Abstract: The present invention relates to a Bifidobacterium bifidum inducing regulatory T cells (Treg), a polysaccharide derived from Bifidobacterium bifidum, and a probiotic strain producing a polysaccharide and, more particularly, a polysaccharide containing ?-1-6-glucan as an effective ingredient, a probiotic strain producing ?-1-6-glucan, a food comprising the polysaccharide or strain as an effective ingredient for alleviation of immune disease or inflammatory disease, a therapeutic agent comprising the polysaccharide or strain as an effective ingredient for alleviation of immune disease or inflammatory disease, a method for preparing induced regulatory T cells (iTreg) by treatment with the polysaccharide or strain, and a cell therapy product for prevention or treatment of immune disease or inflammatory disease, comprising the induced regulatory T cells prepared by the method.

Abstract: A composite manufacturing system and method are provided. The composite manufacturing system comprises a press and a bladder. The press has an upper portion having a desired shape for a composite structure and a lower portion configured to receive layers of composite material. The bladder is associated with the upper portion of the press and is configured to reach a superplastic state when heated such that the bladder forms to the composite structure by applying heat and pressure to the layers of composite material. The bladder cools without appreciable shrinkage, applying a desired amount of pressure to the composite structure during the entire cooling cycle. Once one composite structure is formed using the bladder, the bladder may be reused to form similar structures.

Abstract: A tool head assembly for a solid state additive manufacturing apparatus includes a tool head having a material passage configured to receive a material therein. The tool head is configured to deposit the material from the material passage onto a substrate of the solid state additive manufacturing apparatus to form at least one layer of the material on the substrate. The tool head includes a shoulder configured to contact the material such that rotation of the tool head frictionally stirs the material. The tool head assembly includes a barrier configured to extend along a side surface of the at least one layer as the at least one layer is deposited onto the substrate such that the barrier is configured to constrain the material from extruding past an edge of the shoulder.

Abstract: A teleoperations system that collaboratively works with an autonomous vehicle guidance system to generate a path for controlling the autonomous vehicle may comprise generating one or more trajectories at the teleoperations system based at least in part on environment data received from the autonomous vehicle and presenting the one or more trajectories to a teleoperator (e.g., a human user, machine-learned model, or artificial intelligence component). A selection of one of the trajectories may be received at the teleoperations system and transmitted to the autonomous vehicle. The one or more trajectories may be generated at the teleoperations system and/or received from the autonomous vehicle. Regardless, the autonomous vehicle may generate a control trajectory based on the trajectory received from teleoperations, instead of merely implementing the trajectory from the teleoperations system.

Abstract: Methods and systems for Resonant Raman spectroscopy are provided. Methods according to certain embodiments include irradiating a sample with a monochromatic light source at a first irradiation intensity and a second irradiation intensity, determining the intensity of one or more of the Resonant Raman scattering and fluorescence scattering at the first irradiation intensity and second irradiation intensity, calculating a rate of change of one or more of the intensity of Resonant Raman scattering and fluorescence in response to the change in irradiation intensity from the first irradiation intensity to the second irradiation intensity and comparing one or more of the rate of change in the intensity of Resonant Raman scattering and the rate of change in the intensity of fluorescence scattering with the rate of change in the irradiation intensity by the monochromatic light source to determine the Resonant Raman response of the sample.

Abstract: A method (200) for configuring a workflow is described. The method (200) comprises initiating (202), by a workflow engine (122), a task in the workflow and identifying (210), by a rule engine (124), at least one upcoming task in the workflow based on data associated with at least one parameter of the task. The method (200) further comprises determining (212), by a task engine (126), at least one additional parameter of the identified at least one upcoming task and obtaining (214), by the task engine (126), data associated with the at least one additional parameter. The method (200) further comprises completing (216), by the task engine (126), the task based on the data associated with the at least one additional parameter.

Abstract: Provided are methods of separating an absorption spectrum into a Rayleigh scattering contribution and an absorption contribution. By performing such separations and removing the influence of Rayleigh scattering, the absorption of a sample can be more accurately measured. Provided are additional methods that involve separating an absorption spectrum into a Rayleigh scattering contribution and an absorption contribution: assessing whether or not a microorganism is present in a biological fluid, assessing the effect of a pharmaceutical drug on a microorganism, and treating a subject suspected of having an infection. Provided are systems and non-transitory computer readable storage media for separating an absorption spectrum into a Rayleigh scattering and an absorption contribution.

Abstract: A non-covalent complex of an albumin molecule and a hydrophobic ligand, compositions containing the same, and methods of use thereof are provided. The present complex may find use in delivering the hydrophobic ligand to microorganisms that have albumin-binding outer surfaces, such as a cell wall.

Abstract: Methods and systems for Resonant Raman spectroscopy are provided. Methods according to certain embodiments include irradiating a sample with a monochromatic light source at a first irradiation intensity and a second irradiation intensity, determining the intensity of one or more of the Resonant Raman scattering and fluorescence scattering at the first irradiation intensity and second irradiation intensity, calculating a rate of change of one or more of the intensity of Resonant Raman scattering and fluorescence in response to the change in irradiation intensity from the first irradiation intensity to the second irradiation intensity and comparing one or more of the rate of change in the intensity of Resonant Raman scattering and the rate of change in the intensity of fluorescence scattering with the rate of change in the irradiation intensity by the monochromatic light source to determine the Resonant Raman response of the sample.

Abstract: Provisioning for a cloud service is provided. An instance of a provisioning object is created and initialized, and a graphical user interface (GUI) is generated. The GUI includes a home window, a configure window, an orchestrate window and a deploy window. The provisioning parameters are received from the GUI. The provisioning parameters indicate whether to deploy the software application on a local network or a remote network. A location object and a deployment object are created and initialized based on the provisioning parameters. The location object includes an on-premises object for a local network deployment or a cloud object for a remote network deployment. A command to deploy the software application is received from the GUI, and the software application is deployed to a local network or a remote network using the provisioning object, the location object and the deployment object.

Abstract: The present invention relates to a Bifidobacterium bifidum inducing regulatory T cells (Treg), a polysaccharide derived from Bifidobacterium bifidum, and a probiotic strain producing a polysaccharide and, more particularly, a polysaccharide containing ?-1-6-glucan as an effective ingredient, a probiotic strain producing ?-1-6-glucan, a food comprising the polysaccharide or strain as an effective ingredient for alleviation of immune disease or inflammatory disease, a therapeutic agent comprising the polysaccharide or strain as an effective ingredient for alleviation of immune disease or inflammatory disease, a method for preparing induced regulatory T cells (iTreg) by treatment with the polysaccharide or strain, and a cell therapy product for prevention or treatment of immune disease or inflammatory disease, comprising the induced regulatory T cells prepared by the method.

Abstract: A non-covalent complex of an albumin molecule and a hydrophobic ligand, compositions containing the same, and methods of use thereof are provided. The present complex may find use in delivering the hydrophobic ligand to microorganisms that have albumin-binding outer surfaces, such as a cell wall.

Abstract: Described is a method of modifying material properties of a workpiece using a high-pressure-torsion apparatus, comprising a working axis, a first anvil, a second anvil, and an annular body, comprising a first conductive chiller, a second conductive chiller, and a heater, positioned between the first conductive chiller and the second conductive chiller along the working axis. The method comprises compressing the workpiece along a central axis of the workpiece and, simultaneously with compressing the workpiece alone the central axis, twisting the workpiece about the central axis. The method further comprises, while compressing the workpiece along the central axis and twisting the workpiece about the central axis, translating the annular body along the working axis of the high-pressure-torsion apparatus, collinear with the central axis of the workpiece, and heating the workpiece with the heater.

Abstract: Described is a method of modifying material properties of a workpiece using a high-pressure-torsion apparatus, comprising a working axis, a first anvil, a second anvil, and an annular body, comprising a first recirculating convective chiller, a second recirculating convective chiller, and a heater, positioned between the first recirculating convective chiller and the second recirculating convective chiller along the working axis. The method comprises compressing the workpiece along a central axis of the workpiece and. simultaneously with compressing the workpiece along the central axis, twisting the workpiece about the central axis. The method further comprises. while compressing the workpiece along the central axis and twisting the workpiece about the central axis, translating the annular body along the working, axis of the high-pressure-torsion apparatus, collinear with the central axis of the workpiece, and heating the workpiece with the heater.

Abstract: Described is a method of modifying material properties of a workpiece using a high-pressure-torsion apparatus, comprising a working axis, a first anvil, a second anvil, and an annular body, comprising a first total-loss convective chiller, a second total-loss convective chiller, and a heater, positioned between the first total-loss convective chiller and the second total-loss convective chiller along the working axis. The method comprises compressing the workpiece along a central axis of the workpiece and, simultaneously with compressing the workpiece along the central axis, twisting the workpiece about the central axis. The method further comprises, while compressing the workpiece along the central axis and twisting the workpiece about the central axis, translating the annular body along the working axis of the high-pressure-torsion apparatus, collinear with the central axis of the workpiece, and heating the workpiece with the heater.

Abstract: A composite manufacturing system and method are provided. The composite manufacturing system comprises a press and a bladder. The press has an upper portion having a desired shape for a composite structure and a lower portion configured to receive layers of composite material. The bladder is associated with the upper portion of the press and is configured to reach a superplastic state when heated such that the bladder forms to the composite structure by applying heat and pressure to the layers of composite material. The bladder cools without appreciable shrinkage, applying a desired amount of pressure to the composite structure during the entire cooling cycle. Once one composite structure is formed using the bladder, the bladder may be reused to form similar structures.

Abstract: A tool head assembly for a solid state additive manufacturing apparatus includes a tool head having a material passage configured to receive a material therein. The tool head is configured to deposit the material from the material passage onto a substrate of the solid state additive manufacturing apparatus to form at least one layer of the material on the substrate. The tool head includes a shoulder configured to contact the material such that rotation of the tool head frictionally stirs the material. The tool head assembly includes a barrier configured to extend along a side surface of the at least one layer as the at least one layer is deposited onto the substrate such that the barrier is configured to constrain the material from extruding past an edge of the shoulder.

Abstract: A high-pressure-torsion apparatus (100), comprising a working axis (102), a first anvil (110), a second anvil (120), and an annular body (130). The annular body (130) comprises a first total-loss convective chiller (140), a second total-loss convective chiller (150), and a heater (160). Each of the first total-loss convective chiller (140) and the second total-loss convective chiller (150) is translatable between the first anvil (110) and the second anvil (120) along the working axis (102), is configured to be thermally convectively coupled with a workpiece (190), and is configured to selectively cool the workpiece (190). The heater (160) is positioned between the first total-loss convective chiller (140) and the second total-loss convective chiller (150) along the working axis (102), is translatable between the first anvil (110) and the second anvil (120) along the working axis (102), and is configured to selectively heat the workpiece (190).

Abstract: A high-pressure-torsion apparatus (100) comprises a working axis (102), a first anvil (110), a second anvil (120), and an annular body (130). The annular body (130) comprises a a first recirculating convective chiller (140), a second recirculating convective chiller (150), and a heater (160). Each of the first recirculating convective chiller (140) and the second recirculating convective chiller (150) is translatable between the first anvil (110) and the second anvil (120) along the working axis (102), is configured to be thermally convectively coupled with a workpiece (190), and is configured to selectively cool the workpiece (190). The heater (160) is positioned between the first recirculating convective chiller (140) and the second recirculating convective chiller (150) along the working axis (102), is translatable between the first anvil (110) and the second anvil (120) along the working axis (102), and is configured to selectively heat the workpiece (190).

Abstract: A high-pressure-torsion apparatus (100) comprises a working axis (102), a first anvil (110), a second anvil (120), and an annular body (130). The annular body (130) comprises a first conductive chiller (140), a second conductive chiller (150), and a heater (160). Each of the first conductive chiller (140) and the second conductive chiller (150) is translatable between the first anvil (110) and the second anvil (120) along the working axis (102), is configured to be thermally conductively coupled with a workpiece (190), and is configured to selectively cool the workpiece (190). The heater (160) is positioned between the first conductive chiller (140) and the second conductive chiller (150) along the working axis (102), is translatable between the first anvil (110) and the second anvil (120) along the working axis (102), and is configured to selectively heat the workpiece (190).