Abstract: The present invention provided a method of manufacturing a duct for a gas turbine engine or the like from sheet metal material; the method comprising the steps of: fabricating a duct from sheet material (10,12,14) including rolling or folding metal sheet along ruled lines to form a ruled surface geometry approximately corresponding to at least part of a desired irregular final duct geometry; welding corresponding rolled or folded parts of the duct skin together and positioning the duct on a heat treatment fixture (30) having a shape corresponding to the said desired irregular duct geometry; the material of the heat treatment fixture having a greater thermal expansion coefficient than the duct material; heating the duct and fixture substantially to a stress relieving temperature of the duct material such that differential thermal expansion of the duct and fixture at the said stress relieving temperature causes the duct to distort and adopt the shape of the exterior surface of the fixture on which the duct is l

Abstract: A first aspect of the invention relates to a combination comprising a CDK inhibitor and 1-(2-C-cyano-2-dioxy-?-D-arabino-pentofuranosyl)-N4-palmitoyl cytosine, or a metabolite thereof. A second aspect of the invention relates to a pharmaceutical product comprising a CDK inhibitor and 1-(2-C-cyano-2-dioxy-?-D-arabino-pentofuranosyl)-N4-palmitoyl cytosine, or a metabolite thereof, as a combined preparation for simultaneous, sequential or separate use in therapy. A third aspect of the invention relates to a method of treating a proliferative disorder, said method comprising simultaneously, sequentially or separately administering a CDK inhibitor and 1-(2-C-cyano-2-dioxy-?-D-arabino-pentofuranosyl)-N4-palmitoyl cytosine, or a metabolite thereof, to a subject.

Abstract: The present disclosure relates to antioxidant-stabilized composition containing at least one omega 3 polyunsaturated fatty acid (PUFA). The omega 3 PUFA may include eicosapentanoic acid, docosahexaneoic acid and combinations thereof. The compositions additionally contain an antioxidant package made from a mixture of: at least one form of vitamin E; ascorbyl palmitate; rosemary extract; and grape seed oil. The present disclosure further relates to a method of increasing the oxidative stability of concentrated fish oil.

Abstract: A method of manufacturing a thin wall isogrid or the like casing by a machining process comprising the steps of: mating a surface of a casing precursor (10,50) with a substantially continuous support surface (20,60) of a hollow support sleeve (18, 58); engaging an engagement surface (26, 66) of a deformation member (24, 64) with an engagement surface (22,62) of the support sleeve (18,58), the engagement surface (22, 62) of the support sleeve (18,58) being opposite the support surface (20,60) and the deformation member (24,64) being co-axially arranged with the support sleeve (18,58); axially displacing the support sleeve (18,58) and deformation member (24,64) relative to one another, the deformation member (24,64) engagement surface (22,62) and support sleeve (18,58) engagement surface (22,62) being configured such that the support sleeve (18,58) is deformed by the deformation member (24,64) by the relative axial displacement in order to mate the support surface (20,60) with substantially the whole of the sur

Abstract: A cooling apparatus includes a manifold defining a fluid channel, and also includes a plurality of cooling fins connected to the manifold, wherein at least a portion of a surface of the fins includes porous material.

Abstract: A method of manufacturing a thin wall isogrid or the like casing by a machining process includes the steps of mating a casing with a support, the said support having a substantially continuous support surface engaging at least part of the inner or outer surface of the casing and machining a plurality of recessed pockets in the inner or outer surface of the casing opposite the surface engaged by the said support. The support reacts loads acting on the casing by a machining tool during machining, thereby minimizing distortion of the casing and tearing of the pockets being formed. During the mating process, the casing is deformed such that the support surface engages substantially the whole of the inner or outer surface of the casing.

Abstract: The invention provides a method of identifying compounds that either increase or decrease skin and/or hair pigmentation, the method comprising determining the ability of a test compound to modulate NCKX-mediated calcium ion movement across a membrane (e.g. NCKX5). The method may comprise the steps of exposing a membrane comprising a NCKX molecule or variant, fusion or derivative thereof to a test compound and measuring either directly or indirectly the calcium ion concentration on one or both sides of the membrane. The invention also relates to kits, nucleic acid molecules, polypeptides and cells useful in the method of the invention.

Abstract: A core for casting a container comprising a casting surface, where the core is divided into at least two core segments. The casting surface of each core segment adjoins a division surface, and the division surface of each core segment is spaced apart from the division surface of a neighbouring core segment by a gap. The gap is spanned by a frangible collapsible member such that substantially all of the casting surface is free of the collapsible member.

Abstract: A therapeutic and/or cosmetic formulation comprising at least one anti-sense polynucleotide to a connexin protein together with a pharmaceutically acceptable carrier or vehicle is useful in site specific down regulation of connexin protein expression, particularly in reduction of neuronal cells death, wound healing, reduction of inflammation, decrease of scar formation and skin rejuvenation and thickening.

Abstract: A therapeutic and/or cosmetic formulation comprising at least one anti-sense polynucleotide to a connexin protein together with a pharmaceutically acceptable carrier or vehicle is useful in site specific down regulation of connexin protein expression, particularly in reduction of neuronal cells death, wound healing, reduction of inflammation, decrease of scar formation and skin rejuvenation and thickening.

Abstract: The invention relates to a process of forming a compact bipolar junction transistor (BJT) that includes forming a self-aligned collector tap adjacent the emitter stack and an isolation structure. A base layer is formed from epitaxial silicon that is disposed in the substrate.

Abstract: A cooling apparatus includes a manifold defining a fluid channel, and also includes a plurality of cooling fins connected to the manifold, wherein at least a portion of a surface of the fins includes porous material.

Abstract: A sheet metal blank for the manufacture of a casing of a gas turbine engine comprising a sheet of substantially constant wall thickness and a raised or thicker region extending along substantially the full length of the sheet metal blank. A raised or thicker region is provided between edges of the sheet metal blank. The raised or thicker region comprises at least one boss and at least one ridge extending way from the or each boss.

Abstract: Systems and methods are provided for remotely navigating an elongate medical device in an operating region in a subject's body at a local procedure site, under the control of a user at a remote site. A navigation system having a controller responsive to signals from a local computer is provided. An imaging system displays an image of the operating region on a local display, and a physiology monitoring system displays information about the subject. The system utilizes a local computer for providing instructions from a local user to the navigation system controller, and a remote computer for providing instructions from a remote user to the navigation system controller. A display is provided at the remote site, and a video linking system provides a combined video display at the remote site. The system further includes an audio linking system and a data linking system for providing data communication between the remote and local sites.

Abstract: Determination of the morphology and motility of a population of cells in vitro is possible via a series of steps. The cells are imaged using a microscope and camera. A first frame of image data allows identification of parts of the image data corresponding to a cell or cells of interest. Cell morphology is determined from this data. A second frame of image data, captured subsequent to the first, allows the determination of the relative displacement of the cell or cells of interest. This provides motility data. The invention has particular application in male fertility investigations.

Abstract: Described herein are avian follistatin products, and methods for producing such products, in which such products are effective for a variety of conditions, including increasing muscle mass. Avian follistatin products described herein are packaged as dietary supplements or nutritional supplements are useful in muscle regeneration.

Abstract: A cooling apparatus includes a manifold defining a fluid channel, and also includes a plurality of cooling fins connected to the manifold, wherein at least a portion of a surface of the fins includes porous material.

Abstract: A device for operating a lock assembly for a door or window assembly is disclosed. The lock assembly has a first configuration when mounted in a right hand door and a second configuration when mounted in a left hand door. The device has a handle having a first position and a second position. A member is operably connected to the handle. The member has structure adapted to cooperate with the lock assembly such that the first position of the handle when the member is adapted to be connected to the lock assembly in the first configuration is the same as the first position of the handle when the member is adapted to be connected to the lock assembly in the second configuration.

Abstract: Processes for purifying oligosaccharides including contacting a basic oligosaccharide solution with a basic boronate resin to bind monosaccharides to the basic boronate resin and obtain a purified oligosaccharide solution. The basic boronate resin can bind about 50% of the monosaccharides and about 10% of oligosaccharides in the basic oligosaccharide solution, by weight of total carbohydrates therein.

Abstract: The present invention relates to novel pyridine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.