Patents by Inventor Reinhard Fleer

Reinhard Fleer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fusion polypeptides of human serum albumin and a therapeutically active polypeptide
    Publication number: 20030036171
    Abstract: Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.
    Type: Application
    Filed: September 10, 2002
    Publication date: February 20, 2003
    Applicant: Aventis Behring L.L.C.
    Inventors: Reinhard Fleer, Alain Fournier, Jean-Dominique Guitton, Gerard Jung, Patrice Yeh
  • Fusion polypeptides of human serum albumin and a therapeutically active polypeptide
    Publication number: 20030036170
    Abstract: Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.
    Type: Application
    Filed: September 10, 2002
    Publication date: February 20, 2003
    Applicant: Aventis Behring L.L.C.
    Inventors: Reinhard Fleer, Alain Fournier, Jean-Dominque Guitton, Gerard Jung, Patrice Yeh
  • Fusion polypeptides of human serum albumin and a therapeutically active polypeptide
    Publication number: 20030036172
    Abstract: Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.
    Type: Application
    Filed: September 10, 2002
    Publication date: February 20, 2003
    Applicant: Aventis Behring L.L.C.
    Inventors: Reinhard Fleer, Alain Fournier, Jean-Dominique Guitton, Gerard Jung, Patrice Yeh
  • Fusion polypeptides of human serum albumin and a therapeutically active polypeptide
    Publication number: 20030022308
    Abstract: Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.
    Type: Application
    Filed: September 10, 2002
    Publication date: January 30, 2003
    Applicant: Aventis Behring L.L.C.
    Inventors: Reinhard Fleer, Alain Fournier, Jean-Dominique Guitton, Gerard Jung, Patrice Yeh
  • Fusion polypeptides of human serum albumin and a therapeutically active polypeptide
    Publication number: 20020151011
    Abstract: Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.
    Type: Application
    Filed: October 29, 2001
    Publication date: October 17, 2002
    Inventors: Reinhard Fleer, Alain Fournier, Jean-Dominique Guitton, Gerard Jung, Patrice Yeh
  • Albumin derivatives with therapeutic functions
    Patent number: 6165470
    Abstract: Utilization of albumin as a stable plasma transporter with a therapeutic function that is derived from a membrane receptor. The present invention is exemplified by the description of new therapeutic agents that can be used in the treatment of Acquired Immunodeficiency Syndrome: hybrid macromolecules composed of albumin derivatives coupled to derivatives of the CD4 receptor having a normal or a higher affinity for the HIV-1 virus.
    Type: Grant
    Filed: January 8, 1998
    Date of Patent: December 26, 2000
    Assignee: Rhone-Poulenc
    Inventors: Jerome Becquart, Reinhard Fleer, Philippe Hirel, David Klatzmann, Didier Landais, Jean-Fran.cedilla.ois Mayaux, Patrice Yeh
  • Fusion polypeptides comprising human serum albumin, nucleic acids encoding same, and recombinant expression thereof
    Patent number: 5876969
    Abstract: Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a natural variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: March 2, 1999
    Inventors: Reinhard Fleer, Alain Fournier, Jean-Dominique Guitton, Gerard Jung, Patrice Yeh
  • Yeast with modified permeability
    Patent number: 5821038
    Abstract: The present invention relates to a modified yeast wherein at least two of the genes controlling the cellular permeability of said yeast are modified, said modifications having an additive or synergic effect. It also relates to a method for the preparation of said yeast as well as to its utilizations.
    Type: Grant
    Filed: March 20, 1997
    Date of Patent: October 13, 1998
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Reinhard Fleer, Daniel Scherman, Christophe Marcireau
  • Modified fungal cells and method for producing recombinant products
    Patent number: 5714377
    Abstract: This invention relates to improved fungal cells and methods for producing recombinant products of improved quality and in high yields. More specifically, the present invention relates to fungal cells carrying specific modifications within their DNA sequences which cause them to exhibit at least a reduced capacity for O-glycosylating homologous and/or heterologous proteins, and the use of these cells as host cells to produce high yields of recombinant products.
    Type: Grant
    Filed: April 18, 1995
    Date of Patent: February 3, 1998
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Widmar Tanner, Sabine Strahl-Bolsinger, Reinhard Fleer, Alain Fournier
  • Modified Kluyveromyces yeasts, their preparation and use
    Patent number: 5679544
    Abstract: The present invention concerns yeasts of the genus Kluyveromyces having one or more genetic modifications of at least one gene coding for a protease, said gene reducing or modifying the proteolytic actively of said yeasts, as well as their use as a cellular host for the secretion of recombinant proteins.
    Type: Grant
    Filed: February 6, 1995
    Date of Patent: October 21, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Reinhard Fleer, Alain Fournier, Patrice Yeh
  • Yeast promoter and use thereof
    Patent number: 5646012
    Abstract: The present invention concerns DNA sequences from the K. lactis PGK gene having transcriptional promoter activity, to expression vectors comprising these sequences and to their use for the production of proteins.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 8, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Reinhard Fleer, Alain Fournier, Jean-Francois Mayaux, Patrice Yeh
  • Method for producing recombinant proteins and host cells used therein
    Patent number: 5633146
    Abstract: Novel genetically engineered yeast strains of genus Kluyveromyces lactis, their preparation, and the use thereof for producing recombinant proteins, are described.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: May 27, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Reinhard Fleer, Alain Fournier, Patrice Yeh
  • Yeast promoter and its use
    Patent number: 5627046
    Abstract: DNA sequences comprising all or part of the ADH4 gene promoter of K. lactis or a derivative of the latter, and having transcriptional promoter activity. The invention also concerns the use of said sequences for the expression of recombined genes.
    Type: Grant
    Filed: February 22, 1994
    Date of Patent: May 6, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Claudio Falcone, Reinhard Fleer, Michele Saliola
  • Human serun albumin, preparation and use
    Patent number: 5612196
    Abstract: The present invention relates to a preparation of serum-human albumin having a colorimetry index lower than 0.2 resulting from the expression, in a eukaryotic or prokaryotic host, of an exogenous DNA sequence.
    Type: Grant
    Filed: July 27, 1994
    Date of Patent: March 18, 1997
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: J er ome Becquart, Reinhard Fleer, G erard Jung
  • Highly stable recombinant yeasts for the production of recombinant proteins
    Patent number: 5593858
    Abstract: Novel recombinant yeasts are disclosed which are highly stable in a complex medium. Said yeasts are of the Kluyveromyces genus in which an essential gene is non-functional, containing a vector bearing a functional copy of said gene.
    Type: Grant
    Filed: May 20, 1994
    Date of Patent: January 14, 1997
    Assignee: Rhone-Poulenc Rorer SA
    Inventors: Reinhard Fleer, Alain Fournier, Patrice Yeh
  • Modified Kluyveromyces yeasts, their preparation and use
    Patent number: RE37447
    Abstract: The present invention concerns yeasts of the genus Kluyveromyces having one or more genetic modifications of at least one gene coding for a protease, said gene reducing or modifying the proteolytic actively of said yeasts, as well as their use as a cellular host for the secretion of recombinant proteins.
    Type: Grant
    Filed: August 16, 2000
    Date of Patent: November 13, 2001
    Assignee: Aventis Pharma S.A.
    Inventors: Reinhard Fleer, Alain Fournier, Patrice Yeh
  • Highly stable recombinant yeasts for the production of recombinant proteins
    Patent number: RE37767
    Abstract: Novel recombinant yeasts are disclosed which are highly stable in a complex medium. Said yeasts are of the Kluyveromyces genus in which an essential gene is nonfunctional, containing a vector bearing a functional copy of said gene.
    Type: Grant
    Filed: August 16, 2000
    Date of Patent: June 25, 2002
    Assignee: Aventis Pharma S.A.
    Inventors: Reinhard Fleer, Alain Fournier, Patrice Yeh