Patents by Inventor Reid W. von Borstel

Reid W. von Borstel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8678002
    Abstract: A facial mask for use in decreasing the transmission of one or more than one human pathogen to and from a human wearer of the facial mask, the facial mask comprising a facepiece; where the facepiece comprises three or more than three layers; where one or more than one of the three or more than three layers comprises a fabric comprising one or more than one binding substance comprising one or more than one human pathogen binding group for chemically attaching the human pathogen to the binding substance; where the fabric further comprises one or more than one type of multivalent metallic ion or metallic salt; and where one or more than one of the three or more than three layers comprises a heat-moldable fabric.
    Type: Grant
    Filed: June 25, 2008
    Date of Patent: March 25, 2014
    Assignee: Filligent Limited
    Inventors: Neal G. Stewart, Lok Yuen Lo, Francis Chi Nan Lau, Dacey J. Ryan, Reid W. von Borstel
  • Publication number: 20130331452
    Abstract: Uric acid in mammalian subjects is reduced and excretion of uric acid is increased by administering a compound of Formula (I). The uric acid-lowering effects of the compounds of this invention are used to treat or prevent a variety of conditions including gout, hyperuricemia, elevated levels of uric acid that do not meet the levels customarily justifying a diagnosis of hyperuricemia, renal dysfunction, kidney stones, cardiovascular disease, risk for developing cardiovascular disease, tumor-lysis syndrome, cognitive impairment, early-onset essential hypertension, and Plasmodium falciparum-induced inflammation. In Formula I, t, q, r, R6, R7, X and A are as defined herein.
    Type: Application
    Filed: September 6, 2011
    Publication date: December 12, 2013
    Applicant: WELLSTAT THERAPEUTICS CORPORATION
    Inventors: Shalini Sharma, Reid W von Borstel
  • Patent number: 8604083
    Abstract: Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
    Type: Grant
    Filed: July 2, 2007
    Date of Patent: December 10, 2013
    Assignee: Wellstat Therapeutics Corporation
    Inventors: Shalini Sharma, Reid W. Von Borstel, Kirvin L. Hodge, Michael K. Bamat, Stephen D. Wolpe
  • Patent number: 8552062
    Abstract: Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
    Type: Grant
    Filed: September 27, 2006
    Date of Patent: October 8, 2013
    Assignee: Wellstat Therapeutics Corporation
    Inventors: Shalini Sharma, Reid W. von Borstel, Kirvin L. Hodge
  • Publication number: 20130259850
    Abstract: Uric acid in mammalian subjects is reduced and excretion of uric acid is increased by administering a compound of Formula I or a pharmaceutically acceptable salt thereof. In Formula I m is 0, 1, 2, 3 or 4; n is 0 or 1; m+n is not more than 4; t is 0 or 1; q is 0 or 1; and r is 0, 1 or 2. R6 is hydrogen, methyl or ethyl and R12 is hydrogen or methyl, or R6 is hydroxy and R12 is hydrogen, or R6 is O and R12 is absent, or R6 and R12 together are —CH2CH2—. R7 is hydrogen or alkyl having from 1 to 3 carbon atoms. One of R8 and R9 is alkyl having from 1 to 3 carbon atoms, and the other is hydrogen or alkyl having from 1 to 3 carbon atoms. R10 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms or alkoxy having from 1 to 3 carbon atoms. X is C(O) and r is 0 and t is 0; or X is NH(R11) wherein R11 is hydrogen or alkyl having from 1 to 3 carbon atoms.
    Type: Application
    Filed: May 9, 2013
    Publication date: October 3, 2013
    Applicant: WELLSTAT THERAPEUTICS CORPORATION
    Inventors: James Dennen O'NEIL, Michael K. BAMAT, Reid W. von BORSTEL, Shalini SHARMA, Ramachandran ARUDCHANDRAN
  • Patent number: 8546448
    Abstract: A process for forming a solid electrolytic capacitor and an electrolytic capacitor formed by the process. The process includes: providing an anode wherein the anode comprises a porous body and an anode wire extending from the porous body; applying a thin polymer layer onto the dielectric, and forming a dielectric on the porous body to form an anodized anode; applying a first slurry to the anodized anode to form a blocking layer wherein the first slurry comprises a first conducting polymer with an median particle size of at least 0.05 ?m forming a layer of crosslinker on the blocking layer; and applying a layer of a second conducting polymer on the layer of crosslinker.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: October 1, 2013
    Assignee: Wellstat Therapeutics Corporation
    Inventors: Shalini Sharma, Reid W. von Borstel, Ramchandran Arudchandran, Rita O'Neil
  • Patent number: 8487000
    Abstract: Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
    Type: Grant
    Filed: December 6, 2004
    Date of Patent: July 16, 2013
    Assignee: Wellstat Therapertics Corporation
    Inventors: Shalini Sharma, Reid W. von Borstel
  • Patent number: 8481595
    Abstract: Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. The agent is a compound of Formula (I): wherein m is 0, 1, 2, 3, 4, 5, 6, 7 or 8; R1 is hydrogen or alkyl having from 1 to 3 carbon atoms; and R2 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms.
    Type: Grant
    Filed: January 13, 2009
    Date of Patent: July 9, 2013
    Assignee: Wellstat Therapeutics Corporation
    Inventors: Shalini Sharma, Reid W. von Borstel
  • Patent number: 8338480
    Abstract: Various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis can be treated with a combination of a direct PPAR-gamma agonist and a Compound of Formula (I) or a pharmaceutically acceptable salt thereof (I) Three of R1, R2, R3, R4 and R5 are hydrogen and the remainder are independently selected from the group consisting of hydrogen, halo, hydroxy, methyl, ethyl, perfluoromethyl, methoxy, ethoxy, and perfluoromethoxy; and m is 0, 2 or 4. R6 is hydrogen, O or hydroxy, and X is —OR7, wherein R7 is hydrogen or alkyl having from 1 to 3 carbon atoms; or R6 is hydrogen, and X is —NR8R9, wherein R8 is hydrogen or hydroxy and R9 is hydrogen, methyl or ethyl. When X is —NR8R9, hydroxy none of R1, R2, R3, R4 and R5 is hydroxy.
    Type: Grant
    Filed: March 5, 2007
    Date of Patent: December 25, 2012
    Assignee: Wellstat Therapeutics Corporation
    Inventors: Reid W. von Borstel, Kirvin L. Hodge
  • Publication number: 20120201803
    Abstract: A process for forming a solid electrolytic capacitor and an electrolytic capacitor formed by the process. The process includes: providing an anode wherein the anode comprises a porous body and an anode wire extending from the porous body; applying a thin polymer layer onto the dielectric, and forming a dielectric on the porous body to form an anodized anode; applying a first slurry to the anodized anode to form a blocking layer wherein the first slurry comprises a first conducting polymer with an median particle size of at least 0.05 ?m forming a layer of crosslinker on the blocking layer; and applying a layer of a second conducting polymer on the layer of crosslinker.
    Type: Application
    Filed: September 15, 2011
    Publication date: August 9, 2012
    Applicant: WELLSTAT THERAPEUTICS CORPORATION
    Inventors: Shalini Sharma, James Dennen O'Neil, Reid W. von Borstel, Ramchandran Arudchandran
  • Patent number: 8178675
    Abstract: Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyper-lipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed as Formula (I).
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: May 15, 2012
    Assignee: Wellstat Therapeutics Corporation
    Inventors: Fedor Evgenievich Romantsev, Shalini Sharma, Reid W. von Borstel, Stephen D. Wolpe
  • Publication number: 20120078529
    Abstract: A severity score for 5-fluorouracil (5FU) toxicity is calculated by taking the square root of the sum of: (a) the square of the logarithm of the dose of 5-fluorouracil administered to the patient; and (b) the square of the logarithm of the administration rate of the 5-fluorouracil to the patient. Severity Score=[(log Dose)2+(log Rate)2]1/2.
    Type: Application
    Filed: May 11, 2010
    Publication date: March 29, 2012
    Applicant: WELLSTAT THERAPEUTICS CORPORATION
    Inventors: James Dennen O'Neil, Reid W. von Borstel
  • Publication number: 20120071526
    Abstract: Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. wherein n is 1 or 2; m is 0, 1, 2, 3 or 4; q is 0 or 1; t is 0 or 1; R1 is alkyl having from 1 to 3 carbon atoms; R2 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms; one of R3 and R4 is hydrogen or hydroxy and the other is hydrogen; or R3 and R4 together are ?O.
    Type: Application
    Filed: August 25, 2011
    Publication date: March 22, 2012
    Applicant: WELLSTAT THERAPEUTICS CORPORATION
    Inventors: Shalini Sharma, Reid W. von Borstel
  • Publication number: 20120060258
    Abstract: A composition for coating a polypropylene-based fabric or polypropylene-based material for use in decreasing the transmission of human pathogens. A device such as a protective face mask made from a polypropylene-based fabric or polypropylene-based material coated with the composition.
    Type: Application
    Filed: May 21, 2010
    Publication date: March 15, 2012
    Inventors: Neal G. Stewart, Francis Chi Nan Lau, Tai Wai Kung, Lok Yuen Lo, Dacey J. Ryan, Reid W. Von Borstel
  • Patent number: 8105578
    Abstract: The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.
    Type: Grant
    Filed: January 29, 2007
    Date of Patent: January 31, 2012
    Assignee: Wellstat Biologics Corporation
    Inventors: Michael S. Roberts, Robert M. Lorence, William S. Groene, Harvey Rabin, Reid W. von Borstel
  • Patent number: 8067392
    Abstract: Compounds, compositions, and methods are provided for treatment of disorders related to mitochondrial dysfunction. The methods comprise administering to a mammal a composition containing pyrimidien nucleotide precursors in amounts sufficient to treat symptoms resulting from mitochondrial respiratory chain deficiencies.
    Type: Grant
    Filed: February 16, 2011
    Date of Patent: November 29, 2011
    Assignee: Wellstat Therapeutics Corporation
    Inventor: Reid W. Von Borstel
  • Patent number: 8044243
    Abstract: Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. Formula (I) wherein n is 1 or 2; q is 0 or 1; t is 0 or 1; R1 is alkyl having from 1 to 3 carbon atoms; R2 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms; A is unsubstituted or substituted phenyl; or cycloalkyl; or a 5 or 6 membered heteroaromatic ring. Alternatively, the agent can be a pharmaceutically acceptable salt of the compound of Formula I.
    Type: Grant
    Filed: February 9, 2007
    Date of Patent: October 25, 2011
    Assignee: Wellstat Therapeutics Corporation
    Inventors: Shalini Sharma, Reid W. von Borstel
  • Patent number: 8043612
    Abstract: The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.
    Type: Grant
    Filed: November 18, 2008
    Date of Patent: October 25, 2011
    Assignee: Wellstat Biologics Corporation
    Inventors: Michael S. Roberts, Robert M. Lorence, William S. Groene, Harvey Rabin, Reid W. von Borstel
  • Patent number: 8022249
    Abstract: Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: September 20, 2011
    Assignee: Wellstat Therapeutics Corporation
    Inventors: Shalini Sharma, Reid W. von Borstel
  • Publication number: 20110166233
    Abstract: Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed.
    Type: Application
    Filed: February 24, 2011
    Publication date: July 7, 2011
    Applicant: WELLSTAT THERAPEUTICS CORPORATION
    Inventors: Shalini Sharma, Reid W. Von Borstel