Patents by Inventor Rangarajan Sampath

Rangarajan Sampath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IDENTIFICATION OF SWINE-ORIGIN INFLUENZA A (H1N1) VIRUS
    Publication number: 20120094274
    Abstract: The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses (e.g., swine-origin influenza A (H1N1) virus) which are members of the influenza virus family by amplification of a segment of viral nucleic acid followed by molecular mass analysis.
    Type: Application
    Filed: May 4, 2010
    Publication date: April 19, 2012
    Applicant: Ibis Biosciences, Inc.
    Inventors: Rangarajan Sampath, David J. Ecker, Lawrence B. Blyn, Feng Li, Thomas A. Hall, Christian Massire, Roberta Housley, Robert J. Lovari
  • Bioagent Detection Systems, Devices, And Methods
    Publication number: 20120064523
    Abstract: The present invention relates to portable systems and devices, and corresponding methods, for detecting bioagents. In particular, the present invention provides systems, devices, and methods that utilize one or more of a sample preparation component, sample analysis component employing broad range primers, and sample detection component.
    Type: Application
    Filed: March 30, 2010
    Publication date: March 15, 2012
    Applicant: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Steven A. Hofstadler, Rangarajan Sampath, Lawrence B. Blyn, Thomas A. Hall, Mark W. Eshoo
  • Compositions for use in identification of alphaviruses
    Patent number: 8119336
    Abstract: The present invention provides oligonucleotide primers and compositions and kits containing the same for rapid identification of alphaviruses by amplification of a segment of viral nucleic acid followed by molecular mass analysis.
    Type: Grant
    Filed: March 2, 2005
    Date of Patent: February 21, 2012
    Assignee: Ibis Biosciences, Inc.
    Inventors: Rangarajan Sampath, Thomas A. Hall, Mark W. Eshoo
  • COMPOSITIONS FOR USE IN IDENTIFICATION OF PAPILLOMAVIRUS
    Publication number: 20120015349
    Abstract: The present invention relates generally to identification of HPV, and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.
    Type: Application
    Filed: September 23, 2011
    Publication date: January 19, 2012
    Applicant: IBIS Biosciences, Inc.
    Inventors: Rangarajan Sampath, Lawrence B. Blyn, Rachael Kreft, Thomas A. Hall, Feng Li
  • Methods for identification of sepsis-causing bacteria
    Patent number: 8097416
    Abstract: The present invention provides compositions, kits and methods for rapid identification and quantification of sepsis-causing bacteria by molecular mass and base composition analysis.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: January 17, 2012
    Assignee: Ibis Biosciences, Inc.
    Inventors: Thomas A. Hall, Rangarajan Sampath, Vanessa Harpin, Steven A. Hofstadler, Yun Jiang
  • Compositions for the use in identification of fungi
    Patent number: 8088582
    Abstract: The present invention provides compositions, kits and methods for rapid identification and quantification of fungi by molecular mass and base composition analysis.
    Type: Grant
    Filed: April 6, 2007
    Date of Patent: January 3, 2012
    Assignee: Ibis Biosciences, Inc.
    Inventors: Rangarajan Sampath, Thomas A. Hall, David J. Ecker
  • Compositions for use in identification of papillomavirus
    Patent number: 8084207
    Abstract: The present invention relates generally to identification of HPV, and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.
    Type: Grant
    Filed: October 1, 2009
    Date of Patent: December 27, 2011
    Assignee: Ibis Bioscience, Inc.
    Inventors: Rangarajan Sampath, Lawrence B. Blyn, Rachael Kreft, Thomas A. Hall, Feng Li
  • System for indentification of pathogens
    Patent number: 8073627
    Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
    Type: Grant
    Filed: January 9, 2004
    Date of Patent: December 6, 2011
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke
  • Methods for rapid identification of pathogens in humans and animals
    Patent number: 8071309
    Abstract: The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: December 6, 2011
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence Blyn, Ray Ranken, Thomas A. Hall
  • Methods for identification of coronaviruses
    Patent number: 8057993
    Abstract: The present invention provides a method for rapid identification and quantitation of bacteria by amplification of a segment of bacterial nucleic acid followed by analysis by mass spectrometry. The compositions provide for characterization of the molecular masses and base compositions of bacterial nucleic acids which are used to rapidly identify bacteria.
    Type: Grant
    Filed: April 22, 2004
    Date of Patent: November 15, 2011
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Steven A. Hofstadler, Rangarajan Sampath, Lawrence B. Blyn, Thomas A. Hall, Christian Massire
  • Methods and apparatus for genetic evaluation
    Patent number: 8046171
    Abstract: Rapid and definitive bioagent detection and identification can be carried out without nucleic acid sequencing. Analysis of a variety of bioagents and samples, such as air, fluid, and body samples, can be carried out to provide information useful for industrial, medical, and environmental purposes. Nucleic acid samples of unknown or suspected bioagents may be collected, optimal primer pairs may be selected, and the nucleic acid may be amplified. Expected mass spectra signal models may be generated and selected, the actual mass spectra of the amplicons may be obtained. The expected mass spectra most closely correlating with the actual mass spectra may be determined using a joint maximum likelihood analysis, and base counts for the actual mass spectra and the expected mass spectra may be obtained. The most likely candidate bioagents may then be determined.
    Type: Grant
    Filed: April 18, 2003
    Date of Patent: October 25, 2011
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Dino J. Sofianos, Karl H. Rudnick, Duane J. Knize, Roland B. Stoughton, Cecil L. Basham, Jr., Clifford T. Lewis, Brons M. Larson, Jonathan R. Bar-on, Dennis P. Murray, David W. Robbins, John P. Penhune
  • SECONDARY STRUCTURE DEFINING DATABASE AND METHODS FOR DETERMINING IDENTITY AND GEOGRAPHIC ORIGIN OF AN UNKNOWN BIOAGENT THEREBY
    Publication number: 20110238316
    Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
    Type: Application
    Filed: January 9, 2004
    Publication date: September 29, 2011
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke
  • Method for rapid detection and identification of bioagents
    Patent number: 8017358
    Abstract: Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
    Type: Grant
    Filed: January 13, 2006
    Date of Patent: September 13, 2011
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven Hofstadler, John McNeil
  • Method for rapid detection and identification of bioagents
    Patent number: 8017743
    Abstract: Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: September 13, 2011
    Assignee: Ibis Bioscience, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil
  • Method for rapid detection and identification of bioagents
    Patent number: 8017322
    Abstract: Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: September 13, 2011
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil
  • Compositions for use in identification of bacteria
    Patent number: 8013142
    Abstract: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.
    Type: Grant
    Filed: March 13, 2007
    Date of Patent: September 6, 2011
    Assignee: Ibis Biosciences, Inc.
    Inventors: Rangarajan Sampath, Thomas A. Hall, David J. Ecker, Lawrence Blyn
  • COMPOSITIONS FOR USE IN IDENTIFICATION OF HERPESVIRUSES
    Publication number: 20110200985
    Abstract: The present invention relates generally to identification of herpesviruses and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.
    Type: Application
    Filed: September 29, 2009
    Publication date: August 18, 2011
    Inventors: Rangarajan Sampath, Rachael Kreft, Lawrence B. Blyn, Feng Li, Thomas A. Hall, David J. Ecker
  • COMPOSITIONS FOR USE IN IDENTIFICATION OF ANTIBIOTIC-RESISTANT BACTERIA
    Publication number: 20110190170
    Abstract: The present invention relates generally to identification of antibiotic-resistant bacteria and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.
    Type: Application
    Filed: September 30, 2009
    Publication date: August 4, 2011
    Inventors: Rangarajan Sampath, David J. Ecker, Robert J. Lovari, Feng Li, Lawrence B. Blyn, Thomas A. Hall
  • COMPOSITIONS FOR USE IN IDENTIFICATION OF MEMBERS OF THE BACTERIAL GENUS MYCOPLASMA
    Publication number: 20110189687
    Abstract: The present invention relates generally to identification of members of the bacterial class Mollicutes or the bacterial genus Mycoplasma and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.
    Type: Application
    Filed: September 30, 2009
    Publication date: August 4, 2011
    Applicant: Ibis Bioscience, Inc.
    Inventors: Rangarajan Sampath, Lawrence B. Blyn, Feng Li, Javier P. Fernandez, Thomas A. Hall
  • COMPOSITIONS FOR USE IN IDENTIFICATION OF FUNGI
    Publication number: 20110189676
    Abstract: The present invention relates generally to identification of fungi pathogens, and provides methods, compositions, systems and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.
    Type: Application
    Filed: September 30, 2009
    Publication date: August 4, 2011
    Inventors: Thomas A. Hall, Mark Frinder, Raymond Ranken, Miriam Reyes, Sherilynn Manalili Wheeler, Lawrence B. Blyn, Rangarajan Sampath, David J. Ecker