Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: A container (1) which includes a base (16), a pair of opposed end walls (2) and a pair of opposed sidewalls (5) into which an insert (9) also having a pair of opposed end walls (11) and a pair of opposed sidewalls (12) is located and secured in position by tabs (14) protruding from the lower edges of the said pair of opposed sidewalls (12). A set of tabs (10) protruding from the upper edges of the end walls (11) and sidewalls. (12) The lower tabs are engaged in rectangular precut slots (8) in the base (16) of the container. (1) The upper tabs(10) are held in position by tabs(4) which are bent at right angles to the end and side walls (2&5) respectively and which have precut rectangular slots(7) which engage the lugs protruding from the pair of end walls (2) and side walls (5) of the insert. (9) The engagement of the lugs (14) and (10) position the insert (9) thus creating a gap between the side walls (2&5) and the sidewalls (11&12) of the insert.

Abstract: The present application relates broadly neutralizing monoclonal antibodies directed against HIV-1. In particular, monoclonal antibodies VRC-PG04 and VRC-PG05 are disclosed.

Abstract: A semiconductor device includes a gate and a first active contact adjacent to the gate. Such a device further includes a first stacked contact electrically coupled to the first active contact, including a first isolation layer on sidewalls electrically isolating the first stacked contact from the gate. The device also includes a first via electrically coupled to the gate and landing on the first stacked contact. The first via electrically couples the first stacked contact and the first active contact to the gate to ground the gate.

Abstract: A pneumatic tire comprises a sidewall, an annular tire cavity, and a hydraulic actuator connected to the sidewall inside the annular tire cavity, wherein the hydraulic actuator has a flexible reservoir for containing a hydraulic fluid, and an opening allowing hydraulic fluid to enter the reservoir and to exit the reservoir. Further, the hydraulic actuator comprises a lever arm connected to the sidewall and holding the flexible reservoir between the lever arm and the sidewall, wherein the lever arm comprises a fluid channel allowing hydraulic fluid to flow from the reservoir through the opening out of the lever arm.

Abstract: A direct orientation vector rotor (DOVER) for use on rotary wing aircraft includes a gear set for multidirectional rotor orientation based on the spherical coordinate system; an inclination mechanism, wherein the rotor is moved from the 0° horizontal position to an inclined position; a rotational turret, wherein the rotor is moved along the azimuth and wherein the inclination mechanism is housed; and a motion-adapted gear lubrication housing.

Abstract: A self-inflating tire assembly includes an air tube connected to a tire and defining an air passageway, the air tube being composed of a flexible material operative to allow an air tube segment opposite a tire footprint to flatten, closing the passageway, and resiliently unflatten into an original configuration. The air tube is sequentially flattened by the tire footprint in a direction opposite to a tire direction of rotation to pump air along the passageway to a regulator device. The regulator device regulates the inlet air flow to the air tube and the outlet air flow to the tire cavity.

Abstract: A direct orientation vector rotor (DOVER) for use on rotary wing aircraft includes a gear set for multidirectional rotor orientation based on the spherical coordinate system; an inclination mechanism, wherein the rotor is moved from the 0° horizontal position to an inclined position; a rotational turret, wherein the rotor is moved along the azimuth and wherein the inclination mechanism is housed; and a motion-adapted gear lubrication housing.

Abstract: In one embodiment, a variable surface landing platform (VARSLAP) includes a base for contacting a landing surface; at least 3 adjustable struts interconnected with the base, wherein each strut is bisected by a strut actuator-housing, and wherein the at least 3 adjustable struts are interconnected to a main body aerospace craft (MAC); a sensor array on the base; and an attitude determination and control system (ADCS).

Abstract: A method of designing conductive interconnects includes determining a residual spacing value based at least in part on an integer multiple of a interconnect trace pitch and a designated cell height. The method also includes allocating the residual spacing to at least one interconnect trace width or interconnect trace space within the interconnect trace pitch.

Abstract: A semiconductor device includes a gate and a first active contact adjacent to the gate. Such a device further includes a first stacked contact electrically coupled to the first active contact, including a first isolation layer on sidewalls electrically isolating the first stacked contact from the gate. The device also includes a first via electrically coupled to the gate and landing on the first stacked contact. The first via electrically couples the first stacked contact and the first active contact to the gate to ground the gate.

Abstract: A method for corrections of measurements of points of interests measured by beams of radiation propagating through stratified media including performance of ray-tracing of at least one ray lunched from a metrology instrument in a direction of an apparent point of interest, calculation a path length of the ray through stratified medium, and determination of coordinates of true position of the point interest using the at least one path length and the direction of propagation of the ray.

Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: In one embodiment, a variable surface landing platform (VARSLAP) includes a base for contacting a landing surface; at least 3 adjustable struts interconnected with the base, wherein each strut is bisected by a strut actuator-housing, and wherein the at least 3 adjustable struts are interconnected to a main body aerospace craft (MAC); a sensor array on the base; and an attitude determination and control system (ADCS).

Abstract: A self-inflating tire assembly includes an air tube connected to a tire and defining an air passageway, the air tube being composed of a flexible material operative to allow an air tube segment opposite a tire footprint to flatten, closing the passageway, and resiliently unflatten into an original configuration. The air tube is sequentially flattened by the tire footprint in a direction opposite to a tire direction of rotation to pump air along the passageway to a regulator device. The regulator device regulates the inlet air flow to the air tube and the outlet air flow to the tire cavity.

Abstract: A pneumatic tire assembly includes a pneumatic tire having an inner cavity and an inner surface at least partially defining the inner cavity, a rigid structure for facilitating operation of the tire assembly, and a docking base for securing the rigid structure to the inner surface of the inner cavity. The docking base has been integrally bonded to the inner surface during curing of the pneumatic tire. The docking base has a shape formed by a mold attached to the inner surface of the inner cavity during curing of the pneumatic tire. The mold subsequently is removed thereby resulting in the docking base integrally secured to the inner surface.

Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies are characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: A reactor is provided which comprises: a plurality of reaction units located within a reaction zone, each of the reaction units being adapted to enable carrying out a chemical reaction of one or more raw gases (e.g. at least one of CO2 and H20); ingress means to allow introduction of the one or more raw gases into the reaction zone and to allow distributing the incoming gas to the plurality of reaction units; egress means to allow exit of reaction products from the reaction zone; and a heating system. The reaction units extend essentially along a longitudinal axis of the reaction zone and are arranged in a spaced-apart relationship along a lateral axis of the reaction zone. The heating system comprises a plurality of heating sources extending along the reaction zone, thereby providing at least a part of the energy to carry out the reaction process within the reaction units.

Abstract: A pneumatic tire assembly includes a pneumatic tire having an inner cavity and an inner surface at least partially defining the inner cavity, a rigid structure for facilitating operation of the tire assembly, and a docking base for securing the rigid structure to the inner surface of the inner cavity. The docking base has been integrally bonded to the inner surface during curing of the pneumatic tire. The docking base has a shape formed by a mold attached to the inner surface of the inner cavity during curing of the pneumatic tire. The mold subsequently is removed thereby resulting in the docking base integrally secured to the inner surface.

Abstract: A pneumatic tire comprises a sidewall, an annular tire cavity, and a hydraulic actuator connected to the sidewall inside the annular tire cavity, wherein the hydraulic actuator has a flexible reservoir for containing a hydraulic fluid, and an opening allowing hydraulic fluid to enter the reservoir and to exit the reservoir. Further, the hydraulic actuator comprises a lever arm connected to the sidewall and holding the flexible reservoir between the lever arm and the sidewall, wherein the lever arm comprises a fluid channel allowing hydraulic fluid to flow from the reservoir through the opening out of the lever arm.