Abstract: The present invention provides a method of designing a modulator of a myosin, the method comprising molecular modeling of a compound such that the modeled compound interacts with at least three amino acid residues of said myosin, said residues being selected from (a) ranges K265-V268, V411-L441, N588-Q593, D614-T629, and V630-E646 of SEQ ID NO: 2, said myosin comprising or consisting of (i) the sequence of SEQ ID NO: 2; (ii) the sequence encoded by the sequence of SEQ ID NO: 1; (iii) a sequence being at least 40% identical to the sequence of SEQ ID NO: 2 or to the sequence encoded by the sequence of SEQ ID NO: 1; or (iv) a sequence encoded by a sequence being at least 40% identical to the sequence of SEQ ID NO: 1; wherein said sequence of (iii) or (iv) comprises said three amino acid residues, and wherein said residues comprise K265; or (b) ranges of any one of SEQ ID NOs: 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 7

Abstract: The invention relates to a biochip comprising a substrate presenting a reflecting main surface and wherein the main surface presents localized sites that are made sensitive to fluorescence detection by a transparent layer having optical thickness (2k+1)?/4 where k is a positive or zero integer and where ? designates a wavelength lying between a wavelength ?0 at which fluorescence is excited and a wavelength ?1 at which fluorescence is emitted. The biochip can be manufactured by depositing a transparent layer of thickness m??/2 on a substrate and by making studs or wells of thickness (2k+1)?/4 in said layer to form said sensitive sites.

Abstract: A device for the secured start-up of a computer installation comprising a first connection interface to the computer installation and a second connection interface to an external data medium unit separate from the computer installation and which contains data and executable codes for a start-up program of the computer installation. The device also includes means for securing the use of data and executable codes and for transmitting data and executable codes of the start-up program from the external data medium unit via the second connection interface to the computer installation via the first connection interface, and after executing the means of security, to start-up the computer installation using transmitted executable codes and data.

Abstract: A network communications method communicates a certificate from a client machine to a server machine through a security module. The protocol used between the client and server machines is HTTP or an equivalent protocol, and a security protocol such as SSL or an equivalent is implemented between the client machine and the security module. The steps of the method include inserting the certificate into a cookie header of a request in HTTP or an equivalent protocol, and then transmitting the request from the security module to the server machine.

Abstract: A method of ex situ fabrication of at least one biochip, the method being of the type consisting in projecting onto a substrate a microvolume of reagent comprising at least one probe diluted in a suitable solvent so as to form, after the solvent has been eliminated, a spot comprising said probe, the method consisting in using a microprojection device comprising at least one tank in which the reagent is stored, and at least one source of gas under pressure put into communication with the tank, and in projecting the microvolume of reagent through an ejection nozzle under drive from the pressure exerted by the gas on the reagent.

Abstract: A security and protection device (1) for protection of the data and executable codes of any fixed or portable computer system and that has a memory medium to be protected. The security and protection device (1) is located physically between the computer system (2) and the memory medium (MP) to be protected, in order to allow the computer system (2) access to the data and codes to be protected after execution of the protection functions independently of the machine code executed by the computer system (2) and requires no interaction with the processor of the system for the execution of these functions.

Abstract: This invention concerns the use, for synthesizing and immobilising nucleic acids, of a solid support modified by an organized self-assembled monolayer of one or several organosilicon compounds. The invention also concerns methods for synthesizing and immobilizing nucleic acids on such a silanized solid support, and DNA chips obtained by said methods.

Abstract: A method of ex situ fabrication of at least one biochip, the method being of the type consisting in projecting onto a substrate a microvolume of reagent comprising at least one probe diluted in a suitable solvent so as to form, after the solvent has been eliminated, a spot comprising said probe, the method consisting in using a microprojection device comprising at least one tank in which the reagent is stored, and at least one source of gas under pressure put into communication with the tank, and in projecting the microvolume of reagent through an ejection nozzle under drive from the pressure exerted by the gas on the reagent.

Abstract: The invention relates to a biochip comprising a substrate presenting a reflecting main surface and wherein the main surface presents localized sites that are made sensitive to fluorescence detection by a transparent layer having optical thickness (2k+1)&lgr;/4 where k is a positive or zero integer and where &lgr; designates a wavelength lying between a wavelength &lgr;0 at which fluorescence is excited and a wavelength &lgr;1 at which fluorescence is emitted. The biochip can be manufactured by depositing a transparent layer of thickness m&lgr;′/2 on a substrate and by making studs or wells of thickness (2k+1)&lgr;/4 in said layer to form said sensitive sites.

Abstract: The present invention relates to a procedure for the qualitative and/or quantitative analysis of biological substances, which are preferably biological substances, that are present in a conductive liquid medium, with the aid of at least one affinity sensor that includes at least one structure that includes at least one semiconductor material, which is coated on one of its surface with at least one layer of an isolating material, which in turn is affixed adhesively to at least one sensitive membrane, which is in contact with the conductive medium and which includes ligands that are complementary to the biological substances in question and which are capable of, and suitable for, forming pairs specifically with the latter biological substances, with the said procedure being characterized by the fact that it consists essentially of applying a voltage between the semiconductor and the conductive medium; of gathering the variations in the electrical signals induced by a charge-effect phenomenon directly and essent

Abstract: System for automatic selection of messages from a message source (1) to a user terminal (2). A server (3) comprises a register (5) for storing an interest vector of the terminal user. Vectorising means (7) generate a content vector for each message. Comparison means (9) compare the content vector with the interest vector and calculate their distance, while transmission means (6) transfer to the user terminal messages for which the distance between the two vectors does not exceed a threshold value. The vectorising means reduce the content vector by means of “Latent Semantic Indexing”. The user terminal (2) comprises means (12) for assigning to each message a first relevance weighting and also means (14) for measuring treatment variables from the user's treatment of the presented message and for calculating from this a second relevance weighting. Means (13) in the server update the terminal user's interest profile on the basis of the transferred first and second relevance weighting.

Abstract: The present invention relates to a procedure for the qualitative and/or quantitative analysis of biological substances, which are preferably biological substances, that are present in a conductive liquid medium, with the aid of at least one affinity sensor that includes at least one structure that includes at least one semiconductor material, which is coated on one of its surface with at least one layer of an isolating material, which in turn is affixed adhesively to at least one sensitive membrane, which is in contact with the conductive medium and which includes ligands that are complementary to the biological substances in question and which are capable of, and suitable for, forming pairs specifically with the latter biological substances, with the said procedure being characterized by the fact that it consists essentially of applying a voltage between the semiconductor and the conductive medium; of gathering the variations in the electrical signals induced by a charge-effect phenomenon directly and essent

Abstract: The invention concerns the use, for synthesising and immobilising nucleic acids, of a solid support modified by an organised self-assembled monolayer of one or several organosilicon compounds. The invention also concerns methods for synthesising and immobilising nucleic acids on such a silanized solid support, and DNA chips obtained by said methods.

Abstract: The present invention relates to a procedure for the qualitative and/or quantitative analysis of biological substances, which are preferably biological substances, that are present in a conductive liquid medium, with the aid of at least one affinity sensor that includes at least one structure that includes at least one semiconductor material, which is coated on one of its surface with at least one layer of an isolating material, which in turn is affixed adhesively to at least one sensitive membrane, which is in contact with the conductive medium and which includes ligands that are complementary to the biological substances in question and which are capable of, and suitable for, forming pairs specifically with the latter biological substances, with the said procedure being characterized by the fact that it consists essentially of applying a voltage between the semiconductor and the conductive medium; of gathering the variations in the electrical signals induced by a charge-effect phenomenon directly and essent

Abstract: An apparatus and method for identifying and/or quantifying a charged biological substance in a conductive liquid medium.

Abstract: A client application (16) establishes in a client network (10), a first connection having a first security level, directly with a first port (1) of a server application (17) hosted in a server machine (13) linked to a server network (11), in order to send messages addressed to the server machine (13). The messages pass from the client network (10) to the server network (11) through a network layer (CR) of a gateway machine (9). In the gateway machine, a secure application proxy reroutes the messages from the first connection, in a way that is transparent for the client application, and establishes a second connection having a second security level with the server application; the second connection is unknown to the client application.

Abstract: The problem posed by the present invention is the lack of means for communicating a certificate from a client (2a) between a security module (2c) and a server (2b), the protocol used between the client and the server being HTTP or an equivalent protocol, a security protocol like SSL or an equivalent protocol being implemented between the client and the security module (2c).

Abstract: A flat roof structure having a recess with a surrounding area in which is mounted a drain for evacuating standing water on the flat roof. The drain including a housing extending upwardly and outwardly from the flat roof, a sump extending downwardly and inside the flat roof, a liquid pump for draining the water collected from the flat roof, a discharge line connected to the liquid pump and being located in the sump of the drain. The discharge line passing through one of the four walls of the sump, thus allowing it to extend under the flat roof and inside the building. The drain also including a heating element for keeping the standing water collected in the sump in a substantially liquid state within the drain so as to allow continuous discharging of the collected standing water even in sub-zero weather conditions.

Abstract: The present invention relates to a procedure for the qualitative and/or quantitative analysis of biological substances, which are preferably biological substances, that are present in a conductive liquid medium, with the aid of at least one affinity sensor that includes at least one structure that includes at least one semiconductor material, which is coated on one of its surface with at least one layer of an isolating material, which in turn is affixed adhesively to at least one sensitive membrane, which is in contact with the conductive medium and which includes ligands that are complementary to the biological substances in question and which are capable of, and suitable for, forming pairs specifically with the latter biological substances, with the said procedure being characterized by the fact that it consists essentially of applying a voltage between the semiconductor and the conductive medium; of gathering the variations in the electrical signals induced by a charge-effect phenomenon directly and essent

Abstract: The present invention relates to a procedure for the qualitative and/or quantitative analysis of biological substances, which are preferably biological substances, that are present in a conductive liquid medium, with the aid of at least one affinity sensor that includes at least one structure that includes at least one semiconductor material, which is coated on one of its surface with at least one layer of an isolating material, which in turn is affixed adhesively to at least one sensitive membrane, which is in contact with the conductive medium and which includes ligands that are complementary to the biological substances in question and which are capable of, and suitable for, forming pairs specifically with the latter biological substances, with the said procedure being characterized by the fact that it consists essentially of applying a voltage between the semiconductor and the conductive medium; of gathering the variations in the electrical signals induced by a charge-effect phenomenon directly and essent