Abstract: The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.

Abstract: The present invention relates to a continuous process for preparing permselective hollow fiber membranes being suitable e.g. for hemodialysis, hemodiafiltration and hemofiltration of blood which comprises a two-stage drying and tempering treatment of the hollow fiber membranes. According to a further aspect, the invention relates to a continuous process for drying permselective hollow fiber membranes on-line. The invention also relates to devices for on-line drying of permselective hollow fiber membranes.

Abstract: The present invention relates to a continuous process for preparing permselective hollow fiber membranes being suitable e.g. for hemodialysis, hemodiafiltration and hemofiltration of blood which comprises a two-stage drying and tempering treatment of the hollow fiber membranes. According to a further aspect, the invention relates to a continuous process for drying permselective hollow fiber membranes on-line. The invention also relates to devices for on-line drying of permselective hollow fiber membranes.

Abstract: A semipermeable asymmetric hollow fiber membrane is provided, based on a hydrophobic polymer, such as polyethersulfone or polysulfone, and on a hydrophilic polymer, such as PVP. The PVP polymer comprises a high molecular weight component and a low molecular weight component. The membrane has a significantly improved permeability and selectivity, based on its structure, composition, and the method of manufacture of the membrane A process for manufacturing such a membrane by a solvent phase inversion spinning process is also provided.

Abstract: The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.

Abstract: The present disclosure relates to capillary dialyzers for blood purification, in particular, capillary dialyzers suitable for home hemodialysis systems.

Abstract: The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (MWRO) of between 9.0 kD and 14.5 kD and a molecular weight cut-off (MWCO) of between 55 kD and 130 kD as determined by dextran sieving curves and can be prepared by industrially feasible processes excluding a treatment with salt before drying. The invention therefore also relates to a process for the production of the membranes and to their use in medical applications.

Abstract: The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (MWRO) of between 9.0 kD and 14.5 kD and a molecular weight cut-off (MWCO) of between 55 kD and 130 kD as determined by dextran sieving curves and can be prepared by industrially feasible processes excluding a treatment with salt before drying. The invention therefore also relates to a process for the production of the membranes and to their use in medical applications.

Abstract: The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.

Abstract: A pressure sensor includes a sensor assembly and an evaluation unit. The; sensor assembly includes a sensor and an electrode arrangement. The sensor is configured to generate signals under the action of a pressure profile. The electrode arrangement is configured to transmit the signals to the evaluation unit. The evaluation unit includes an electric circuit board. The electric circuit board includes a base material that is electrically insulating with a specific volume resistance that is at least equal to 1015 ?cm at room temperature. The electric circuit board includes a high temperature region facing the sensor assembly and a normal temperature region that faces away from the sensor assembly.

Abstract: A pressure sensor includes an evaluation unit and a sensor assembly, which includes a sensor and an electrode arrangement. The sensor generates signals under the action of a pressure profile, and the electrode arrangement transmits the signals to the evaluation unit, which includes an evaluation unit housing, an electric circuit board and a reinforcement element, which is arranged in a radial plane between the electric circuit board and the evaluation unit housing. The reinforcement element is mechanically connected to the electric circuit board and dampens mechanical resonance vibrations of the electric circuit board that occur in the radial plane.

Abstract: A pressure sensor includes a sensor assembly and an evaluation unit. The sensor assembly includes a sensor and an electrode arrangement. The sensor generates signals under the action of a pressure profile, and the electrode arrangement transmits the signals to the evaluation unit. The evaluation unit includes an electric circuit board that is connected to the electrode arrangement by material bonding.

Abstract: A piezoelectric pressure sensor includes a sensor housing that accommodates a membrane, a piezoelectric sensor, a charge pick-off and a pre-stressing assembly. The membrane captures a pressure profile, and polarization charges are generated accordingly on the piezoelectric sensor by the captured pressure profile. The pre-stressing assembly includes a pre-stressing body and a pre-stressing sleeve and mechanically pre-stresses the piezoelectric sensor. The charge pick-off receives the polarization charges and is electrically insulated from the pre-stressing sleeve by a second gap. The charge pick-off is mechanically connected to the pre-stressing body via a first electric insulation body on a side of the pre-stressing body that faces away from the membrane and seals the second gap in a pressure-tight manner from an environment of the second gap.

Abstract: A piezoelectric pressure sensor includes a sensor housing enclosing a membrane, a piezoelectric sensor, an electrode arrangement and a pre-stressing body. The membrane captures a pressure profile causing polarization charges generated on the piezoelectric sensor. The electrode arrangement receives the polarization charges generated and includes a charge-pick-off and a charge output. The charge pick-off is electrically and mechanically connected to the charge output, which is electrically is mechanically connected to the pre-stressing body via an electrical feedthrough arrangement on a side of the pre-stressing body that faces away from the membrane and seals the third gap in a pressure-tight manner from an environment of the third gap.

Abstract: The present disclosure relates to capillary dialyzers for blood purification comprising from 85-95% crimped fibers and from 5-15% non-crimped fibers.

Abstract: A piezoelectric pressure sensor includes a membrane for detecting a pressure profile, a piezoelectric sensor on which polarization charges are produced by the detected pressure profile, an electrode arrangement receiving and transmitting the generated polarization charges as signals via a charge output. The sensor further includes an electrical connecting element and an electrical signal conductor. The electrical connecting element is electrically and mechanically connected to the electrical signal conductor. The charge output is connected to the electrical connecting element in certain areas and transmits signals through the electrical connecting element into the electrical signal conductor.

Abstract: The present invention relates to a continuous process for preparing permselective hollow fiber membranes being suitable e.g. for hemodialysis, hemodiafiltration and hemofiltration of blood which comprises a two-stage drying and tempering treatment of the hollow fiber membranes. According to a further aspect, the invention relates to a continuous process for drying permselective hollow fiber membranes on-line. The invention also relates to devices for on-line drying of permselective hollow fiber membranes.

Abstract: The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.

Abstract: The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (MWRO) of between 9.0 kD and 14.5 kD and a molecular weight cut-off (MWCO) of between 55 kD and 130 kD as determined by dextran sieving curves and can be prepared by industrially feasible processes excluding a treatment with salt before drying. The invention therefore also relates to a process for the production of the membranes and to their use in medical applications.

Abstract: A piezoelectric pressure sensor includes a sensor housing enclosing a membrane, a piezoelectric sensor, an electrode arrangement and a pre-stressing body. The membrane captures a pressure profile causing polarization charges generated on the piezoelectric sensor. The electrode arrangement receives the polarization charges generated and includes a charge-pick-off and a charge output. The charge pick-off is electrically and mechanically connected to the charge output, which is electrically is mechanically connected to the pre-stressing body via an electrical feedthrough arrangement on a side of the pre-stressing body that faces away from the membrane and seals the third gap in a pressure-tight manner from an environment of the third gap.