Abstract: Compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.

Abstract: A wound treatment apparatus is provided for treating tissue damage, which comprises a fluid impermeable wound cover sealed over a site for purposes of applying a reduced pressure to the site. The apparatus also can include a cover with protrusions on its surface for purposes of monitoring pressure at the site. One or more sensors can be positioned under the cover to provide feedback to a suction pump controller. The apparatus can have a miniature and portable vacuum source connected to the wound cover.

Abstract: A tape machine includes a base, one or more wheels connected to the base, one or more uprights extending upwards from the base, a roller connected to the base, and a tape roll housing connected to the uprights and configured to receive a roll of tape therein to allow for rotational unwinding of the roll of tape. A cutter connected to the base and moveable between an idle position and a cut position. A blade on the cutter is moveable to cut the tape when in cut position.

Abstract: A portable railroad spike remover comprises a claw assembly extractor that is shaped to engage and secure a railroad spike previously installed into a rail tie. The claw assembly extractor may include a pair of jaw members that are pivotally connected to each other by a pivoting pin and a rotating pin. Each jaw member may include a lower end configured to contact and secure a railroad spike and a pair of upper members interlocked with each other and pivotally connected to the clevis fastener with the rotating pin. When the drive shaft is rotated, the claw assembly extractor and the mounting flange may move inside the main housing in a vertical direction to extract the railroad spike from the rail tie.

Abstract: A nacelle system is disclosed. In various embodiments, the nacelle system may include a nacelle component; an attachment structure; and a bracket configured to secure the nacelle component to the attachment structure, the bracket comprising a first arm having a first bead structure disposed between a proximal end and a distal end of the bracket.

Abstract: A portable railroad spike remover comprises an extractor that is shaped to engage and secure a railroad spike previously installed into a rail tie. A drive shaft is connected to the extractor such that as the drive shaft is rotated, the extractor is vertically raised and lowered within a main column. The extractor may have an opening extending through at least one side to engage the railroad spike.

Abstract: A system and method for constructing a digital composite image of a three-dimensional biological sample. The system includes an optical system that captures images of cells and tissue presented on a specimen slide. The system systematically acquires a stack of images at different segments across the specimen slide. For each segment, the system dynamically calculates an optimal focal plane. Once an optimal focal plane is determined for each of the stacks of images, the system generates a composite image by copying the sharpest objects from each of the optimal focal planes.

Abstract: A panel for attenuating noise is disclosed comprising a face skin having a first inner surface, a base skin having a second inner surface, a cellular core connected to and forming a plurality of cells between the face skin and the base skin, wherein the cellular core is defined by a cell structure having a plurality of cell walls extending between the face skin and the base skin defining each of the plurality of cells and a septum disposed within each of the plurality of cells, the septum defining an upper chamber proximate the face skin and a lower chamber proximate the base skin, wherein the face skin comprises a plurality of perforations fully through the face skin and in fluid communication with the upper chamber.

Abstract: Certain aspects and features of the present disclosure relate to systems and methods for automatically classifying hosts in real-time. For instance, classifying hosts as bots, and subsequently mitigating or blocking traffic from the hosts classified as bots can be advantageous in real-time data exchange systems. In a real-time data exchange system, data can be exchanged between a server and a target host in real-time when the target host accesses a webpage. Inhibiting data communication between servers and hosts operated by bot scripts can reduce fraudulent activity. In some implementations, hosts can be automatically classified into various groups based at least in part on the data included in requests received from the hosts.

Abstract: In one or more arrangements, an umbrella system includes a support pole connected to a rotating tube positioned around a center tube that extends between the support pole and a upper hub that is connected to an umbrella frame. The rotating tube has one or more helical grooves therein that are engaged by a lower hub which is connected to the umbrella frame. As the rotating tube is rotated, the lower hub is driven along the length of the rotating tube, thereby opening and closing the umbrella frame. In one or more arrangements, the system includes a rotational lock assembly configured to prevent rotation of the rotating tube when locked and permit rotation of the rotating tube when unlocked. In one or more arrangements, the system includes a counterbalance assembly that provides a counterbalance force positioned within a upper hub of the umbrella frame.

Abstract: An engineered stone product is made using a material that includes ceramic powder, glass sand, and a binder.

Abstract: An image sensor may include a shared pixel circuit having multiple photodiodes coupled to a common floating diffusion node via respective charge transfer gates. First, the pixel circuit may be reset, and a sample-and-hold reset (SHR) value may be read out. Charge from a first of the photodiodes may be transferred to the floating diffusion node, and a first sample-and-hold signal (SHS) value may be read out. A first correlated double sampling (CDS) value is obtained by computing the difference between the SHR value and the first SHS value. Without resetting again, charge from a second of the photodiodes may be transferred to the floating diffusion node, and a second SHS value may be read out. A second CDS value is obtained by computing the difference between the first and second SHS values. Reading out the shared pixel circuit in this way substantially reduces power consumption.

Abstract: A system for managing collections having multiple content types can include a screen data capture module to capture screen data in a window having a window privacy setting presented to a user on a display device, a mixed-media collection (MMC) managing module configured to manage an MMC incorporating the captured screen data, and an MMC storage module configured to store the MMC. The MMC managing module can alter the captured screen data based on the window privacy setting.

Abstract: Disclosed herein are apparatuses and methods for treating, a wound by applying reduced or negative pressure to the wound. The apparatus can include a wound cover, a fluid collection container, a vacuum pump, an inflation pump, and one or more conduits. The wound cover can be configured to move between at least a relatively rigid, generally raised position and a relatively flexible, generally collapsed position according to a predetermined program or in response to input from a user or one or more sensors. In some embodiments, the wound cover can be configured to move between at least the relatively rigid, generally raised position and the relatively flexible, generally collapsed position by adjusting the air pressure in one or more channels in the wound cover or by adjusting the length of piezoelectric or other length changing material supported by the wound cover.

Abstract: A portable railroad spike remover comprises an extractor that is shaped to engage and secure a railroad spike previously installed into a rail tie. A drive shaft is connected to the extractor such that as the drive shaft is rotated, the extractor is vertically raised and lowered within a main column. The extractor may have an opening extending through at least one side to engage the railroad spike.

Abstract: Spent nuclear fuel is added to an electro-reduction cell, wherein the electro-reduction cell includes a halide salt electrolyte, and anode, and a cathode including an alloy of uranium and a first metal forming a low melting point alloy with uranium, the first metal being one or more of: iron; chromium; nickel; manganese; and cobalt. The spent nuclear fuel is electrochemically reduced at a potential sufficient to reduce plutonium and lanthanides in the spent nuclear fuel, to form a molten alloy of the first metal, uranium and higher actinides present in the spent nuclear fuel. The alloy is extracted from the electro-reduction cell while uranium oxide is present in the electro-reduction cell. The spent nuclear fuel includes uranium oxide and at least 1 mol of lanthanides per tonne of uranium in the spent nuclear fuel, and the electro-reduction cell is operated at a temperature above the melting point of the alloy.

Abstract: An umbrella system includes a support pole connected to a rotating tube positioned around a center tube that extends between the support pole and a center support that is connected to an umbrella frame. The rotating tube has one or more helical grooves therein that are engaged by teeth of a hub which is connected to the umbrella frame. As the rotating tube is rotated, the hub is driven along the length of the rotating tube thereby opening and closing the umbrella frame. In one arrangement system includes a motor housing assembly including a plurality of batteries and a motor that includes a driven gear that meshes with a stationary gear which causes rotation of the rotating tube.

Abstract: According to one aspect, a packaging comprises a substrate comprising a first panel including a first end, a second end spaced a first distance from the first end, and opposing first and second perimeter side edges extending the first distance between the first end and the second end. The entire first panel is symmetric about a first longitudinal axis thereof extending between the first end and the second end and each of the first and second perimeter side edges is disposed at first and second widths, respectively, from the first longitudinal axis at a first portion of the first panel. The first portion is disposed at least one of at the second end and proximal the second end and the first portion has a longitudinal extent along the first longitudinal axis less than the first distance.

Abstract: A tape machine includes a base, one or more wheels connected to the base, one or more uprights extending upwards from the base, a roller connected to the base, and a tape roll housing connected to the uprights and configured to receive a roll of tape therein to allow for rotational unwinding of the roll of tape. A cutter connected to the base and moveable between an idle position and a cut position. A blade on the cutter is moveable to cut the tape when in cut position.

Abstract: A portable railroad spike remover comprises an extractor that is shaped to engage and secure a railroad spike previously installed into a rail tie. A drive shaft is connected to the extractor such that as the drive shaft is rotated, the extractor is vertically raised and lowered within a main column. The extractor may have an opening extending through at least one side to engage the railroad spike.