Patents by Inventor Richard A. Lewis

Richard A. Lewis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GLS1 INHIBITORS FOR TREATING DISEASE
    Publication number: 20160009704
    Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
    Type: Application
    Filed: July 2, 2015
    Publication date: January 14, 2016
    Applicant: Board of Regents, The University of Texas System
    Inventors: Maria Emilia Di Francesco, Philip Jones, Timothy Heffernan, Matthew M. Hamilton, Zhijun Kang, Michael J. Soth, Jason P. Burke, Kang Le, Christopher Lawrence Carroll, Wylie S. Palmer, Richard Lewis, Timothy McAfoos, Barbara Czako, Gang Liu, Jay Theroff, Zachary Herrera, Anne Yau
  • Ketone bodies and ketone body esters as blood lipid lowering agents
    Patent number: 9211275
    Abstract: The subject disclosure provides compositions for reducing serum cholesterol and/or triglyceride levels in subjects. These compositions can comprise racemic ?-hydroxybutyrate or D-?-hydroxybutyrate, optionally in the acid form, physiologically compatible salts of racemic ?-hydroxybutyrate or D-?-hydroxybutyrate, esters of D-?-hydroxybutyrate, oligomers of D-?-hydroxybutyrate containing from 2 to 20 or more monomeric units in either linear or cyclic form, racemic 1,3 butandiol or R-1,3 butandiol alone and can be, optionally, administered in conjunction with a low fat diet to a subject.
    Type: Grant
    Filed: January 5, 2009
    Date of Patent: December 15, 2015
    Assignees: ISIS INNOVATION LTD., The United States of America, as represented by the Secretary of the Department of Health and Human Services (DHSS)
    Inventors: Kieran Clarke, Richard Lewis Veech
  • Method to predict dense hydrocarbon saturations for high pressure high temperature
    Patent number: 9194974
    Abstract: A method for characterizing one or more properties of a geological formation including brine and a dense vapor phase includes inputting at least one first property of the geological formation including resistivity of a vapor phase into a model including an equation of state (EOS) model, the model accounting for a high temperature effect on the dense vapor where that the dense vapor has a non-infinite resistivity. At least the EOS model is solves to provide data relating to at least one second property of the geological formation. The data relating to the at least one second property is output to a display device for visual inspection.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: November 24, 2015
    Assignee: Schlumberger Technology Corporation
    Inventors: Indranil Roy, Chris Wilkinson, Partha Ganguly, Richard Lewis, Oliver Mullins, Colin Longfield
  • METHODS AND SYSTEMS FOR FAST PCR HEATING
    Publication number: 20150307910
    Abstract: A microplate for polymerase chain reaction (PCR) comprises a substrate having a metallic material for heating PCR samples, and a barrier layer disposed adjacent to the substrate. In some cases, the barrier layer is formed of a first polymeric material. The microplate includes one or more wells for containing PCR samples. The one or more wells are formed of a second polymeric material sealed to the barrier layer. In some cases, the substrate can provide a PCR ramp rate of at least about 5° C./second.
    Type: Application
    Filed: July 6, 2015
    Publication date: October 29, 2015
    Inventors: Ian GUNTER, Richard LEWIS
  • Methods and systems for fast PCR heating
    Patent number: 9168530
    Abstract: A microplate for polymerase chain reaction (PCR) comprises a substrate having a metallic material for heating PCR samples, and a barrier layer disposed adjacent to the substrate. In some cases, the barrier layer is formed of a first polymeric material. The microplate includes one or more wells for containing PCR samples. The one or more wells are formed of a second polymeric material sealed to the barrier layer. In some cases, the substrate can provide a PCR ramp rate of at least about 5° C./second.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: October 27, 2015
    Assignee: BJS IP LTD.
    Inventors: Ian Gunter, Richard Lewis
  • METAL TREATMENT
    Publication number: 20150299865
    Abstract: Metal objects are treated by anodising (P, SE) the metal object in contact with an acidic solution, and then subjecting the anodised metal object to a reversed voltage (VR). The anodising is performed in two stages, firstly to passivate (P) with the formation of a surface layer, and secondly to form pits in this surface layer (SE). The second stage (SE) of anodising is performed at a lower voltage than the first stage (P). After the reversed voltage step (VR) the metal object is then contacted with a biocidal metal-containing solution. Biocidal metal is absorbed into the surface of the metal object, resulting in improved biocidal properties. The lower voltage of the second stage anodising (SE) results in reduced processing time.
    Type: Application
    Filed: June 29, 2015
    Publication date: October 22, 2015
    Applicant: ACCENTUS MEDICAL LIMITED
    Inventors: James Timothy Shawcross, David Richard Lewis, Andrew Derek Turner
  • SHUNT PLACEMENT THROUGH THE SCLERA
    Publication number: 20150290035
    Abstract: An intraocular shunt can be placed into a human eye using a hollow shaft having a distal tip with a bevel. The hollow shaft can be advanced through the anterior chamber while the hollow shaft holds the intraocular shunt. The sclera can be penetrated with the beveled distal tip until all of the bevel is positioned distal to a distal wall of the sclera. The shunt can be advanced at least partially from the hollow shaft into a drainage space of lower pressure than the anterior chamber. The hollow shaft can be withdrawn from the eye, leaving the shunt extending from the anterior chamber completely through the sclera to the drainage space.
    Type: Application
    Filed: April 27, 2015
    Publication date: October 15, 2015
    Inventors: Christopher HORVATH, Laszlo O. ROMODA, Richard A. LEWIS
  • PHOTOVOLTAIC-CLAD MASONRY UNIT
    Publication number: 20150280640
    Abstract: A masonry unit including a photovoltaic cell for generation of electricity is described herein. More particularly a photovoltaic-clad concrete block that combines the structural attributes of concrete block (or other masonry unit) and the energy production of solar photovoltaics is described herein. Methods for manufacturing, installing, and electrically connecting such photovoltaic-clad concrete blocks are also described herein.
    Type: Application
    Filed: June 12, 2015
    Publication date: October 1, 2015
    Inventors: Patrick John Adrian Quinlan, Jonathan Richard Lewis, Jason Michael Laverty
  • ROTATING POWER GROMMET
    Publication number: 20150270673
    Abstract: A 360° rotatable power grommet mounted in an aperture in a work surface, three vertical copper strips, each connected to a wire which passes through a base to connect to an electrical power source. The copper strips are mounted in a vertical shaft which connects to a base. There are one or more electrical receptacles having arms which rotate horizontally and close to form a central bore, the arms having inner surfaces which are molded with horizontal copper strips, the central bore clamping to the vertical shaft to transfer power from the vertical shaft to the horizontal copper strips, the central bore allowing each electrical receptacle to separately rotate 360° around the vertical shaft.
    Type: Application
    Filed: March 19, 2014
    Publication date: September 24, 2015
    Applicant: Doug Mockett & Company, Inc.
    Inventor: Charles Richard Lewis, JR.
  • Self-healing of operating system components
    Patent number: 9141803
    Abstract: Aspects of the subject matter described herein relate to operating system technology. In aspects, a mechanism is described that allows self-healing actions to correct operating system problems. The self-healing actions may be performed at virtually any time during the loading and executing of operating system components. Earlier placement of the self-healing actions may allow correction of more operating system component problems than later placement. In one implementation, while self-healing actions are occurring, the instantiating of additional operating system components is not allowed. After the self-healing actions have completed, the instantiating of additional operating system components may continue.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: September 22, 2015
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: Andriy Klyuchevskyy, Richard Lewis
  • Diagnostics system for remotely located televisions
    Patent number: 9131214
    Abstract: In a central television diagnostics system, a plurality of remotely located televisions are connected to a central television distribution facility. The remote televisions each have a microprocessor receiving signal quality values and a memory for storing the quality values. One of the quality values comprises a base line measurement value and another comprises a current measurement value. The microprocessor selectively displays on a display of said television a history of said measurement values upon command by a user or service technician desiring to diagnose the status of signal quality at said television.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: September 8, 2015
    Assignee: Zenith Electronics LLC
    Inventor: Richard Lewis
  • Rotating power grommet
    Patent number: 9124056
    Abstract: A 360° rotatable power grommet mounted in an aperture in a work surface, three vertical copper strips, each connected to a wire which passes through a base to connect to an electrical power source. The copper strips are mounted in a vertical shaft which connects to a base. There are one or more electrical receptacles having arms which rotate horizontally and close to form a central bore, the arms having inner surfaces which are molded with horizontal copper strips, the central bore clamping to the vertical shaft to transfer power from the vertical shaft to the horizontal copper strips, the central bore allowing each electrical receptacle to separately rotate 360° around the vertical shaft.
    Type: Grant
    Filed: March 19, 2014
    Date of Patent: September 1, 2015
    Assignee: Doug Mockett & Company, Inc.
    Inventor: Charles Richard Lewis, Jr.
  • Metal treatment
    Patent number: 9096943
    Abstract: Metal objects are treated by anodising (P, SE) the metal object in contact with an acidic solution, and then subjecting the anodised metal object to a reversed voltage (VR). The anodising is performed in two stages, firstly to passivate (P) with the formation of a surface layer, and secondly to form pits in this surface layer (SE). The second stage (SE) of anodising is performed at a lower voltage than the first stage (P). After the reversed voltage step (VR) the metal object is then contacted with a biocidal metal-containing solution. Biocidal metal is absorbed into the surface of the metal object, resulting in improved biocidal properties. The lower voltage of the second stage anodising (SE) results in reduced processing time.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: August 4, 2015
    Assignee: Accentus Medical Limited
    Inventors: James Timothy Shawcross, David Richard Lewis, Andrew Derek Turner
  • Photovoltaic-clad masonry unit
    Patent number: 9059348
    Abstract: A masonry unit including a photovoltaic cell for generation of electricity is described herein. More particularly a photovoltaic-clad concrete block that combines the structural attributes of concrete block (or other masonry unit) and the energy production of solar photovoltaics is described herein. Methods for manufacturing, installing, and electrically connecting such photovoltaic-clad concrete blocks are also described herein.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: June 16, 2015
    Assignee: SolaBlock LLC
    Inventors: Patrick John Adrian Quinlan, Jonathan Richard Lewis, Jason Michael Laverty
  • SYSTEMS AND METHODS FOR PROBABILITY BASED RISK PREDICTION
    Publication number: 20150148616
    Abstract: Systems and methods for probability based prediction of risks are disclosed herein. In one embodiment, a method includes measuring, using sensing elements individually associated with multiple users, a first set of data associated with the users. The method also includes transmitting to and storing in a computing device the measured first set of data and applying a performance model to the first set of data to generate a first set of performance values. The method further includes estimating a second set of data associated with the one or more users and applying the performance model to the second set of data to generate a second set of performance values. The method yet further includes determining if the first and second sets of performance values are statistically equivalent to each other.
    Type: Application
    Filed: November 26, 2014
    Publication date: May 28, 2015
    Inventors: Hans P.A. Van Dongen, Suresh Rangan, Richard A. Lewis
  • Process for the preparation of (3R)-hydroxybutyl (3R)-hydroxybutyrate by enzymatic enantioselective reduction employing alcohol dehydrogenase
    Patent number: 9034613
    Abstract: A process for producing a compound which is (3R)-hydroxybutyl (3R)-hydroxybutyrate of formula (I) which process comprises submitting, to enantioselective reduction, a compound of the following formula (II), (III) or (IV).
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: May 19, 2015
    Assignees: ISIS Innovation Limited, The United States of America, as Represented by the Secretary, Department of Health & Human Services
    Inventors: Jeremy Robertson, Kieran Clarke, Richard Lewis Veech
  • DEVELOPMENT OF LATENT FRICTION RIDGE PRINTS
    Publication number: 20150133295
    Abstract: Apparatus to produce a spatially and temporally uniform heat source is described and this is used to visualize latent fingerprints deposited onto thermal paper by raising the temperature of the paper. Results show an improvement over previous techniques, particularly when fingerprint deposits are aged or the developed fingerprints faint; visualization being enhanced by the use of an LED light source. An investigation of the components in fingerprint sweat likely to affect the solubility and hence colour change of the dye present in the thermal paper has shown that polar protic solvents able to donate a proton are favoured and a polar amino acid found commonly in eccrine fingerprint sweat (lysine) has been shown able to produce the desired colour change. Aged fingerprint deposits on thermal paper from a variety of sources up to four years old have been visualized with this technique.
    Type: Application
    Filed: December 21, 2012
    Publication date: May 14, 2015
    Inventors: Nicholas Rice, John Bond, Kevin Byrne, James Price, Christopher King, Richard Lewis
  • Power and communications grommet
    Patent number: 9024211
    Abstract: A power, communications and data grommet mounted in an aperture in a work surface comprising, a housing adapted to fit into the aperture, the housing comprising a cap removably connected to a liner, the liner comprising an upper liner and a lower liner, the upper liner flaring outwardly to prevent the grommet from falling through the aperture, and a substantially cylindrical lower liner having a threaded outer surface, and a lock ring having inner threads to be threadably attached to the lower liner.
    Type: Grant
    Filed: June 4, 2013
    Date of Patent: May 5, 2015
    Assignee: Doug Mockett & Company, Inc.
    Inventors: Peter Stathis, Derrick Hurst, Charles Richard Lewis, Jr.
  • Shunt placement through the sclera
    Patent number: 9017276
    Abstract: The present invention generally relates to intraocular shunts, and in particular, to intraocular shunts configured to form a drainage pathway between the anterior chamber and the intra-Tenon's space.
    Type: Grant
    Filed: July 26, 2013
    Date of Patent: April 28, 2015
    Assignee: AqueSys, Inc.
    Inventors: Christopher Horvath, Laszlo O. Romoda, Richard A. Lewis
  • Metal implants
    Patent number: 9011665
    Abstract: A metal implant for use in a surgical procedure is provided with a surface layer that is integral with the metal substrate, and which incorporates a biocidal material. The surface layer is grown by anodizing at a voltage between 50 and 150 V, and the biocidal material incorporated in it by ion exchange. This produces a significantly harder surface than anodizing at low voltage, and generates pits containing ion-absorbing material.
    Type: Grant
    Filed: March 3, 2005
    Date of Patent: April 21, 2015
    Assignee: Accentus Medical Limited
    Inventors: Martin Edward Lee Pickford, David Richard Lewis, Andrew Derek Turner