Patents by Inventor Reinhard Kirsch

Reinhard Kirsch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treatment with combinations of statin and aryl-substituted propanolamine derivatives
    Patent number: 6897198
    Abstract: Substituted propanolamine derivatives, their pharmaceutically tolerated salts and physiologically functional derivatives thereof are described. Also described are compounds of formula I in which the radicals have the abovementioned meanings, and their physiologically tolerated salts, physiologically functional derivates and processes for their preparation. The compounds are suitable as, for example, hypolipidemics.
    Type: Grant
    Filed: January 27, 2003
    Date of Patent: May 24, 2005
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Wendelin Frick, Reinhard Kirsch, Heiner Glombik, Werner Kramer, Hans-Ludwig Schäfer
  • Imino acid derivatives as inhibitors of matrix metalloproteinases
    Publication number: 20050004166
    Abstract: The invention relates to a bicycloazaheterocyclyl carboxylic acid sulfonamide derivative of formula I herein, pharmaceutical preparation comprising it, process for preparing it and method for its pharmaceutical use.
    Type: Application
    Filed: January 5, 2004
    Publication date: January 6, 2005
    Applicant: AVENTIS PHARMA DEUTSCHLAND GMBH
    Inventors: Manfred Schudok, Sven Ruf, Hans Matter, Volkmar Wehner, Reinhard Kirsch, Petra Stahl
  • Selective MMP-13 inhibitors
    Publication number: 20050004111
    Abstract: The invention relates to a pyrimidine-4,6-dicarboxylic acid diamide compound, pharmaceutical preparation comprising it, process for preparing it and method for its pharmaceutical use. Particularly, the pyrimidine-4,6-dicarboxylic acid diamide compound is useful for selectively inhibiting collagenase matrix metalloproteinase (MMP) 13, or for treating a degenerative joint disease.
    Type: Application
    Filed: January 5, 2004
    Publication date: January 6, 2005
    Applicant: AVENTIS PHARMA DEUTSCHLAND GMBH
    Inventors: Otmar Klingler, Reinhard Kirsch, Joerg Habermann, Klaus-Ulrich Weithmann, Christian Engel, Bernard Pirard
  • Novel Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases
    Publication number: 20040167120
    Abstract: Pyrimidine-4,6-dicarboxylic acid diamides of the formula I 1
    Type: Application
    Filed: November 3, 2003
    Publication date: August 26, 2004
    Applicant: AVENTIS PHARMA DEUTSCHLAND GMBH
    Inventors: Otmar Klingler, Reinhard Kirsch, Joerg Habermann, Klaus-Ulrich Weithmann, Christian Engel, Bernard Pirard
  • Cyclic N-substituted alpha-imino carboxylic acids for selective inhibition of collogenase
    Patent number: 6716853
    Abstract: The invention is related to compounds of formula I to pharmaceutical compositions comprising such compounds, to processes for the preparation of such compounds, and to methods of prevention and treatment of disorders, the progression of which involve an enhanced activity of matrix metalloproteinase 13, by administering to a patient in need thereof, a pharmaceutically effective amount of such compounds.
    Type: Grant
    Filed: February 26, 2003
    Date of Patent: April 6, 2004
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Petra Stahl, Reinhard Kirsch, Sven Ruf, Volkmar Wehner, Klaus-Ulrich Weithmann
  • PYRIDINE-2,4-DICARBOXYLIC ACID DIAMIDES AND PYRIMIDINE-4,6-DICARBOXYLIC ACID DIAMIDES AND THE USE THEREOF FOR SELECTIVELY INHIBITING COLLAGENASES
    Publication number: 20030229103
    Abstract: Pyridine-2,4-dicarboxylic acid diamides and pyrimidine-4,6-dicarboxylic acid diamides of formula I. These compounds are found to possess the property of selectively inhibiting collagenase (MMP). They may therefore be useful in prophylaxis and therapy of diseases whose course involves an increased activity of matrix metalloproteinase 13.
    Type: Application
    Filed: December 9, 2002
    Publication date: December 11, 2003
    Inventors: Klaus-Ulrich Weithmann , Jorg Habermann , Herbert Kogler , Reinhard Kirsch , Volkmar Wehner
  • Cyclic N-substituted alpha-imino carboxylic acids for selective inhibition of collogenase
    Publication number: 20030199543
    Abstract: The invention is related to compounds of formula I 1
    Type: Application
    Filed: February 26, 2003
    Publication date: October 23, 2003
    Applicant: Aventis Pharma Deutschland GmBH
    Inventors: Petra Stahl, Reinhard Kirsch, Sven Ruf, Volkmar Wehner, Klaus-Ulrich Weithmann
  • Methods of treatment with combinations of statin and aryl-substituted propanolamine derivatives
    Publication number: 20030195145
    Abstract: Substituted propanolamine derivatives, their pharmaceutically tolerated salts and physiologically functional derivatives thereof are described.
    Type: Application
    Filed: January 27, 2003
    Publication date: October 16, 2003
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Wendelin Frick, Reinhard Kirsch, Heiner Glombik, Werner Kramer, Hans-Ludwig Schafer
  • Use of bissulfonamides for producing medicines for the treatment of hyperlipidemia
    Patent number: 6632838
    Abstract: The use of bissulfonamides for producing medicines for the treatment of hyperlipidemia. The invention relates to the use of bissulfonamides and their salts for producing medicines for the treatment of hyperlipidemia. The use of compounds of formula I in which the radicals have the stated meanings, and of their salts for producing a medicine for the treatment of hyperlipidemia is described.
    Type: Grant
    Filed: August 31, 2000
    Date of Patent: October 14, 2003
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Reinhard Kirsch, Hans-Ludwig Schaefer, Eugen Falk, Norbert Krass
  • Substituted 1,3-diaryl-2-pyrid-2-yl-3-(pyrid-2-ylamino)propanol derivatives, process for their preparation, pharmaceuticals comprising these compounds and their use
    Patent number: 6596728
    Abstract: Substituted 1,3-diaryl-2-pyridin-2-yl-3-(pyridin-2-ylamino)propanol derivatives of the formula (I), and salts thereof, in which the radicals have the meanings given in the specification, and physiologically tolerated salts thereof and processes for their preparation are described. The compounds are suitable, for example, as hypolipidemic agents.
    Type: Grant
    Filed: October 1, 1999
    Date of Patent: July 22, 2003
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Reinhard Kirsch, Alfons Enhsen, Heiner Glombik, Werner Kramer, Eugen Falk
  • Combinations with statin and aryl-substituted propanolamine derivatives, their preparation pharmaceuticals comprising them, and their use
    Patent number: 6569835
    Abstract: Substituted propanolamine derivatives, their pharmaceutically tolerated salts and physiologically functional derivatives thereof are described. Also described are compounds of formula I in which the radicals have the abovementioned meanings, and their physiologically tolerated salts, physiologically functional derivates and processes for their preparation. The compounds are suitable as, for example, hypolipidemics.
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: May 27, 2003
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Wendelin Frick, Reinhard Kirsch, Heiner Glombik, Werner Kramer, Hans-Ludwig Schäfer
  • Aryl-substituted propanolamine derivatives, their preparation, pharmaceuticals comprising them, and their use
    Patent number: 6566340
    Abstract: Substituted propanolamine derivatives, their pharmaceutically tolerated salts and physiologically functional derivatives thereof are described. Also described are compounds of formula I in which the radicals have the abovementioned meanings, and their physiologically tolerated salts, physiologically functional derivates and processes for their preparation. The compounds are suitable as, for example, hypolipidemics.
    Type: Grant
    Filed: April 13, 2001
    Date of Patent: May 20, 2003
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Wendelin Frick, Reinhard Kirsch, Heiner Glombik, Werner Kramer, Hans-Ludwig Schäfer
  • Sulfonylcarboxamide derivatives, process for their preparation and their use as pharmaceuticals
    Patent number: 6552048
    Abstract: Sulfonylcarboxamide derivatives of formula I, their physiologically acceptable salts and/or physiologically functional derivatives, methods of making these compounds, their use for preparing medicines for the prevention and treatment of hyperlipidemia and arteriosclerotic disorders. The compounds of formula I have the following structure: in which the radicals are as defined and their physiologically acceptable salts and physiologically functional derivatives are described.
    Type: Grant
    Filed: September 27, 2001
    Date of Patent: April 22, 2003
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Reinhard Kirsch, Hans-Ludwig Schaefer, Eugen Falk, Horst Hemmerle
  • Combinations with statin and aryl-substituted propanolamine derivatives, their preparation, pharmaceuticals comprising them, and their use
    Publication number: 20020177610
    Abstract: Substituted propanolamine derivatives, their pharmaceutically tolerated salts and physiologically functional derivatives thereof are described.
    Type: Application
    Filed: November 1, 2001
    Publication date: November 28, 2002
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Wendelin Frick, Reinhard Kirsch, Heiner Glombik, Werner Kramer, Hans-Ludwig Schafer
  • Sulfonylcarboxamide derivatives, process for their preparation and their use as pharmaceuticals
    Publication number: 20020072520
    Abstract: Sulfonylcarboxamide derivatives of formula I, their physiologically acceptable salts and/or physiologically functional derivatives, methods of making these compounds, their use for preparing medicines for the prevention and treatment of hyperlipidemia and arteriosclerotic disorders.
    Type: Application
    Filed: September 27, 2001
    Publication date: June 13, 2002
    Inventors: Reinhard Kirsch, Hans-Ludwig Schaefer, Eugen Falk, Horst Hemmerle
  • Aryl-substituted propanolamine derivatives, their preparation, pharmaceuticals comprising them, and their use
    Publication number: 20020042381
    Abstract: Substituted propanolamine derivatives, their pharmaceutically tolerated salts and physiologically functional derivatives thereof are described.
    Type: Application
    Filed: April 13, 2001
    Publication date: April 11, 2002
    Applicant: Hoechst Marion Roussel Deutschland GmbH
    Inventors: Wendelin Frick, Reinhard Kirsch, Heiner Glombik, Werner Krammer, Hans-Ludwig Schafer
  • Sulfonylcarboxamide derivatives, process for their preparation and their use as pharmaceuticals
    Patent number: 6342512
    Abstract: Sulfonylcarboxamide derivatives of formula I, their physiologically acceptable salts and/or physiologically functional derivatives, methods of making these compounds, their use for preparing medicines for the prevention and treatment of hyperlipidemia and arteriosclerotic disorders. The compounds of formula I have the following structure: in which the radicals are as defined and their physiologically acceptable salts and physiologically functional derivatives are described.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: January 29, 2002
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Reinhard Kirsch, Hans-Ludwig Schaefer, Eugen Falk, Horst Hemmerle
  • Propanolamine derivatives substituted by heterocyclic radicals, processes for their preparation, pharmaceuticals comprising these compounds and their use
    Patent number: 6303639
    Abstract: Substituted propanolamine derivatives and pharmaceutically tolerated salts and physiologically functional derivatives thereof are described. Also described are compounds of formula (I), in which the radicals have the meanings given in the specification and claims, and physiologically tolerated salts and physiologically functional derivatives thereof, and processes for their preparation, are described. The compounds are suitable, for example, as hypolipidemic agents.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: October 16, 2001
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Wendelin Frick, Reinhard Kirsch, Heiner Glombik, Hubert Heuer
  • Aryl-substituted propanolamine derivatives, their preparation, pharmaceuticals comprising them, and their use
    Patent number: 6245744
    Abstract: Substituted propanolamine derivatives, their pharmaceutically tolerated salts and physiologically functional derivatives thereof are described. Also described are compounds of formula I in which the radicals have the abovementioned meanings, and their physiologically tolerated salts, physiologically functional derivates and processes for their preparation. The compounds are suitable as, for example, hypolipidemics.
    Type: Grant
    Filed: October 1, 1999
    Date of Patent: June 12, 2001
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Wendelin Frick, Reinhard Kirsch, Heiner Glombik, Werner Kramer, Hans-Ludwig Schäfer
  • Substituted quinoline derivatives with antiviral action
    Patent number: 6114349
    Abstract: Substituted quinoline derivatives, processes for their preparation, and their use.Compounds of the formula I ##STR1## and their tautomeric forms, of the formula Ia ##STR2## in which m, n and the substituents X and R.sup.1 to R.sup.5 have the meanings mentioned, have an action against viruses.
    Type: Grant
    Filed: March 3, 1999
    Date of Patent: September 5, 2000
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Reinhard Kirsch, Jorg-Peter Kleim, Gunther Riess, Bernd Rosenstock, Manfred Rosner, Irvin Winkler