Patents by Inventor Rene Hoet

Rene Hoet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metalloproteinase binding proteins
    Patent number: 8106168
    Abstract: Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: January 31, 2012
    Assignee: Dyax Corp.
    Inventors: Laetitia Devy, Henk Pieters, Robert C. Ladner, Rene Hoet, Daniel T. Dransfield, Clive R. Wood, Maria Henderikx
  • HUMAN ANTIBODIES AGAINST TISSUE FACTOR
    Publication number: 20110300156
    Abstract: Isolated human monoclonal antibodies which bind to human TF and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.
    Type: Application
    Filed: December 9, 2009
    Publication date: December 8, 2011
    Applicant: GENMAB A/S
    Inventors: Sandra Verploegen, David P.E. Satijn, Rene Hoet, Paul Parren, Jan Van De Winkel, Vibeke Miller Breinholt, Eva Ehrnrooth, Ole Baadsgaard, Tom Vink, Willem Karel Bleeker, Mischa Houtkamp, Maroeska Oudshoorn, Rob N. De Jong
  • Methods of using an antibody that binds to apolipoprotein e
    Patent number: 8058016
    Abstract: A human antibody fragment, which antibody or fragment: (i) binds to a polypeptide having the amino acid sequence shown in SEQ ID NO: 1 of the C-terminal domain of Apolipoprotein E (ApoE-CTD) or the amino acid sequence of a part thereof; and (ii) binds to human plaques.
    Type: Grant
    Filed: September 8, 2009
    Date of Patent: November 15, 2011
    Assignees: Astrazeneca AB, Dyax Corporation
    Inventors: Christer Nordstedt, Tom Goldschmidt, Maria Henderikx, René Hoet, Henricus Hoogenboom, Simon Hufton, Christin V. Andersson, Johanna Lindquist, Dan Sunnemark, Sergy Leonov
  • TIE COMPLEX BINDING PROTEINS
    Publication number: 20110059105
    Abstract: Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity.
    Type: Application
    Filed: June 28, 2010
    Publication date: March 10, 2011
    Applicant: DYAX CORP.
    Inventors: Clive R. Wood, Daniel T. Dransfield, Henk Pieters, Rene Hoet, Simon E. Hufton
  • Antibodies to Tie1 ectodomain
    Patent number: 7871610
    Abstract: Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity.
    Type: Grant
    Filed: February 2, 2005
    Date of Patent: January 18, 2011
    Assignee: Dyax Corp.
    Inventors: Clive R. Wood, Daniel T. Dransfield, Henk Pieters, Rene Hoet, Simon E. Hufton
  • Metalloproteinase Binding Proteins
    Publication number: 20100266490
    Abstract: Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
    Type: Application
    Filed: May 7, 2010
    Publication date: October 21, 2010
    Applicant: DYAX CORP.
    Inventors: Laetitia Devy, Henk Pieters, Robert C. Ladner, Rene Hoet, Daniel T. Dransfield, Clive R. Wood, Maria Henderikx
  • ANTI MIF ANTIBODIES
    Publication number: 20100260768
    Abstract: The present invention relates to monoclonal antibodies and antigen-binding portions thereof that specifically bind to the C-terminal or the center region of macrophage migration inhibitory factor (MIF). These anti-MIF antibodies and antigen-binding portions thereof further inhibit human MIF biological function. The invention also relates to isolated heavy and light chain immunoglobulins derived from anti-MIF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to a method of identifying anti-MIF antibodies, pharmaceutical compositions comprising these antibodies and a method of using these antibodies and compositions for the treatment of MIF-related conditions.
    Type: Application
    Filed: April 26, 2010
    Publication date: October 14, 2010
    Applicants: Baxter International Inc., Baxter Healthcare S.A., Dyax Corp.
    Inventors: Randolf Kerschbaumer, Friedrich Scheiflinger, Manfred Rieger, Michael Thiele, Geert C. Mudde, Juergen Muellberg, Rene Hoet
  • Method of inhibition of vascular development using an antibody
    Publication number: 20100196361
    Abstract: Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity and angiogenesis. The agents can be used to treat angiogenesis-associated disorders.
    Type: Application
    Filed: December 17, 2008
    Publication date: August 5, 2010
    Applicant: DYAX CORP.
    Inventors: Clive R. Wood, Daniel T. Dransfield, Henk Pieters, Rene Hoet, Simon E. Hufton
  • Antibodies that bind MMP-14
    Patent number: 7745587
    Abstract: Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
    Type: Grant
    Filed: December 29, 2006
    Date of Patent: June 29, 2010
    Assignee: Dyax Corp.
    Inventors: Laetitia Devy, Henk Pieters, Robert C. Ladner, Rene Hoet, Daniel T. Dransfield, Clive R. Wood, Maria Henderikx
  • Antibodies
    Publication number: 20100061993
    Abstract: A human antibody fragment, which antibody or fragment: (i) binds to a polypeptide having the amino acid sequence shown in SEQ ID NO: 1 of the C-terminal domain of Apolipoprotein E (ApoE-CTD) or the amino acid sequence of a part thereof; and (ii) binds to human plaques.
    Type: Application
    Filed: September 8, 2009
    Publication date: March 11, 2010
    Applicants: ASTRAZENECA AB, DYAX CORPORATION
    Inventors: Christer Nordstedt, Tom Goldschmidt, Maria Henderikx, René Hoet, Henricus Hoogenboom, Simon Hufton, Christin V. Andersson, Johanna Lindquist, Dan Sunnemark, Sergy Leonov
  • METALLOPROTEINASE 12 BINDING PROTEINS
    Publication number: 20090311183
    Abstract: Proteins that bind to matrix metalloproteinase 12 and methods of using such proteins are described.
    Type: Application
    Filed: March 3, 2009
    Publication date: December 17, 2009
    Applicant: DYAX CORP.
    Inventors: Laetitia Devy, Sonia Schoonbroodt, Rene Hoet, Nicholas Frans
  • antibodies binding to a C-terminal fragment of apoliopoprotein E
    Patent number: 7612179
    Abstract: A human antibody fragment, which antibody or fragment: (i) binds to a polypeptide having the amino acid sequence shown in SEQ ID NO: 1 of the C-terminal domain of Apolipoprotein E (ApoE-CTD) or the amino acid sequence of a part thereof; and (ii) binds to human plaques.
    Type: Grant
    Filed: November 26, 2004
    Date of Patent: November 3, 2009
    Assignees: Astrazeneca AB, Dyax Corporation
    Inventors: Christer Nordstedt, Tom Goldschmidt, Maria Henderikx, René Hoet, Henricus Hoogenboom, Simon Hufton, Christin V. Andersson, Johanna Lindquist, Dan Sunnemark, Sergy Leonov
  • Anti MIF Antibodies
    Publication number: 20090220521
    Abstract: The present invention relates to monoclonal antibodies and antigen-binding portions thereof that specifically bind to the C-terminal or the center region of macrophage migration inhibitory factor (MIF). These anti-MIF antibodies and antigen-binding portions thereof further inhibit human MIF biological function. The invention also relates to isolated heavy and light chain immunoglobulins derived from anti-MIF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to a method of identifying anti-MIF antibodies, pharmaceutical compositions comprising these antibodies and a method of using these antibodies and compositions for the treatment of MIF-related conditions.
    Type: Application
    Filed: December 30, 2008
    Publication date: September 3, 2009
    Inventors: Randolf Kerschbaumer, Friedrich Scheiflinger, Manfred Rieger, Michael Thiele, Geert C. Mudde, Juergen Muellberg, Rene Hoet
  • Novel methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
    Publication number: 20090162835
    Abstract: Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.
    Type: Application
    Filed: October 25, 2001
    Publication date: June 25, 2009
    Applicant: Dyax Corp.
    Inventors: Robert Ladner, Edward Cohen, Horacio Nastri, Kristin Rookey, Rene Hoet, Hendricus Mattheus Hoogenboom
  • Method of inhibition of vascular development using an antibody
    Patent number: 7485297
    Abstract: Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity and angiogenesis. The agents can be used to treat angiogenesis-associated disorders.
    Type: Grant
    Filed: August 9, 2005
    Date of Patent: February 3, 2009
    Assignee: Dyax Corp.
    Inventors: Clive R. Wood, Daniel T. Dransfield, Henk Pieters, Rene Hoet, Simon E. Hufton
  • TIE1-BINDING LIGANDS
    Publication number: 20080254021
    Abstract: Tie1 is a receptor tyrosine kinase protein that includes a transmembrane domain. Tie1 is present on endothelial cells. This disclosure described antibodies that bind to Tie1, including ones that inhibit endothelial cell activity.
    Type: Application
    Filed: January 25, 2008
    Publication date: October 16, 2008
    Applicant: DYAX CORP.
    Inventors: Simon E. Hufton, Rene Hoet, Henk Pieters
  • Tie1-binding ligands
    Patent number: 7348001
    Abstract: Tie1 is a receptor tyrosine kinase protein that includes a transmembrane domain. Tie1 is present on endothelial cells. This disclosure described antibodies that bind to Tie1, including ones that inhibit endothelial cell activity.
    Type: Grant
    Filed: August 12, 2004
    Date of Patent: March 25, 2008
    Assignee: Dyax Corp.
    Inventors: Simon E. Hufton, Rene Hoet, Henk Pieters
  • PEPTIDES IMMUNOREACTIVE WITH AUTOANTIBODIES FROM PATIENTS SUFFERING FROM RHEUMATOID ARTHRITIS
    Publication number: 20080050841
    Abstract: The invention relates to a peptide derived from an antigen recognized by autoantibodies, which peptide is reactive with autoimmune antibodies from a patient suffering from rheumatoid arthritis. The peptide according to the invention possesses a modified arginine residue. The invention also relates to antibodies against the peptide and a method of detecting autoimmune antibodies.
    Type: Application
    Filed: August 6, 2007
    Publication date: February 28, 2008
    Applicant: Stichting Voor De Technische Wetenschappen
    Inventors: Waltherus VAN VENROOIJ, Gerardus Schellekens, Jozef Raats, Rene Hoet
  • Metalloproteinase binding proteins
    Publication number: 20070217997
    Abstract: Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
    Type: Application
    Filed: December 29, 2006
    Publication date: September 20, 2007
    Inventors: Laetitia Devy, Henk Pieters, Robert Ladner, Rene Hoet, Daniel Dransfield, Clive Wood
  • Antibodies binding to a c-terminal fragment of apoliopoprotein e
    Publication number: 20070104715
    Abstract: A human antibody fragment, which antibody or fragment: (i) binds to a polypeptide having the amino acid sequence shown in SEQ ID NO: 1 of the C-terminal domain of Apolipoprotein E (ApoE-CTD) or the amino acid sequence of a part thereof; and (ii) binds to human plaques.
    Type: Application
    Filed: November 26, 2004
    Publication date: May 10, 2007
    Applicants: ASTRAZENECA AB, DYAX CORP.
    Inventors: Christer Nordstedt, Tom Goldschmidt, Maria Henderikx, Rene Hoet, Henricus Hoogenboom, Simon Hufton, Christian Andersson, Johanna Lindquist, Dan Sunnemark, Sergy Leonov