provided herein are compositions for the treatment of bone disorders that are associated with kidney disease and compositions for the treatment of low turnover bone disorders and vascular calcification.

Abstract: A method of ameliorating pain for a duration of at least 3 months due to an intermetatarsal neuroma in a patient, comprising administering by injection into or adjacent to the patient's intermetatarsal space having an intermetatarsal neuroma at least a first dose of capsaicin and a second dose of capsaicin, no sooner than one month after the first dose, to ameliorate pain due to the intermetatarsal neuroma.

Abstract: Among other things, at a central server, management of a document sharing process includes uploading from client devices through a communication network, storing at the server, and downloading to client devices through the communication network documents that are shared between users of the client devices. Encryption keys are used to protect features of the documents from unauthorized or unintended disclosure. Operations are performed on encryption keys or encrypted data as a result of which protection of features of the documents from unauthorized or unintended disclosure may be compromised. A determination is made whether performance of a given one of the operations on any of the encryption keys or encrypted data meets predefined conditions for approval by members of an approval group. Performance of the operation on the encryption key or encrypted data is controlled based on a result of the determination.

Abstract: Among other things, at a central server, management of a document sharing process includes uploading from client devices through a communication network, storing at the server, and downloading to client devices through the communication network documents that are shared between users of the client devices. Encryption keys are used to protect features of the documents from unauthorized or unintended disclosure. Operations are performed on encryption keys or encrypted data as a result of which protection of features of the documents from unauthorized or unintended disclosure may be compromised. A determination is made whether performance of a given one of the operations on any of the encryption keys or encrypted data meets predefined conditions for approval by members of an approval group. Performance of the operation on the encryption key or encrypted data is controlled based on a result of the determination.

Abstract: Among other things, at a central server, management of a document sharing process includes uploading from client devices through a communication network, storing at the server, and downloading to client devices through the communication network documents that are shared between users of the client devices. Encryption keys are used to protect features of the documents from unauthorized or unintended disclosure. Operations are performed on encryption keys or encrypted data as a result of which protection of features of the documents from unauthorized or unintended disclosure may be compromised. A determination is made whether performance of a given one of the operations on any of the encryption keys or encrypted data meets predefined conditions for approval by members of an approval group. Performance of the operation on the encryption key or encrypted data is controlled based on a result of the determination.