Abstract: A marine autopilot system configured to control a marine vessel through a marine environment is disclosed herein. The marine autopilot system may obtain data of the marine environment from charts and community shared data and generate a path from a first location to a destination location in the marine environment. The marine autopilot system may control the marine vessel along the path based on the marine vessel dynamics and weather and water current conditions. Sensors may detect hazards on and in the water and object detections systems may classify the hazards. The marine autopilot system may control the marine vessel to avoid the hazards based on the location and classification of the hazards. Furthermore, sensors may be utilized to generate detailed 3D maps that change with time to dock the marine vessel at known and unknown locations.

Abstract: A marine vessel control system operable to be used with a shallow water anchor and a motor. The marine vessel control system comprising a memory and a processor. The processor is configured to receive a user command to maintain a position of a marine vessel, receive sonar data, determine a water depth relative to a water bottom based on the sonar data in response to receiving the user command, and transmit a command to use the shallow water anchor and/or the motor based on the water depth.

Abstract: A combining unit for combining a first optical input and a second optical input, the first optical input comprising a first polarisation maintaining fibre “PMF” having a fast optical axis and a slow optical axis, the second optical input comprising a second PMF having a fast optical axis and a slow optical axis, the combining unit being configured to combine the first optical input with the second optical input in free space such that the fast and slow optical axis of the first PMF and the second PMF are rotated with respect to one another by a non-zero angle to produce a combined signal.

Abstract: A marine autopilot system configured to control a marine vessel through a marine environment is disclosed herein. The marine autopilot system may obtain data of the marine environment from charts and community shared data and generate a path from a first location to a destination location in the marine environment. The marine autopilot system may control the marine vessel along the path based on the marine vessel dynamics and weather and water current conditions. Sensors may detect hazards on and in the water and object detections systems may classify the hazards. The marine autopilot system may control the marine vessel to avoid the hazards based on the location and classification of the hazards. Furthermore, sensors may be utilized to generate detailed 3D maps that change with time to dock the marine vessel at known and unknown locations.

Abstract: A marine vessel control system operable to be used with a shallow water anchor and a motor. The marine vessel control system comprising a memory and a processor. The processor is configured to receive a user command to maintain a position of a marine vessel, receive sonar data, determine a water depth relative to a water bottom based on the sonar data in response to receiving the user command, and transmit a command to use the shallow water anchor and/or the motor based on the water depth.

Abstract: The present disclosure provides catheters comprising polytetrafluoroethylene (PTFE) tubes with advantageous combinations of strength, flexibility, and size. Such tubes can exhibit features including an average wall thickness of 0.001? or less, a tensile stress at break of greater than 5000 psi, and a storage modulus of less than 100,000 psi at 37° C. These tubes can be also be provided independently (i.e., not within a catheter) and can be employed in various applications.

Abstract: A navigation device is disclosed that provides navigational guidance to boats needing to cross a boundary line at a milestone event time. Port and starboard laylines and guidelines may be displayed with the boundary line using wind direction data. The port and starboard layline angles may change with the wind direction, while their lengths may represent a distance traversed by the boat tacking at the port and starboard layline angles for a target time period at a target speed. A predictor line may be displayed extending from the boat in the direction in which the boat is traveling and may have a length indicating a distance traversed by the boat at its current speed until the milestone event time. The predictor line length and color may provide feedback regarding whether the boat will cross the boundary too early or too late given its current speed and direction.

Abstract: A navigation device is disclosed that provides navigational guidance to boats needing to cross a boundary line at a milestone event time. Port and starboard laylines and guidelines may be displayed with the boundary line using wind direction data. The port and starboard layline angles may change with the wind direction, while their lengths may represent a distance traversed by the boat tacking at the port and starboard layline angles for a target time period at a target speed. A predictor line may be displayed extending from the boat in the direction in which the boat is traveling and may have a length indicating a distance traversed by the boat at its current speed until the milestone event time. The predictor line length and color may provide feedback regarding whether the boat will cross the boundary too early or too late given its current speed and direction.

Abstract: A navigation device is disclosed that provides navigational guidance to boats needing to cross a boundary line at a milestone event time. Port and starboard laylines and guidelines may be displayed with the boundary line using wind direction data. The port and starboard layline angles may change with the wind direction, while their lengths may represent a distance traversed by the boat tacking at the port and starboard layline angles for a target time period at a target speed. A predictor line may be displayed extending from the boat in the direction in which the boat is traveling and may have a length indicating a distance traversed by the boat at its current speed until the milestone event time. The predictor line length and color may provide feedback regarding whether the boat will cross the boundary too early or too late given its current speed and direction.

Abstract: A display system for a marine vessel implements a plurality of modes of operation, each of which presents information representative of data from selected marine input sources on one or more electronic displays of the system. A mode of operation may be selected automatically when a determination is made that the marine vessel is within a geographic area, defined by a boundary, or crosses a boundary line with which the mode of operation is associated.

Abstract: A display system for a marine vessel implements a plurality of modes of operation, each of which presents information representative of data from selected marine input sources on one or more electronic displays of the system. A mode of operation may be selected automatically when a determination is made that the marine vessel is within a geographic area, defined by a boundary, or crosses a boundary line with which the mode of operation is associated.

Abstract: The present invention relates to a once daily pharmaceutical composition comprising doxycycline and one or more pharmaceutically acceptable excipients, wherein the pharmaceutical composition exhibits a reduced food effect. The invention further provides a method of treatment of rosacea by administering to a person in need thereof the doxycycline pharmaceutical composition with or without food. A process of preparing such pharmaceutical composition is also provided.

Abstract: The present invention relates to a once daily pharmaceutical composition comprising doxycycline, a controlled-release polymer, and one or more pharmaceutically acceptable excipients. The invention further provides a method of treatment of rosacea by administering such pharmaceutical composition. A process of preparing such pharmaceutical composition is also provided.

Abstract: The present invention relates to a once daily tablet comprising doxycycline at sub-antibiotic dose and one or more pharmaceutically acceptable excipients, wherein the tablet exhibits a reduced food effect. The invention further provides a method of treatment of rosacea by administering to a person in need thereof the doxycycline tablet with or without food. A process of preparing the tablet is also provided.

Abstract: The present invention relates to a once daily pharmaceutical composition comprising doxycycline and one or more pharmaceutically acceptable excipients, wherein the pharmaceutical composition exhibits a reduced food effect. The invention further provides a method of treatment of rosacea by administering to a person in need thereof the doxycycline pharmaceutical composition with or without food. A process of preparing such pharmaceutical composition is also provided.

Abstract: The present invention relates to a once daily pharmaceutical composition comprising doxycycline, a controlled-release polymer, and one or more pharmaceutically acceptable excipients. The invention further provides a method of treatment of rosacea by administering such pharmaceutical composition. A process of preparing such pharmaceutical composition is also provided.

Abstract: The present invention relates to a low dose pharmaceutical composition comprising 24 mg to 36 mg doxycycline and one or more pharmaceutically acceptable excipients for the treatment of acne and/or rosacea, and processes for its preparation.

Abstract: A navigation device is disclosed that provides navigational guidance to boats needing to cross a boundary line at a milestone event time. Port and starboard laylines and guidelines may be displayed with the boundary line using wind direction data. The port and starboard layline angles may change with the wind direction, while their lengths may represent a distance traversed by the boat tacking at the port and starboard layline angles for a target time period at a target speed. A predictor line may be displayed extending from the boat in the direction in which the boat is traveling and may have a length indicating a distance traversed by the boat at its current speed until the milestone event time. The predictor line length and color may provide feedback regarding whether the boat will cross the boundary too early or too late given its current speed and direction.

Abstract: The present invention relates to a once daily tablet comprising doxycycline at sub-antibiotic dose and one or more pharmaceutically acceptable excipients, wherein the tablet exhibits a reduced food effect. The invention further provides a method of treatment of rosacea by administering to a person in need thereof the doxycycline tablet with or without food. A process of preparing the tablet is also provided.

Abstract: The present invention relates to a once daily tablet comprising doxycycline at sub-antibiotic dose and one or more pharmaceutically acceptable excipients, wherein the tablet exhibits a reduced food effect. The invention further provides a method of treatment of rosacea by administering to a person in need thereof the doxycycline tablet with or without food. A process of preparing the tablet is also provided.