Patents by Inventor Rene Trussardi

Rene Trussardi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing 1,2-diamino compounds
    Patent number: 6437171
    Abstract: The invention provides a multistep process for preparing 1,2-diamino compounds of formula wherein R1, R1′, R2, R2′, R3 and R4 have the meaning given in the specification and pharmaceutically acceptable addition salts thereof, from 1,2-epoxides of formula wherein R1, R′, R2 and R2′ have the meaning given in the specification.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: August 20, 2002
    Assignee: Hoffman-La Roche Inc.
    Inventors: Martin Karpf, René Trussardi
  • Process for preparing 1,2-diamino compounds
    Publication number: 20020095040
    Abstract: The invention provides a multistep process for preparing 1,2-diamino compounds and pharmaceutically acceptable addition salts thereof from 1,2-epoxides.
    Type: Application
    Filed: February 22, 2002
    Publication date: July 18, 2002
    Inventors: Martin Karpf, Rene Trussardi
  • Process for the preparation of mixed anhydrides
    Publication number: 20020077481
    Abstract: The present invention is concerned with an improved process for the manufacture of mixed anhydrides. The process comprises adding an adjuvant base to a mixture of acid and reactive acid derivative. It is especially suitable for use in the synthesis of peptides and/or for the manufacture of pharmaceutically active substances or corresponding intermediates.
    Type: Application
    Filed: December 6, 2001
    Publication date: June 20, 2002
    Inventors: Martin Karpf, Rene Trussardi
  • Process for the preparation for 4,5-diamino shikimic acid derivatives
    Patent number: 6403824
    Abstract: The invention provides a multistep synthesis for the preparation of 4,5-diamino shikimic acid derivatives of formula wherein R1, R2, R3 and R4 are defined in the specification, starting from furan. 4,5-Diamino shikimic acid derivatives are potent inhibitors of viral neuraminidase.
    Type: Grant
    Filed: February 6, 2001
    Date of Patent: June 11, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Stefan Abrecht, Martin Karpf, René Trussardi, Beat Wirz
  • 2,3-oxidosqualene-lanosterol cyclase inhibitors
    Publication number: 20020045777
    Abstract: The present invention relates to aminocyclohexanol derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
    Type: Application
    Filed: August 9, 2001
    Publication date: April 18, 2002
    Inventors: Jean Ackermann, Johannes Aebi, Denise Blum, Alexander Chucholowski, Henrietta Dehmlow, Hans-Peter Maerki, Olivier Morand, Rene Trussardi, Elisabeth von der Mark, Sabine Wallbaum, Thomas Weller
  • Process for the preparation fo 4,5-diamino shikimic acid derivatives
    Publication number: 20020006960
    Abstract: The invention provides a multistep synthesis for the preparation of 4,5-diamino shikimic acid derivatives of formula 1
    Type: Application
    Filed: February 6, 2001
    Publication date: January 17, 2002
    Inventors: Stefan Abrecht, Martin Karpf, Rene Trussardi, Beat Wirz
  • Process for the manufacture of a tricyclic compound
    Patent number: 5892040
    Abstract: A process for preparing a compound of formula (I) or a phamaceutically-acceptable salt thereof, comprising: 1) reacting a compound. of formula (III), in which R is a straight or branched chain alkyl having from one to four carbon atoms, with an alkali metal hydroxide in an aqueous medium at a temperature of about 80.degree. to 120.degree. C. and time of about 20 to 100 hours to form a reaction product; 2) cyclizing the reaction product of step 1) with formic acid and formaldehyde to form a formiate compound; and 3) neutralizing the formiate compound of step 2) with an aqueous base.
    Type: Grant
    Filed: January 4, 1996
    Date of Patent: April 6, 1999
    Assignee: Pfizer. Inc
    Inventors: Martin Karpf, Rene Trussardi