Patents by Inventor Raymond P. Goodrich

Raymond P. Goodrich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6251644
    Abstract: A method is presented for inactivating non-enveloped viruses that may be contaminating a biological solution or suspension by mixing the solution or suspension with a photosensitizer to form a mixture, adjusting the operating conditions of the mixture so as to increase the permeability of the viruses to the photosensitizer, and then irradiating the adjusted mixture.
    Type: Grant
    Filed: November 22, 1994
    Date of Patent: June 26, 2001
    Assignee: Baxter International, Inc.
    Inventors: Samuel O. Sowemimo-Coker, Raymond P. Goodrich, Jr.
  • Patent number: 6235508
    Abstract: Viral and bacterial contaminants present in biological solutions are inactivated by mixing one of a novel class of photosensitizer with said solution and irradiating the mixture. Quinoline and quinolone compounds are useful as photosensitizers in this method. With certain photosensitizers a blocking agent may also be employed.
    Type: Grant
    Filed: September 15, 1998
    Date of Patent: May 22, 2001
    Assignee: Baxter International Inc.
    Inventors: Samuel O. Sowemimo-Coker, Nagender Yerram, Raymond P. Goodrich, Jr., Matthew S. Platz
  • Patent number: 6187572
    Abstract: A method is provided for inactivating viral and/or bacterial contamination in blood cellular matter, such as erythrocytes and platelets, or protein fractions. The cells or protein fractions are mixed with chemical sensitizers, frozen or freeze-dried, and irradiated with, for example, UV, visible, gamma or X-ray radiation while in the solid state.
    Type: Grant
    Filed: April 14, 1993
    Date of Patent: February 13, 2001
    Assignee: Baxter International Inc.
    Inventors: Matthew S. Platz, Raymond P. Goodrich, Jr., Nagender Yerram
  • Patent number: 6169109
    Abstract: Viral and bacterial contaminants present in biological solutions are inactivated by mixing one of a novel class of photosensitizer with said solution and irradiating the mixture.
    Type: Grant
    Filed: September 4, 1998
    Date of Patent: January 2, 2001
    Assignee: Baxter International Inc.
    Inventors: Sang Chul Park, Raymond P. Goodrich, Jr., Nagender Yerram, Samuel O. Sowemimo-Coker, Matthew S. Platz, Brian M. Aquila
  • Patent number: 6153113
    Abstract: A system and method are disclosed for separating particles having different sedimentation velocities. The system includes a container containing a binding substance including first particles and ligands attached to the first particles. When the binding substance is mixed with a liquid carrying at least second and third particles, the ligands bind the first and second particles together to form groups of bound particles. The groups of bound particles are separated from the third particles in a fluid chamber configured to be mounted on a centrifuge rotor. One of the disclosed methods includes forming a saturated fluidized bed of particles to retain the particles groups in the fluid chamber. Another of the disclosed methods includes removing at least some of the first particles after the binding substance is mixed with the liquid carrying second and third particles.
    Type: Grant
    Filed: February 22, 1999
    Date of Patent: November 28, 2000
    Assignee: Cobe Laboratories, Inc.
    Inventors: Raymond P. Goodrich, Todd Curtis Green
  • Patent number: 6051146
    Abstract: A system and method are disclosed for separating particles having different sedimentation velocities. The system includes a fluid chamber for separating the particles form one another. Conduits are provided for flowing liquid carrying particles to the fluid chamber and for mixing the liquid with a diluting liquid. Structure is also provided for separating particles from the liquids after the particles are separated in the fluid chamber. The disclosed methods include forming a saturated fluidized bed of first particles to retain second particles in the fluid chamber. A diluting liquid having a density less than that of the particles is mixed with the liquid carrying particles to reduce overall density of substances in the fluid chamber and thereby reduce Coriolis jetting of liquids in the fluid chamber.
    Type: Grant
    Filed: January 20, 1998
    Date of Patent: April 18, 2000
    Assignee: COBE Laboratories, Inc.
    Inventors: Todd Curtis Green, Raymond P. Goodrich
  • Patent number: 6007978
    Abstract: A process is provided for freezing, including freeze-drying of cells, cell-membranes or cell-like materials using a cryoprotectant medium which stabilizes the cells or membranes for freezing or freeze-drying and allows for freezing or freeze-drying to be performed at -60.degree. C. or higher.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 28, 1999
    Assignee: COBE Laboratories, Inc.
    Inventors: Raymond P. Goodrich, Jr., Samuel O. S. Coker, Francoise Arnaud, Roger W. Hackett
  • Patent number: 5958670
    Abstract: A process is provided for freezing, including freeze-drying of cells, cell-membranes or cell-like materials using a cryoprotectant medium which stabilizes the cells or membranes for freezing or freeze-drying and allows for freezing or freeze-drying to be performed at -60.degree. C. or higher.
    Type: Grant
    Filed: June 15, 1994
    Date of Patent: September 28, 1999
    Assignee: COBE Laboratories, Inc.
    Inventors: Raymond P. Goodrich, Jr., Samuel O.S. Coker, Francoise Arnaud, Roger W. Hackett
  • Patent number: 5955256
    Abstract: Viral, bacterial and parasitic contaminants in blood and cell culture containing compositions are inactivated by adding a photosensitizer and a blocking agent to the composition and irradiating the resulting mixture with electromagnetic radiation. Blocking agents reduce photolysis of the photosensitizer by mechanisms not involving the quenching of reactive oxygen species. The blocking agents reduce photolysis which occurs by ring opening. Preferred photosensitizers are quinoline or quinolone.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 21, 1999
    Assignee: Baxter International Inc.
    Inventors: Samuel O. Sowemimo-Coker, Nagender Yerram, Raymond P. Goodrich, Jr., Matthew S. Platz
  • Patent number: 5869701
    Abstract: Viral and bacterial contaminants present in biological solutions are inactivated by mixing one of a novel class of photosensitizer with said solution and irradiating the mixture.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 9, 1999
    Assignee: Baxter International Inc.
    Inventors: Sang Chul Park, Raymond P. Goodrich, Jr., Nagender Yerram, Samuel O. Sowemimo-Coker, Matthew S. Platz, Brian M. Aquila
  • Patent number: 5849473
    Abstract: A method is provided for the lyophilization of mammalian sperm cells which can be stored and reconstituted to provide morphologically intact cells. The method is advantageous in that the sperm cells may be stored at ambient temperatures for extended periods of time and recovered morphologically intact with DNA-containing heads and intact flagella. The lyophilization medium comprises a carbohydrate and a polymer selected from PVP, HES, dextran and poloxamers or mixtures thereof.
    Type: Grant
    Filed: February 15, 1991
    Date of Patent: December 15, 1998
    Assignee: COBE Laboratories, Inc.
    Inventors: Gonzalo M. Cabrera, Raymond P. Goodrich, Jr.
  • Patent number: 5800978
    Abstract: A process is provided for freezing, including freeze-drying of cells, cell-membranes or cell-like materials using a cryoprotectant medium which stabilizes the cells or membranes for freezing or freeze-drying and allows for freezing or freeze-drying to be performed at -60.degree. C. or higher.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 1, 1998
    Assignee: COBE Laboratories, Inc.
    Inventors: Raymond P. Goodrich, Jr., Samuel O. S. Coker, Francoise Arnaud, Roger W. Hackett
  • Patent number: 5798238
    Abstract: Viral and bacterial contaminants present in biological solutions are inactivated by mixing one of a novel class of photosensitizer with said solution and irradiating the mixture. Quinoline and quinolone compounds are useful as photosensitizers in this method. With certain photosensitizers a blocking agent may also be employed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 25, 1998
    Assignee: Baxter International Inc.
    Inventors: Raymond P. Goodrich, Jr., Sang Chul Park
  • Patent number: 5789601
    Abstract: Viral and bacterial contaminants present in biological solutions are inactivated by mixing one of a novel class of photosensitizer with said solution and irradiating the mixture.
    Type: Grant
    Filed: April 21, 1995
    Date of Patent: August 4, 1998
    Assignee: Baxter International Inc.
    Inventors: Sang Chul Park, Raymond P. Goodrich, Jr., Nagender Yerram, Samuel O. Sowemimo-Coker, Matthew S. Platz, Brian M. Aquila
  • Patent number: 5759774
    Abstract: A method is provided for qualitatively detecting in vitro the presence or absence of selected circulating antibody types using a diagnostic kit comprising reconstituted, after lyophilization or evaporative drying, red blood cell samples or other cell or cell-like material which have antigens which are recognized and bound by the selected antibody-type to be screened. Diagnostic kits containing the lyophilized blood samples according to the present invention have improved shelf life, and may comprise lyophilized samples packaged in a variety of forms convenient for manual single-test uses or automated multiple-test uses.
    Type: Grant
    Filed: September 11, 1992
    Date of Patent: June 2, 1998
    Assignee: COBE Laboratories, Inc.
    Inventors: Roger W. Hackett, Raymond P. Goodrich, Jr., Christine M. Williams, Jon A. Olson, Miller Cho, Richard F. Galle
  • Patent number: 5648206
    Abstract: A process and medium are disclosed for the lyophilization of cells which comprises the use of solutions including monosaccharide hexoses and pentoses, and/or biocompatible amphipathic polymers to permit the reconstitution of viable cells.
    Type: Grant
    Filed: March 29, 1995
    Date of Patent: July 15, 1997
    Assignee: Cobe Laboratories, Inc.
    Inventors: Raymond P. Goodrich, Jr., Christine M. Williams
  • Patent number: 5641637
    Abstract: A method is disclosed for preparing lyophilized and frozen cells as cytometry standards.
    Type: Grant
    Filed: April 5, 1993
    Date of Patent: June 24, 1997
    Assignee: Cobe Laboratories, Inc.
    Inventors: Robert Hudak, Iris Williams, Vijay Adda, Raymond P. Goodrich, Jr.
  • Patent number: 5587490
    Abstract: A compound is provided for inactivating viral, bacterial or other contamination in cells, body fluids or fractions thereof. The compound comprises a psoralen with a single substituent that is either a quaternary phosphonium or ammonium moiety, and at least one substituent that is a halogen. The compound selectively binds to the contaminant, and upon activation by irradiation, damages the contaminant.
    Type: Grant
    Filed: December 10, 1993
    Date of Patent: December 24, 1996
    Assignee: Credit Managers Association of California
    Inventors: Raymond P. Goodrich, Jr., Matthew S. Platz, Nagender Yerram, Roger W. Hackett, Marjan van Borssum Waalkes, Christine M. Williams-Hughes, Victoria A. Wong
  • Patent number: 5516629
    Abstract: A method for photoinactivating viral and/or bacterial contaminants in blood, blood products or cell cultures is presented. The blood, blood product or cell culture is mixed with an halogenated coumarin sensitizer and irradiated with UV light to inactivate the viral and/or bacterial contaminants.
    Type: Grant
    Filed: September 22, 1994
    Date of Patent: May 14, 1996
    Assignee: Cryopharm Corporation
    Inventors: Sang C. Park, Raymond P. Goodrich, Jr., Nagender Yerram, Samuel O. Sowemimo-Coker, Matthew S. Platz, Brian M. Aquila
  • Patent number: 5425951
    Abstract: A process and medium are disclosed for the lyophilization of cells which comprises the use of solutions including monosaccharide hexoses and pentoses, and/or biocompatible amphipathic polymers to permit the reconstitution of viable cells.
    Type: Grant
    Filed: May 31, 1991
    Date of Patent: June 20, 1995
    Assignee: Cryopharm Corporation
    Inventors: Raymond P. Goodrich, Jr., Christine M. Williams