Abstract: In accordance with a designation of a private alias endpoint as a routing target for traffic directed to a service from within an isolated virtual network of a provider network, a tunneling intermediary receives a baseline packet generated at a compute instance. The baseline packet indicates a public IP (Internet Protocol) address of the service as the destination, and a private IP address of the compute instance as the source. In accordance with a tunneling protocol, the tunneling intermediary generates an encapsulation packet comprising at least a portion of the baseline packet and a header indicating the isolated virtual network. The encapsulation packet is transmitted to a node of the service.

Abstract: The present invention relates to the novel use of certain piperidinyl-indole derivatives in the treatment of patients suffering from renal diseases or disorders, and in particular for the treatment of patients suffering from C3G (C3 glomerulopathy) and IgAN (IgA nephropathy).

Abstract: Embodiments herein describe tools, instruments and methods for aseptic loading, dispensing and/or delivering cells into an implantable device and aseptically and selectively sealing a device inside a sterile package as well as and storing and preparing for shipment the cell-filled device.

Abstract: Methods and systems for transferring restricted distribution medical products to an over-the-counter general sales environment are provided. Methods and systems of dispensing non-prescription, behind-the-counter medical products from a vending machine in a general sales location are also provided. In some embodiments, methods and systems are provided for dispensing a medical product from a vending machine in a general sales location based, at least in part, on biometric data collected from the purchaser and, in some instances, based on self-selection and/or de-selection criteria, is provided. Further, methods and systems of switching prescription medical products to non-prescription, over-the-counter medical products are provided.

Abstract: A threat analyzer that is configured to receive cybersecurity threat data, perform an analysis of the cybersecurity threat data, and determine an action to be performed by response software on response computers in response to a cybersecurity threat. The threat analyzer is also configured to add the cybersecurity threat data to a private threat repository on a private database.

Abstract: The present specification discloses wheel mounts for personal vehicles, such as skateboards and scooters. Wheel mount embodiments disclosed herein provide for the interchangeable mounting of wheels having differently shaped wheel cores. The present invention allows users to forego the previous limitation of having a specific wheel mount that only provides for the mounting a specific wheel having one specific wheel core geometry. Embodiments can be utilized on motorized personal vehicles, such as motorized skateboards and scooters that utilize various motors, such as direct drive or belt drive motors.

Abstract: Solid pharmaceutical compositions with high drug loading are provided. A formulation useful for the solid pharmaceutical composition includes valbenazine, or a pharmaceutically acceptable salt thereof, silicified microcrystalline cellulose, isomalt, hydroxypropyl methylcellulose, partially pregelatinized maize starch, and magnesium stearate.

Abstract: Embodiments herein describe tools, instruments and methods for aseptic loading, dispensing and/or delivering cells into an implantable device and aseptically and selectively sealing a device inside a sterile package as well as and storing and preparing for shipment the cell-filled device.

Abstract: Systems and methods for controlling shelf display units and for graphically presenting information on shelf display units are disclosed. A system includes one or more display units configured to be coupled to shelves of a modular shelving system, one or more processors communicatively coupled to the one or more display units, one or more memory components communicatively coupled to the one or more processors, and machine readable instructions stored in the one or more memory components. When executed by the one or more processors, the machine readable instructions cause the system to determine a product identifier corresponding to a product, identify one or more display units to update in response to determining the product identifier corresponding to the product, and update a graphical output of the one or more display units identified to be updated in response to identifying the one or more display units to update.

Abstract: An equipment management system is provided for use in a facility having an inventory of items. The system includes an inventory database, a user database, a person identification system and an inventory management system. The inventory database has inventory data stored therein, wherein the inventory data corresponds to the items of the inventory. The user database has user data stored therein, wherein the user data corresponding to an identity of a user. The person identification system generates a user identification signal based on a detected biometric parameter of the user and based on a detected non-biometric parameter associated with the user. The inventory management system generates an inventory identification signal based on a determination as to whether the user has removed an item of the inventory of items.

Abstract: A composite charge positioning assembly configured to position a composite charge onto a forming tool is presented. The composite charge positioning assembly comprises a base; a first charge support arm associated with the base and movable in a first direction towards or away from the base; and a second charge support arm associated with the base and movable in the first direction. The first charge support arm has a first surface configured to contact a portion of a composite charge. The second charge support arm has a second surface configured to contact a second portion of the composite charge.

Abstract: A method for gas detection including monitoring a concentration of a gas measured by a gas detection device to determine whether or not the concentration of the gas exceeds a threshold, when the concentration of the gas is determined to exceed the threshold, obtaining an image from a camera, the image capturing an area in proximity to the gas detection device at a time when the concentration of the gas is determined to exceed the threshold, annotating the obtained image to overlay a value of the concentration of the gas that exceeds the threshold on the captured area in proximity to the gas detection device, and transmitting the augmented image.

Abstract: A radius filler material positioned at an intersection of a mandrel and a placement surface is heated to form a heated radius filler material. Mechanical pressure is applied to the heated radius filler material to shape the heated radius filler material to a shaped radius filler having a desired shape against a radius of the mandrel. A composite ply is applied over the mandrel and the shaped radius filler.

Abstract: Systems and methods for controlling shelf display units and for graphically presenting information on shelf display units are disclosed. A system includes one or more display units configured to be coupled to shelves of a modular shelving system, one or more processors communicatively coupled to the one or more display units, one or more memory components communicatively coupled to the one or more processors, and machine readable instructions stored in the one or more memory components. When executed by the one or more processors, the machine readable instructions cause the system to determine a product identifier corresponding to a product, identify one or more display units to update in response to determining the product identifier corresponding to the product, and update a graphical output of the one or more display units identified to be updated in response to identifying the one or more display units to update.

Abstract: In a first technique one or more tuned circuits (“traps”) are placed in series in the metal detector coil, tuned to the operating frequency of the other sensor. In another technique a single turn coil of wire, or a small number of turns coil, is used as the metal detector coil, in combination with a step up transformer at the coil feed, to increase the EMF of the coil. In a further technique, the metal detector coil is formed in a plane that has regard to the sensing field of the other sensor. In another technique, the feed for the metal detector coil comprises a twisted pair of wires, which are routed along an axis in order to try to minimize and equalize the effect of the metal detector feed on the operation of the other antenna.

Abstract: The invention provides a method of detecting a target polynucleotide in a sample comprising: (a) contacting the sample with a guide polynucleotide that binds to a sequence in the target polynucleotide and a polynucleotide-guided effector protein, wherein the guide polynucleotide and polynucleotide-guided effector protein form a complex with any target polynucleotide present in the sample; (b) contacting the sample with a membrane comprising a transmembrane pore; (c) applying a potential to the membrane; and (d) monitoring for the presence or absence of an effect resulting from the interaction of the complex with the transmembrane pore to determine the presence or absence of the complex, thereby detecting the target polynucleotide in the sample.

Abstract: A cup rotation system can include a motor configured to rotate a shaft, a form engagable with a cup, a first coupler engaged with the shaft, a second coupler engaged with the form, and a magnet fixed to the first or second coupler. At least a portion of the system is formed of a ferromagnetic material, and the magnet removably connects the second coupler to the shaft via magnetic coupling to render the form in rotatable communication with the shaft.

Abstract: In accordance with a designation of a private alias endpoint as a routing target for traffic directed to a service from within an isolated virtual network of a provider network, a tunneling intermediary receives a baseline packet generated at a compute instance. The baseline packet indicates a public IP (Internet Protocol) address of the service as the destination, and a private IP address of the compute instance as the source. In accordance with a tunneling protocol, the tunneling intermediary generates an encapsulation packet comprising at least a portion of the baseline packet and a header indicating the isolated virtual network. The encapsulation packet is transmitted to a node of the service.

Abstract: A composite laminate such as a hat-type stringer is formed on a contoured mandrel using a combination of mechanical sweeping and vacuum forming.

Abstract: Systems and methods for controlling shelf display units and for graphically presenting information on shelf display units are disclosed. A system includes one or more display units configured to be coupled to shelves of a modular shelving system, one or more processors communicatively coupled to the one or more display units, one or more memory components communicatively coupled to the one or more processors, and machine readable instructions stored in the one or more memory components. When executed by the one or more processors, the machine readable instructions cause the system to determine a product identifier corresponding to a product, identify one or more display units to update in response to determining the product identifier corresponding to the product, and update a graphical output of the one or more display units identified to be updated in response to identifying the one or more display units to update.