Patents by Inventor Richard A. Fisher

Richard A. Fisher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Apparatus and method for recovery of material
    Patent number: 10829834
    Abstract: Systems and methods for recovering material from a gas phase are provided. Exemplary systems include a moving bed of particles onto which material can be deposited. The systems can operate in a continuous or semi-continuous mode.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: November 10, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO A Body Corporate
    Inventors: Alan W. Weimer, Aaron W. Palumbo, Illias Hischier, Arto J. Groehn, Boris A. Chubukov, Scott C. Rowe, Richard Fisher
  • Methods Of Treating Pruritus
    Publication number: 20200345698
    Abstract: The present disclosure related to methods of treating pruritus in a subject by topically administering detomidine, or a pharmaceutically acceptable salt thereof, to the subject.
    Type: Application
    Filed: May 1, 2020
    Publication date: November 5, 2020
    Inventors: Yael Rosen, David Dangoor, Richard Fisher
  • Polypeptides comprising a modified bacteriophage G3P amino acid sequence lacking a glycosylation signal
    Patent number: 10722551
    Abstract: The invention relates to polypeptides that comprise a portion of filamentous bacteriophage gene 3 protein (g3p) sufficient to bind to and/or disaggregate amyloid, e.g., the N1-N2 portion of g3p and mutants and fragments thereof, wherein that g3p amino acid sequence has been modified through amino acid deletion, insertion or substitution to remove a putative glycosylation signal. The invention further relates to such polypeptides that are also modified through additional amino acid substitution to be substantially less immunogenic than the corresponding wild-type g3p amino acid sequence when used in vivo. The polypeptides of the invention retain their ability to bind and/or disaggregate amyloid. The invention further relates to the use of these g3p-modified polypeptides in the treatment and/or prevention of diseases associated with misfolding or aggregation of amyloid.
    Type: Grant
    Filed: December 2, 2015
    Date of Patent: July 28, 2020
    Assignee: Proclara Biosciences, Inc.
    Inventors: Rajaraman Krishnan, Eva Asp, Ming Proschitsky, Richard Fisher, Francis J. Carr, Robert G. E. Holgate, Timothy D. Jones
  • Fusion proteins comprising P3 of bacteriophage
    Patent number: 10526377
    Abstract: The invention relates to agents and to pharmaceutical compositions for reducing the formation of amyloid and/or for promoting the disaggregation of an proteins. The compositions may also be used to detect amyloid.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: January 7, 2020
    Assignee: PROCLARA BIOSCIENCES, INC.
    Inventors: Rajaraman Krishnan, Richard Fisher
  • Carbothermal reduction reactor system, components thereof, and methods of using same
    Patent number: 10400309
    Abstract: Methods, systems, and components suitable for carbothermal reduction processes are disclosed. Exemplary systems include a reactor, such as hybrid solarthermal-electric reactor, a solar thermal reactor, an electric reactor, or a reactor heated by gas combustion, a pellet source, a gas reactant source, and a vacuum source. The reactor can operate as a moving bed or pseudo moving bed reactor.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: September 3, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A Body Corporate
    Inventors: Alan W. Weimer, Aaron Palumbo, Illias Hischier, Boris A. Chubukov, Scott C. Rowe, Richard Fisher, Arto J. Groehn
  • Fusion proteins comprising P3 of bacteriophage
    Patent number: 10208090
    Abstract: The invention relates to agents and to pharmaceutical compositions for reducing the formation of amyloid and/or for promoting the disaggregation of amyloid proteins. The compositions may also be used to detect amyloid.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: February 19, 2019
    Assignee: PROCLARA BIOSCIENCES, INC.
    Inventors: Rajaraman Krishnan, Richard Fisher
  • FUSION PROTEINS COMPRISING P3 OF BACTERIOPHAGE
    Publication number: 20180354994
    Abstract: The invention relates to agents and to pharmaceutical compositions for reducing the formation of amyloid and/or for promoting the disaggregation of an proteins. The compositions may also be used to detect amyloid.
    Type: Application
    Filed: May 9, 2018
    Publication date: December 13, 2018
    Inventors: Rajaraman KRISHNAN, Richard FISHER
  • Bacteriophage gene 3 protein compositions and use as amyloid binding agents
    Patent number: 10151762
    Abstract: The invention relates to agents and to pharmaceutical compositions for reducing the formation of amyloid and/or for promoting the disaggregation of amyloid proteins. The compositions may also be used to detect amyloid.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: December 11, 2018
    Assignee: Proclara Biosciences, Inc.
    Inventors: Rajaraman Krishnan, Richard Fisher
  • POLYPEPTIDES COMPRISING A MODIFIED BACTERIOPHAGE G3P AMINO ACID SEQUENCE WITH REDUCED IMMUNOGENICITY
    Publication number: 20180251534
    Abstract: The invention relates to polypeptides that comprise a portion of filamentous bacteriophage gene 3 protein (g3p) sufficient to bind to and/or disaggregate amyloid, e.g., the N1-N2 portion of g3p and mutants and fragments thereof, wherein that g3p amino acid sequence has been modified through amino acid substitution to be substantially less immunogenic than the corresponding wild-type g3p amino acid sequence when used in vivo. The polypeptides of the invention retain their ability bind to and/or disaggregate amyloid. The invention relates furthermore to the use of these variant g3p-polypeptides in the treatment and/or prevention of diseases associated with misfolding or aggregation of amyloid.
    Type: Application
    Filed: May 4, 2018
    Publication date: September 6, 2018
    Inventors: Richard A. Fisher, Robert George Edward Holgate, Francis Joseph Carr, Timothy David Jones
  • POLYPEPTIDES COMPRISING A MODIFIED BACTERIOPHAGE G3P AMINO ACID SEQUENCE LACKING A GLYCOSYLATION SIGNAL
    Publication number: 20180207231
    Abstract: The invention relates to polypeptides that comprise a portion of filamentous bacteriophage gene 3 protein (g3p) sufficient to bind to and/or disaggregate amyloid, e.g., the N1-N2 portion of g3p and mutants and fragments thereof, wherein that g3p amino acid sequence has been modified through amino acid deletion, insertion or substitution to remove a putative glycosylation signal. The invention further relates to such polypeptides that are also modified through additional amino acid substitution to be substantially less immunogenic than the corresponding wild-type g3p amino acid sequence when used in vivo. The polypeptides of the invention retain their ability to bind and/or disaggregate amyloid. The invention further relates to the use of these g3p-modified polypeptides in the treatment and/or prevention of diseases associated with misfolding or aggregation of amyloid.
    Type: Application
    Filed: December 2, 2015
    Publication date: July 26, 2018
    Inventors: Rajaraman Krishnan, Eva Asp, Ming Proschitsky, Richard Fisher, Francis J. Carr, Robert G.E. Holgate, Timothy D. Jones
  • APPARATUS AND METHOD FOR RECOVERY OF MATERIAL
    Publication number: 20180195148
    Abstract: Systems and methods for recovering material from a gas phase are provided. Exemplary systems include a moving bed of particles onto which material can be deposited. The systems can operate in a continuous or semi-continuous mode.
    Type: Application
    Filed: March 4, 2016
    Publication date: July 12, 2018
    Inventors: Alan W. Weimer, Aaron W. Palumbo, Illias Hischier, Arto J. Groehn, Boris A. Chubukov, Scott C. Rowe, Richard Fisher
  • Polypeptides comprising a modified bacteriophage g3p amino acid sequence with reduced immunogenicity
    Patent number: 9988444
    Abstract: The invention relates to polypeptides that comprise a portion of filamentous bacteriophage gene 3 protein (g3p) sufficient to bind to and/or disaggregate amyloid, e.g., the N1-N2 portion of g3p and mutants and fragments thereof, wherein that g3p amino acid sequence has been modified through amino acid substitution to be substantially less immunogenic than the corresponding wild-type g3p amino acid sequence when used in vivo. The polypeptides of the invention retain their ability bind to and/or disaggregate amyloid. The invention relates furthermore to the use of these variant g3p-polypeptides in the treatment and/or prevention of diseases associated with misfolding or aggregation of amyloid.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: June 5, 2018
    Assignee: PROCLARA BIOSCIENCES, INC.
    Inventors: Richard A. Fisher, Robert George Edward Holgate, Francis Joseph Carr, Timothy David Jones
  • Deuterium-Substituted Oxazepin Compounds
    Publication number: 20180064726
    Abstract: Described are deuterium-substituted oxazepin compounds of structural Formula I, which are inhibitors/blockers of the late sodium current. Also described are pharmaceutical compositions comprising the deuterium-substituted oxazepin compounds, and methods of use thereof.
    Type: Application
    Filed: September 7, 2017
    Publication date: March 8, 2018
    Inventors: Richard FISHER, Chengzhi ZHANG
  • FUSION PROTEINS COMPRISING P3 OF BACTERIOPHAGE
    Publication number: 20170305975
    Abstract: The invention relates to agents and to pharmaceutical compositions for reducing the formation of amyloid and/or for promoting the disaggregation of amyloid proteins. The compositions may also be used to detect amyloid.
    Type: Application
    Filed: May 4, 2017
    Publication date: October 26, 2017
    Inventors: Rajaraman KRISHNAN, Richard FISHER
  • Bacteriophage gene 3 protein compositions and use as amyloid binding agents
    Patent number: 9688728
    Abstract: The invention relates to agents and to pharmaceutical compositions for reducing the formation of amyloid and/or for promoting the disaggregation of amyloid proteins. The compositions may also be used to detect amyloid.
    Type: Grant
    Filed: October 1, 2013
    Date of Patent: June 27, 2017
    Assignee: PROCLARA BIOSCIENCES, INC.
    Inventors: Rajaraman Krishnan, Richard Fisher
  • POLYPEPTIDES COMPRISING A MODIFIED BACTERIOPHAGE G3P AMINO ACID SEQUENCE WITH REDUCED IMMUNOGENICITY
    Publication number: 20170129945
    Abstract: The invention relates to polypeptides that comprise a portion of filamentous bacteriophage gene 3 protein (g3p) sufficient to bind to and/or disaggregate amyloid, e.g., the N1-N2 portion of g3p and mutants and fragments thereof wherein that g3p amino acid sequence has been modified through amino acid substitution to be substantially less immunogenic than the corresponding wild-type g3p amino acid sequence when used in vivo. The polypeptides of the invention retain their ability bind to and/or disaggregate amyloid. The invention relates furthermore to the use of these variant g3p-polypeptides in the treatment and/or prevention of diseases associated with misfolding or aggregation of amyloid.
    Type: Application
    Filed: May 28, 2014
    Publication date: May 11, 2017
    Inventors: Richard A. FISHER, Robert George Edward HOLGATE, Francis Joseph CARR, Timothy David JONES
  • BACTERIOPHAGE GENE 3 PROTEIN COMPOSITIONS AND USE AS AMYLOID BINDING AGENTS
    Publication number: 20170115311
    Abstract: The invention relates to agents and to pharmaceutical compositions for reducing the formation of amyloid and/or for promoting the disaggregation of an proteins. The compositions may also be used to detect amyloid.
    Type: Application
    Filed: October 7, 2016
    Publication date: April 27, 2017
    Applicant: PROCLARA BIOSCIENCES, INC.
    Inventors: Rajaraman KRISHNAN, Richard FISHER
  • METHOD FOR PRODUCING A COMPOSITE MATERIAL
    Publication number: 20160339417
    Abstract: The present invention relates to a method for producing a composite material which contains a support material and an ionic liquid, as well as a composite material and its use as synthetic catalyst.
    Type: Application
    Filed: April 12, 2016
    Publication date: November 24, 2016
    Applicant: Clariant International AG
    Inventors: Normen SZESNI, Melanie Kaiser, Richard FISHER, Hans-Joerg WOELK
  • Bacteriophage gene 3 protein compositions and use as amyloid binding agents
    Patent number: 9493516
    Abstract: The invention relates to agents and to pharmaceutical compositions for reducing the formation of amyloid and/or for promoting the disaggregation of amyloid proteins. The compositions may also be used to detect amyloid.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: November 15, 2016
    Assignee: PROCLARA BIOSCIENCES, INC.
    Inventors: Rajaraman Krishnan, Richard Fisher
  • Bacteriophage gene 3 protein compositions and use as amyloid binding agents
    Patent number: 9493515
    Abstract: The invention relates to agents and to pharmaceutical compositions for reducing the formation of amyloid and/or for promoting the disaggregation of amyloid proteins. The compositions may also be used to detect amyloid.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: November 15, 2016
    Assignee: PROCLARA BIOSCIENCES, INC.
    Inventors: Rajaraman Krishnan, Richard Fisher