Abstract: The invention provides a method of detecting a target polynucleotide in a sample comprising: (a) contacting the sample with a guide polynucleotide that binds to a sequence in the target polynucleotide and a polynucleotide-guided effector protein, wherein the guide polynucleotide and polynucleotide-guided effector protein form a complex with any target polynucleotide present in the sample; (b) contacting the sample with a membrane comprising a transmembrane pore; (c) applying a potential to the membrane; and (d) monitoring for the presence or absence of an effect resulting from the interaction of the complex with the transmembrane pore to determine the presence or absence of the complex, thereby detecting the target polynucleotide in the sample.

Abstract: The present invention relates to the novel use of certain piperidinyl-indole derivatives in the treatment of patients suffering from renal diseases or disorders, and in particular for the treatment of patients suffering from C3G (C3 glomerulopathy) and IgAN (IgA nephropathy).

Abstract: An anaerobic digestion system is provided. The system includes a biomass storage container and a cover positioned over the biomass storage container, where the cover is sealed at an outer edge of the anaerobic digester. Weights may be arranged on the surface of the cover, and the sealed edges may form a water collection region. Additional systems, including thermal management, gas processing, energy storage and recovery, and sensing can also be included.

Abstract: A method apparatus, and system method for manufacturing a composite part. A set of composite preforms is placed on a set of slip sheets. The set of slip sheets with the set of composite preforms is attached to a cure mandrel to form a composite preform assembly.

Abstract: Described herein are methods and systems for forming composite stringer assemblies or, more specifically, for shaping composite charges while forming these stringer assemblies. A system comprises a bladder, having a bladder core, and a bladder skin. The bladder core is formed from foam. The bladder skin is formed from an elastic material and encloses the bladder core. When a composite stringer assembly is formed, the bladder is positioned over a charge base. The charge base later becomes a stringer base, such as a fuselage section or a wing skin. A charge hat is then positioned over the bladder and is conformed to the bladder. A combination of the bladder skin and the bladder core provides support during this forming operation and later while the stringer assembly is cured. In some examples, the bladder core is collapsible for the removal of the bladder from the cavity of the stringer assembly.

Abstract: A zinc complex of a compound where the zinc complex is either a complex of JBIR-141 and a zinc ion and has the chemical formula C31H48N6O11Zn, or when the zinc complex is a complex of JBIR-142 and a zinc ion and has the chemical formula C31H48N6O12Zn.

Abstract: Embodiments herein describe tools, instruments and methods for aseptic loading, dispensing and/or delivering cells into an implantable device and aseptically and selectively sealing a device inside a sterile package as well as and storing and preparing for shipment the cell-filled device.

Abstract: A sensor arrangement located on a baler for detecting rotation of a dispensing reel of wrapping material and including a rotary element having a textured surface and a sensor mounted on a displaceable mounting bracket wherein the rotary element is rotated by the dispensing reel during baling.

Abstract: Techniques for instantiating containers in a network are discussed herein. A container controller component can receive a request from a user equipment (UE) for a service, whereby a portion of the service is performed by a containerized application. The container controller component can determine a location of the UE and can determine a number of requests for the service associated with that location. If the number of requests meet or exceed a threshold number, and/or if one or more metrics associated with the service are indicative of a quality level below a threshold, the container controller component can instantiate a container associated with the service at a computing device associated with the location. In some examples, the container can run an application, such as a presentation layer of the service, which can respond to the request from the UE.

Abstract: The present invention relates to monolithic bodies, uses thereof and processes for the preparation thereof. Certain embodiments of the present invention relate to the use of a monolithic body in the preparation of a radioactive substance, for example a radiopharmaceutical, as part of a microfluidic flow system and a process for the preparation of such a monolithic body.

Abstract: A tissue anchor for use in holding a tissue to a bone is provided. The anchor includes a distal tip, a proximal end, and an elongated body extending from the distal tip to the proximal end along a longitudinal axis. The elongated body can include a cannulated tunnel having an opening at the proximal end. An engagement member can be disposed inside of the elongated body and configured to enable the loading of a first thread-like fixation element through the cannulated tunnel. The distal tip of the tissue anchor can include an opening dimensioned and configured to capture and retain a second thread-like fixation element.

Abstract: Provided are methods for clinical treatment of vitiligo using an anti-CS antibody or antigen binding fragment thereof.

Abstract: Techniques for instantiating containers in a network are discussed herein. A container controller component can receive a request from a user equipment (UE) for a service, whereby a portion of the service is performed by a containerized application. The container controller component can determine a location of the UE and can determine a number of requests for the service associated with that location. If the number of requests meet or exceed a threshold number, and/or if one or more metrics associated with the service are indicative of a quality level below a threshold, the container controller component can instantiate a container associated with the service at a computing device associated with the location. In some examples, the container can run an application, such as a presentation layer of the service, which can respond to the request from the UE.

Abstract: Embodiments of the present invention relate to microfluidic devices and systems comprising such devices for use in the determination of sample characteristics. Certain embodiments relate to methods for determining one or more characteristics of a sample comprising a compound for in vivo use. Aptly, certain embodiments of the present invention relate to devices and methods for assessing radiopharmaceuticals and their suitability for administration to a patient in need thereof.

Abstract: The present invention relates to the novel use of certain piperidinyl-indole derivatives in the treatment of patients suffering from renal diseases or disorders, and in particular for the treatment of patients suffering from C3G (C3 glomerulopathy) and IgAN (IgA nephropathy).

Abstract: Described herein are methods and systems for forming composite stringer assemblies or, more specifically, for shaping composite charges while forming these stringer assemblies. A system comprises a bladder, having a bladder core, and a bladder skin. The bladder core is formed from foam. The bladder skin is formed from an elastic material and encloses the bladder core. When a composite stringer assembly is formed, the bladder is positioned over a charge base. The charge base later becomes a stringer base, such as a fuselage section or a wing skin. A charge hat is then positioned over the bladder and is conformed to the bladder. A combination of the bladder skin and the bladder core provides support during this forming operation and later while the stringer assembly is cured. In some examples, the bladder core is collapsible for the removal of the bladder from the cavity of the stringer assembly.

Abstract: Solid pharmaceutical compositions with high drug loading are provided. A formulation useful for the solid pharmaceutical composition includes valbenazine, or a pharmaceutically acceptable salt thereof, silicified microcrystalline cellulose, isomalt, hydroxypropyl methylcellulose, partially pregelatinized maize starch, and magnesium stearate.

Abstract: A method of forming a composite part from a mufti-ply prepreg composite charge comprises reducing pressure inside a bladder, located in a chamber that is at atmospheric pressure, below the atmospheric pressure. The method also comprises placing the multi-ply prepreg composite charge, having a first shape, in the chamber and reducing pressure inside the chamber below the atmospheric pressure. The method additionally comprises, while maintaining pressure inside the chamber below the atmospheric pressure, expanding the bladder within the chamber by increasing pressure inside the bladder to the atmospheric pressure, so that the multi-ply prepreg composite charge is compressed between the bladder and a forming tool, which is located inside the chamber, and the multi-ply prepreg composite charge is configured by the forming tool to a second shape, different from the first shape. The method also comprises curing the multi-ply prepreg composite charge, having the second shape.

Abstract: Embodiments herein describe tools, instruments and methods for aseptic loading, dispensing and/or delivering cells into an implantable device and aseptically and selectively sealing a device inside a sterile package as well as and storing and preparing for shipment the cell-filled device.

Abstract: The invention provides a method of detecting a target polynucleotide in a sample comprising: (a) contacting the sample with a guide polynucleotide that binds to a sequence in the target polynucleotide and a polynucleotide-guided effector protein, wherein the guide polynucleotide and polynucleotide-guided effector protein form a complex with any target polynucleotide present in the sample; (b) contacting the sample with a membrane comprising a transmembrane pore; (c) applying a potential to the membrane; and (d) monitoring for the presence or absence of an effect resulting from the interaction of the complex with the transmembrane pore to determine the presence or absence of the complex, thereby detecting the target polynucleotide in the sample.