Abstract: The present disclosure relates to an automated peritoneal dialysis (APD) system using gravity to deliver fluid from one or more source dialysate bags to the patient as the destination. The present disclosure further relates to a quick release mechanism useful in the assembly and disassembly of components, including a heater unit and a control unit of a peritoneal dialysis system.

Abstract: The present disclosure relates to an automated peritoneal dialysis (APD) system using gravity to deliver fluid from one or more source dialysate bags to the patient as the destination. The present disclosure further relates to a drain container arrangement for receiving and storing spent dialysis effluent from a patient, wherein the drain containers include self-opening valves activated when the containers are arranged together, and the valves are self-sealing when the containers are disconnected from one another.

Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g.

Abstract: A mass spectrometer is disclosed comprising a rotatable isolation valve 1 having a curved, spherical, cylindrical or concave portion. At least a portion of an ion guide 2 is positioned so as to extend within a swept volume of the isolation valve 1 enabling the ion guide 2 to be positioned close to a second downstream ion guide 3 and for ions to be transmitted from the first 2 ion guide to the second ion guide 3 with high ion transmission efficiency.

Abstract: A device may operate a guide wire and be operable by a single operator digit. The device may include an insertion control device for advancing the guide wire in a forward and in a reverse direction and along a longitudinal axis of the guide wire; and a rotary device for rolling a guide wire about the longitudinal axis. A robotic instrument driver may be operatively coupled to the device and configured to control axial movement of the guide wire along the longitudinal axis according to input received from the insertion control device and to control rotational movement of the guide wire according to input received from the rotary device.

Abstract: An automated peritoneal dialysis (APD) device, system and method is provided, which utilizes mechanisms to admix customized dialysate solutions from multiple sources, while maximizing volumetric accuracy. The present automated peritoneal dialysis (APD) device can accomplish these goals all within the convenience and comfort of the patient's home utilizing filtered tap water.

Abstract: An electrical submersible pump (ESP) system, comprises a motor rotationally coupled to a pump. The system has at least one of (i) a rotation stop operable to stop transfer of rotation of the pump to the motor when the ESP is switched off and (ii) a flow control valve operable to stop flow through the pump in both flow directions when the ESP is switched off.

Abstract: The present disclosure relates to an automated peritoneal dialysis (APD) system using gravity to deliver fluid from one or more source dialysate bags to the patient as the destination. The present disclosure further relates to a load cell protection assembly that prevents the load cells associated with the delivery of fluid in the system from experiencing an overload condition in either the down direction or the up direction, while maximizing safety and efficiency of the system while minimizing excess cost and complexity.

Abstract: The invention deals with a patch antenna (28) for a near field radiation. The patch antenna comprises an element (52) that has a surface intended to cover a skin of a user. Furthermore, the element (52) intended to cover the skin is arranged to make the impedance of the antenna (28) matching an impedance of skin.

Abstract: A device may operate a guide wire and be operable by a single operator digit. The device may include an insertion control device for advancing the guide wire in a forward and in a reverse direction and along a longitudinal axis of the guide wire; and a rotary device for rolling a guide wire about the longitudinal axis. A robotic instrument driver may be operatively coupled to the device and configured to control axial movement of the guide wire along the longitudinal axis according to input received from the insertion control device and to control rotational movement of the guide wire according to input received from the rotary device.

Abstract: The invention relates to mutant G-protein coupled receptors with increased conformational stability, and methods of use thereof. In some aspects, polynucleotides encoding the mutant G-protein coupled receptors are provided. In some aspects, host cells comprising the polynucleotides are provided. In some aspects, the invention relates to crystallized forms of the mutant G-protein coupled receptors, and methods of preparing the same.

Abstract: The invention relates to mutant G-protein coupled receptors with increased conformational stability, and methods of use thereof. In some aspects, polynucleotides encoding the mutant G-protein coupled receptors are provided. In some aspects, host cells comprising the polynucleotides are provided. In some aspects, the invention relates to crystallized forms of the mutant G-protein coupled receptors, and methods of preparing the same.

Abstract: A system and corresponding method for electron cryomicroscopy, comprising: a field-emission gun for generating an electron beam, the field-emission gun being energized, in use, to generate a 80 keV to 120 keV electron beam which is emitted into a vacuum enclosure and towards a specimen holder; the vacuum enclosure containing, at least in part: an objective lens for focusing an image of the specimen, the objective lens being disposed in the path of the electron beam and having a chromatic aberration coefficient, Cc, selected to achieve a resolution value better than a desired amount; the specimen holder for holding a specimen, the specimen holder being disposed in the path of the electron beam; a cryostage for cooling a specimen; a cryo-shield for surrounding a specimen and reducing an ice contamination rate of the specimen; and a direct electron detector comprising an array of pixels, each pixel capable of detecting an incident electron that has passed through a sample and struck the pixel.

Abstract: Systems and methods for automatically adjusting an ultrasound display are provided according to one or more embodiments. The present disclosure provides a method for automatically adjusting a display, the method including: initializing an automated display control; receiving image data; determining a position or an orientation of a target relative to the display based on the image data; calculating an adjustment of the display based on the position or the orientation of the target relative to the display; and controlling at least one actuator based on the adjustment of the display to move the display.

Abstract: A method of performing a redirect in a browser viewing a page in a first-party domain is provided. The method includes the steps of checking for the presence of a cookie in the browser associated with a third-party domain, and in the absence of the third-party cookie, the method includes redirecting the browser from the first-party domain to the third-party domain and, in response, returning from the third-party domain, a fixed value cookie for storage in the browser.

Abstract: A method of producing a conformational specific binding partner of a GPCR, the method comprising: a) providing a mutant GPCR of a parent GPCR, wherein the mutant GPCR has increased stability in a particular conformation relative to the parent GPCR; b) providing a test compound; c) determining whether the test compound binds to the mutant GPCR when residing in a particular conformation; and d) isolating a test compound that binds to the mutant GPCR when residing in the particular formation. Methods of producing GPCRs with increased stability relative to a parent GPCR are also disclosed.

Abstract: The invention relates to mutant G-protein coupled receptors with increased conformational stability, and methods of use thereof. In some aspects, polynucleotides encoding the mutant G-protein coupled receptors are provided. In some aspects, host cells comprising the polynucleotides are provided. In some aspects, the invention relates to crystallized forms of the mutant G-protein coupled receptors, and methods of preparing the same.

Abstract: A device may operate a guide wire and be operable by a single operator digit. The device may include an insertion control device for advancing the guide wire in a forward and in a reverse direction and along a longitudinal axis of the guide wire; and a rotary device for rolling a guide wire about the longitudinal axis. A robotic instrument driver may be operatively coupled to the device and configured to control axial movement of the guide wire along the longitudinal axis according to input received from the insertion control device and to control rotational movement of the guide wire according to input received from the rotary device.

Abstract: A device may operate a guide wire and be operable by a single operator digit. The device may include an insertion control device for advancing the guide wire in a forward and in a reverse direction and along a longitudinal axis of the guide wire; and a rotary device for rolling a guide wire about the longitudinal axis. A robotic instrument driver may be operatively coupled to the device and configured to control axial movement of the guide wire along the longitudinal axis according to input received from the insertion control device and to control rotational movement of the guide wire according to input received from the rotary device.