Abstract: Methods of treating, managing or preventing liver disease are disclosed. Specific methods encompass the administration of apremilast, alone or in combination with additional active agents or treatment regimens.

Abstract: Provided herein are methods of treating, preventing and/or managing bone loss using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-4-acetylaminoisoindolin-1,3-dione, alone or in combination with other therapeutics.

Abstract: Provided herein are methods for the treatment of bone disorders that are associated with kidney disease wherein the methods comprise administration of Activin-ActRIIA inhibitors to a subject in need of the treatment. Also provided herein are methods and compositions for the treatment of low turnover bone disorders wherein the methods comprise administration of Activin-ActRIIA inhibitors to a subject in need of the treatment. Further provided herein are compositions for the treatment of bone disorders that are associated with kidney disease and compositions for the treatment of low turnover bone disorders and vascular calcification.

Abstract: A base block for a cutting drum is disclosed. The base block may have a first end. The first end may have an opening configured to receive a tool. The first end may also have a flat surface surrounding the opening. The base block may have a second end configured to abut the cutting drum. The base block may further have an internal passageway commencing at the opening configured to receive the tool. The passageway may define a longitudinal axis that is offset by an acute angle from being perpendicular to the flat surface.

Abstract: Provided herein are Heteroaryl Compounds of formula (I): wherein R1 and R2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.

Abstract: Provided herein are Heteroaryl Compounds of formula (I): wherein R1 and R2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.

Abstract: A base block for a cutting drum is disclosed. The base block may have a first end. The first end may have an opening configured to receive a tool. The first end may also have a flat surface surrounding the opening. The base block may have a second end configured to abut the cutting drum. The base block may further have an internal passageway commencing at the opening configured to receive the tool. The passageway may define a longitudinal axis that is offset by an acute angle from being perpendicular to the flat surface.

Abstract: Provided herein are Heteroaryl Compounds of formula (I): wherein R1 and R2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.

Abstract: A shielded electrical transmission cable includes an elongate inner conductor and an elongate shield member surrounding the inner conductor. The shield member is formed of at least one copper clad aluminum shield wire including a core including aluminum and a cladding surrounding the core and including copper.

Abstract: An apparatus for the management of the fluid level in a media coating system. In one embodiment, the apparatus has a supply item for the storage of a media coating fluid and an applicator having a trough for receiving the media coating fluid from the supply item. The apparatus utilizes a fluid level detection sensor that is located within the applicator to measure whether the media coating fluid level within the trough of the applicator is either above or below a threshold position and to generates an output signal. The apparatus has a controller for receiving the output signal and controlling delivery of the media coating fluid from the supply item to the applicator.

Abstract: A coating apparatus for applying a coating liquid to a printing substrate. The coating apparatus has a rotatable first roll and a rotatable second roll, each having a surface energy. The second roll is positioned adjacent to the first roll and defines with the first roll a first nip through which the printing substrate passes A metering device is provided for applying a substantially uniform layer of coating liquid onto the second roll. The second roll in turn transfers the coating liquid to the printing substrate. The surface energy of the second roll is greater than the surface energy of the coating liquid. In one embodiment, the metering device includes a rotatable third roll and a doctor blade contacting the third roll, each having a surface energy. The surface energy of at least a portion of either or both the third roll and doctor blade is less than the surface energy of the coating liquid.

Abstract: A fluidic valve (125, 300, 500, 900, 1000, 1100, 1200, 1300) switches a state of flow of a fluid in a fluid communication channel of a fluid guiding structure (505). Heating a bi-phase valve element (515, 1065, 1215) causes a change a state of the bi-phase valve element from a high viscosity state to a low viscosity state. A bi-phase valve element that clogs the fluid communication channel can be pushed into an expanded portion (135, 320, 520, 915, 1220) of the fluid communication channel by an application of pressure to the fluid while the bi-phase valve element is in the low viscosity state, unclogging the fluid communication channel. A bi-phase valve element can be pushed from a valve element source chamber (550, 1250) into the fluid communication channel by using a pumped fluid entering the source chamber at a pump inlet (551) while the bi-phase valve element is in the low viscosity state, clogging the fluid communication channel.

Abstract: A fluidic valve (125, 300, 500, 900, 1000, 1100, 1200, 1300) switches a state of flow of a fluid in a fluid communication channel of a fluid guiding structure (505). Heating a bi-phase valve element (515, 1065, 1215) causes a change a state of the bi-phase valve element from a high viscosity state to a low viscosity state. A bi-phase valve element that clogs the fluid communication channel can be pushed into an expanded portion (135, 320, 520, 915, 1220) of the fluid communication channel by an application of pressure to the fluid while the bi-phase valve element is in the low viscosity state, unclogging the fluid communication channel. A bi-phase valve element can be pushed from a valve element source chamber (550, 1250) into the fluid communication channel by using a pumped fluid entering the source chamber at a pump inlet (551) while the bi-phase valve element is in the low viscosity state, clogging the fluid communication channel.

Abstract: A coating apparatus for applying a coating liquid to a printing substrate. The coating apparatus has a rotatable first roll and a rotatable second roll, each having a surface energy. The second roll is positioned adjacent to the first roll and defines with the first roll a first nip through which the printing substrate passes A metering device is provided for applying a substantially uniform layer of coating liquid onto the second roll. The second roll in turn transfers the coating liquid to the printing substrate. The surface energy of the second roll is greater than the surface energy of the coating liquid. In one embodiment, the metering device includes a rotatable third roll and a doctor blade contacting the third roll, each having a surface energy. The surface energy of at least a portion of either or both the third roll and doctor blade is less than the surface energy of the coating liquid.

Abstract: An apparatus for the management of the fluid level in a media coating system. In one embodiment, the apparatus has a supply item for the storage of a media coating fluid and an applicator having a trough for receiving the media coating fluid from the supply item. The apparatus utilizes a fluid level detection sensor that is located within the applicator to measure whether the media coating fluid level within the trough of the applicator is either above or below a threshold position and to generates an output signal. The apparatus has a controller for receiving the output signal and controlling delivery of the media coating fluid from the supply item to the applicator.

Abstract: Substantially uniform spacing between a printhead and a platen throughout a print zone associated with said printhead in an ink jet printer is provided. The ink jet printer includes a printer frame, and the platen is slideably coupled to the printer frame. A first carrier guide rod is attached to the printer frame, and a second carrier guide rod has at least one end adjustably attached to the printer frame. A position of the second carrier guide rod is adjusted to provide parallelism between the first carrier guide rod and the second carrier guide rod. The platen is biased to a position relative to a position of at least one of the first carrier guide rod and the second carrier guide rod.

Abstract: A robotic safety clutch that provides a wireless connection between the safety clutch and an robotic/automatic arm controller. The safety clutch includes a sensor for sensing a crash event and a radio frequency transmitter for transmitting a crash signal in response to the sensed crash event to a radio frequency receiver. The radio frequency receiver is connected to the robotic/automatic arm controller. Upon receiving the crash signal from the transmitter, the receiver sends a crash signal to the controller and in response to the crash signal, the controller shuts down all robotic/automatic functions.

Abstract: A printer has one or more stacked sheet output units on top of it for increasing the printer's output capacity. Each unit includes a housing having a diverter as does the printer. The position of each diverter is controlled by a diverter/drive mechanism in the unit stacked on top of it. In its first position, the diverter of the printer or the unit diverts a fed sheet from a substantially vertical path therein to a sheet receiving area. In its second position, the diverter allows the fed sheet to be advanced by driven rolls to the unit thereabove. The feed rolls of a unit are driven only when the diverter in each of the printer and in any unit therebeneath are in the second position.

Abstract: The tunnel-erase-type guard band "writing" along the tracks of a disk in a disk file is controlled by the same microcomputer which controls transducer repositioning in the seek mode. The micro-computer meters different delays for onset and cessation of erasing in relation to a signal (write gate) accompanying the data to be recorded; and these delays are longer for tracks having smaller diameters. The leading and trailing edges of the write gate signal trigger interrupts for the microcomputer, the interrupt channel is released only after the particular delay has been metered.

Abstract: A disk drive for one or more spinning disks has a voice coil motor, driving the transducer carriage and controlled by two feedback loops, respectively, for hold and seek modes and enabled by a microcomputer which is additionally inserted into the seek mode feedback loop. The microcomputer receives step pulses from a controller host as well as detent pulses through a path of that seek loop; the pulses serve as interrupts and the microcomputer selects digital speed signals on the basis of step and detect pulse counts. An a/d converter inserts that signal as command into the seek loop.