Abstract: Magnetic Susceptibility Imaging (MSI) comprises a generator to magnetize the tissue to be imaged, such as a first Helmholtz coil, which produces a high-strength external magnetic field to which unpaired electrons of paramagnetic molecules of tissue, which includes primarily deoxyhemoglobin and oxygen, couple in a positive sense, and to which orbital electrons of diamagnetic molecules of tissue, such as proteins and water, couple in a negative sense to produce a secondary magnetic field. The imaging system further comprises a nullifier to null the external magnetizing field, such as a second Helmholtz coil which, for example, confines the flux of both of the coils to a single plane such that the component of the secondary field perpendicular to this plane is the only field with a nonzero component. The secondary field component is detected by a detector, such as an array of Hall voltage detectors.

Abstract: A method of determining the nucleotide sequence of a DNA molecule of arbitrary length as a single procedure by sequencing portions of the molecule in a fashion such that the sequence of the 5' end of the succeeding contiguous portion is sequenced as the 3' end of its preceeding portion is sequenced, for all portions, where the order of contiguous portions is determined by the sequence of the DNA molecule.

Abstract: An imaging system wherein the subject or patient to be examined is placed in a uniform constant magnetic field which is movable over the patient. A secondary magnetic field is generated by paramagnetic substances within the subject when located within the constant magnetic field. In a human body, the primary paramagnetic substance is deoxygenated blood, whereupon the presence of deoxygenated blood in the constant magnetic field produces the above-mentioned secondary field. The secondary field is detected by a two-dimensional array of magnetic field detectors, in close proximity with the patient, mechanically moved simultaneously with the source of primary magnetic field through a region, whose resulting electrical signals are received and processed by an array processor which operates to provide a reconstructed three-dimensional image. In the preferred embodiment as a medical scanner, the present invention provides three-dimensional imaging of arterial and venous blood throughout the human body.

Abstract: Frequency selective radiation therapy providing selective tissue damage or necrosis by irradiating a component element of the target tissue at the corresponding Mossbauer absorption frequency. The component radiation absorption at the Mossbauer absorption frequency is thus enhanced many times over the absorption of the surrounding tissue having a different Mossbauer absorption frequency. The energy thusly absorbed by the target tissue component is converted to and remitted as Auger electrons, which provide intranuclear radiation resulting in lethal double strand breaks in the DNA molecules of the target tissue. The therapy is administered in frequency and tissue selective modes of treatment, and may be combined with conventional chemotherapeutic agents to provide a further enhanced treatment modality. Moreover, the source frequency can be adjusted to enhance the killing effect.

Abstract: Frequency selective radiation therapy providing selective tissue damage or necrosis by irradiating a component element of the target tissue at the corresponding Mossbauer absorption frequency. The component radiation absorption at the Mossbauer absorption frequency is thus enhanced many times over the absorption of the surrounding tissue having a different Mossbauer absorption frequency. The energy thusly absorbed by the target tissue component is converted to and remitted as Auger electrons, which provide intranuclear radiation resulting in lethal double strand breaks in the DNA molecules of the target tissue. The therapy is administered in frequency and tissue selective modes of treatment, and may be combined with conventional chemotherapeutic agents to provide a further enhanced treatment modality. Moreover, the source frequency can be adjusted to enhance the killing effect.