Abstract: A golf club head having a slot in the sole filled with an insert in which the slot is positioned close to the striking face. The slot can be a uniform distance from the striking face or the slot can curve away from the striking face in the toe region. The insert can have a uniform height or a non-uniform height. Inserts with uniform heights can have a low height profile. Inserts with non-uniform heights can have a lower height in a central portion of the insert compared to an edge portion or a perimeter portion of the insert. The insert can also have flanges or protrusions for installation into the slot. The resulting golf club head improves performance, as the sole slot with insert allows the striking face to have a profile that meets the needs at that location.

Abstract: Described herein are fixed doses and dosing regimens for long-acting insulin receptor agonists suitable for once-weekly dosing, such as weekly basal insulin-Fc (BIF).

Abstract: A pharmaceutical composition and methods of administering the same for treatment of cardiovascular disease comprising a pepducin having a sequence SEQ ID No. 1, wherein said composition stimulates cardiomyocyte contractility and activating the ?2AR/?-arrestin signaling pathway.

Abstract: The invention concerns bicyclic compounds of Formula I wherein R1, R2, L1, L2, J, Y, k, n, p and r are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment of androgen-receptor associated conditions, particularly prostate cancer.

Abstract: The invention concerns bicyclic compounds of Formula I wherein , R1, R2, L1, L2, J, Y, k, n, p and r are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment of androgen-receptor associated conditions, particularly prostate cancer.

Abstract: The invention concerns bicyclic compounds of Formula I wherein , R1, R2, L1, L2, J, Y, k, n, p and r are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment of androgen-receptor associated conditions, particularly prostate cancer.

Abstract: The invention provides compounds of the formula (I) having PKA and PKB kinase inhibiting compounds of the formula (I): GP 1 J T 2 J N 4 R N H (I) or salts, solvates, tautomers or N-oxides thereof, wherein (1) GP is a group GP1: HET 2a a Q G (HNCO)f 7 (R)x N * (GP1) (2) GP is a group GP2: 10 (R)r O 2a a QG (CH2)w N V H N * (GP2) wherein HET is a monocyclic or bicyclic heterocyclic group containing up to 4 heteroatom ring members; the ring V is a monocyclic or bicyclic heteroaryl group of 5 to 10 ring members; and J1, J2, R4, R7, R10, Q2a, Ga, x, w and f are as defined in the claims

Abstract: An apparatus, method, and computer readable storage medium for dynamically maintaining data structures and executing business rules in an electronic procurement system. The method includes (a) dynamically maintaining a plurality of organizational profiles containing data structures, a plurality of users each being associated with a particular organizational profile; and (b) implementing a user requested transaction on a hosted e-procurement system with an application system by using information from the data structures stored in an organizational profile associated with the user.

Abstract: The present invention is related to a method and composition for treatment of diabetes, hypertension, chronic heart failure and fluid retentive states comprising administering inhibitors of the enzymes NEP and DPP-IV to individuals suffering from one or more of those conditions. Inhibition of the activity of the two enzymes will potentiate the insulin releasing activity of endogenous GLP-1 and other DPP-IV substrates like GIP.

Abstract: Methods and uses for the treatment and prevention of cardiac and cardiovascular diseases comprising administration of a GLP-1 agonist.

Abstract: Surfactant compositions contain one or more compounds according to formula (I) wherein R1 is methyl, ethyl, or 1-propyl; R is a C4-C20 aryl, alkaryl, aralkyl, cyclic, alicyclic, or secondary, branched or bicyclic alkyl group, or a polyhydroxyalkyl group according to formula (A) wherein u is an integer from 0 to 2 and R2 is H, ?-D-glucopyranosyl, ?-D-pyranosyl, or ?-D-galactopyranosyl; and Z is a linking group selected from the group consisting of 4,4?-methylenebis(cyclohexyl); CH2(CH2)n{N+O—R1—CH2(CH2)o}p, where p is an integer from 1 to 10 and n and o are each independently integers from 1 to 5; (CH2)r[O(CH2)s]tO(CH2)q, where s is an integer from 2 to 4, t is an integer from 0 to 2, and r and q are each individually 2 or 3; (CH2)m, where m is an integer from 2 to 6; and isophorone residue (B)

Abstract: A boat drive system is provided for a power boat which includes an engine having a drive shaft, connected to a pair of propeller shafts. The drive system includes a primary gearbox and opposed outboard gearboxes. The primary gearbox includes a housing and a gear arrangement connected to the engine shaft and the outboard gearboxes, which are connected to the primary gearbox by a transverse shaft, include a housing and a gear arrangement connected to associated propeller shafts. A cooling system is provided including a cooling pad for each gearbox. A support system is provided for each outboard gearbox including a cradle connected to the bearing points on the hull. The engine includes an adapter plate attached to the primary gearbox for movement of the primary gearbox with the engine. In a modified drive system only one outboard gearbox is used in conjunction with a single engine. In another modified drive system a single engine and propeller are used in conjunction with a gearbox having a take-off shaft.

Abstract: A microfluidic analysis system with a flow channel block, possessing at least one recessed channel, clamped to a sensor surface, such as a surface plasmon resonance (SPR) sensor. Flatness and hardness lead to a liquid leak-proof seal. Surface tension forces prevent liquid from leaking between the flow cell block and sensor surfaces. The fluid channels formed are reversible upon removal of the clamping pressure.

Abstract: A disposable, portable, miniature surface plasmon resonance sensor (30) having real-time referencing capability in the presence of any interaction, without changing the sensing surface condition is disclosed herein. The sensor (30) includes an electromagnetic radiation source (32) which generates a beam of electromagnetic radiation (52) that passes through a liquid crystal switch that includes a polarizer, plates and liquid crystal material sandwiched between the plates. The liquid crystal switch is disposed between the source (32) and an array of detectors (48). The liquid crystal switch has the ability to switch between a first and a second state of polarized radiation such that it provides the transverse magnetic component of the electromagnetic radiation for detection of SPR on a target element and, in the alternative, provides the transverse electric component of the electromagnetic radiation to determine a reference signal for the sensor (30).

Abstract: In processing system that includes a processing element communicatively coupled to a storage system for storage of database files (35) managed by a database management system (34) having a transaction management facility (36), file access operations from application processes are intercepted and checked to determine if the operation is from a non-transactional process, and if so, whether an automatic transaction should be started for the operation.

Abstract: Disclosed herein is a fluorinated bridged carbocyclic compound that can be polymerized by itself or with at least one other ethylenically unsaturated monomer to provide a polymer. The polymer may be used, for example, within a sub-300 nm photoresist composition. Also disclosed is a method to make the bridged carbocyclic compound.

Abstract: A miniaturized integrated sensor (50) useful for indicating the presence of a sample analyte is disclosed. The sensor (50) has a platform (52) with an upper surface (53) and a detector (62), light source (60), waveguide (58), and reflective fixtures (60, 62) embedded in the platform (52). The light source (60) is preferably a light emitting diode and sits in a cup-shaped dimple (68) that directs light from the light source (60) toward one of the reflective fixtures (64) to uniformly distribute light across the waveguide (58). The waveguide (58) is coupled to an upper surface (53) of the sensor platform (52) and is coated with a thin film of indicator chemistry (70) which interacts with the sample analyte to produce optic signal changes that are measurable by the detector (62). A lead frame (51) in the platform (52) has pins (54, 55, 56) which provide the interface to the outside world.

Abstract: A disposable, portable, miniature surface plasmon resonance sensor (30) having real-time referencing capability in the presence of any interaction, without changing the sensing surface condition is disclosed herein. The sensor (30) includes an electromagnetic radiation source (32) which generates a beam of electromagnetic radiation (52) that passes through a liquid crystal switch that includes a polarizer, plates and liquid crystal material sandwiched between the plates. The liquid crystal switch is disposed between the source (32) and an array of detectors (48). The liquid crystal switch has the ability to switch between a first and a second state of polarized radiation such that it provides the transverse magnetic component of the electromagnetic radiation for detection of SPR on a target element and, in the alternative, provides the transverse electric component of the electromagnetic radiation to determine a reference signal for the sensor (30).

Abstract: An apparatus, method, and computer readable storage medium for integrating an electronic purchasing system with a plurality of financial systems. The method includes (a) decoding transaction data representing a transaction, from a transaction database, using a parameter based mapper directed to a selected application system selected from a plurality of application systems; and (b) transferring the decoded transaction data to the selected application system.

Abstract: An apparatus, method, and computer readable storage medium for dynamically maintaining data structures and executing business rules in an electronic procurement system. The method includes (a) dynamically maintaining a plurality of organizational profiles containing data structures, a plurality of users each being associated with a particular organizational profile; and (b) implementing a user requested transaction on a hosted e-procurement system with an application system by using information from the data structures stored in an organizational profile associated with the user.