Abstract: Targeted Factor VIII molecules comprising a Factor VIII linked with at least one domain that specifically binds to a membrane protein on a red blood cell is provided. The disclosed targeted coagulation factors prolong their duration of action and thus, are an improvement for the treatment of hematological diseases such as hemophilia A.

Abstract: Targeted Factor VIII molecules comprising a Factor VIII linked with at least one domain that specifically binds to a membrane protein on a red blood cell is provided. The disclosed targeted coagulation factors prolong their duration of action and thus, are an improvement for the treatment of hematological diseases such as hemophilia A.

Abstract: An application programming interface (API) that enables installation of an application as one or more key-value objects on a data storage drive such as a hard disk drive, a solid state drive or a hybrid drive. The API also enables execution of the application within a controlled environment of the data storage drive.

Abstract: An application programming interface (API) that enables installation of an application as one or more key-value objects on a data storage drive such as a hard disk drive, a solid state drive or a hybrid drive. The API also enables execution of the application within a controlled environment of the data storage drive.

Abstract: An application programming interface (API) that enables installation of an application as one or more key-value objects on a data storage drive such as a hard disk drive, a solid state drive or a hybrid drive. The API also enables execution of the application within a controlled environment of the data storage drive.

Abstract: A data storage device includes a data store optimized organized into allocation units sized according to an sequential writing unit or garbage collection unit of the data store. Information is written to the allocation units as either coarse or fine-grained packets, which are packets of data that are self-describing and written together. Random writes received from a host to data already written into allocation units is written to another allocation unit, and a coarse-grained forward map is updated to reflect the physical location of the valid data that superseded data in the allocation unit until the allocation unit can be rewritten. Promotion operations are disclosed to compact data and garbage collect data by rewriting allocation units.

Abstract: Targeted Factor VIII molecules comprising a Factor VIII linked with at least one domain that specifically binds to a membrane protein on a red blood cell is provided. The disclosed targeted coagulation factors prolong their duration of action and thus, are an improvement for the treatment of hematological diseases such as hemophilia A.

Abstract: A data storage device includes a data store optimized organized into allocation units sized according to an sequential writing unit or garbage collection unit of the data store. Information is written to the allocation units as either coarse or fine-grained packets, which are packets of data that are self-describing and written together. Random writes received from a host to data already written into allocation units is written to another allocation unit, and a coarse-grained forward map is updated to reflect the physical location of the valid data that superseded data in the allocation unit until the allocation unit can be rewritten. Promotion operations are disclosed to compact data and garbage collect data by rewriting allocation units.

Abstract: A data storage device includes a data store optimized organized into allocation units sized according to an sequential writing unit or garbage collection unit of the data store. Information is written to the allocation units as either coarse or fine-grained packets, which are packets of data that are self-describing and written together. Random writes received from a host to data already written into allocation units is written to another allocation unit, and a coarse-grained forward map is updated to reflect the physical location of the valid data that superseded data in the allocation unit until the allocation unit can be rewritten. Promotion operations are disclosed to compact data and garbage collect data by rewriting allocation units.

Abstract: A data storage device includes a data store optimized organized into allocation units sized according to an sequential writing unit or garbage collection unit of the data store. Information is written to the allocation units as either coarse or fine-grained packets, which are packets of data that are self-describing and written together. Random writes received from a host to data already written into allocation units is written to another allocation unit, and a coarse-grained forward map is updated to reflect the physical location of the valid data that superseded data in the allocation unit until the allocation unit can be rewritten. Promotion operations are disclosed to compact data and garbage collect data by rewriting allocation units.

Abstract: Targeted coagulation factors comprising a coagulation factor linked with at least one domain that specifically binds to a membrane protein on a blood cell is provided. The disclosed targeted coagulation factors increase the efficiency of coagulation factors and prolong their duration of action and thus, are an improvement for the treatment of hematological diseases such as hemophilia A.

Abstract: An application programming interface (API) that enables installation of an application as one or more key-value objects on a data storage drive such as a hard disk drive, a solid state drive or a hybrid drive. The API also enables execution of the application within a controlled environment of the data storage drive.

Abstract: Compositions and methods are provided for therapeutic treatment using recombinant Hemopexin molecules having sufficient sialyation and/or absence of neutral glycans to allow for sufficient circulation to remove free heme from a biological organism. In other embodiments, a recombinant Hemopexin molecule is provided for therapeutic treatment having a percentage of neutral glycans to total glycans in a range of from about 2 to about 30 percent as measured by HPLC after labelling with fluorescent probe 2-aminobenzoic acid. Methods of treatment and making a recombinant Hemopexin molecule are also described.

Abstract: Apparatus and method for managing a media cache through the monitoring of operational vibration of a data storage device. In some embodiments, a non-volatile media cache of the data storage device is partitioned into at least first and second zones having different data recording characteristics. Input data are received for storage in a non-volatile main memory of the data storage device. An amount of operational vibration associated with the data storage device is measured. The input data are stored in a selected one of the first or second zones of the media cache prior to transfer to the main memory responsive to a comparison of the measured amount of operational vibration to a predetermined operational vibration threshold.

Abstract: Targeted coagulation factors comprising a coagulation factor linked with at least one domain that specifically binds to a membrane protein on a blood cell is provided. The disclosed targeted coagulation factors increase the efficiency of coagulation factors and prolong their duration of action and thus, are an improvement for the treatment of hematological diseases such as hemophilia A.

Abstract: Targeted coagulation factors comprising a coagulation factor linked with at least one domain that specifically binds to a membrane protein on a blood cell is provided. The disclosed targeted coagulation factors increase the efficiency of coagulation factors and prolong their duration of action and thus, are an improvement for the treatment of hematological diseases such as hemophilia A.

Abstract: The disclosure is related to systems and methods of controlling wear of a memory. In a particular embodiment, a system is disclosed that comprises a memory and a performance governor circuit coupled to the memory. The performance governor circuit is adapted to control a wear of the memory as a function of time.

Abstract: Apparatus and method for managing a media cache through the monitoring of operational vibration of a data storage device. In some embodiments, a non-volatile media cache of the data storage device is partitioned into at least first and second zones having different data recording characteristics. Input data are received for storage in a non-volatile main memory of the data storage device. An amount of operational vibration associated with the data storage device is measured. The input data are stored in a selected one of the first or second zones of the media cache prior to transfer to the main memory responsive to a comparison of the measured amount of operational vibration to a predetermined operational vibration threshold.

Abstract: A method or system comprising iteratively updating a value of an operating parameter of a storage region of a storage device based on dynamic characterization of the storage region during operation of the storage device and using the updated value of the operating parameter during access to the storage region.

Abstract: A method or system for determining storage location of an isolation region based on a data region sizing specified by a host device. In one implementation, the isolation region comprises a set of storage locations required for isolation of or more data region of the storage device.