Patents by Inventor Rene Hoet

Rene Hoet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Libraries and methods for isolating antibodies
    Publication number: 20060234302
    Abstract: The disclosure features methods for identifying antibodies that bind to a carbohydrate moiety. Libraries coding for antibodies that bind to a carbohydrate moiety are provided. The libraries can be provided by modifying a pre-existing nucleic acid library. Antibodies that bind to a carbohydrate moiety are described.
    Type: Application
    Filed: February 1, 2006
    Publication date: October 19, 2006
    Inventors: Rene Hoet, Sonia Schoonbroodt, Robert Ladner
  • Novel methods of constructing libraries of genetic packages that collectively display the members of a diverse family of peptides, polypeptides or proteins
    Publication number: 20060166252
    Abstract: Methods useful in constructing libraries that collectively display members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.
    Type: Application
    Filed: February 28, 2006
    Publication date: July 27, 2006
    Inventors: Robert Ladner, Edward Cohen, Horacio Nastri, Kristin Rookey, Rene Hoet
  • Tie complex binding proteins
    Publication number: 20060057138
    Abstract: Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity and angiogenesis. The agents can be used to treat angiogenesis-associated disorders.
    Type: Application
    Filed: August 9, 2005
    Publication date: March 16, 2006
    Inventors: Clive Wood, Daniel Dransfield, Henk Pieters, Rene Hoet, Simon Hufton
  • Isolated antibodies crossreactive with peptides used to detect rheumatoid arthritis
    Publication number: 20060039924
    Abstract: The invention relates to a peptide derived from an antigen recognized by autoantibodies, which peptide is reactive with autoimmune antibodies from a patient suffering from rheumatoid arthritis. The peptide according to the invention possesses a modified arginine residue. The invention also relates to antibodies against the peptide and a method of detecting autoimmune antibodies.
    Type: Application
    Filed: June 23, 2005
    Publication date: February 23, 2006
    Inventors: Waltherus Van Venrooij, Gerardus Schellekens, Jozef Raats, Rene Hoet
  • Tie complex binding proteins
    Publication number: 20060024297
    Abstract: Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity.
    Type: Application
    Filed: February 2, 2005
    Publication date: February 2, 2006
    Inventors: Clive Wood, Daniel Dransfield, Henk Pieters, Rene Hoet, Simon Hufton
  • Peptides immunoreactive with autoantibodies from patients suffering from rheumatoid arthritis
    Publication number: 20050186201
    Abstract: The invention relates to a peptide derived from an antigen recognized by autoantibodies, which peptide is reactive with autoimmune antibodies from a patient suffering from rheumatoid arthritis. The peptide according to the invention possesses a modified arginine residue. The invention also relates to antibodies against the peptide and a method of detecting autoimmune antibodies.
    Type: Application
    Filed: February 16, 2005
    Publication date: August 25, 2005
    Inventors: Waltherus Van Venrooij, Gerardus Schellekens, Jozef Raats, Rene Hoet
  • Tie1-binding ligands
    Publication number: 20050136053
    Abstract: Tie1 is a receptor tyrosine kinase protein that includes a transmembrane domain. Tie1 is present on endothelial cells. This disclosure described antibodies that bind to Tie1, including ones that inhibit endothelial cell activity.
    Type: Application
    Filed: August 12, 2004
    Publication date: June 23, 2005
    Inventors: Simon Hufton, Rene Hoet, Henk Pieters
  • Methods and compositions for controlling valency of phage display
    Publication number: 20040180422
    Abstract: Disclosed are methods and compositions useful, e.g., for controlling the valency of display proteins during display library screenings and selections. In one embodiment, they are applicable to phage and phage libraries that are based on bacteriophage, e.g., filamentous bacteriophage.
    Type: Application
    Filed: November 26, 2003
    Publication date: September 16, 2004
    Applicant: DYAX CORP.
    Inventors: Rene Hoet, Robert Charles Ladner, Nicolas Frans
  • Novel methods of constructing libraries of genetic packages that collectively display the members of a diverse family of peptides, polypeptides or proteins
    Publication number: 20040029113
    Abstract: The present invention relates to constructing libraries of genetic packages that display a member of a diverse family of peptides, polypeptides or proteins and collectively display at least a portion of the diversity of the family. In a preferred embodiment, the displayed polypeptides are human Fabs.
    Type: Application
    Filed: April 17, 2001
    Publication date: February 12, 2004
    Inventors: Robert C. Ladner, Edward H. Cohen, Horacio G. Nastri, Kristin L. Rookey, Rene Hoet
  • Novel methods of constructing librabries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel librabries
    Publication number: 20030232333
    Abstract: Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.
    Type: Application
    Filed: October 25, 2001
    Publication date: December 18, 2003
    Applicant: Dyax Corp.
    Inventors: Robert C. Ladner, Edward H. Cohen, Horacio G. Nastri, Kristin L. Rookey, Rene Hoet, Hendricus Renerus Jacobus Mattheus Hoogenboom
  • Method and apparatus for washing magnetically responsive particles
    Publication number: 20030170686
    Abstract: The invention features apparati and methods for washing magnetically responsive particles such as paramagnetic beads. One exemplary apparatus includes a flow chamber having an inlet and an outlet; and at least a first magnetic field inducer. The apparatus is configured such that a first magnetic field can be selectively applied in the flow chamber. The apparatus can also apply a flow of fluid to the chamber in coordination with the selective application of the magnetic field.
    Type: Application
    Filed: December 6, 2002
    Publication date: September 11, 2003
    Inventors: Rene Hoet, Henricus Renerus Jacobus Mattheus Hoogenboom, Henk Pieters, Robert C. Ladner, Shannon Hogan, Kristin Rookey