Patents by Inventor Reginald Donovan Smith
Reginald Donovan Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20200231921Abstract: A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.Type: ApplicationFiled: October 3, 2018Publication date: July 23, 2020Inventors: Chengkun Zhang, Kashan A. Shaikh, Weston B. Griffin, Reginald Donovan Smith
-
Patent number: 10691773Abstract: The present disclosure relates to cell processing techniques. By way of example, a cell processing system may include a plurality of sample processing devices configured to process patient samples and a plurality of readers respectively associated with the plurality of sample processing devices, wherein each reader is configured to read information from tracking devices associated with respective patient samples. The system may also include a controller that uses information from the readers to provide an estimated completion time for a patient sample based on availability of the sample processing devices.Type: GrantFiled: December 30, 2015Date of Patent: June 23, 2020Assignee: GENERAL ELECTRIC COMPANYInventors: Nichole Lea Wood, Lynn Ann DeRose, Kunter Seref Akbay, Christopher Donald Johnson, Reginald Donovan Smith, Dolores Baksh
-
Publication number: 20200181572Abstract: Provided herein are methods of activating immune cells. The method includes providing a population of immune cells and contacting the population of immune cells with a first agent and a second agent. The first agent includes an immune cell activator attached to a first binder moiety, and the second agent includes at least one capture oligomer. The at least one capture oligomer is capable of associating with the first binder moiety. Also provided are kits for activating immune cells.Type: ApplicationFiled: August 24, 2017Publication date: June 11, 2020Inventors: Ernest William Kovacs, Anup Sood, Reginald Donovan Smith, Evelina Roxana Loghin, Padmaparna Chaudhuri, Vandana Keskar, Chrystal Mae Chadwick, Martin James Brown
-
Publication number: 20200148987Abstract: A bioreactor vessel includes a body having upper and lowerends and a hollow interior cavity formed in the body, the interior cavity located between the upper and lower ends, the interior cavity being configured to receive biomaterials for processing. The interior cavity includes a lower boundary that is angled toward the lower end of the body such that the vessel may be tilted to allow biomaterials within the interior cavity to be extracted and. concentrated and/or washed without the need for a separate bioprocessing device.Type: ApplicationFiled: November 13, 2018Publication date: May 14, 2020Applicant: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: REGINALD DONOVAN SMITH, Chengkun Zhang, Jason Castle, Kenneth Conway
-
Patent number: 10465157Abstract: A sampling assembly configured to be coupled to a sample source is provided. The sampling assembly is configured to facilitate aseptic sampling at one or more instances in time. The sampling assembly includes a first conduit having a first port and a second port, where the first port is configured to be coupled to the sample source, and where the second port is configured to be hermetically sealed. The sampling assembly further includes a plurality of sub-conduits having corresponding sub-ports, where each of the plurality of sub-conduits is operatively coupled to the first conduit at respective connection points, and where each of the sub-ports is in fluidic communication with the first conduit. Moreover, the sampling assembly includes a plurality of sampling kits, where each sampling kit of the plurality of sampling kits is operatively connected to a respective sub-port of a corresponding sub-conduit.Type: GrantFiled: August 19, 2014Date of Patent: November 5, 2019Assignee: GENERAL ELECTRIC COMPANYInventors: Chengkun Zhang, Kenneth Roger Conway, Donald Joseph Buckley, Eugene Pauling Boden, Weston Blaine Griffin, Anshika Bajaj, Reginald Donovan Smith, Zhipeng Zhang
-
Publication number: 20190249130Abstract: A method includes introducing a suspension including cells suspended in a cell culture medium through a feed port or a drain port into a cavity of a cell culture vessel, the suspension being in an amount sufficient to cover a gas permeable, liquid impermeable membrane positioned at a bottom of the cell culture vessel, the feed port being disposed through a surface of the cell culture vessel and configured to permit additional cell culture medium into the cavity, and the drain port being disposed through the surface of the cell culture vessel and configured to permit removal of the cells, cell culture medium, and used cell culture medium from the cavity, allowing the cells to settle on the gas permeable, liquid impermeable membrane by gravity, removing the used cell culture medium through the drain port and introducing the additional cell culture medium through the feed port such that a constant volume is maintained in the cell culture vessel until the cells expand to a desired cell density, wherein the removiType: ApplicationFiled: February 9, 2018Publication date: August 15, 2019Inventors: Weston Blaine Griffin, Xiaohua Zhang, Reginald Donovan Smith, Vandana Keskar
-
Patent number: 10294454Abstract: Provided are methods and kits for activating T cells, the method comprising providing a population of T cells, adding a plurality of first agents, where the first agent comprises a T-cell activator and a first binder moiety, and adding a second agent comprising a plurality of capture oligomers, where at least a segment of at least one of the plurality of capture oligomers is capable of associating with the first binder moiety. The method further comprises incubating the population of T cells, whereby at least a portion of the population of T cells is activated.Type: GrantFiled: August 24, 2016Date of Patent: May 21, 2019Assignee: General Electric CompanyInventors: Ernest William Kovacs, Anup Sood, Reginald Donovan Smith, Evelina Roxana Loghin, Padmaparna Chadhuri, Vandana Keskar, Chrystal Mae Chadwick, Martin James Brown
-
Publication number: 20190105609Abstract: A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.Type: ApplicationFiled: October 5, 2017Publication date: April 11, 2019Inventors: Chengkun Zhang, Kashan Ali Shaikh, Reginald Donovan Smith, Weston Blaine Griffin
-
Patent number: 10190950Abstract: A semi-automated sampling assembly configured for aseptic sampling at one or more instances from a sample source having a biological inoculum is provided. The semi-automated sampling assembly includes a sampling conduit, a recovery conduit, one or more sampling kits, and a pumping device. The sampling conduit includes a first port and a second port, where the first port of the sampling conduit is configured to be operatively coupled to the sample source. Further, the recovery conduit includes a first port and a second port, where the first port of the recovery conduit is configured to be operatively coupled to the sample source. Also, the second port of the recovery conduit is operatively coupled to at least a portion of the sampling conduit. Moreover, the one or more sampling kits are operatively coupled to the sampling conduit, and the pumping device is operatively coupled to the sampling conduit.Type: GrantFiled: October 31, 2014Date of Patent: January 29, 2019Assignee: GENERAL ELECTRIC COMPANYInventors: Weston Blaine Griffin, Chengkun Zhang, Kenneth Roger Conway, Reginald Donovan Smith
-
Patent number: 10131874Abstract: A cell culture support comprising a substrate, and a dual stimuli responsive block copolymer immobilized on the substrate, wherein the dual stimuli responsive block copolymer is both thermoresponsive and pH responsive. A method of culturing cells comprising the cell culture support having a dual stimuli responsive copolymer immobilized on a substrate, wherein the dual stimuli responsive copolymer is thermoresponsive and pH responsive; and growing the cells on the cell culture support. By lowering the temperature, cells are released from the cell culture support.Type: GrantFiled: September 12, 2016Date of Patent: November 20, 2018Assignee: GENERAL ELECTRIC COMPANYInventors: Reginald Donovan Smith, Prameela Susarla, Slawomir Rubinsztajn, Brian David Polizzotti, Anton Beletskii
-
Publication number: 20180292298Abstract: Provided herein are kit for providing a gamma sterilized aqueous dextran solution that increase the efficiency of blood separation by allowing the dextran solution to be sterilized by exposure to gamma radiation while maintaining sufficient molecular weight to act as a red blood cell aggregate. Also provided are methods of use.Type: ApplicationFiled: June 15, 2018Publication date: October 11, 2018Inventors: Reginald Donovan SMITH, Patrick Joseph McCloskey
-
Patent number: 9920292Abstract: System and methods are provided for initiating a cell culture. The systems and methods include a first enclosure containing a thermal mass positioned on a surface area of a platform. The systems and methods include a second enclosure, containing a culture fluid and a gas mixture, placed on the first enclosure such that the first enclosure is positioned between the second enclosure and the platform. The systems and methods further include a cover secured on the second enclosure, and generating first thermal energy on the surface area of the platform and second thermal energy from the cover.Type: GrantFiled: August 31, 2015Date of Patent: March 20, 2018Assignee: GENERAL ELECTRIC COMPANYInventors: Chengkun Zhang, Reginald Donovan Smith, Kenneth Roger Conway, Anshika Bajaj
-
Publication number: 20180057791Abstract: Provided are methods and kits for activating T cells, the method comprising providing a population of T cells, adding a plurality of first agents, where the first agent comprises a T-cell activator and a first binder moiety, and adding a second agent comprising a plurality of capture oligomers, where at least a segment of at least one of the plurality of capture oligomers is capable of associating with the first binder moiety. The method further comprises incubating the population of T cells, whereby at least a portion of the population of T cells is activated.Type: ApplicationFiled: August 24, 2016Publication date: March 1, 2018Inventors: Ernest William Kovacs, Anup Sood, Reginald Donovan Smith, Evelina Roxana Loghin, Padmaparna Chadhuri, Vandana Keskar, Chrystal Mae Chadwick, Martin James Brown
-
Publication number: 20180005156Abstract: The present invention provides improved methods, facilities and systems for parallel processing of biological cellular samples in an efficient and scalable manner. The invention enables parallel processing of biological cellular samples, such as patient samples, in a space and time efficient fashion. Process simulation may be used to determine the optimal arrangement and/or quantity of cell processing equipment needed. The methods, facilities and systems of the invention find particular utility in processing patient samples for use in cell therapy.Type: ApplicationFiled: January 20, 2016Publication date: January 4, 2018Inventors: Dolores Baksh, Kunter Seref Abkay, Nichole Lea Wood, Reginald Donovan Smith
-
Patent number: 9709549Abstract: Method and systems, for processing biological material, that contain a biological material in a vessel; add an aggregating agent to the material in the vessel and allow the material to separate into two or more distinct submaterials; extract one or more of the submaterials from the vessel; automatically transport one or more of the submaterials remaining in the vessel to a filtration device; and collect a resulting target retentate into a target retentate receptacle.Type: GrantFiled: December 9, 2014Date of Patent: July 18, 2017Assignee: General Electric CompanyInventors: Nichole Lea Wood, Reginald Donovan Smith, Hongyi Zhou, Liming Yu, Brian David Polizzotti, Peter D. Miller
-
Publication number: 20170193168Abstract: The present disclosure relates to cell processing techniques. By way of example, a cell processing system may include a plurality of sample processing devices configured to process patient samples and a plurality of readers respectively associated with the plurality of sample processing devices, wherein each reader is configured to read information from tracking devices associated with respective patient samples. The system may also include a controller that uses information from the readers to provide an estimated completion time for a patient sample based on availability of the sample processing devices.Type: ApplicationFiled: December 30, 2015Publication date: July 6, 2017Inventors: Nichole Lea Wood, Lynn Ann DeRose, Kunter Seref Akbay, Christopher Donald Johnson, Reginald Donovan Smith, Dolores Baksh
-
Patent number: 9677975Abstract: A sampling assembly configured to be coupled to a sample source and facilitate aseptic sampling at one or more instances in time is provided. Further, the sampling assembly includes a first conduit having first and second ports, where the first port is configured to be coupled to the sample source. The sampling assembly also includes a plurality of sub-conduits having corresponding sub-ports, where each of the plurality of sub-conduits is operatively coupled to the first conduit at respective connector junctions. Also, each of the sub-ports is in fluidic communication with the first conduit. The sampling assembly also includes a plurality of sampling kits and one or more pumping devices. Further, each sampling kit is operatively coupled to a respective sub-port of a corresponding sub-conduit. Moreover, the one or more pumping devices are operatively and aseptically coupled to the second port of the first conduit.Type: GrantFiled: October 31, 2014Date of Patent: June 13, 2017Assignee: General Electric CompanyInventors: Chengkun Zhang, Kenneth Roger Conway, Donald Joseph Buckley, Eugene Pauling Boden, Weston Blaine Griffin, Anshika Bajaj, Reginald Donovan Smith
-
Patent number: 9587215Abstract: A coupling device configured to form a sample access assembly is provided. The sample access assembly is configured to house a sample. The coupling device includes a heating component and a separating component. Further, the separating component is configured to separate portions of first and second containers that form first and second compartments of the sample access assembly. Moreover, the heating component is configured to heat at least a portion of the sample.Type: GrantFiled: August 7, 2014Date of Patent: March 7, 2017Assignee: General Electric CompanyInventors: Ying Mao, Kenneth Roger Conway, Weston Blaine Griffin, Reginald Donovan Smith, Evelina Roxana Loghin, Vandana Keskar, Chengkun Zhang, Zhipeng Zhang
-
Publication number: 20170058252Abstract: System and methods are provided for initiating a cell culture. The systems and methods include a first enclosure containing a thermal mass positioned on a surface area of a platform. The systems and methods include a second enclosure, containing a culture fluid and a gas mixture, placed on the first enclosure such that the first enclosure is positioned between the second enclosure and the platform. The systems and methods further include a cover secured on the second enclosure, and generating first thermal energy on the surface area of the platform and second thermal energy from the cover.Type: ApplicationFiled: August 31, 2015Publication date: March 2, 2017Inventors: Chengkun Zhang, Reginald Donovan Smith, Kenneth Roger Conway, Anshika Bajaj
-
Publication number: 20160376550Abstract: A cell culture support comprising a substrate, and a dual stimuli responsive block copolymer immobilized on the substrate, wherein the dual stimuli responsive block copolymer is both thermoresponsive and pH responsive. A method of culturing cells comprising the cell culture support having a dual stimuli responsive copolymer immobilized on a substrate, wherein the dual stimuli responsive copolymer is thermoresponsive and pH responsive; and growing the cells on the cell culture support. By lowering the temperature, cells are released from the cell culture support.Type: ApplicationFiled: September 12, 2016Publication date: December 29, 2016Inventors: Reginald Donovan Smith, Prameela Susarla, Slawomir Rubinsztajn, Brian David Polizzotti, Anton Beletskii