Patents by Inventor Richard A. Dybas

Richard A. Dybas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4172094
    Abstract: Novel diphenyl and loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like. They also can be used for topical treatment of dermatological conditions having a bacterial origin or implication such as Acne vulgaris.
    Type: Grant
    Filed: December 3, 1976
    Date of Patent: October 23, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Richard A. Dybas, Nathaniel Grier, Bruce E. Witzel
  • Patent number: 4145426
    Abstract: Compounds of the structure: ##STR1## where A is either ##STR2## where R.sub.1 to R.sub.4 are various substituents are active as antibacterials and antifungals.
    Type: Grant
    Filed: July 18, 1977
    Date of Patent: March 20, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Bruce E. Witzel
  • Patent number: 4139559
    Abstract: A process for preparing 1-[1,5-di-(3,3-dimethylnorborn-2-yl)-3-pentyl]-1,5,9-triazanonane from 1,5-di-(3,3-dimethylnorborn-2-yl)-3-pentanone by reaction with ammonia to form, after reduction, 3-amino-[1,5-di-(3,3-dimethylnorborn-2-yl)pentane]. This latter compound is reacted with acrylonitrile, reduced, and the diamine product again reacted with acrylonitrile and again reduced. Alternative routes wherein the ketone is reduced to the novel alcohol and optionally the novel halide and either then reacted with 3,3'-iminobispropylamine to form the desired polyamine are also shown.
    Type: Grant
    Filed: January 16, 1978
    Date of Patent: February 13, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • Patent number: 4100193
    Abstract: Novel dibicyclo [2.2.2] octyl dibicyclo [2.2.2] octenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful as hard surface disinfectants and as additives to oil well drilling muds, injection brines and industrial water where bacterial control is desired.
    Type: Grant
    Filed: June 10, 1976
    Date of Patent: July 11, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • Patent number: 4094976
    Abstract: Novel anticoccidial poultry compositions comprising an anticoccidially effective amount of a compound of the formula: ##STR1## wherein n is 3, 4 or 5 and R is hydrogen or an acyl radical derived from a non-toxic carboxylic acid or a non-toxic acid addition salt thereof methods of combatting poultry coccidiosis, novel compounds and methods of preparing these novel compounds.
    Type: Grant
    Filed: December 29, 1976
    Date of Patent: June 13, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Richard A. Dybas, Donald W. Graham, Jeannette E. Brown
  • Patent number: 4091020
    Abstract: Novel di-bicyclo[3.1.1] and [2.2.1]heptyl and dibicyclo[3.1.1] and [2.2.1]heptenyl ketones are useful as intermediates for preparing novel polyamines useful as antimicrobial agents, as well as algae inhibitors.
    Type: Grant
    Filed: August 23, 1976
    Date of Patent: May 23, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas
  • Patent number: 4079059
    Abstract: Novel diphenyl and loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like. They also can be used for topical treatment of dermatological conditions having a bacterial origin or implication such as Acne vulgaris.
    Type: Grant
    Filed: February 12, 1976
    Date of Patent: March 14, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Richard A. Dybas, Nathaniel Grier, Bruce E. Witzel
  • Patent number: 4070400
    Abstract: Novel diphenyl and loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like. They also can be used for topical treatment of dermatological conditions having a bacterial origin or implication such as Acne vulgaris.
    Type: Grant
    Filed: October 16, 1975
    Date of Patent: January 24, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Richard A. Dybas, Nathaniel Grier, Bruce E. Witzel
  • Patent number: 4065497
    Abstract: Novel dibicyclo [3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful as hard surface disinfectants and as additives to oil well drilling muds, injection brines and industrial water where bacterial control is desired.
    Type: Grant
    Filed: February 17, 1977
    Date of Patent: December 27, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • Patent number: 4061775
    Abstract: Novel diphenyl and loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like. They also can be used for topical treatment of dermatological conditions having a bacterial origin or implication such as Acne vulgaris.
    Type: Grant
    Filed: September 2, 1975
    Date of Patent: December 6, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Richard A. Dybas, Nathaniel Grier, Bruce E. Witzel
  • Patent number: 4049559
    Abstract: An antimicrobial composition for secondary and tertiary oil recovery comprising a flooding composition consisting of displacement and driving fluids having incorporated therein an antimicrobially effective amount of a di-bicyclo[3.1.1] or [2.2.1] heptyl or di-bicyclo[3.1.1] and [2.2.1] heptenyl polyamines or salts thereof.
    Type: Grant
    Filed: May 18, 1976
    Date of Patent: September 20, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • Patent number: 4049417
    Abstract: Novel dicyclohexyl, dicyclohexenyl and cyclohexylcyclohexenylalkyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful in agriculture to protect plants against diseases such as leaf, stem, and fruit spotting, internal discoloration and decay of fruits and vegetables. These compounds are particularly active against diseases caused by the genera Pseudomonas, Xanthomonas, Erwinia, and Corynebacterium.
    Type: Grant
    Filed: March 8, 1976
    Date of Patent: September 20, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Bruce E. Witzel, Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • Patent number: 4044133
    Abstract: Novel compounds of the following formula: ##STR1## wherein R' is alkyl of 1 to 3 carbon atoms, X.sup.- is a nontoxic anion; b and c are positive numbers having values such that the positive charge of b moles of cation are neutralized by c moles of anion X.sup.- ; and -.sup.+ is a bicyclic heterocyclic base, of the group consisting of: ##STR2## wherein the dotted lines indicates that the methyl group can be present or a hydrogen group can be present, with the proviso that the two alpha methyl groups are not present at the same time, but that one alpha methyl group is required. These compounds have superior coccidiostatic activity.
    Type: Grant
    Filed: October 16, 1975
    Date of Patent: August 23, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Edward F. Rogers, John Hannah, Richard A. Dybas
  • Patent number: 4035174
    Abstract: Novel dibicyclo [3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenyl polyamines having a cyclohexylene group in the polyamine moiety are useful antimicrobial agents, as well as algae inhibitors. They are especially useful as hard surface disinfectants and as additives to oil well drilling muds, injection brines and industrial waters where microbial control is desired.
    Type: Grant
    Filed: March 26, 1976
    Date of Patent: July 12, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • Patent number: 4033748
    Abstract: Novel dibicyclo [3.1.1] and [2.2.1] heptyl and dibicyclo [3.1.1] and [2.2.1] heptenylalkyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful as hard surface disinfectants and as additives to oil well drilling muds, injection brines and industrial water where bacterial control is desired.
    Type: Grant
    Filed: July 2, 1976
    Date of Patent: July 5, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Robert A. Strelitz
  • Patent number: 4017505
    Abstract: New benzimidazoles substituted at the 1-position with carbonyl substituents and at the 2-position with a 4-thiazolyl group are effective fungicides and anthelmintics. The compounds as well as processes for their preparation are described along with antifungal and anthelmintic compositions for their use. The 1-position substituent is a hydrocarbon group of from 5 to 12 carbon atoms connected to the carbonyl group through an oxygen or a sulfur atom. The compounds are generally prepared by contacting a 1-unsubstituted benzimidazole with a hydrocarbon radical substituted chloroformate or chlorothiol formate.
    Type: Grant
    Filed: October 23, 1975
    Date of Patent: April 12, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Edward F. Rogers, Wallace T. Ashton, Richard A. Dybas
  • Patent number: 4006143
    Abstract: Novel compounds of the following formula: ##STR1## WHEREIN R' is alkyl of 1 to 3 carbon atoms, X.sup.- is a nontoxic anion; b and c are positive numbers having values such that the positive charge of b moles of cation are neutralized by c moles of anion X.sup.-; and -N is a bicyclic heterocyclic base, of the group consisting of: ##STR2## wherein the dotted line indicates that the methyl group can be present or a hydrogen group can be present, with the proviso that the two alpha methyl groups are not present at the same time, but that one alpha methyl group is required. These compounds have superior coccidiostatic activity.
    Type: Grant
    Filed: October 16, 1975
    Date of Patent: February 1, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Edward F. Rogers, John Hannah, Richard A. Dybas
  • Patent number: 4003934
    Abstract: Novel di-bicyclo[3.1.1] and [2.2.1]heptyl and dibicyclo[3.1.1] and [2.2.1]heptenyl ketones are useful as intermediates for preparing novel polyamines useful as antimicrobial agents, as well as algae inhibitors.
    Type: Grant
    Filed: September 2, 1975
    Date of Patent: January 18, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas
  • Patent number: 3957997
    Abstract: Substituted 2- and 4-pyridones, pyrimidin-2- and 6-ones and tetrahydroquinolones when complexed with 4,4'-dinitrocarbanilide provide agents which are active coccidiostats and which produce minimal toxic side effects. Processes for the preparation of these complexes as well as compositions suitable for administration to poultry for the prevention and cure of coccidiosis are also disclosed.
    Type: Grant
    Filed: September 26, 1974
    Date of Patent: May 18, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Edward F. Rogers, Richard A. Dybas, John Hannah