Abstract: An vapor purge system for a turbocharged internal combustion engine having an evaporative emissions turbo purge valve incorporating a venturi vacuum generator and a hose-off detection function. The turbo purge valve includes a pressure sensor, and a low restriction check valve which is integrated into the outlet port of the venturi vacuum generator. The pressure sensor is capable of detecting the small pressure drop (i.e., vacuum) generated at the air inlet tube or air box during naturally aspirated conditions. The check valve closes the venturi vacuum generator on the purge side during naturally aspirated conditions, allowing fluid communication to the air intake system through one port only, and the detection of the vacuum during these conditions. If a hose becomes detached, either at the outlet port of the venturi vacuum generator or at the air box, the small vacuum is not detected, and the ECU then diagnoses the hose-off condition.

Abstract: A three-port turbo purge module, including a housing having a cavity, and two check valves. During a first mode of operation, the first check valve is open and the second check valve is closed by vacuum pressure generated in an intake manifold, such that purge vapor flows from an inlet port into the cavity, through the first check valve, and into a first port. During a second mode of operation, where the intake manifold is operating under positive pressure, the first check valve is closed such that pressurized air flowing into the first port is accelerated through a venturi device disposed in the cavity, and the second check valve is open such that purge vapor flows from the inlet port into the cavity, through the venturi device and mixes with the high-velocity air, through the second check valve into the second port.

Abstract: A navigation device is disclosed that provides navigational guidance to boats needing to cross a boundary line at a milestone event time. Port and starboard laylines and guidelines may be displayed with the boundary line using wind direction data. The port and starboard layline angles may change with the wind direction, while their lengths may represent a distance traversed by the boat tacking at the port and starboard layline angles for a target time period at a target speed. A predictor line may be displayed extending from the boat in the direction in which the boat is traveling and may have a length indicating a distance traversed by the boat at its current speed until the milestone event time. The predictor line length and color may provide feedback regarding whether the boat will cross the boundary too early or too late given its current speed and direction.

Abstract: The present invention is to provide a preparation of variant recombinant whole cell biocatalysts, referred herein as “designer cells” having significantly enhanced carbonyl reductase activity for use in the efficient production of variant industrially important enantiomerically enriched alcohols. More specifically, the alcohol is optically pure ethyl (S)-4-chloro-3-hydroxybutyrate, which is useful as chiral building block and an intermediate for the production of hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors.

Abstract: A navigation device is disclosed that provides navigational guidance to boats needing to cross a boundary line at a milestone event time. Port and starboard laylines and guidelines may be displayed with the boundary line using wind direction data. The port and starboard layline angles may change with the wind direction, while their lengths may represent a distance traversed by the boat tacking at the port and starboard layline angles for a target time period at a target speed. A predictor line may be displayed extending from the boat in the direction in which the boat is traveling and may have a length indicating a distance traversed by the boat at its current speed until the milestone event time. The predictor line length and color may provide feedback regarding whether the boat will cross the boundary too early or too late given its current speed and direction.

Abstract: A display system for a marine vessel implements a plurality of modes of operation, each of which presents information representative of data from selected marine input sources on one or more electronic displays of the system. A mode of operation may be selected automatically when a determination is made that the marine vessel is within a geographic area, defined by a boundary, or crosses a boundary line with which the mode of operation is associated.

Abstract: A display system for a marine vessel implements a plurality of modes of operation, each of which presents information representative of data from selected marine input sources on one or more electronic displays of the system. A mode of operation may be selected automatically when a determination is made that the marine vessel is within a geographic area, defined by a boundary, or crosses a boundary line with which the mode of operation is associated.

Abstract: The present invention relates to a once daily pharmaceutical composition comprising doxycycline and one or more pharmaceutically acceptable excipients, wherein the pharmaceutical composition exhibits a reduced food effect. The invention further provides a method of treatment of rosacea by administering to a person in need thereof the doxycycline pharmaceutical composition with or without food. A process of preparing such pharmaceutical composition is also provided.

Abstract: The present invention relates to a once daily pharmaceutical composition comprising doxycycline, a controlled-release polymer, and one or more pharmaceutically acceptable excipients. The invention further provides a method of treatment of rosacea by administering such pharmaceutical composition. A process of preparing such pharmaceutical composition is also provided.

Abstract: The present invention relates to a once daily tablet comprising doxycycline at sub-antibiotic dose and one or more pharmaceutically acceptable excipients, wherein the tablet exhibits a reduced food effect. The invention further provides a method of treatment of rosacea by administering to a person in need thereof the doxycycline tablet with or without food. A process of preparing the tablet is also provided.

Abstract: The present invention is to provide a preparation of variant recombinant whole cell biocatalysts, referred herein as “designer cells” having significantly enhanced carbonyl reductase activity for use in the efficient production of variant industrially important enantiomerically enriched alcohols. More specifically, the alcohol is optically pure ethyl (S)-4-chloro-3-hydroxybutyrate, which is useful as chiral building block and an intermediate for the production of hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors.

Abstract: Systems and methods are provided to incentivize early registration for events to facilitate scheduling of sub-events within the event by allowing event participants, in order of registration, to select and fix sub-event variables preferred by the event participants.

Abstract: The present invention relates to a once daily pharmaceutical composition comprising doxycycline, a controlled-release polymer, and one or more pharmaceutically acceptable excipients. The invention further provides a method of treatment of rosacea by administering such pharmaceutical composition. A process of preparing such pharmaceutical composition is also provided.

Abstract: The present invention relates to a once daily pharmaceutical composition comprising doxycycline and one or more pharmaceutically acceptable excipients, wherein the pharmaceutical composition exhibits a reduced food effect. The invention further provides a method of treatment of rosacea by administering to a person in need thereof the doxycycline pharmaceutical composition with or without food. A process of preparing such pharmaceutical composition is also provided.

Abstract: The present invention relates to a low dose pharmaceutical composition comprising 24 mg to 36 mg doxycycline and one or more pharmaceutically acceptable excipients for the treatment of acne and/or rosacea, and processes for its preparation.

Abstract: A navigation device is disclosed that provides navigational guidance to boats needing to cross a boundary line at a milestone event time. Port and starboard laylines and guidelines may be displayed with the boundary line using wind direction data. The port and starboard layline angles may change with the wind direction, while their lengths may represent a distance traversed by the boat tacking at the port and starboard layline angles for a target time period at a target speed. A predictor line may be displayed extending from the boat in the direction in which the boat is traveling and may have a length indicating a distance traversed by the boat at its current speed until the milestone event time. The predictor line length and color may provide feedback regarding whether the boat will cross the boundary too early or too late given its current speed and direction.

Abstract: The present invention relates to a once daily tablet comprising doxycycline at sub-antibiotic dose and one or more pharmaceutically acceptable excipients, wherein the tablet exhibits a reduced food effect. The invention further provides a method of treatment of rosacea by administering to a person in need thereof the doxycycline tablet with or without food. A process of preparing the tablet is also provided.

Abstract: The present invention relates to a once daily tablet comprising doxycycline at sub-antibiotic dose and one or more pharmaceutically acceptable excipients, wherein the tablet exhibits a reduced food effect. The invention further provides a method of treatment of rosacea by administering to a person in need thereof the doxycycline tablet with or without food. A process of preparing the tablet is also provided.

Abstract: The present invention relates to a pharmaceutical composition comprising (i) 50% to 99% of doxycycline as an immediate-release portion; (ii) 1% to 50% of doxycycline as a controlled-release portion; and (iii) one or more pharmaceutically acceptable excipients; wherein the pharmaceutical composition provides a total daily dosage of 40 mg when administered once daily. It also relates to process for preparation of the pharmaceutical composition and its use for treating rosacea.

Abstract: An electronic device enclosure configured to shield against electromagnetic interference (EMI). The electronic device enclosure includes an electronic device-enclosure base and at least one laterally disposed blunt boss. The electronic device-enclosure base includes a bottom, and sides and attached to the bottom in a boxlike configuration. The laterally disposed blunt boss is configured so as to be disposed between, and to couple electrically, a side of the electronic device-enclosure base and a vertical flange of an electronic device-enclosure cover. The electronic device-enclosure base and the electronic device-enclosure cover are configurable with respect to said laterally disposed blunt boss to shield an interior space enclosed by the electronic device-enclosure base and the electronic device-enclosure cover against EMI at a resonant frequency of a slot of the electronic device enclosure.