Abstract: A therapeutic and/or cosmetic formulation comprising at least one anti-sense polynucleotide to a connexin protein together with a pharmaceutically acceptable carrier or vehicle is useful in site specific down regulation of connexin protein expression, particularly in reduction of neuronal cells death, wound healing, reduction of inflammation, decrease of scar formation and skin rejuvenation and thickening.

Abstract: The invention is directed to mixtures comprising C10-C13 alkylphenyl sulfonates having alkyl groups in a particular distribution (e.g., bimodal, peaked, and skewed). These C10-C13 alkylphenyl sulfonates are optionally renewable and unexpectedly provide superior results when used in consumer product cleaning and personal care compositions (e.g., dishcare, laundry, hard surface cleaners, shampoos, conditioners, and soaps). The invention is further directed to a method of making a mixture of partially or wholly renewable C10-C13 alkylphenyl sulfonates having a particular alkyl group distribution.

Abstract: The invention disclosed herein relates to a pharmaceutical composition comprising a carrier and an active ingredient, wherein the carrier is fish gelatin and the composition is a fast-dispersing dosage form designed to release the active ingredient rapidly on contact with a fluid. In one embodiment, the composition is designed for oral administration and releases the active ingredient rapidly in the oral cavity on contact with saliva. The fish gelatin can be obtained from cold water fish sources and is preferably the non-gelling, non-hydrolyzed form. A process for preparing such a composition and a method of using fish gelatin in a fast dispersing dosage form are also provided.

Abstract: A sensing system and method for use with a gas filter in a gas conduit attached to a gas blower, having a motor for producing a first gas flow blower speed, discards readings taken when the blower is off or during blower startup and shutdown, and recalculates a clog threshold in response to changes in the fan speed of a multi-speed blower.

Abstract: A gas filter clogging detection system for monitoring filter performance and condition based on indicators of the accumulation of dirt and other particles on a filter positioned in a gas conduit, in which a notification system provides alerts and reports when the amount of clogging reaches a pre-determined threshold.

Abstract: Connexin modulation for the treatment of wounds that do not heal at expected rates, including delayed healing wounds, incompletely healing wounds, and chronic wounds, and associated methods, compositions and articles.

Abstract: Medical devices comprising an anti-connexin agent suitable for introduction into a subject.

Abstract: A gas filter clogging detection system for monitoring filter performance and condition based on indicators of the accumulation of dirt and other particles on a filter positioned in a gas conduit, in which a notification system provides alerts and reports when the amount of clogging reaches a pre-determined threshold.

Abstract: Treatment of fibrosis and fibrotic diseases, disorders, and conditions, and associated methods, compositions, formulations and articles.

Abstract: Connexin modulation for the treatment of wounds that do not heal at expected rates, including delayed healing wounds, incompletely healing wounds, and chronic wounds, and associated methods, compositions and articles.

Abstract: A shaping apparatus for shaping a workpiece. The apparatus comprises first and second pairs of shaping members and a spacer located between the first and second pairs of shaping members. The first pair of shaping members comprises a material having a first linear coefficient of thermal expansion, and the second pair of shaping members comprises a material having a third linear coefficient of thermal expansion. The first linear coefficient of thermal expansion is higher than the second linear coefficient of thermal expansion such that on heating of the apparatus, thermal expansion of the shaping members causes the first pair of shaping members to expand outwardly, and the second pair of shaping members to expand inwardly.

Abstract: A sheet metal blank for the manufacture of a casing of a gas turbine engine comprising a sheet of substantially constant wall thickness and a raised or thicker region extending along substantially the full length of the sheet metal blank. A raised or thicker region is provided between edges of the sheet metal blank. The raised or thicker region comprises at least one boss and at least one ridge extending way from the or each boss.

Abstract: A first aspect of the invention relates to a combination comprising a DNA methyltransferase inhibitor and 1-(2-C-cyano-2-dioxy-?-D-arabino-pentofuranosyl)-N4-palmitoyl cytosine, or a metabolite thereof. A second aspect of the invention relates to a pharmaceutical product comprising a DNA methyltransferase inhibitor and 1-(2-C-cyano-2-dioxy-?-D-arabino-pentofuranosyl)-N4-palmitoyl cytosine, or a metabolite thereof, as a combined preparation for simultaneous, sequential or separate use in therapy. A third aspect of the invention relates to a method of treating a proliferative disorder, said method comprising simultaneously, sequentially or separately administering a DNA methyltransferase inhibitor and 1-(2-C-cyano-2-dioxy-?-D-arabino-pentofuranosyl)-N4-palmitoyl cytosine, or a metabolite thereof, to a subject.

Abstract: Systems and methods are disclosed for returning RF components which exhibit a mismatch with a coupled load. A tuning circuit may be coupled to a signal path of the RF component, wherein the tuning circuit includes a plurality of loads, a switching element associated with each load, wherein each switching element brings the associated load into and out of the signal path, a control line for each switching element, and a phase stage configured to introduce a phase shift, such as 90°, between a first subset of the loads and a second subset of the loads. The disclosure also includes routines for establishing optimum settings for the tuning circuit.

Abstract: Disclosed herein are novel mixtures of scattered-branched chain fatty acids and derivatives of scattered-branched chain fatty acids. Further disclosed are uses of these mixtures in cleaning compositions (e.g., dishcare, laundry, hard surface cleaners) and/or personal care compositions (e.g., skin cleansers, shampoo, hair conditioners).

Abstract: An exercise slide board is disclosed having a main board, a pair of backstops and a floor grip device. The main board has a top surface and a bottom surface. The top surface is smooth and low friction to allow a user wearing low-friction footwear to easily slide across the board. The first and second backstops are positioned at or near a first end of the main board and a second end of the main board, respectively. The first and second backstops may have a base surface configured to abut against the top surface of the main board. The first and second backstops may also have a strike surface facing toward a center of the main board and extending away from the top surface of the main board at an angle away from the center of the board. The floor grip device is affixed on the bottom surface of the main board. The floor grip device is configured to grip both a hard flooring surface and a carpeted flooring surface. A non-slip mesh may be used.

Abstract: Methods and compositions for modulating the activities of connexins are provided, including, for example, for use in post-surgical, trauma, or tissue engineering applications. These compounds and methods can be used therapeutically, for example, to reduce the severity of adverse effects associated diseases and disorders where localized disruption in direct cell-cell communication is desirable.

Abstract: Disclosed herein are novel mixtures of near terminal-branched compounds and derivatives thereof. Further disclosed are methods of making these mixtures, and uses of these mixtures in cleaning compositions (e.g., dishcare, laundry, hard surface cleaners,) and/or personal care compositions (e.g., skin cleansers, shampoo, hair conditioners).

Abstract: An exercise slide board is disclosed having a main board, a pair of backstops and a floor grip device. The main board has a top surface and a bottom surface. The top surface is smooth and low friction to allow a user wearing low-friction footwear to easily slide across the board. The first and second backstops are positioned at or near a first end of the main board and a second end of the main board, respectively. The first and second backstops may have a base surface configured to abut against the top surface of the main board. The first and second backstops may also have a strike surface facing toward a center of the main board and extending away from the top surface of the main board at an angle away from the center of the board. The floor grip device is affixed on the bottom surface of the main board. The floor grip device is configured to grip both a hard flooring surface and a carpeted flooring surface. A non-slip mesh may be used.

Abstract: Methods for processing glass using select wavelength radiation in a convective environment, broadly referred to as “Local Temporary Annealing”, “LASER Edge Strengthening” and “LASER Enhanced Thermal Strengthening.” Local Temporary Annealing allows strengthened glass to be brought to a neutral stress state so daughter units can be cut from strengthened glass and other processes usually only performed on annealed glass. LASER Edge Strengthening allows surface compression to be thermally imparted to the edges of a whole sheet or daughter units cut from annealed glass, or modification of residual edge stress profiles in strengthened glass to produce stable, strengthened edges. LASER Enhanced Thermal Strengthening allows surface compression to be imparted to a sheet of annealed glass whilst maintaining reduced surface temperatures so the glass has superior geometric stability and surface compression can be imparted at levels not conventionally possible.