Abstract: Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.

Abstract: The present invention comprises novel analogs of ecstasy-class compounds and novel ecstasy-class immunogens leashed out of, i.e., derived from, the methylenedioxy position. The invention also comprises unique monoclonal antibodies generated using MDO-leashed MDMA immunogens as well as unique conjugates and tracers. These antibodies, conjugates, and tracers are useful in immunoassays for the detection of ecstasy-class compounds in biological fluids.

Abstract: The invention provides derivatives of efavirenz and methods of making derivatives of efavirenz. The derivatives include immunogenic compounds for producing antibodies to efavirenz and labeled efavirenz tracers. These compounds are useful in immunoassay methods for determining efavirenz.

Abstract: Activated haptens useful for generating immunogens to the HIV protease inhibitor atazanavir, immunogens useful for producing antibodies to atazanavir, and antibodies and labeled conjugates useful in immunoassays for determination of atazanavir. The haptens feature an activated functionality at the central, non-terminal hydroxyl group.

Abstract: The present invention comprises novel analogs of ecstasy-class compounds and novel ecstasy-class immunogens leashed out of, i.e., derived from, the methylenedioxy position. The invention also comprises unique monoclonal antibodies generated using MDO-leashed MDMA immunogens as well as unique conjugates and tracers. These antibodies, conjugates, and tracers are useful in immunoassays for the detection of ecstasy-class compounds in biological fluids.

Abstract: A blade for use in a tire mold, a combination of the blade with the tire mold, and a method of attaching the blade to the tire mold. An edge portion of the blade is received in a slot in the tire mold, and a body portion extends therefrom to form a sipe in a tire. One or a pair of tab portions attached to the edge portion is received in an indent in the slot, and a wedge forces the tab portion or portions into a locked position as the blade is driven into the slot. A break-away tendon or tendons attach the wedge to the tab portion or portions and break to allow wedge movement for achieving the locked position when the blade is driven into the slot. Alternatively, a wedge is pre-positioned in an housing in the indent whereby blade tab portions move into a locked position upon contact with the wedge. The mold is engraved, and the blade is formed by laser or water jet cutting.

Abstract: An electrochemical reformer 1 using reactant feed structures having both hydrophilic and hydrophobic regions to provide mechanisms for the wicking of liquid reactants into reformer 1 and for the separation and removal of gaseous products from reformer 1. The electrical reformer 1 may be combined with a fuel cell, a portion of the output of which is used to power reformer 1, to create a compact, portable power source.

Abstract: A liquid sampling device is disclosed which is particularly suitable for sampling chemical wastes or hazardous chemicals. The device has a low resistance to flow so that composite samples can be obtained from a singal draw. A representative sample can be obtained of a liquid in a container throughout its depth, as opposed to taking several samples at various depths. The possibility of cross-contamination, when taking samples from several containers, is reduced as a result of fewer internal components and simplified replacement of contaminated parts. The overall structure, particularly that of the container for receiving and holding the sample, is simplified to make its production cost low enough for a disposable arrangement.

Abstract: A gas-to-liquid heat exchanger system which transfers heat from a gas, generally the combustion gas of a direct-fired generator of an absorption machine, to a liquid, generally an absorbent solution. The heat exchanger system is in a counterflow fluid arrangement which creates a more efficient heat transfer.

Abstract: A recuperator which recovers heat from a gas, generally the combustion gas of a direct-fired generator of an absorption machine. The recuperator includes a housing with liquid flowing therethrough, the liquid being in direct contact with the combustion gas for increasing the effectiveness of the heat transfer between the gas and the liquid.

Abstract: Apparatus for cleaning a selected surface portion of the interior liner of a tire includes a frame; three cooperative fingers adapted to be spread apart to engage the beads of a tire and to spread such beads proximate the portion of the liner to be cleaned; a brush; actuators arranged to move the brush into engagement with the liner portion; a rotary actuator arranged to spray solvent on to the liner portion; and a drain insertable into the tire to withdraw dirty solvent therefrom.